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DRD5 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol DRD5
Entrez Gene ID 1816
Full Name dopamine receptor D5
Synonyms DBDR,DRD1B,DRD1L2
General protein information
Preferred Names

dopamine receptor D5

Names

D(1B) dopamine receptor
D1beta dopamine receptor
d(5) dopamine receptor
dopamine D5 receptor
dopamine receptor D1B

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

4

4p16.1

Summary This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008].
Disorder MIM:

126453

Disorder Html: {Blepharospasm, primary benign}, 606798 (3); Dystonia, primary

mRNA and Protein(s)

mRNA Protein Name
NM_000798.4 NP_000789.1 D(1B) dopamine receptor



Pan troglodytes (chimpanzee) DRD5 XP_528711.2
Bos taurus (cattle) DRD5 NP_001193558.1
Rattus norvegicus (Norway rat) Drd5 NP_036900.1
Gallus gallus (chicken) SPATA2L XP_004936358.1
Danio rerio (zebrafish) drd7 NP_001107115.1
Mus musculus (house mouse) Drd5 NP_038531.1
Homo sapiens (human) DRD5 NP_000789.1
Canis lupus familiaris (dog) DRD5 XP_005618635.1
Xenopus tropicalis (tropical clawed frog) LOC100495174 XP_004911296.1
Macaca mulatta (rhesus monkey) DRD5 XP_001097117.1


Related articles in PubMed

D5 dopamine receptor carboxyl tail involved in D5-D2 heteromer formation.
O'Dowd BF, Nguyen T, Ji X, George SR
Biochemical and biophysical research communications431(3)586-9(2013 Feb)

[Dopamine receptor signaling regulates human osteoclastogenesis].
Hanami K, Nakano K, Tanaka Y
Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology36(1)35-9(2013)

Sorting nexin 1 loss results in D5 dopamine receptor dysfunction in human renal proximal tubule cells and hypertension in mice.
Villar VA, Jones JE, Armando I, Asico LD, Escano CS Jr, Lee H, Wang X, Yang Y, Pascua-Crusan AM, Palmes-Saloma CP, Felder RA, Jose PA
The Journal of biological chemistry288(1)152-63(2013 Jan)

Adenosine, dopamine and serotonin receptors imbalance in lymphocytes of Lesch-Nyhan patients.
García MG, Puig JG, Torres RJ
Journal of inherited metabolic disease35(6)1129-35(2012 Nov)

Dopamine and angiotensin type 2 receptors cooperatively inhibit sodium transport in human renal proximal tubule cells.
Gildea JJ, Wang X, Shah N, Tran H, Spinosa M, Van Sciver R, Sasaki M, Yatabe J, Carey RM, Jose PA, Felder RA
Hypertension (Dallas, Tex. : 1979)60(2)396-403(2012 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

DRD5 gene expression reduction in breast cancer patients after spiritual intervention
Title: The effects of spiritual intervention and changes in dopamine receptor gene expression in breast cancer patients.

This study reveled that DRD5 are up regulation in CD4+ T effector and regulatory cells in patient with multiple sclerosis.
Title: Dopaminergic receptors and adrenoceptors in circulating lymphocytes as putative biomarkers for the early onset and progression of multiple sclerosis.

Conserved residues in intracellular loop 1 and transmembrane region 2 of DRD1 and DRD5 are essential in ligand binding and signal transduction.
Title: Functional importance of two conserved residues in intracellular loop 1 and transmembrane region 2 of Family A GPCRs: insights from ligand binding and signal transduction responses of D1 and D5 dopaminergic receptor mutants.

This study shown DRD5 to be the risk factor for attention deficit/hyperactivity disorder.
Title: Multiple epigenetic factors predict the attention deficit/hyperactivity disorder among the Chinese Han children.

This study demonistrated that Lymphocyte DR D5 is reduced in MS and IFN-beta restores their expression and responsiveness.
Title: Levels of mRNA for dopaminergic receptor D₅ in circulating lymphocytes may be associated with subsequent response to interferon-β in patients with multiple sclerosis.

The following DRD5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DRD5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu19349 NM_000798.4
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Homo sapiens dopamine receptor D5 (DRD5), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu19349
Clone ID Related Accession (Same CDS sequence) NM_000798.4
Accession Version NM_000798.4 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1434bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2015-12-29
Organism Homo sapiens(Human)
Product D(1B) dopamine receptor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC098976.2 and BC009748.2. This sequence is a reference standard in the RefSeqGene project. On Apr 3, 2008 this sequence version replaced NM_000798.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGCTGCCGC CAGGCAGCAA CGGCACCGCG TACCCGGGGC AGTTCGCTCT ATACCAGCAG 
CTGGCGCAGG GGAACGCCGT GGGGGGCTCG GCGGGGGCAC CGCCACTGGG GCCCTCACAG
GTGGTCACCG CCTGCCTGCT GACCCTACTC ATCATCTGGA CCCTGCTGGG CAACGTGCTG
GTGTGCGCAG CCATCGTGCG GAGCCGCCAC CTGCGCGCCA ACATGACCAA CGTCTTCATC
GTGTCTCTGG CCGTGTCAGA CCTTTTCGTG GCGCTGCTGG TCATGCCCTG GAAGGCAGTC
GCCGAGGTGG CCGGTTACTG GCCCTTTGGA GCGTTCTGCG ACGTCTGGGT GGCCTTCGAC
ATCATGTGCT CCACTGCCTC CATCCTGAAC CTGTGCGTCA TCAGCGTGGA CCGCTACTGG
GCCATCTCCA GGCCCTTCCG CTACAAGCGC AAGATGACTC AGCGCATGGC CTTGGTCATG
GTCGGCCTGG CATGGACCTT GTCCATCCTC ATCTCCTTCA TTCCGGTCCA GCTCAACTGG
CACAGGGACC AGGCGGCCTC TTGGGGCGGG CTGGACCTGC CAAACAACCT GGCCAACTGG
ACGCCCTGGG AGGAGGACTT TTGGGAGCCC GACGTGAATG CAGAGAACTG TGACTCCAGC
CTGAATCGAA CCTACGCCAT CTCTTCCTCG CTCATCAGCT TCTACATCCC CGTTGCCATC
ATGATCGTGA CCTACACGCG CATCTACCGC ATCGCCCAGG TGCAGATCCG CAGGATTTCC
TCCCTGGAGA GGGCCGCAGA GCACGCGCAG AGCTGCCGGA GCAGCGCAGC CTGCGCGCCC
GACACCAGCC TGCGCGCTTC CATCAAGAAG GAGACCAAGG TTCTCAAGAC CCTGTCGGTG
ATCATGGGGG TCTTCGTGTG TTGCTGGCTG CCCTTCTTCA TCCTTAACTG CATGGTCCCT
TTCTGCAGTG GACACCCCGA AGGCCCTCCG GCCGGCTTCC CCTGCGTCAG TGAGACCACC
TTCGACGTCT TCGTCTGGTT CGGCTGGGCT AACTCCTCAC TCAACCCCGT CATCTATGCC
TTCAACGCCG ACTTTCAGAA GGTGTTTGCC CAGCTGCTGG GGTGCAGCCA CTTCTGCTCC
CGCACGCCGG TGGAGACGGT GAACATCAGC AATGAGCTCA TCTCCTACAA CCAAGACATC
GTCTTCCACA AGGAAATCGC AGCTGCCTAC ATCCACATGA TGCCCAACGC CGTTACCCCC
GGCAACCGGG AGGTGGACAA CGACGAGGAG GAGGGTCCTT TCGATCGCAT GTTCCAGATC
TATCAGACGT CCCCAGATGG TGACCCTGTT GCTGAGTCTG TCTGGGAGCT GGACTGCGAG
GGGGAGATTT CTTTAGACAA AATAACACCT TTCACCCCGA ATGGATTCCA TTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000789.1
CDS397..1830
Misc Feature(1)352..354
Misc Feature(2)514..594
Misc Feature(3)565..1473
Misc Feature(4)628..708
Misc Feature(5)739..804
Misc Feature(6)<763..>921
Misc Feature(7)871..936
Misc Feature(8)1066..1134
Misc Feature(9)1285..1356
Misc Feature(10)1417..1476
Exon (1)1..2376
Translation

Target ORF information:

RefSeq Version NM_000798.4
Organism Homo sapiens(Human)
Definition Homo sapiens dopamine receptor D5 (DRD5), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000798.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGCTGCCGC CAGGCAGCAA CGGCACCGCG TACCCGGGGC AGTTCGCTCT ATACCAGCAG 
CTGGCGCAGG GGAACGCCGT GGGGGGCTCG GCGGGGGCAC CGCCACTGGG GCCCTCACAG
GTGGTCACCG CCTGCCTGCT GACCCTACTC ATCATCTGGA CCCTGCTGGG CAACGTGCTG
GTGTGCGCAG CCATCGTGCG GAGCCGCCAC CTGCGCGCCA ACATGACCAA CGTCTTCATC
GTGTCTCTGG CCGTGTCAGA CCTTTTCGTG GCGCTGCTGG TCATGCCCTG GAAGGCAGTC
GCCGAGGTGG CCGGTTACTG GCCCTTTGGA GCGTTCTGCG ACGTCTGGGT GGCCTTCGAC
ATCATGTGCT CCACTGCCTC CATCCTGAAC CTGTGCGTCA TCAGCGTGGA CCGCTACTGG
GCCATCTCCA GGCCCTTCCG CTACAAGCGC AAGATGACTC AGCGCATGGC CTTGGTCATG
GTCGGCCTGG CATGGACCTT GTCCATCCTC ATCTCCTTCA TTCCGGTCCA GCTCAACTGG
CACAGGGACC AGGCGGCCTC TTGGGGCGGG CTGGACCTGC CAAACAACCT GGCCAACTGG
ACGCCCTGGG AGGAGGACTT TTGGGAGCCC GACGTGAATG CAGAGAACTG TGACTCCAGC
CTGAATCGAA CCTACGCCAT CTCTTCCTCG CTCATCAGCT TCTACATCCC CGTTGCCATC
ATGATCGTGA CCTACACGCG CATCTACCGC ATCGCCCAGG TGCAGATCCG CAGGATTTCC
TCCCTGGAGA GGGCCGCAGA GCACGCGCAG AGCTGCCGGA GCAGCGCAGC CTGCGCGCCC
GACACCAGCC TGCGCGCTTC CATCAAGAAG GAGACCAAGG TTCTCAAGAC CCTGTCGGTG
ATCATGGGGG TCTTCGTGTG TTGCTGGCTG CCCTTCTTCA TCCTTAACTG CATGGTCCCT
TTCTGCAGTG GACACCCCGA AGGCCCTCCG GCCGGCTTCC CCTGCGTCAG TGAGACCACC
TTCGACGTCT TCGTCTGGTT CGGCTGGGCT AACTCCTCAC TCAACCCCGT CATCTATGCC
TTCAACGCCG ACTTTCAGAA GGTGTTTGCC CAGCTGCTGG GGTGCAGCCA CTTCTGCTCC
CGCACGCCGG TGGAGACGGT GAACATCAGC AATGAGCTCA TCTCCTACAA CCAAGACATC
GTCTTCCACA AGGAAATCGC AGCTGCCTAC ATCCACATGA TGCCCAACGC CGTTACCCCC
GGCAACCGGG AGGTGGACAA CGACGAGGAG GAGGGTCCTT TCGATCGCAT GTTCCAGATC
TATCAGACGT CCCCAGATGG TGACCCTGTT GCTGAGTCTG TCTGGGAGCT GGACTGCGAG
GGGGAGATTT CTTTAGACAA AATAACACCT TTCACCCCGA ATGGATTCCA TTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

D5 dopamine receptor carboxyl tail involved in D5-D2 heteromer formation.
Biochemical and biophysical research communications431(3)586-9(2013 Feb)
O'Dowd BF,Nguyen T,Ji X,George SR


book

[Dopamine receptor signaling regulates human osteoclastogenesis].
Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology36(1)35-9(2013)
Hanami K,Nakano K,Tanaka Y


book

Sorting nexin 1 loss results in D5 dopamine receptor dysfunction in human renal proximal tubule cells and hypertension in mice.
The Journal of biological chemistry288(1)152-63(2013 Jan)
Villar VA,Jones JE,Armando I,Asico LD,Escano CS Jr,Lee H,Wang X,Yang Y,Pascua-Crusan AM,Palmes-Saloma CP,Felder RA,Jose PA


book

Adenosine, dopamine and serotonin receptors imbalance in lymphocytes of Lesch-Nyhan patients.
Journal of inherited metabolic disease35(6)1129-35(2012 Nov)
García MG,Puig JG,Torres RJ


book

Dopamine and angiotensin type 2 receptors cooperatively inhibit sodium transport in human renal proximal tubule cells.
Hypertension (Dallas, Tex. : 1979)60(2)396-403(2012 Aug)
Gildea JJ,Wang X,Shah N,Tran H,Spinosa M,Van Sciver R,Sasaki M,Yatabe J,Carey RM,Jose PA,Felder RA


 
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