PSMB7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PSMB7
Entrez Gene ID	5695
Full Name	proteasome subunit beta 7
Synonyms	Z
General protein information	Preferred Names proteasome subunit beta 7 Names proteasome subunit beta type-7 macropain chain Z multicatalytic endopeptidase complex chain Z proteasome (prosome, macropain) subunit, beta type, 7 proteasome catalytic subunit 2 proteasome subunit Z proteasome subunit alpha protein serine kinase c17
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9q33.3
Summary	The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon, and proteolytic processing is required to generate a mature subunit. A pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Jul 2012].
Disorder MIM:	604030

mRNA and Protein(s)

mRNA	Protein	Name
NM_002799.3	NP_002790.1	proteasome subunit beta type-7 precursor
NM_002799.4	NP_002790.1	proteasome subunit beta type-7 precursor

Pathways from BioSystems

Homologies

	PSMB7	XP_001083368.1
Danio rerio (zebrafish)	psmb7	NP_001039029.2
Schizosaccharomyces pombe (fission yeast)	pup1	NP_594544.1
Magnaporthe oryzae (rice blast fungus)	MGG_04529	XP_003713580.1
Arabidopsis thaliana (thale cress)	PBB2	NP_851108.1
Pan troglodytes (chimpanzee)	PSMB7	XP_520247.2
Drosophila melanogaster (fruit fly)	Prosbeta2	NP_524076.2
Xenopus tropicalis (tropical clawed frog)	psmb7	XP_002938794.1
Canis lupus familiaris (dog)	PSMB7	XP_003435386.1
Saccharomyces cerevisiae (baker's yeast)	PUP1	NP_014800.3
Arabidopsis thaliana (thale cress)	PBB1	NP_566818.1
Oryza sativa (rice)	Os05g0187000	NP_001054834.1
Bos taurus (cattle)	PSMB7	NP_001033616.1
Gallus gallus (chicken)	PSMB7	NP_989728.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011423	XP_317882.3
Kluyveromyces lactis	KLLA0A02233g	XP_451099.1
Homo sapiens (human)	PSMB7	NP_002790.1
Mus musculus (house mouse)	Psmb7	NP_035317.1
Rattus norvegicus (Norway rat)	Psmb7	NP_445984.1
Neurospora crassa	NCU08605	XP_964037.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Protein Z and Endothelin-1 genetic polymorphisms in pediatric Egyptian sickle cell disease patients.
Khorshied MM, Mohamed NS, Hamza RS, Ali RM, El-Ghamrawy MK
Journal of clinical laboratory analysis(2017 May)

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.
Hasson SA, Kane LA, Yamano K, Huang CH, Sliter DA, Buehler E, Wang C, Heman-Ackah SM, Hessa T, Guha R, Martin SE, Youle RJ
Nature504(7479)291-5(2013 Dec)

Decreased proteinZ levels in patients with rheumatoid arthritis: links with inflammation.
Krawiec P, Gluszko P, Kwasny-Krochin B, Undas A
Thrombosis and haemostasis106(3)548-50(2011 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

reduced protein levels in patients with rheumatoid arthritis in association with disease progression
Title: Decreased proteinZ levels in patients with rheumatoid arthritis: links with inflammation.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

high PSMB7 expression is associated with anthracycline resistance in breast cancer.
Title: PSMB7 is associated with anthracycline resistance and is a prognostic biomarker in breast cancer.

we have identified and characterized a new phosphorylated isoform of the human 20S proteasome b7 subunit and showed its differential expression in tumor vs. normal cell lines
Title: Characterization and differential expression of a newly identified phosphorylated isoform of the human 20S proteasome beta7 subunit in tumor vs. normal cell lines.

ZPI functions like other serpins to regulate the activity of FXa but in a manner uniquely dependent on protein Z, procoagulant membranes, and pH
Title: Kinetic characterization of the protein Z-dependent protease inhibitor reaction with blood coagulation factor Xa.

The following PSMB7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PSMB7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03114	NM_002799.4 Latest version!	Homo sapiens proteasome 20S subunit beta 7 (PSMB7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
View Old Accession Versions >>
OHu03114	NM_002799.3	Homo sapiens proteasome subunit beta 7 (PSMB7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PSMB7 ( NM_002799.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002790.1 Homo sapiens proteasome subunit beta 7 (PSMB7), mRNA.

Price & Availability↑

CloneID	OHu03114
Clone ID Related Accession (Same CDS sequence)	NM_002799.3 , NM_002799.4
Accession Version	NM_002799.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 834bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	proteasome subunit beta type-7 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK308756.1 and GU727627.1. On Jul 7, 2012 this sequence version replaced NM_002799.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: GU727627.1, SRR1163657.420081.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2157437, SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCTG TGTCGGTGTA TGCTCCACCA GTTGGAGGCT TCTCTTTTGA TAACTGCCGC 
AGGAATGCCG TCTTGGAAGC CGATTTTGCA AAGAGGGGAT ACAAGCTTCC AAAGGTCCGG 
AAAACTGGCA CGACCATCGC TGGGGTGGTC TATAAGGATG GCATAGTTCT TGGAGCAGAT 
ACAAGAGCAA CTGAAGGGAT GGTTGTTGCT GACAAGAACT GTTCAAAAAT ACACTTCATA 
TCTCCTAATA TTTATTGTTG TGGTGCTGGG ACAGCTGCAG ACACAGACAT GACAACCCAG 
CTCATTTCTT CCAACCTGGA GCTCCACTCC CTCTCCACTG GCCGTCTTCC CAGAGTTGTG 
ACAGCCAATC GGATGCTGAA GCAGATGCTT TTCAGGTATC AAGGTTACAT TGGTGCAGCC 
CTAGTTTTAG GGGGAGTAGA TGTTACTGGA CCTCACCTCT ACAGCATCTA TCCTCATGGA 
TCAACTGATA AGTTGCCTTA TGTCACCATG GGTTCTGGCT CCTTGGCAGC AATGGCTGTA 
TTTGAAGATA AGTTTAGGCC AGACATGGAG GAGGAGGAAG CCAAGAATCT GGTGAGCGAA 
GCCATCGCAG CTGGCATCTT CAACGACCTG GGCTCCGGAA GCAACATTGA CCTCTGCGTC 
ATCAGCAAGA ACAAGCTGGA TTTTCTCCGC CCATACACAG TGCCCAACAA GAAGGGGACC 
AGGCTTGGCC GGTACAGGTG TGAGAAAGGG ACTACTGCAG TCCTCACTGA GAAAATCACT 
CCTCTGGAGA TTGAGGTGCT GGAAGAAACA GTCCAAACAA TGGACACTTC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002790.1
CDS	49..882
Translation	MAAVSVYAPPVGGFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGTRLGRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDTS

Target ORF information:

RefSeq Version	NM_002799.3
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome subunit beta 7 (PSMB7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002799.3

ORF Insert Sequence:

ATGGCGGCTG TGTCGGTGTA TGCTCCACCA GTTGGAGGCT TCTCTTTTGA TAACTGCCGC 
AGGAATGCCG TCTTGGAAGC CGATTTTGCA AAGAGGGGAT ACAAGCTTCC AAAGGTCCGG 
AAAACTGGCA CGACCATCGC TGGGGTGGTC TATAAGGATG GCATAGTTCT TGGAGCAGAT 
ACAAGAGCAA CTGAAGGGAT GGTTGTTGCT GACAAGAACT GTTCAAAAAT ACACTTCATA 
TCTCCTAATA TTTATTGTTG TGGTGCTGGG ACAGCTGCAG ACACAGACAT GACAACCCAG 
CTCATTTCTT CCAACCTGGA GCTCCACTCC CTCTCCACTG GCCGTCTTCC CAGAGTTGTG 
ACAGCCAATC GGATGCTGAA GCAGATGCTT TTCAGGTATC AAGGTTACAT TGGTGCAGCC 
CTAGTTTTAG GGGGAGTAGA TGTTACTGGA CCTCACCTCT ACAGCATCTA TCCTCATGGA 
TCAACTGATA AGTTGCCTTA TGTCACCATG GGTTCTGGCT CCTTGGCAGC AATGGCTGTA 
TTTGAAGATA AGTTTAGGCC AGACATGGAG GAGGAGGAAG CCAAGAATCT GGTGAGCGAA 
GCCATCGCAG CTGGCATCTT CAACGACCTG GGCTCCGGAA GCAACATTGA CCTCTGCGTC 
ATCAGCAAGA ACAAGCTGGA TTTTCTCCGC CCATACACAG TGCCCAACAA GAAGGGGACC 
AGGCTTGGCC GGTACAGGTG TGAGAAAGGG ACTACTGCAG TCCTCACTGA GAAAATCACT 
CCTCTGGAGA TTGAGGTGCT GGAAGAAACA GTCCAAACAA TGGACACTTC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSMB7 ( NM_002799.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002790.1 Homo sapiens proteasome 20S subunit beta 7 (PSMB7), mRNA.

Price & Availability↑

CloneID	OHu03114
Clone ID Related Accession (Same CDS sequence)	NM_002799.3 , NM_002799.4
Accession Version	NM_002799.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 834bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	proteasome subunit beta type-7 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from GU727627.1. On Nov 23, 2018 this sequence version replaced NM_002799.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: GU727627.1, SRR5189652.206633.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2157437, SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000259457.8/ ENSP00000259457.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCTG TGTCGGTGTA TGCTCCACCA GTTGGAGGCT TCTCTTTTGA TAACTGCCGC 
AGGAATGCCG TCTTGGAAGC CGATTTTGCA AAGAGGGGAT ACAAGCTTCC AAAGGTCCGG 
AAAACTGGCA CGACCATCGC TGGGGTGGTC TATAAGGATG GCATAGTTCT TGGAGCAGAT 
ACAAGAGCAA CTGAAGGGAT GGTTGTTGCT GACAAGAACT GTTCAAAAAT ACACTTCATA 
TCTCCTAATA TTTATTGTTG TGGTGCTGGG ACAGCTGCAG ACACAGACAT GACAACCCAG 
CTCATTTCTT CCAACCTGGA GCTCCACTCC CTCTCCACTG GCCGTCTTCC CAGAGTTGTG 
ACAGCCAATC GGATGCTGAA GCAGATGCTT TTCAGGTATC AAGGTTACAT TGGTGCAGCC 
CTAGTTTTAG GGGGAGTAGA TGTTACTGGA CCTCACCTCT ACAGCATCTA TCCTCATGGA 
TCAACTGATA AGTTGCCTTA TGTCACCATG GGTTCTGGCT CCTTGGCAGC AATGGCTGTA 
TTTGAAGATA AGTTTAGGCC AGACATGGAG GAGGAGGAAG CCAAGAATCT GGTGAGCGAA 
GCCATCGCAG CTGGCATCTT CAACGACCTG GGCTCCGGAA GCAACATTGA CCTCTGCGTC 
ATCAGCAAGA ACAAGCTGGA TTTTCTCCGC CCATACACAG TGCCCAACAA GAAGGGGACC 
AGGCTTGGCC GGTACAGGTG TGAGAAAGGG ACTACTGCAG TCCTCACTGA GAAAATCACT 
CCTCTGGAGA TTGAGGTGCT GGAAGAAACA GTCCAAACAA TGGACACTTC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002790.1
CDS	18..851
Translation	MAAVSVYAPPVGGFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGTRLGRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDTS

Target ORF information:

RefSeq Version	NM_002799.4
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome 20S subunit beta 7 (PSMB7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002799.4

ORF Insert Sequence:

ATGGCGGCTG TGTCGGTGTA TGCTCCACCA GTTGGAGGCT TCTCTTTTGA TAACTGCCGC 
AGGAATGCCG TCTTGGAAGC CGATTTTGCA AAGAGGGGAT ACAAGCTTCC AAAGGTCCGG 
AAAACTGGCA CGACCATCGC TGGGGTGGTC TATAAGGATG GCATAGTTCT TGGAGCAGAT 
ACAAGAGCAA CTGAAGGGAT GGTTGTTGCT GACAAGAACT GTTCAAAAAT ACACTTCATA 
TCTCCTAATA TTTATTGTTG TGGTGCTGGG ACAGCTGCAG ACACAGACAT GACAACCCAG 
CTCATTTCTT CCAACCTGGA GCTCCACTCC CTCTCCACTG GCCGTCTTCC CAGAGTTGTG 
ACAGCCAATC GGATGCTGAA GCAGATGCTT TTCAGGTATC AAGGTTACAT TGGTGCAGCC 
CTAGTTTTAG GGGGAGTAGA TGTTACTGGA CCTCACCTCT ACAGCATCTA TCCTCATGGA 
TCAACTGATA AGTTGCCTTA TGTCACCATG GGTTCTGGCT CCTTGGCAGC AATGGCTGTA 
TTTGAAGATA AGTTTAGGCC AGACATGGAG GAGGAGGAAG CCAAGAATCT GGTGAGCGAA 
GCCATCGCAG CTGGCATCTT CAACGACCTG GGCTCCGGAA GCAACATTGA CCTCTGCGTC 
ATCAGCAAGA ACAAGCTGGA TTTTCTCCGC CCATACACAG TGCCCAACAA GAAGGGGACC 
AGGCTTGGCC GGTACAGGTG TGAGAAAGGG ACTACTGCAG TCCTCACTGA GAAAATCACT 
CCTCTGGAGA TTGAGGTGCT GGAAGAAACA GTCCAAACAA TGGACACTTC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Protein Z and Endothelin-1 genetic polymorphisms in pediatric Egyptian sickle cell disease patients.
Journal of clinical laboratory analysis(2017 May)
Khorshied MM,Mohamed NS,Hamza RS,Ali RM,El-Ghamrawy MK

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.
Nature504(7479)291-5(2013 Dec)
Hasson SA,Kane LA,Yamano K,Huang CH,Sliter DA,Buehler E,Wang C,Heman-Ackah SM,Hessa T,Guha R,Martin SE,Youle RJ

Decreased proteinZ levels in patients with rheumatoid arthritis: links with inflammation.
Thrombosis and haemostasis106(3)548-50(2011 Sep)
Krawiec P,Gluszko P,Kwasny-Krochin B,Undas A

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PSMB7 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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