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DRD1 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol DRD1
Entrez Gene ID 1812
Full Name dopamine receptor D1
Synonyms DADR,DRD1A
General protein information
Preferred Names

dopamine receptor D1

Names

D(1A) dopamine receptor
dopamine D1 receptor

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

5

5q35.2

Summary This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008].
Disorder MIM:

126449


mRNA and Protein(s)

mRNA Protein Name
NM_000794.3 NP_000785.1 D(1A) dopamine receptor



Mus musculus (house mouse) Drd1a NP_034206.1
Canis lupus familiaris (dog) DRD1 XP_005619252.1
Rattus norvegicus (Norway rat) Drd1 NP_036678.2
Gallus gallus (chicken) DRD1 NP_001138320.1
Danio rerio (zebrafish) drd1b NP_001129448.1
Xenopus tropicalis (tropical clawed frog) drd1 XP_004912926.1
Homo sapiens (human) DRD1 NP_000785.1
Pan troglodytes (chimpanzee) DRD1 XP_001149473.2
Bos taurus (cattle) DRD1 NP_776467.1


Related articles in PubMed

Genetic variants of dopamine D2 receptor impact heterodimerization with dopamine D1 receptor.
Błasiak E, Łukasiewicz S, Szafran-Pilch K, Dziedzicka-Wasylewska M
Pharmacological reports : PR69(2)235-241(2017 Apr)

Polymorphisms of dopamine receptor genes and risk of visual hallucinations in Parkinson's patients.
Ferrari M, Comi C, Marino F, Magistrelli L, De Marchi F, Cantello R, Riboldazzi G, Bono G, Cosentino M
European journal of clinical pharmacology72(11)1335-1341(2016 Nov)

VPS35 regulates cell surface recycling and signaling of dopamine receptor D1.
Wang C, Niu M, Zhou Z, Zheng X, Zhang L, Tian Y, Yu X, Bu G, Xu H, Ma Q, Zhang YW
Neurobiology of aging4622-31(2016 Oct)

Associations between a locus downstream DRD1 gene and cerebrospinal fluid dopamine metabolite concentrations in psychosis.
Andreou D, Söderman E, Axelsson T, Sedvall GC, Terenius L, Agartz I, Jönsson EG
Neuroscience letters619126-30(2016 Apr)

Association between GRK4 and DRD1 gene polymorphisms and hypertension: a meta-analysis.
Zhang H, Sun ZQ, Liu SS, Yang LN
Clinical interventions in aging1117-27(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Here, using PET with [(11)C]raclopride, we identified in the AKT1 gene a new variable number tandem repeat (VNTR) marker associated with baseline striatal dopamine D2/D3 receptor availability and with methylphenidate-induced striatal dopamine increases in healthy volunteers.
Title: New Repeat Polymorphism in the

Polymorphic mutations in the D2 receptor play a role in dimmer formation with the dopamine D1 receptor.
Title: Genetic variants of dopamine D2 receptor impact heterodimerization with dopamine D1 receptor.

We explore the role of mothers' executive function in mediating the relation between oxytocin and dopamine gene variants and maternal responsiveness and examined single nucleotide polymorphisms (SNPs) related to the dopamine system DRD1 rs686, DRD1 rs265976,. Dopamine SNPs were not associated with any measure of executive function or parenting (all P > 0.05).
Title: Thinking and doing: the effects of dopamine and oxytocin genes and executive function on mothering behaviours.

Parkinson's patients carrying allele T at DRD1C62T had an increased risk of visual hallucinations (VHs), expressed as OR (95 % CI, p value), of 10.7 (2.9-40, p = 0.0001). Moreover, patients with DRD1-48 GG and 62TT genotype displayed shorter time to VHs, whereas a longer time to VHs was found in subjects carrying the DRD4 CG alleles
Title: Polymorphisms of dopamine receptor genes and risk of visual hallucinations in Parkinson's patients.

the DRD1 gene is implicated in the pathophysiology of psychosis and support the dopamine hypothesis of schizophrenia.
Title: Associations between a locus downstream DRD1 gene and cerebrospinal fluid dopamine metabolite concentrations in psychosis.

The following DRD1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DRD1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu23409 NM_000794.3
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Homo sapiens dopamine receptor D1 (DRD1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu23409
Clone ID Related Accession (Same CDS sequence) NM_000794.3
Accession Version NM_000794.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1341bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-28
Organism Homo sapiens(Human)
Product D(1A) dopamine receptor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA249160.1, AC091393.3 and X58987.1. This sequence is a reference standard in the RefSeqGene project. On Feb 23, 2006 this sequence version replaced NM_000794.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.48887.1, SRR1660809.113948.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142363, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 5' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGAGGACTC TGAACACCTC TGCCATGGAC GGGACTGGGC TGGTGGTGGA GAGGGACTTC 
TCTGTTCGTA TCCTCACTGC CTGTTTCCTG TCGCTGCTCA TCCTGTCCAC GCTCCTGGGG
AACACGCTGG TCTGTGCTGC CGTTATCAGG TTCCGACACC TGCGGTCCAA GGTGACCAAC
TTCTTTGTCA TCTCCTTGGC TGTGTCAGAT CTCTTGGTGG CCGTCCTGGT CATGCCCTGG
AAGGCAGTGG CTGAGATTGC TGGCTTCTGG CCCTTTGGGT CCTTCTGTAA CATCTGGGTG
GCCTTTGACA TCATGTGCTC CACTGCATCC ATCCTCAACC TCTGTGTGAT CAGCGTGGAC
AGGTATTGGG CTATCTCCAG CCCTTTCCGG TATGAGAGAA AGATGACCCC CAAGGCAGCC
TTCATCCTGA TCAGTGTGGC ATGGACCTTG TCTGTACTCA TCTCCTTCAT CCCAGTGCAG
CTCAGCTGGC ACAAGGCAAA ACCCACAAGC CCCTCTGATG GAAATGCCAC TTCCCTGGCT
GAGACCATAG ACAACTGTGA CTCCAGCCTC AGCAGGACAT ATGCCATCTC ATCCTCTGTA
ATAAGCTTTT ACATCCCTGT GGCCATCATG ATTGTCACCT ACACCAGGAT CTACAGGATT
GCTCAGAAAC AAATACGGCG CATTGCGGCC TTGGAGAGGG CAGCAGTCCA CGCCAAGAAT
TGCCAGACCA CCACAGGTAA TGGAAAGCCT GTCGAATGTT CTCAACCGGA AAGTTCTTTT
AAGATGTCCT TCAAAAGAGA AACTAAAGTC CTGAAGACTC TGTCGGTGAT CATGGGTGTG
TTTGTGTGCT GTTGGCTACC TTTCTTCATC TTGAACTGCA TTTTGCCCTT CTGTGGGTCT
GGGGAGACGC AGCCCTTCTG CATTGATTCC AACACCTTTG ACGTGTTTGT GTGGTTTGGG
TGGGCTAATT CATCCTTGAA CCCCATCATT TATGCCTTTA ATGCTGATTT TCGGAAGGCA
TTTTCAACCC TCTTAGGATG CTACAGACTT TGCCCTGCGA CGAATAATGC CATAGAGACG
GTGAGTATCA ATAACAATGG GGCCGCGATG TTTTCCAGCC ATCATGAGCC ACGAGGCTCC
ATCTCCAAGG AGTGCAATCT GGTTTACCTG ATCCCACATG CTGTGGGCTC CTCTGAGGAC
CTGAAAAAGG AGGAGGCAGC TGGCATCGCC AGACCCTTGG AGAAGCTGTC CCCAGCCCTA
TCAGTCATAT TGGACTATGA CACTGACGTC TCTCTGGAGA AGATCCAACC CATCACACAA
AACGGTCAGC ACCCAACCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000785.1
CDS946..2286
Misc Feature(1)463
Misc Feature(2)805..807
Misc Feature(3)1015..1092
Misc Feature(4)1063..1938
Misc Feature(5)1066..>1419
Misc Feature(6)1126..1206
Misc Feature(7)1234..1302
Misc Feature(8)1360..1434
Misc Feature(9)1522..1599
Misc Feature(10)1762..1842
Misc Feature(11)1882..1956
Misc Feature(12)1984..1986
Misc Feature(13)1996..1998
Misc Feature(14)2023..2025
Exon (1)1..462
Exon (2)463..3373
Translation

Target ORF information:

RefSeq Version NM_000794.3
Organism Homo sapiens(Human)
Definition Homo sapiens dopamine receptor D1 (DRD1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000794.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGAGGACTC TGAACACCTC TGCCATGGAC GGGACTGGGC TGGTGGTGGA GAGGGACTTC 
TCTGTTCGTA TCCTCACTGC CTGTTTCCTG TCGCTGCTCA TCCTGTCCAC GCTCCTGGGG
AACACGCTGG TCTGTGCTGC CGTTATCAGG TTCCGACACC TGCGGTCCAA GGTGACCAAC
TTCTTTGTCA TCTCCTTGGC TGTGTCAGAT CTCTTGGTGG CCGTCCTGGT CATGCCCTGG
AAGGCAGTGG CTGAGATTGC TGGCTTCTGG CCCTTTGGGT CCTTCTGTAA CATCTGGGTG
GCCTTTGACA TCATGTGCTC CACTGCATCC ATCCTCAACC TCTGTGTGAT CAGCGTGGAC
AGGTATTGGG CTATCTCCAG CCCTTTCCGG TATGAGAGAA AGATGACCCC CAAGGCAGCC
TTCATCCTGA TCAGTGTGGC ATGGACCTTG TCTGTACTCA TCTCCTTCAT CCCAGTGCAG
CTCAGCTGGC ACAAGGCAAA ACCCACAAGC CCCTCTGATG GAAATGCCAC TTCCCTGGCT
GAGACCATAG ACAACTGTGA CTCCAGCCTC AGCAGGACAT ATGCCATCTC ATCCTCTGTA
ATAAGCTTTT ACATCCCTGT GGCCATCATG ATTGTCACCT ACACCAGGAT CTACAGGATT
GCTCAGAAAC AAATACGGCG CATTGCGGCC TTGGAGAGGG CAGCAGTCCA CGCCAAGAAT
TGCCAGACCA CCACAGGTAA TGGAAAGCCT GTCGAATGTT CTCAACCGGA AAGTTCTTTT
AAGATGTCCT TCAAAAGAGA AACTAAAGTC CTGAAGACTC TGTCGGTGAT CATGGGTGTG
TTTGTGTGCT GTTGGCTACC TTTCTTCATC TTGAACTGCA TTTTGCCCTT CTGTGGGTCT
GGGGAGACGC AGCCCTTCTG CATTGATTCC AACACCTTTG ACGTGTTTGT GTGGTTTGGG
TGGGCTAATT CATCCTTGAA CCCCATCATT TATGCCTTTA ATGCTGATTT TCGGAAGGCA
TTTTCAACCC TCTTAGGATG CTACAGACTT TGCCCTGCGA CGAATAATGC CATAGAGACG
GTGAGTATCA ATAACAATGG GGCCGCGATG TTTTCCAGCC ATCATGAGCC ACGAGGCTCC
ATCTCCAAGG AGTGCAATCT GGTTTACCTG ATCCCACATG CTGTGGGCTC CTCTGAGGAC
CTGAAAAAGG AGGAGGCAGC TGGCATCGCC AGACCCTTGG AGAAGCTGTC CCCAGCCCTA
TCAGTCATAT TGGACTATGA CACTGACGTC TCTCTGGAGA AGATCCAACC CATCACACAA
AACGGTCAGC ACCCAACCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Genetic variants of dopamine D2 receptor impact heterodimerization with dopamine D1 receptor.
Pharmacological reports : PR69(2)235-241(2017 Apr)
Błasiak E,Łukasiewicz S,Szafran-Pilch K,Dziedzicka-Wasylewska M


book

Polymorphisms of dopamine receptor genes and risk of visual hallucinations in Parkinson's patients.
European journal of clinical pharmacology72(11)1335-1341(2016 Nov)
Ferrari M,Comi C,Marino F,Magistrelli L,De Marchi F,Cantello R,Riboldazzi G,Bono G,Cosentino M


book

VPS35 regulates cell surface recycling and signaling of dopamine receptor D1.
Neurobiology of aging4622-31(2016 Oct)
Wang C,Niu M,Zhou Z,Zheng X,Zhang L,Tian Y,Yu X,Bu G,Xu H,Ma Q,Zhang YW


book

Associations between a locus downstream DRD1 gene and cerebrospinal fluid dopamine metabolite concentrations in psychosis.
Neuroscience letters619126-30(2016 Apr)
Andreou D,Söderman E,Axelsson T,Sedvall GC,Terenius L,Agartz I,Jönsson EG


book

Association between GRK4 and DRD1 gene polymorphisms and hypertension: a meta-analysis.
Clinical interventions in aging1117-27(2016)
Zhang H,Sun ZQ,Liu SS,Yang LN


 
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