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ADRA2A cDNA ORF clone, Homo sapiens (human)

Gene Symbol ADRA2A
Entrez Gene ID 150
Full Name adrenoceptor alpha 2A
Synonyms ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10q25.2

Summary Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

104210


mRNA and Protein(s)

mRNA Protein Name
NM_000681 NP_000672 alpha-2A adrenergic receptor



Homo sapiens (human) ADRA2A NP_000672.3
Pan troglodytes (chimpanzee) ADRA2A XP_003312813.1
Macaca mulatta (Rhesus monkey) ADRA2A XP_001087738.2
Bos taurus (cattle) ADRA2A NP_776924.1
Mus musculus (house mouse) Adra2a NP_031443.4
Rattus norvegicus (Norway rat) Adra2a NP_036871.3
Gallus gallus (chicken) ADRA2A XP_004942333.1
Danio rerio (zebrafish) adra2a NP_997520.2
Drosophila melanogaster (fruit fly) CG18208 NP_001262714.1
Caenorhabditis elegans octr-1 NP_001024569.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following ADRA2A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ADRA2A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu19050
NM_000681 Homo sapiens adrenoceptor alpha 2A (ADRA2A), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$189.50-$265.30
$379.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu19050
Clone ID Related Accession (Same CDS sequence) NM_000681
Accession Version NM_000681.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1398bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 03-MAY-2014
Organism Homo sapiens (human)
Product alpha-2A adrenergic receptor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL158163.11, AF284095.1 and BM682651.1. This sequence is a reference standard in the RefSeqGene project. On Jul 22, 2008 this sequence version replaced gi:15718669. Sequence Note: The 5'-most in-frame translation initiation codon is selected for this RefSeq based on good conservation across mammalian species. A possible downstream start codon would result in a protein that is 15 aa shorter at the N-terminus. The literature, including PMIDs:2823383, 2568356, 1354394 and 1678390, assumes the use of the downstream start codon based on initial cloning reports, but there is no experimental evidence indicating which start codon is preferentially used in vivo. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGTTCCGCC AGGAGCAGCC GTTGGCCGAG GGCAGCTTTG CGCCCATGGG CTCCCTGCAG 
CCGGACGCGG GCAACGCGAG CTGGAACGGG ACCGAGGCGC CGGGGGGCGG CGCCCGGGCC
ACCCCTTACT CCCTGCAGGT GACGCTGACG CTGGTGTGCC TGGCCGGCCT GCTCATGCTG
CTCACCGTGT TCGGCAACGT GCTCGTCATC ATCGCCGTGT TCACGAGCCG CGCGCTCAAG
GCGCCCCAAA ACCTCTTCCT GGTGTCTCTG GCCTCGGCCG ACATCCTGGT GGCCACGCTC
GTCATCCCTT TCTCGCTGGC CAACGAGGTC ATGGGCTACT GGTACTTCGG CAAGGCTTGG
TGCGAGATCT ACCTGGCGCT CGACGTGCTC TTCTGCACGT CGTCCATCGT GCACCTGTGC
GCCATCAGCC TGGACCGCTA CTGGTCCATC ACACAGGCCA TCGAGTACAA CCTGAAGCGC
ACGCCGCGCC GCATCAAGGC CATCATCATC ACCGTGTGGG TCATCTCGGC CGTCATCTCC
TTCCCGCCGC TCATCTCCAT CGAGAAGAAG GGCGGCGGCG GCGGCCCGCA GCCGGCCGAG
CCGCGCTGCG AGATCAACGA CCAGAAGTGG TACGTCATCT CGTCGTGCAT CGGCTCCTTC
TTCGCTCCCT GCCTCATCAT GATCCTGGTC TACGTGCGCA TCTACCAGAT CGCCAAGCGT
CGCACCCGCG TGCCACCCAG CCGCCGGGGT CCGGACGCCG TCGCCGCGCC GCCGGGGGGC
ACCGAGCGCA GGCCCAACGG TCTGGGCCCC GAGCGCAGCG CGGGCCCGGG GGGCGCAGAG
GCCGAACCGC TGCCCACCCA GCTCAACGGC GCCCCTGGCG AGCCCGCGCC GGCCGGGCCG
CGCGACACCG ACGCGCTGGA CCTGGAGGAG AGCTCGTCTT CCGACCACGC CGAGCGGCCT
CCAGGGCCCC GCAGACCCGA GCGCGGTCCC CGGGGCAAAG GCAAGGCCCG AGCGAGCCAG
GTGAAGCCGG GCGACAGCCT GCCGCGGCGC GGGCCGGGGG CGACGGGGAT CGGGACGCCG
GCTGCAGGGC CGGGGGAGGA GCGCGTCGGG GCTGCCAAGG CGTCGCGCTG GCGCGGGCGG
CAGAACCGCG AGAAGCGCTT CACGTTCGTG CTGGCCGTGG TCATCGGAGT GTTCGTGGTG
TGCTGGTTCC CCTTCTTCTT CACCTACACG CTCACGGCCG TCGGGTGCTC CGTGCCACGC
ACGCTCTTCA AATTCTTCTT CTGGTTCGGC TACTGCAACA GCTCGTTGAA CCCGGTCATC
TACACCATCT TCAACCACGA TTTCCGCCGC GCCTTCAAGA AGATCCTCTG TCGGGGGGAC
AGGAAGCGGA TCGTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000672.3
CDS966..2363
Misc Feature(1)861..863(+)
Misc Feature(2)1011..1013(+)
Misc Feature(3)1134..>1520(+)
Misc Feature(4)1176..2288(+)
Exon (1)1..3876
Gene:ADRA2A
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000681
Organism Homo sapiens (human)
Definition Homo sapiens adrenoceptor alpha 2A (ADRA2A), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000681

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGTTCCGCC AGGAGCAGCC GTTGGCCGAG GGCAGCTTTG CGCCCATGGG CTCCCTGCAG 
CCGGACGCGG GCAACGCGAG CTGGAACGGG ACCGAGGCGC CGGGGGGCGG CGCCCGGGCC
ACCCCTTACT CCCTGCAGGT GACGCTGACG CTGGTGTGCC TGGCCGGCCT GCTCATGCTG
CTCACCGTGT TCGGCAACGT GCTCGTCATC ATCGCCGTGT TCACGAGCCG CGCGCTCAAG
GCGCCCCAAA ACCTCTTCCT GGTGTCTCTG GCCTCGGCCG ACATCCTGGT GGCCACGCTC
GTCATCCCTT TCTCGCTGGC CAACGAGGTC ATGGGCTACT GGTACTTCGG CAAGGCTTGG
TGCGAGATCT ACCTGGCGCT CGACGTGCTC TTCTGCACGT CGTCCATCGT GCACCTGTGC
GCCATCAGCC TGGACCGCTA CTGGTCCATC ACACAGGCCA TCGAGTACAA CCTGAAGCGC
ACGCCGCGCC GCATCAAGGC CATCATCATC ACCGTGTGGG TCATCTCGGC CGTCATCTCC
TTCCCGCCGC TCATCTCCAT CGAGAAGAAG GGCGGCGGCG GCGGCCCGCA GCCGGCCGAG
CCGCGCTGCG AGATCAACGA CCAGAAGTGG TACGTCATCT CGTCGTGCAT CGGCTCCTTC
TTCGCTCCCT GCCTCATCAT GATCCTGGTC TACGTGCGCA TCTACCAGAT CGCCAAGCGT
CGCACCCGCG TGCCACCCAG CCGCCGGGGT CCGGACGCCG TCGCCGCGCC GCCGGGGGGC
ACCGAGCGCA GGCCCAACGG TCTGGGCCCC GAGCGCAGCG CGGGCCCGGG GGGCGCAGAG
GCCGAACCGC TGCCCACCCA GCTCAACGGC GCCCCTGGCG AGCCCGCGCC GGCCGGGCCG
CGCGACACCG ACGCGCTGGA CCTGGAGGAG AGCTCGTCTT CCGACCACGC CGAGCGGCCT
CCAGGGCCCC GCAGACCCGA GCGCGGTCCC CGGGGCAAAG GCAAGGCCCG AGCGAGCCAG
GTGAAGCCGG GCGACAGCCT GCCGCGGCGC GGGCCGGGGG CGACGGGGAT CGGGACGCCG
GCTGCAGGGC CGGGGGAGGA GCGCGTCGGG GCTGCCAAGG CGTCGCGCTG GCGCGGGCGG
CAGAACCGCG AGAAGCGCTT CACGTTCGTG CTGGCCGTGG TCATCGGAGT GTTCGTGGTG
TGCTGGTTCC CCTTCTTCTT CACCTACACG CTCACGGCCG TCGGGTGCTC CGTGCCACGC
ACGCTCTTCA AATTCTTCTT CTGGTTCGGC TACTGCAACA GCTCGTTGAA CCCGGTCATC
TACACCATCT TCAACCACGA TTTCCGCCGC GCCTTCAAGA AGATCCTCTG TCGGGGGGAC
AGGAAGCGGA TCGTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

No association between MspI allele of the ADRA2A polymorphism and ADHD: meta-analysis of family-based studies
Psychiatr. Genet. 23 (4), 174-175 (2013)
Shiffrin ND, Gruber J, Glatt SJ and Faraone SV.


book

Interactive effect of MTHFR and ADRA2A gene polymorphisms on pathogenesis of schizophrenia
Neuro Endocrinol. Lett. 34 (8), 792-797 (2013)
Lochman J, Plesnik J, Janout V, Povova J, Misek I, Dvorakova D and Sery O.


book

White-matter connectivity and methylphenidate-induced changes in attentional performance according to alpha2A-adrenergic receptor gene polymorphisms in Korean children with attention-deficit hyperactivity disorder
J Neuropsychiatry Clin Neurosci 25 (3), 222-228 (2013)
Park,S., Hong,S.B., Kim,J.W., Yang,Y.H., Park,M.H., Kim,B.N., Shin,M.S., Yoo,H.J. and Cho,S.C.


book

Promoter region of the human alpha 2A adrenergic receptor gene
J. Biol. Chem. 267 (33), 24017-24022 (1992)
Handy DE and Gavras H.


book

Differential expression of two alpha 2-adrenergic receptor subtype mRNAs in human tissues
Brain Res. Mol. Brain Res. 16 (1-2), 57-63 (1992)
Perala M, Hirvonen H, Kalimo H, Ala-Uotila S, Regan JW, Akerman KE and Scheinin M.


book

A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents
Science 257 (5072), 977-980 (1992)
Surprenant A, Horstman DA, Akbarali H and Limbird LE.


book

A point mutation in the seventh hydrophobic domain of the alpha 2 adrenergic receptor increases its affinity for a family of beta receptor antagonists
J. Biol. Chem. 266 (23), 15488-15492 (1991)
Suryanarayana S, Daunt DA, Von Zastrow M and Kobilka BK.


book

Site-directed mutagenesis of alpha 2A-adrenergic receptors: identification of amino acids involved in ligand binding and receptor activation by agonists
Mol. Pharmacol. 40 (2), 168-179 (1991)
Wang CD, Buck MA and Fraser CM.


book

Cloning, sequence analysis, and permanent expression of a human alpha 2-adrenergic receptor in Chinese hamster ovary cells. Evidence for independent pathways of receptor coupling to adenylate cyclase attenuation and activation
J. Biol. Chem. 264 (20), 11754-11761 (1989)
Fraser CM, Arakawa S, McCombie WR and Venter JC.


book

Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor
Science 238 (4827), 650-656 (1987)
Kobilka BK, Matsui H, Kobilka TS, Yang-Feng TL, Francke U, Caron MG, Lefkowitz RJ and Regan JW.


 
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