| Gene Symbol | Tsc1 |
| Entrez Gene ID | 42862 |
| Full Name | CG6147 gene product from transcript CG6147-RA |
| Synonyms | CG6147,Dmel\CG6147,TSC,TSC1,dTSC,dTSC-1,dTSC1,dTsc1,dtsc1,rocky,tsc1 |
| Gene Type | protein-coding |
| Organism | Drosophila melanogaster(fruit fly) |
| Genome |
IVD Raw Materials
ORF » Species Summary » Drosophila melanogaster » Tsc1 cDNA ORF clone
| Gene Symbol | Tsc1 |
| Entrez Gene ID | 42862 |
| Full Name | CG6147 gene product from transcript CG6147-RA |
| Synonyms | CG6147,Dmel\CG6147,TSC,TSC1,dTSC,dTSC-1,dTSC1,dTsc1,dtsc1,rocky,tsc1 |
| Gene Type | protein-coding |
| Organism | Drosophila melanogaster(fruit fly) |
| Genome |
| mRNA | Protein | Name |
|---|---|---|
| NM_058067.3 | NP_477415.1 | Tsc1 |
Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
TSC1 is growth and size regulator, inhibit TOR-mediated amino acid availability to S6 kinase and translation initiation, its muscle and fat overactivation significantly extends lifespan.
Title: Basic mechanisms of longevity: A case study of Drosophila pro-longevity genes.
Data indicate that TORC1 activation by PVR involves Tsc1/Tsc2.
Title: Platelet-derived growth factor/vascular endothelial growth factor receptor inactivation by sunitinib results in Tsc1/Tsc2-dependent inhibition of TORC1.
hyperactivation of TORC1 following the loss of TSC1/2 is detrimental to stem cell maintenance and multiple lineage differentiation in the Drosophila intestinal stem cell lineage, a mechanism that could be conserved in other stem cell lineages
Title: TSC1/2 regulates intestinal stem cell maintenance and lineage differentiation through Rheb-TORC1-S6K but independently of nutritional status or Notch regulation.
deregulation of TORC1 induces activation of JNK, indicate that multiple cellular stresses are induced and contribute to the synthetic-lethal interactions between RB and TSC1/TSC2 inactivation.
Title: Deregulated G1-S control and energy stress contribute to the synthetic-lethal interactions between inactivation of RB and TSC1 or TSC2.
study demonstrates that in the Drosophila lymph gland the tumor suppressors TSC and PTEN control blood progenitor proliferation through a common TOR- and 4EBP-dependent pathway
Title: Multifaceted roles of PTEN and TSC orchestrate growth and differentiation of Drosophila blood progenitors.
The following Tsc1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tsc1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OFa05897 | |
| Clone ID Related Accession (Same CDS sequence) | NM_058067.3 | |
| Accession Version | NM_058067.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 3303bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-04-24 | |
| Organism | Drosophila melanogaster(fruit fly) | |
| Product | Tsc1 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033777). On Jul 15, 2014 this sequence version replaced NM_058067.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END## | |
1 | ATGGTGATTG AGAAGATCAT TGGTGACCTG GAGTCCAACA TGACGCTGGA GAACGAGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_477415.1 |
| CDS | 269..3571 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_058067.3 |
1 | ATGGTGATTG AGAAGATCAT TGGTGACCTG GAGTCCAACA TGACGCTGGA GAACGAGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data. |
Gene Model Annotations for Drosophila melanogaster: The Rule-Benders. |
Sequence finishing and mapping of Drosophila melanogaster heterochromatin. |
The Release 5.1 annotation of Drosophila melanogaster heterochromatin. |
Combined evidence annotation of transposable elements in genome sequences. |