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KDEL Peptide Gold Nanoconstructs: A Promising Nanoplatform for Drug Delivery.

Nanomedicine.. 2013-04;  9(3):366-74
Wang G, Norton AS, Pokharel D, Song Y, Hill RA. a Department of Animal and Veterinary Science, University of Idaho, Moscow, ID 83844, USAb Optical Imaging Center, University of Idaho, Moscow, ID 83844, USAc Department of Biochemistry Engineering and Food Science, Institute National des Sciences Appliquées de Toulouse, Toulouse 31077, France
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Gold nanoparticles (AuNPs) have been widely investigated as potential nanocarriers for drug delivery. In the present study, AuNPs were conjugated to a peptide that has a C-terminal Lys–Asp–Glu–Leu (KDEL) motif. In a pulse-chase study, time-course sampling revealed that AuNP-delivered KDEL peptides were rapidly localized to the endoplasmic reticulum (ER) in 5 to 15 min, and after 1 h the majority of peptides were localized to the ER. Clathrin-coated vesicles and Golgi apparatus were also involved during the intracellular trafficking of KDEL peptide gold (AuNP-KDEL) nanoconstructs. Furthermore, overexpression of KDEL receptor (KDELR) significantly enhanced KDEL peptide uptake in both f... More


Gold nanoparticles; Peptide; KDEL receptor; Trafficking; Endocytosis