Overview

About the RHO GTPase Effectors pathway

RHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall 2002)

The longest variant of each gene is displayed. Click the see gene variants link to see all gene variants.

286 geneClick for more »

Gene Symbol Full Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACTB actin, beta
ACTG1 actin gamma 1
BIRC5 baculoviral IAP repeat containing 5
KLK3 kallikrein-related peptidase 3
AR androgen receptor
RHOA ras homolog family member A
RHOB ras homolog family member B
RHOC ras homolog family member C
RHOG ras homolog family member G
BTK Bruton agammaglobulinemia tyrosine kinase
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
FMNL1 formin-like 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALM2 calmodulin 2 (phosphorylase kinase, delta)
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CDC20 cell division cycle 20
CDC25C cell division cycle 25C
CDC42 cell division cycle 42
CDH1 cadherin 1, type 1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPA centromere protein A
CENPC centromere protein C
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYBA cytochrome b-245, alpha polypeptide
CYBB cytochrome b-245, beta polypeptide
DIAPH1 diaphanous-related formin 1
DIAPH2 diaphanous-related formin 2
DLG4 discs, large homolog 4 (Drosophila)
DVL1 dishevelled segment polarity protein 1
DVL2 dishevelled segment polarity protein 2
DVL3 dishevelled segment polarity protein 3
CTTN cortactin
FLNA filamin A, alpha
CENPI centromere protein I
SFN stratifin
GRB2 growth factor receptor-bound protein 2
HIST1H2AE histone cluster 1, H2ae
HIST1H2AD histone cluster 1, H2ad
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HIST1H2BD histone cluster 1, H2bd
HIST1H2BB histone cluster 1, H2bb
H3F3A H3 histone, family 3A
H3F3B H3 histone, family 3B (H3.3B)
NCKAP1L NCK-associated protein 1-like
INCENP inner centromere protein antigens 135/155kDa
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KIF2A kinesin heavy chain member 2A
KIF5A kinesin family member 5A
KIF5B kinesin family member 5B
KLK2 kallikrein-related peptidase 2
KLC1 kinesin light chain 1
KTN1 kinectin 1 (kinesin receptor)
LIMK1 LIM domain kinase 1
LIMK2 LIM domain kinase 2
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MEN1 multiple endocrine neoplasia I
MYH9 myosin, heavy chain 9, non-muscle
MYH10 myosin, heavy chain 10, non-muscle
MYH11 myosin, heavy chain 11, smooth muscle
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
MYLK myosin light chain kinase
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP1R12B protein phosphatase 1, regulatory subunit 12B
NCF2 neutrophil cytosolic factor 2
NCF4 neutrophil cytosolic factor 4, 40kDa
NCK1 NCK adaptor protein 1
NF2 neurofibromin 2 (merlin)
NUP98 nucleoporin 98kDa
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PDPK1 3-phosphoinositide dependent protein kinase 1
PFN1 profilin 1
PFN2 profilin 2
PLK1 polo-like kinase 1
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PKN1 protein kinase N1
PKN2 protein kinase N2
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
PTK2 protein tyrosine kinase 2
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)

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