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An Assay that Predicts Efficacy for DNA Aptamers that Stimulate Remyelination in a Mouse Model of Multiple Sclerosis.

Mol Ther Methods Clin Dev. 2018-06; 
HeiderRobin M，SmestadJohn A，LemusHernan Nicolas，WilbanksBrandon，WarringtonArthur E，PetersJustin P，RodriguezMoses，MaherL J
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Proteins, Expression, Isolation and Analysis … manufacturer. Negative control oligonucleotide sequences are identified using number codes 3060 and 3202. Streptavidin purchased from Genscript (Piscataway, NJ; Z02043-5; 5 mg) was re-suspended in 1 mL PBS. Concentration … Get A Quote

Abstract

Multiple sclerosis (MS) is a debilitating disease for which regenerative therapies are sought. We have previously described human antibodies and DNA aptamer-streptavidin conjugates that promote remyelination after systemic injection into mice infected by Theiler's murine encephalomyelitis virus. Here， we report an assay of myelin binding with results that correlate with remyelination outcome ， as shown for data from a set of DNA aptamer complexes of different size and formulation. This assay will be valuable for future screening of MS regenerative therapies targeting remyelination.

Keywords

aptamer，multiple sclerosis，myelin，oligodendrocyte，regenera
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