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DRD5 cDNA ORF clone, Homo sapiens (human)

Gene Symbol DRD5
Entrez Gene ID 1816
Full Name dopamine receptor D5
Synonyms DBDR, DRD1B, DRD1L2
General protein information
Preferred Names
D(1B) dopamine receptor
Names
D(1B) dopamine receptor
dopamine D5 receptor
dopamine receptor D1B
d(5) dopamine receptor
D1beta dopamine receptor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4p16.1

Summary This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

126453

Disorder Html: {Blepharospasm, primary benign}, 606798 (3); Dystonia, primary

mRNA and Protein(s)

mRNA Protein Name
NM_000798 NP_000789 D(1B) dopamine receptor



Homo sapiens (human) DRD5 NP_000789.1
Pan troglodytes (chimpanzee) DRD5 XP_528711.2
Macaca mulatta (Rhesus monkey) DRD5 XP_001097117.1
Canis lupus familiaris (dog) DRD5 XP_005618635.1
Bos taurus (cattle) DRD5 NP_001193558.1
Mus musculus (house mouse) Drd5 NP_038531.1
Rattus norvegicus (Norway rat) Drd5 NP_036900.1
Gallus gallus (chicken) SPATA2L XP_004936358.1
Danio rerio (zebrafish) drd7 NP_001107115.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100495174 XP_004911296.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following DRD5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DRD5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu19349
NM_000798 Homo sapiens dopamine receptor D5 (DRD5), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$189.50-$265.30
$379.00
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu19349
Clone ID Related Accession (Same CDS sequence) NM_000798
Accession Version NM_000798.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1434bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 03-MAY-2014
Organism Homo sapiens (human)
Product D(1B) dopamine receptor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC098976.2 and BC009748.2. This sequence is a reference standard in the RefSeqGene project. On Apr 3, 2008 this sequence version replaced gi:34328907. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGCTGCCGC CAGGCAGCAA CGGCACCGCG TACCCGGGGC AGTTCGCTCT ATACCAGCAG 
CTGGCGCAGG GGAACGCCGT GGGGGGCTCG GCGGGGGCAC CGCCACTGGG GCCCTCACAG
GTGGTCACCG CCTGCCTGCT GACCCTACTC ATCATCTGGA CCCTGCTGGG CAACGTGCTG
GTGTGCGCAG CCATCGTGCG GAGCCGCCAC CTGCGCGCCA ACATGACCAA CGTCTTCATC
GTGTCTCTGG CCGTGTCAGA CCTTTTCGTG GCGCTGCTGG TCATGCCCTG GAAGGCAGTC
GCCGAGGTGG CCGGTTACTG GCCCTTTGGA GCGTTCTGCG ACGTCTGGGT GGCCTTCGAC
ATCATGTGCT CCACTGCCTC CATCCTGAAC CTGTGCGTCA TCAGCGTGGA CCGCTACTGG
GCCATCTCCA GGCCCTTCCG CTACAAGCGC AAGATGACTC AGCGCATGGC CTTGGTCATG
GTCGGCCTGG CATGGACCTT GTCCATCCTC ATCTCCTTCA TTCCGGTCCA GCTCAACTGG
CACAGGGACC AGGCGGCCTC TTGGGGCGGG CTGGACCTGC CAAACAACCT GGCCAACTGG
ACGCCCTGGG AGGAGGACTT TTGGGAGCCC GACGTGAATG CAGAGAACTG TGACTCCAGC
CTGAATCGAA CCTACGCCAT CTCTTCCTCG CTCATCAGCT TCTACATCCC CGTTGCCATC
ATGATCGTGA CCTACACGCG CATCTACCGC ATCGCCCAGG TGCAGATCCG CAGGATTTCC
TCCCTGGAGA GGGCCGCAGA GCACGCGCAG AGCTGCCGGA GCAGCGCAGC CTGCGCGCCC
GACACCAGCC TGCGCGCTTC CATCAAGAAG GAGACCAAGG TTCTCAAGAC CCTGTCGGTG
ATCATGGGGG TCTTCGTGTG TTGCTGGCTG CCCTTCTTCA TCCTTAACTG CATGGTCCCT
TTCTGCAGTG GACACCCCGA AGGCCCTCCG GCCGGCTTCC CCTGCGTCAG TGAGACCACC
TTCGACGTCT TCGTCTGGTT CGGCTGGGCT AACTCCTCAC TCAACCCCGT CATCTATGCC
TTCAACGCCG ACTTTCAGAA GGTGTTTGCC CAGCTGCTGG GGTGCAGCCA CTTCTGCTCC
CGCACGCCGG TGGAGACGGT GAACATCAGC AATGAGCTCA TCTCCTACAA CCAAGACATC
GTCTTCCACA AGGAAATCGC AGCTGCCTAC ATCCACATGA TGCCCAACGC CGTTACCCCC
GGCAACCGGG AGGTGGACAA CGACGAGGAG GAGGGTCCTT TCGATCGCAT GTTCCAGATC
TATCAGACGT CCCCAGATGG TGACCCTGTT GCTGAGTCTG TCTGGGAGCT GGACTGCGAG
GGGGAGATTT CTTTAGACAA AATAACACCT TTCACCCCGA ATGGATTCCA TTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000789.1
CDS397..1830
Misc Feature(1)352..354(+)
Misc Feature(2)514..594(+)
Misc Feature(3)583..1473(+)
Misc Feature(4)628..708(+)
Misc Feature(5)739..804(+)
Misc Feature(6)763..>921(+)
Misc Feature(7)871..936(+)
Misc Feature(8)1066..1134(+)
Misc Feature(9)1285..1356(+)
Misc Feature(10)1417..1476(+)
Exon (1)1..2376
Gene:DRD5
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000798
Organism Homo sapiens (human)
Definition Homo sapiens dopamine receptor D5 (DRD5), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000798

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGCTGCCGC CAGGCAGCAA CGGCACCGCG TACCCGGGGC AGTTCGCTCT ATACCAGCAG 
CTGGCGCAGG GGAACGCCGT GGGGGGCTCG GCGGGGGCAC CGCCACTGGG GCCCTCACAG
GTGGTCACCG CCTGCCTGCT GACCCTACTC ATCATCTGGA CCCTGCTGGG CAACGTGCTG
GTGTGCGCAG CCATCGTGCG GAGCCGCCAC CTGCGCGCCA ACATGACCAA CGTCTTCATC
GTGTCTCTGG CCGTGTCAGA CCTTTTCGTG GCGCTGCTGG TCATGCCCTG GAAGGCAGTC
GCCGAGGTGG CCGGTTACTG GCCCTTTGGA GCGTTCTGCG ACGTCTGGGT GGCCTTCGAC
ATCATGTGCT CCACTGCCTC CATCCTGAAC CTGTGCGTCA TCAGCGTGGA CCGCTACTGG
GCCATCTCCA GGCCCTTCCG CTACAAGCGC AAGATGACTC AGCGCATGGC CTTGGTCATG
GTCGGCCTGG CATGGACCTT GTCCATCCTC ATCTCCTTCA TTCCGGTCCA GCTCAACTGG
CACAGGGACC AGGCGGCCTC TTGGGGCGGG CTGGACCTGC CAAACAACCT GGCCAACTGG
ACGCCCTGGG AGGAGGACTT TTGGGAGCCC GACGTGAATG CAGAGAACTG TGACTCCAGC
CTGAATCGAA CCTACGCCAT CTCTTCCTCG CTCATCAGCT TCTACATCCC CGTTGCCATC
ATGATCGTGA CCTACACGCG CATCTACCGC ATCGCCCAGG TGCAGATCCG CAGGATTTCC
TCCCTGGAGA GGGCCGCAGA GCACGCGCAG AGCTGCCGGA GCAGCGCAGC CTGCGCGCCC
GACACCAGCC TGCGCGCTTC CATCAAGAAG GAGACCAAGG TTCTCAAGAC CCTGTCGGTG
ATCATGGGGG TCTTCGTGTG TTGCTGGCTG CCCTTCTTCA TCCTTAACTG CATGGTCCCT
TTCTGCAGTG GACACCCCGA AGGCCCTCCG GCCGGCTTCC CCTGCGTCAG TGAGACCACC
TTCGACGTCT TCGTCTGGTT CGGCTGGGCT AACTCCTCAC TCAACCCCGT CATCTATGCC
TTCAACGCCG ACTTTCAGAA GGTGTTTGCC CAGCTGCTGG GGTGCAGCCA CTTCTGCTCC
CGCACGCCGG TGGAGACGGT GAACATCAGC AATGAGCTCA TCTCCTACAA CCAAGACATC
GTCTTCCACA AGGAAATCGC AGCTGCCTAC ATCCACATGA TGCCCAACGC CGTTACCCCC
GGCAACCGGG AGGTGGACAA CGACGAGGAG GAGGGTCCTT TCGATCGCAT GTTCCAGATC
TATCAGACGT CCCCAGATGG TGACCCTGTT GCTGAGTCTG TCTGGGAGCT GGACTGCGAG
GGGGAGATTT CTTTAGACAA AATAACACCT TTCACCCCGA ATGGATTCCA TTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

D5 dopamine receptor carboxyl tail involved in D5-D2 heteromer formation
Biochem. Biophys. Res. Commun. 431 (3), 586-589 (2013)
O'Dowd BF, Nguyen T, Ji X and George SR.


book

Sorting nexin 1 loss results in D5 dopamine receptor dysfunction in human renal proximal tubule cells and hypertension in mice
J. Biol. Chem. 288 (1), 152-163 (2013)
Villar VA, Jones JE, Armando I, Asico LD, Escano CS Jr, Lee H, Wang X, Yang Y, Pascua-Crusan AM, Palmes-Saloma CP, Felder RA and Jose PA.


book

[Dopamine receptor signaling regulates human osteoclastogenesis]
Nihon Rinsho Meneki Gakkai Kaishi 36 (1), 35-39 (2013)
Hanami K, Nakano K and Tanaka Y.


book

Adenosine, dopamine and serotonin receptors imbalance in lymphocytes of Lesch-Nyhan patients
J. Inherit. Metab. Dis. 35 (6), 1129-1135 (2012)
Garcia MG, Puig JG and Torres RJ.


book

Dopamine and angiotensin type 2 receptors cooperatively inhibit sodium transport in human renal proximal tubule cells
Hypertension 60 (2), 396-403 (2012)
Gildea JJ, Wang X, Shah N, Tran H, Spinosa M, Van Sciver R, Sasaki M, Yatabe J, Carey RM, Jose PA and Felder RA.


book

Chromosomal localization of three human D5 dopamine receptor genes
Genomics 13 (4), 968-973 (1992)
Grandy DK, Allen LJ, Zhang Y, Magenis RE and Civelli O.


book

Localization of the D5 dopamine receptor gene to human chromosome 4p15.1-p15.3, centromeric to the Huntington's disease locus
Genomics 12 (3), 510-516 (1992)
Eubanks JH, Altherr M, Wagner-McPherson C, McPherson JD, Wasmuth JJ and Evans GA.


book

The human D5 dopamine receptor (DRD5) maps on chromosome 4
Genomics 11 (3), 777-778 (1991)
Polymeropoulos MH, Xiao H and Merril CR.


book

Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor
Proc. Natl. Acad. Sci. U.S.A. 88 (17), 7491-7495 (1991)
Tiberi M, Jarvie KR, Silvia C, Falardeau P, Gingrich JA, Godinot N, Bertrand L, Yang-Feng TL, Fremeau RT Jr and Caron MG.


book

Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1
Nature 350 (6319), 614-619 (1991)
Sunahara RK, Guan HC, O'Dowd BF, Seeman P, Laurier LG, Ng G, George SR, Torchia J, Van Tol HH and Niznik HB.


 
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