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Home » Gene Synthesis & Molecular Biology Services » ORF » Hot Human pathways » TCF dependent signaling in response to WNT

Overview

About the TCF dependent signaling in response to WNT pathway

19 WNT ligands and 10 FZD receptors have been identified in human cells; interactions amongst these ligands and receptors vary in a developmental and tissue-specific manner and lead to activation of so-called 'canonical' and 'non-canonical' WNT signaling. In the canonical WNT signaling pathway, binding of a WNT ligand to the Frizzled (FZD) and lipoprotein receptor-related protein (LRP) receptors results in the inactivation of the destruction complex, the stabilization and nuclear translocation of beta-catenin and subsequent activation of T-cell factor/lymphoid enhancing factor (TCF/LEF)-dependent transcription. Transcriptional activation in response to canonical WNT signaling controls processes such as cell fate, proliferation and self renewal of stem cells, as well as contributing to oncogenesis (reviewed in MacDonald et al, 2009; Saito-Diaz et al, 2013; Kim et al, 2013).

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Gene Symbol Full Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
APC adenomatous polyposis coli
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
BCL9 B-cell CLL/lymphoma 9
CAV1 caveolin 1, caveolae protein, 22kDa
CREBBP CREB binding protein
CSNK1A1 casein kinase 1, alpha 1
CSNK1E casein kinase 1, epsilon
CSNK1G2 casein kinase 1, gamma 2
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSNK2B casein kinase 2, beta polypeptide
CTBP1 C-terminal binding protein 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DVL1 dishevelled segment polarity protein 1
DVL2 dishevelled segment polarity protein 2
DVL3 dishevelled segment polarity protein 3
EP300 E1A binding protein p300
FZD2 frizzled class receptor 2
GSK3B glycogen synthase kinase 3 beta
HIST1H2AE histone cluster 1, H2ae
HIST1H2AD histone cluster 1, H2ad
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HIST1H2BD histone cluster 1, H2bd
HIST1H2BB histone cluster 1, H2bb
H3F3A H3 histone, family 3A
H3F3B H3 histone, family 3B (H3.3B)
HDAC1 histone deacetylase 1
LRP6 low density lipoprotein receptor-related protein 6
LRP5 low density lipoprotein receptor-related protein 5
MEN1 multiple endocrine neoplasia I
MYC v-myc avian myelocytomatosis viral oncogene homolog
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PSMA1 proteasome subunit alpha 1
PSMA2 proteasome subunit alpha 2
PSMA3 proteasome subunit alpha 3
PSMA4 proteasome subunit alpha 4
PSMA5 proteasome subunit alpha 5
PSMA6 proteasome subunit alpha 6
PSMA7 proteasome subunit alpha 7
PSMB1 proteasome subunit beta 1
PSMB2 proteasome subunit beta 2
PSMB3 proteasome subunit beta 3
PSMB4 proteasome subunit beta 4
PSMB5 proteasome subunit beta 5
PSMB6 proteasome subunit beta 6
PSMB7 proteasome subunit beta 7
PSMB8 proteasome subunit beta 8
PSMB9 proteasome subunit beta 9
PSMB10 proteasome subunit beta 10
PSMC1 proteasome 26S subunit, ATPase 1
PSMC2 proteasome 26S subunit, ATPase 2
PSMC3 proteasome 26S subunit, ATPase 3
PSMC4 proteasome 26S subunit, ATPase 4
PSMC5 proteasome 26S subunit, ATPase 5
PSMC6 proteasome 26S subunit, ATPase 6
PSMD1 proteasome 26S subunit, non-ATPase 1
PSMD2 proteasome 26S subunit, non-ATPase 2
PSMD3 proteasome 26S subunit, non-ATPase 3
PSMD4 proteasome 26S subunit, non-ATPase 4
PSMD5 proteasome 26S subunit, non-ATPase 5
PSMD7 proteasome 26S subunit, non-ATPase 7
PSMD8 proteasome 26S subunit, non-ATPase 8
PSMD9 proteasome 26S subunit, non-ATPase 9
PSMD10 proteasome 26S subunit, non-ATPase 10
PSMD11 proteasome 26S subunit, non-ATPase 11
PSMD12 proteasome 26S subunit, non-ATPase 12
PSMD13 proteasome 26S subunit, non-ATPase 13
PSME1 proteasome activator subunit 1
PSME2 proteasome activator subunit 2
RBBP5 retinoblastoma binding protein 5
RPS27A ribosomal protein S27a
RYK receptor-like tyrosine kinase
SFRP1 secreted frizzled-related protein 1
SFRP2 secreted frizzled-related protein 2
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SOX2 SRY (sex determining region Y)-box 2
SOX3 SRY (sex determining region Y)-box 3
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SRY sex determining region Y
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TERT telomerase reverse transcriptase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLE2 transducin-like enhancer of split 2
TLE3 transducin-like enhancer of split 3
TLE4 transducin-like enhancer of split 4
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B

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