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PPP2R1A cDNA ORF clone, Homo sapiens (human)

Gene Symbol PPP2R1A
Entrez Gene ID 5518
Full Name protein phosphatase 2, regulatory subunit A, alpha
Synonyms MRD36, PP2A-Aalpha, PP2AAALPHA, PR65A
General protein information
Preferred Names
serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Names
serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
PP2A subunit A isoform R1-alpha
PP2A subunit A isoform PR65-alpha
medium tumor antigen-associated 61 KDA protein
protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform
serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit A, alpha isoform
NP_055040.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19q13.41

Summary This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]. lac of sum
Disorder MIM:

605983


mRNA and Protein(s)

mRNA Protein Name
NM_014225 NP_055040 serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform



Homo sapiens (human) PPP2R1A NP_055040.2
Pan troglodytes (chimpanzee) PPP2R1A XP_001174546.1
Macaca mulatta (Rhesus monkey) PPP2R1A XP_001116604.1
Canis lupus familiaris (dog) LOC484335 XP_850993.1
Bos taurus (cattle) PPP2R1A NP_001032554.1
Mus musculus (house mouse) Ppp2r1a NP_058587.1
Rattus norvegicus (Norway rat) Ppp2r1a NP_476481.1
Drosophila melanogaster (fruit fly) Pp2A-29B NP_001027225.1
Caenorhabditis elegans paa-1 NP_498162.2
Arabidopsis thaliana (thale cress) RCN1 NP_173920.1
Xenopus (Silurana) tropicalis (western clawed frog) ppp2r1a NP_989405.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PPP2R1A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PPP2R1A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu32300
NM_014225 Homo sapiens protein phosphatase 2, regulatory subunit A, alpha (PPP2R1A), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu32300
Clone ID Related Accession (Same CDS sequence) NM_014225
Accession Version NM_014225.5 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1770bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 16-MAY-2015
Organism Homo sapiens (human)
Product serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC398468.1, BC026733.1 and CA426613.1. On Apr 16, 2010 this sequence version replaced gi:206725413. Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK290593.1, BC026733.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
ATGGCGGCGG CCGACGGCGA CGACTCGCTG TACCCCATCG CGGTGCTCAT AGACGAACTC 
CGCAATGAGG ACGTTCAGCT TCGCCTCAAC AGCATCAAGA AGCTGTCCAC CATCGCCTTG
GCCCTTGGGG TTGAAAGGAC CCGAAGTGAG CTTCTGCCTT TCCTTACAGA TACCATCTAT
GATGAAGATG AGGTCCTCCT GGCCCTGGCA GAACAGCTGG GAACCTTCAC TACCCTGGTG
GGAGGCCCAG AGTACGTGCA CTGCCTGCTG CCACCGCTGG AGTCGCTGGC CACAGTGGAG
GAGACAGTGG TGCGGGACAA GGCAGTGGAG TCCTTACGGG CCATCTCACA CGAGCACTCG
CCCTCTGACC TGGAGGCGCA CTTTGTGCCG CTAGTGAAGC GGCTGGCGGG CGGCGACTGG
TTCACCTCCC GCACCTCGGC CTGCGGCCTC TTCTCCGTCT GCTACCCCCG AGTGTCCAGT
GCTGTGAAGG CGGAACTTCG ACAGTACTTC CGGAACCTGT GCTCAGATGA CACCCCCATG
GTGCGGCGGG CCGCAGCCTC CAAGCTGGGG GAGTTTGCCA AGGTGCTGGA GCTGGACAAC
GTCAAGAGTG AGATCATCCC CATGTTCTCC AACCTGGCCT CTGACGAGCA GGACTCGGTG
CGGCTGCTGG CGGTGGAGGC GTGCGTGAAC ATCGCCCAGC TTCTGCCCCA GGAGGATCTG
GAGGCCCTGG TGATGCCCAC TCTGCGCCAG GCCGCTGAAG ACAAGTCCTG GCGCGTCCGC
TACATGGTGG CTGACAAGTT CACAGAGCTC CAGAAAGCAG TGGGGCCTGA GATCACCAAG
ACAGACCTGG TCCCTGCCTT CCAGAACCTG ATGAAAGACT GTGAGGCCGA GGTGAGGGCC
GCAGCCTCCC ACAAGGTCAA AGAGTTCTGT GAAAACCTCT CAGCTGACTG TCGGGAGAAT
GTGATCATGT CCCAGATCTT GCCCTGCATC AAGGAGCTGG TGTCCGATGC CAACCAACAT
GTCAAGTCTG CCCTGGCCTC AGTCATCATG GGTCTCTCTC CCATCTTGGG CAAAGACAAC
ACCATCGAGC ACCTCTTGCC CCTCTTCCTG GCTCAGCTGA AGGATGAGTG CCCTGAGGTA
CGGCTGAACA TCATCTCTAA CCTGGACTGT GTGAACGAGG TGATTGGCAT CCGGCAGCTG
TCCCAGTCCC TGCTCCCTGC CATTGTGGAG CTGGCTGAGG ACGCCAAGTG GCGGGTGCGG
CTGGCCATCA TTGAGTACAT GCCCCTCCTG GCTGGACAGC TGGGAGTGGA GTTCTTTGAT
GAGAAACTTA ACTCCTTGTG CATGGCCTGG CTTGTGGATC ATGTATATGC CATCCGCGAG
GCAGCCACCA GCAACCTGAA GAAGCTAGTG GAAAAGTTTG GGAAGGAGTG GGCCCATGCC
ACAATCATCC CCAAGGTCTT GGCCATGTCC GGAGACCCCA ACTACCTGCA CCGCATGACT
ACGCTCTTCT GCATCAATGT GCTGTCTGAG GTCTGTGGGC AGGACATCAC CACCAAGCAC
ATGCTACCCA CGGTTCTGCG CATGGCTGGG GACCCGGTTG CCAATGTCCG CTTCAATGTG
GCCAAGTCTC TGCAGAAGAT AGGGCCCATC CTGGACAACA GCACCTTGCA GAGTGAAGTC
AAGCCCATCC TAGAGAAGCT GACCCAGGAC CAGGATGTGG ACGTCAAATA CTTTGCCCAG
GAGGCTCTGA CTGTTCTGTC TCTCGCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_055040.2
CDS296..2065
Misc Feature(1)272..274(+)
Misc Feature(2)299..301(+)
Misc Feature(3)317..1492(+)
Misc Feature(4)434..1258(+)
Misc Feature(5)548..1012(+)
Misc Feature(6)830..988(+)
Misc Feature(7)854..>1681(+)
Misc Feature(8)1133..1135(+)
Misc Feature(9)1481..>1657(+)
Misc Feature(10)1493..2062(+)
Misc Feature(11)1757..2044(+)
Exon (1)1..373
Gene:PPP2R1A
Gene Synonym:
Exon (2)374..464
Gene:PPP2R1A
Gene Synonym:
Exon (3)465..565
Gene:PPP2R1A
Gene Synonym:
Exon (4)566..798
Gene:PPP2R1A
Gene Synonym:
Exon (5)799..946
Gene:PPP2R1A
Gene Synonym:
Exon (6)947..1102
Gene:PPP2R1A
Gene Synonym:
Exon (7)1103..1217
Gene:PPP2R1A
Gene Synonym:
Exon (8)1218..1288
Gene:PPP2R1A
Gene Synonym:
Exon (9)1289..1423
Gene:PPP2R1A
Gene Synonym:
Exon (10)1424..1597
Gene:PPP2R1A
Gene Synonym:
Exon (11)1598..1658
Gene:PPP2R1A
Gene Synonym:
Exon (12)1659..1813
Gene:PPP2R1A
Gene Synonym:
Exon (13)1814..1956
Gene:PPP2R1A
Gene Synonym:
Exon (14)1957..2048
Gene:PPP2R1A
Gene Synonym:
Exon (15)2049..2509
Gene:PPP2R1A
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_014225
Organism Homo sapiens (human)
Definition Homo sapiens protein phosphatase 2, regulatory subunit A, alpha (PPP2R1A), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_014225

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
ATGGCGGCGG CCGACGGCGA CGACTCGCTG TACCCCATCG CGGTGCTCAT AGACGAACTC 
CGCAATGAGG ACGTTCAGCT TCGCCTCAAC AGCATCAAGA AGCTGTCCAC CATCGCCTTG
GCCCTTGGGG TTGAAAGGAC CCGAAGTGAG CTTCTGCCTT TCCTTACAGA TACCATCTAT
GATGAAGATG AGGTCCTCCT GGCCCTGGCA GAACAGCTGG GAACCTTCAC TACCCTGGTG
GGAGGCCCAG AGTACGTGCA CTGCCTGCTG CCACCGCTGG AGTCGCTGGC CACAGTGGAG
GAGACAGTGG TGCGGGACAA GGCAGTGGAG TCCTTACGGG CCATCTCACA CGAGCACTCG
CCCTCTGACC TGGAGGCGCA CTTTGTGCCG CTAGTGAAGC GGCTGGCGGG CGGCGACTGG
TTCACCTCCC GCACCTCGGC CTGCGGCCTC TTCTCCGTCT GCTACCCCCG AGTGTCCAGT
GCTGTGAAGG CGGAACTTCG ACAGTACTTC CGGAACCTGT GCTCAGATGA CACCCCCATG
GTGCGGCGGG CCGCAGCCTC CAAGCTGGGG GAGTTTGCCA AGGTGCTGGA GCTGGACAAC
GTCAAGAGTG AGATCATCCC CATGTTCTCC AACCTGGCCT CTGACGAGCA GGACTCGGTG
CGGCTGCTGG CGGTGGAGGC GTGCGTGAAC ATCGCCCAGC TTCTGCCCCA GGAGGATCTG
GAGGCCCTGG TGATGCCCAC TCTGCGCCAG GCCGCTGAAG ACAAGTCCTG GCGCGTCCGC
TACATGGTGG CTGACAAGTT CACAGAGCTC CAGAAAGCAG TGGGGCCTGA GATCACCAAG
ACAGACCTGG TCCCTGCCTT CCAGAACCTG ATGAAAGACT GTGAGGCCGA GGTGAGGGCC
GCAGCCTCCC ACAAGGTCAA AGAGTTCTGT GAAAACCTCT CAGCTGACTG TCGGGAGAAT
GTGATCATGT CCCAGATCTT GCCCTGCATC AAGGAGCTGG TGTCCGATGC CAACCAACAT
GTCAAGTCTG CCCTGGCCTC AGTCATCATG GGTCTCTCTC CCATCTTGGG CAAAGACAAC
ACCATCGAGC ACCTCTTGCC CCTCTTCCTG GCTCAGCTGA AGGATGAGTG CCCTGAGGTA
CGGCTGAACA TCATCTCTAA CCTGGACTGT GTGAACGAGG TGATTGGCAT CCGGCAGCTG
TCCCAGTCCC TGCTCCCTGC CATTGTGGAG CTGGCTGAGG ACGCCAAGTG GCGGGTGCGG
CTGGCCATCA TTGAGTACAT GCCCCTCCTG GCTGGACAGC TGGGAGTGGA GTTCTTTGAT
GAGAAACTTA ACTCCTTGTG CATGGCCTGG CTTGTGGATC ATGTATATGC CATCCGCGAG
GCAGCCACCA GCAACCTGAA GAAGCTAGTG GAAAAGTTTG GGAAGGAGTG GGCCCATGCC
ACAATCATCC CCAAGGTCTT GGCCATGTCC GGAGACCCCA ACTACCTGCA CCGCATGACT
ACGCTCTTCT GCATCAATGT GCTGTCTGAG GTCTGTGGGC AGGACATCAC CACCAAGCAC
ATGCTACCCA CGGTTCTGCG CATGGCTGGG GACCCGGTTG CCAATGTCCG CTTCAATGTG
GCCAAGTCTC TGCAGAAGAT AGGGCCCATC CTGGACAACA GCACCTTGCA GAGTGAAGTC
AAGCCCATCC TAGAGAAGCT GACCCAGGAC CAGGATGTGG ACGTCAAATA CTTTGCCCAG
GAGGCTCTGA CTGTTCTGTC TCTCGCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

PR65A phosphorylation regulates PP2A complex signaling
PLoS ONE 9 (1), E85000 (2014)
Kotlo K, Xing Y, Lather S, Grillon JM, Johnson K, Skidgel RA, Solaro RJ and Danziger RS.


book

Intermittent hypoxia-induced protein phosphatase 2A activation reduces PC12 cell proliferation and differentiation
J. Biomed. Sci. 21, 46 (2014)
Chen TI, Chiu HW, Pan YC, Hsu ST, Lin JH and Yang KT.


book

Complex energy landscape of a giant repeat protein
Structure 21 (11), 1954-1965 (2013)
Tsytlonok M, Craig PO, Sivertsson E, Serquera D, Perrett S, Best RB, Wolynes PG and Itzhaki LS.


book

Functional genetic polymorphisms in PP2A subunit genes confer increased risks of lung cancer in southern and eastern Chinese
PLoS ONE 8 (10), E77285 (2013)
Yang R, Yang L, Qiu F, Zhang L, Wang H, Yang X, Deng J, Fang W, Zhou Y and Lu J.


book

Infrequent mutations of the PPP2R1A and PPP2R1B genes in patients with ovarian cancer
Mol Med Rep 7 (6), 1826-1830 (2013)
Wang F, Zou Y, Liu FY, Yu XH, Huang H, Zhang N, Qi YY, Liu RF, Liu XY, Chen J, Huang OP and He M.


book

Identification of a new family of protein phosphatase 2A regulatory subunits
J. Biol. Chem. 270 (44), 26123-26128 (1995)
McCright B and Virshup DM.


book

Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function
J. Cell Biol. 129 (6), 1617-1628 (1995)
Golsteyn RM, Mundt KE, Fry AM and Nigg EA.


book

alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure
Biochemistry 29 (13), 3166-3173 (1990)
Hemmings BA, Adams-Pearson C, Maurer F, Muller P, Goris J, Merlevede W, Hofsteenge J and Stone SR.


book

Association of protein phosphatase 2A with polyoma virus medium tumor antigen
Proc. Natl. Acad. Sci. U.S.A. 87 (7), 2521-2525 (1990)
Walter G, Ruediger R, Slaughter C and Mumby M.


book

Molecular cloning and sequence of cDNA encoding polyoma medium tumor antigen-associated 61-kDa protein
Proc. Natl. Acad. Sci. U.S.A. 86 (22), 8669-8672 (1989)
Walter G, Ferre F, Espiritu O and Carbone-Wiley A.


 
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