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Substance P activates Mas-related G protein-coupled receptors to induce itch

J. Allergy Clin. Immunol.. 2017-08;

AzimiEhsan, ReddyVemuri B, PereiraPaula Juliana Seadi, TalbotSebastien, WoolfClifford J, LernerEth

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Peptide Synthesis	… 15 Here we evaluated the interaction of SP with cultured murine DRG neurons. We deduce that MrgprA1 is responsible for SP-induced scratching behavior. Methods. Peptides and chemicals. SP was obtained from GenScript (Piscataway, NJ) and dissolved in 1× PBS …	Get A Quote

Abstract

Substance P (SP) is linked to itch and inflammation through activation of receptors on mast cells and sensory neurons. There is increasing evidence that SP functions through Mas-related G protein-coupled receptors (Mrgprs) in addition to its conventional receptor， neurokinin-1.

Keywords

Mas-related G protein–coupled receptors，Substance P，calcium imaging，dorsal root ganglion neurons，knockout mice，receptor antago

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