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A Mycobacteriophage-Based Vaccine Platform: SARS-CoV-2 Antigen Expression and Display

Microorganisms. 2021-11; 
Krista G Freeman, Katherine S Wetzel, Yu Zhang, Kira M Zack, Deborah Jacobs-Sera, Sara M Walters, Dominique J Barbeau, Anita K McElroy, John V Williams, Graham F Hatfull
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Recombinant Antibody Expression … Recombinant S1 and RBD proteins were both obtained from GenScript (Piscataway Township, Piscataway, NJ, USA, catalog numbers Z03501 and Z03479, respectively). Each bolus … Get A Quote


The explosion of SARS-CoV-2 infections in 2020 prompted a flurry of activity in vaccine development and exploration of various vaccine platforms, some well-established and some new. Phage-based vaccines were described previously, and we explored the possibility of using mycobacteriophages as a platform for displaying antigens of SARS-CoV-2 or other infectious agents. The potential advantages of using mycobacteriophages are that a large and diverse variety of them have been described and genomically characterized, engineering tools are available, and there is the capacity to display up to 700 antigen copies on a single particle approximately 100 nm in size. The phage body may itself be a good adjuvant, and the p... More


SARS-CoV-2, mycobacteriophage, phage display vaccine