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This Biology terms dictionary provides query services for biology and biochemistry terms. Please enter the biology or biochemistry terms you want to search.
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Dominant-negative is a term used to describe a type of genetic mutation that results in a protein that interferes with the normal function of the wild-type protein. This occurs when the mutant protein product, often non-functional, competes with the standard protein product for binding to other cellular components. In other words, the mutant protein "dominates" the normal protein, preventing it from functioning correctly. Dominant-negative mutations can have a wide range of effects, depending on the protein that is affected. For example, in certain types of cancer, dominant-negative mutations in tumor suppressor genes can lead to the development of tumors. In other cases, dominant-negative mutations can result in developmental defects or other types of disease. One example of a dominant-negative mutation is found in the gene that codes for the p53 protein, a critical tumor suppressor protein. In some cases, mutations in the p53 gene produce a non-functional protein that can actually interfere with the activity of the wild-type protein. This dominant-negative effect can lead to the development of tumors. Dominant-negative mutations can be inherited in a variety of ways. In some cases, they may be inherited in an autosomal dominant manner, meaning that a single copy of the mutant gene is sufficient to cause the dominant-negative effect. In other cases, the mutation may be acquired during an individual's lifetime. Understanding the mechanisms behind dominant-negative mutations is essential for developing treatments for diseases caused by these mutations. Researchers are currently exploring various strategies for counteracting the effects of dominant-negative mutations, including developing drugs targeting the mutant proteins.
GenSmart Optimization is a free online tool for performing codon optimization to improve gene expression. GenScript's patented algorithms are integrated into the tool to optimize the computing capability of high-performance sequence generation.
GenSmart™ Design is a free online DNA construct design tool developed by GenScript. GenSmart™ Design has two design modules, the Create Construct module for individual plasmid design and the Create Library module for DNA library design.
This online tool shows commonly used genetic codon frequency table in expression host organisms including Escherichia coli and other common host organisms.
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If you know of any terms that have been omitted from this glossary that you feel would be useful to include, please send detail to the Editorial Office at GenScript: [email protected]