IAPP cDNA ORF clone, Felis catus(domestic cat)

Gene
Clones
gRNAs

Summary

Gene Symbol	IAPP
Entrez Gene ID	751513
Full Name	islet amyloid polypeptide
Gene Type	protein-coding
Organism	Felis catus(domestic cat)

mRNA and Protein(s)

mRNA	Protein	Name
XM_019833865.1	XP_019689424.1	islet amyloid polypeptide isoform X1
NM_001043338.1	NP_001036803.1	islet amyloid polypeptide precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Evaluation of plasma islet amyloid polypeptide and serum glucose and insulin concentrations in nondiabetic cats classified by body condition score and in cats with naturally occurring diabetes mellitus.
Henson MS, Hegstad-Davies RL, Wang Q, Hardy RM, Armstrong PJ, Jordan K, Johnson KH, O'Brien TD
American journal of veterinary research72(8)1052-8(2011 Aug)

Structure of cat islet amyloid polypeptide and identification of amino acid residues of potential significance for islet amyloid formation.
Betsholtz C, Christmanson L, Engstr?m U, Rorsman F, Jordan K, O'Brien TD, Murtaugh M, Johnson KH, Westermark P
Diabetes39(1)118-22(1990 Jan)

Conservation of the sequence of islet amyloid polypeptide in five mammals is consistent with its putative role as an islet hormone.
Nishi M, Chan SJ, Nagamatsu S, Bell GI, Steiner DF
Proceedings of the National Academy of Sciences of the United States of America86(15)5738-42(1989 Aug)

Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells.
Westermark P, Wernstedt C, Wilander E, Hayden DW, O'Brien TD, Johnson KH
Proceedings of the National Academy of Sciences of the United States of America84(11)3881-5(1987 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results of the present study added to those earlier findings in cats and revealed that nondiabetic moderately obese cats had significantly increased plasma islet amyloid polypeptide concentrations, compared with those of cats of ideal body weight.
Title: Evaluation of plasma islet amyloid polypeptide and serum glucose and insulin concentrations in nondiabetic cats classified by body condition score and in cats with naturally occurring diabetes mellitus.

The following IAPP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IAPP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFb24843	NM_001043338.1 Latest version!	Felis catus islet amyloid polypeptide (IAPP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00
OFb24843	XM_019833865.1 Latest version!	Felis catus islet amyloid polypeptide (IAPP), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IAPP ( NM_001043338.1 ) cDNA ORF clone, Felis catus(domestic cat) -> NP_001036803.1 Felis catus islet amyloid polypeptide (IAPP), mRNA.

Price & Availability↑

CloneID	OFb24843
Clone ID Related Accession (Same CDS sequence)	XM_019833865.1 , NM_001043338.1
Accession Version	NM_001043338.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 270bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Felis catus(domestic cat)
Product	islet amyloid polypeptide precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M25388.1. ##Evidence-Data-START## Transcript exon combination :: M25388.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03490516, SAMN04498517 [ECO:0000348] ##Evidence-Data-END##

ATGTGCCTCC TGAAACTTCC AGTAGTTCTC ATTGTGCTCT TGGTTGCACT ACACCATCTG 
AAAGCTACCC CCATTGAAAG TAACCAAGTG GAAAAGCGGA AATGCAACAC TGCCACATGT 
GCGACCCAAC GCCTGGCAAA TTTCTTAATT CGTTCCAGCA ACAATCTTGG TGCCATTCTT 
TCTCCTACCA ATGTGGGATC CAATACATAT GGAAAGAGGA GCACAGTTGA TATTTTAAAC 
AGGGAACCAT TGAATTACTT ACCCTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001036803.1
CDS	31..300
Translation	MCLLKLPVVLIVLLVALHHLKATPIESNQVEKRKCNTATCATQRLANFLIRSSNNLGAILSPTNVGSNTYGKRSTVDILNREPLNYLPF

Target ORF information:

RefSeq Version	NM_001043338.1
Organism	Felis catus(domestic cat)
Definition	Felis catus islet amyloid polypeptide (IAPP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001043338.1

ORF Insert Sequence:

ATGTGCCTCC TGAAACTTCC AGTAGTTCTC ATTGTGCTCT TGGTTGCACT ACACCATCTG 
AAAGCTACCC CCATTGAAAG TAACCAAGTG GAAAAGCGGA AATGCAACAC TGCCACATGT 
GCGACCCAAC GCCTGGCAAA TTTCTTAATT CGTTCCAGCA ACAATCTTGG TGCCATTCTT 
TCTCCTACCA ATGTGGGATC CAATACATAT GGAAAGAGGA GCACAGTTGA TATTTTAAAC 
AGGGAACCAT TGAATTACTT ACCCTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IAPP ( XM_019833865.1 ) cDNA ORF clone, Felis catus(domestic cat) -> XP_019689424.1 Felis catus islet amyloid polypeptide (IAPP), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OFb24843
Clone ID Related Accession (Same CDS sequence)	XM_019833865.1 , NM_001043338.1
Accession Version	XM_019833865.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 270bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-11
Organism	Felis catus(domestic cat)
Product	islet amyloid polypeptide isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_018729.3) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Felis catus Annotation Release 104 Annotation Version :: 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGCCTCC TGAAACTTCC AGTAGTTCTC ATTGTGCTCT TGGTTGCACT ACACCATCTG 
AAAGCTACCC CCATTGAAAG TAACCAAGTG GAAAAGCGGA AATGCAACAC TGCCACATGT 
GCGACCCAAC GCCTGGCAAA TTTCTTAATT CGTTCCAGCA ACAATCTTGG TGCCATTCTT 
TCTCCTACCA ATGTGGGATC CAATACATAT GGAAAGAGGA GCACAGTTGA TATTTTAAAC 
AGGGAACCAT TGAATTACTT ACCCTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_019689424.1
CDS	245..514
Translation	MCLLKLPVVLIVLLVALHHLKATPIESNQVEKRKCNTATCATQRLANFLIRSSNNLGAILSPTNVGSNTYGKRSTVDILNREPLNYLPF

Target ORF information:

RefSeq Version	XM_019833865.1
Organism	Felis catus(domestic cat)
Definition	Felis catus islet amyloid polypeptide (IAPP), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_019833865.1

ORF Insert Sequence:

ATGTGCCTCC TGAAACTTCC AGTAGTTCTC ATTGTGCTCT TGGTTGCACT ACACCATCTG 
AAAGCTACCC CCATTGAAAG TAACCAAGTG GAAAAGCGGA AATGCAACAC TGCCACATGT 
GCGACCCAAC GCCTGGCAAA TTTCTTAATT CGTTCCAGCA ACAATCTTGG TGCCATTCTT 
TCTCCTACCA ATGTGGGATC CAATACATAT GGAAAGAGGA GCACAGTTGA TATTTTAAAC 
AGGGAACCAT TGAATTACTT ACCCTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Evaluation of plasma islet amyloid polypeptide and serum glucose and insulin concentrations in nondiabetic cats classified by body condition score and in cats with naturally occurring diabetes mellitus.
American journal of veterinary research72(8)1052-8(2011 Aug)
Henson MS,Hegstad-Davies RL,Wang Q,Hardy RM,Armstrong PJ,Jordan K,Johnson KH,O'Brien TD

Structure of cat islet amyloid polypeptide and identification of amino acid residues of potential significance for islet amyloid formation.
Diabetes39(1)118-22(1990 Jan)
Betsholtz C,Christmanson L,Engstr?m U,Rorsman F,Jordan K,O'Brien TD,Murtaugh M,Johnson KH,Westermark P

Conservation of the sequence of islet amyloid polypeptide in five mammals is consistent with its putative role as an islet hormone.
Proceedings of the National Academy of Sciences of the United States of America86(15)5738-42(1989 Aug)
Nishi M,Chan SJ,Nagamatsu S,Bell GI,Steiner DF

Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells.
Proceedings of the National Academy of Sciences of the United States of America84(11)3881-5(1987 Jun)
Westermark P,Wernstedt C,Wilander E,Hayden DW,O'Brien TD,Johnson KH

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IAPP cDNA ORF clone, Felis catus(domestic cat)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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