Overview

About the GPCR ligand binding pathway

There are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all physiological processes (Frederiksson 2003). GPCRs are receptors for a diverse range of ligands from large proteins to photons (Kristiansen et al. 2004) and have an equal diversity of ligand-binding mechanisms (Gether et al. 2002).

The longest variant of each gene is displayed. Click the see gene variants link to see all gene variants.

447 geneClick for more »

Gene Symbol Full Name
ADORA1 adenosine A1 receptor
ADORA2A adenosine A2a receptor
ADORA2B adenosine A2b receptor
ADORA3 adenosine A3 receptor
ADRA1D adrenoceptor alpha 1D
ADRA1B adrenoceptor alpha 1B
ADRA1A adrenoceptor alpha 1A
ADRA2A adrenoceptor alpha 2A
ADRA2B adrenoceptor alpha 2B
ADRA2C adrenoceptor alpha 2C
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
APLNR apelin receptor
ANXA1 annexin A1
APP amyloid beta (A4) precursor protein
AVP arginine vasopressin
AVPR1A arginine vasopressin receptor 1A
AVPR1B arginine vasopressin receptor 1B
AVPR2 arginine vasopressin receptor 2
OPN1SW opsin 1 (cone pigments), short-wave-sensitive
BDKRB1 bradykinin receptor B1
BDKRB2 bradykinin receptor B2
CXCR5 chemokine (C-X-C motif) receptor 5
BRS3 bombesin-like receptor 3
C3 complement component 3
C3AR1 complement component 3a receptor 1
C5 complement component 5
C5AR1 complement component 5a receptor 1
CCK cholecystokinin
CCKAR cholecystokinin A receptor
CCKBR cholecystokinin B receptor
CGA glycoprotein hormones, alpha polypeptide
CHRM1 cholinergic receptor, muscarinic 1
CHRM2 cholinergic receptor, muscarinic 2
CHRM3 cholinergic receptor, muscarinic 3
CHRM4 cholinergic receptor, muscarinic 4
CHRM5 cholinergic receptor, muscarinic 5
CCR1 chemokine (C-C motif) receptor 1
CCR3 chemokine (C-C motif) receptor 3
CCR4 chemokine (C-C motif) receptor 4
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR6 chemokine (C-C motif) receptor 6
CCR7 chemokine (C-C motif) receptor 7
CCR8 chemokine (C-C motif) receptor 8
ACKR2 atypical chemokine receptor 2
LTB4R leukotriene B4 receptor
CNR1 cannabinoid receptor 1 (brain)
CNR2 cannabinoid receptor 2 (macrophage)
CX3CR1 chemokine (C-X3-C motif) receptor 1
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
DRD5 dopamine receptor D5
S1PR1 sphingosine-1-phosphate receptor 1
LPAR1 lysophosphatidic acid receptor 1
S1PR3 sphingosine-1-phosphate receptor 3
EDN1 endothelin 1
EDN2 endothelin 2
EDN3 endothelin 3
EDNRA endothelin receptor type A
EDNRB endothelin receptor type B
F2 coagulation factor II (thrombin)
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
F2RL2 coagulation factor II (thrombin) receptor-like 2
FPR1 formyl peptide receptor 1
FPR2 formyl peptide receptor 2
FPR3 formyl peptide receptor 3
FSHB follicle stimulating hormone, beta polypeptide
FSHR follicle stimulating hormone receptor
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
GALR1 galanin receptor 1
OPN1MW opsin 1 (cone pigments), medium-wave-sensitive
GHSR growth hormone secretagogue receptor
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GNRH2 gonadotropin-releasing hormone 2
GNRHR gonadotropin-releasing hormone receptor
CCR10 chemokine (C-C motif) receptor 10
GPR4 G protein-coupled receptor 4
XCR1 chemokine (C motif) receptor 1
NPBWR1 neuropeptides B/W receptor 1
NPBWR2 neuropeptides B/W receptor 2
CXCR3 chemokine (C-X-C motif) receptor 3
PRLHR prolactin releasing hormone receptor
UTS2R urotensin 2 receptor
GPR17 G protein-coupled receptor 17
GPR18 G protein-coupled receptor 18
LPAR4 lysophosphatidic acid receptor 4
MCHR1 melanin-concentrating hormone receptor 1
GPER1 G protein-coupled estrogen receptor 1
GPR31 G protein-coupled receptor 31
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
MLNR motilin receptor
GPR39 G protein-coupled receptor 39
FFAR1 free fatty acid receptor 1

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