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SLCO1B3 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol SLCO1B3
Entrez Gene ID 28234
Full Name solute carrier organic anion transporter family member 1B3
Synonyms HBLRR,LST-2,LST-3TM13,LST3,OATP-8,OATP1B3,OATP8,SLC21A8
General protein information
Preferred Names

solute carrier organic anion transporter family member 1B3

Names

solute carrier organic anion transporter family member 1B3
liver-specific organic anion transporter 2
liver-specific organic anion transporter 3TM13
organic anion transporter 8
organic anion transporter LST-3c
organic anion-transporting polypeptide 8
solute carrier family 21 (organic anion transporter), member 8

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

12

12p12.2

Disorder MIM:

605495


mRNA and Protein(s)

mRNA Protein Name
NM_001349920.1 NP_001336849.1 solute carrier organic anion transporter family member 1B3 isoform 2
NM_019844.3 NP_062818.1 solute carrier organic anion transporter family member 1B3 isoform 1



Bos taurus (cattle) SLCO1B3 NP_991373.1
Homo sapiens (human) SLCO1B3 NP_062818.1
Mus musculus (house mouse) Slco1b2 NP_065241.1
Rattus norvegicus (Norway rat) Slco1b2 NP_113838.1
Macaca mulatta (rhesus monkey) SLCO1B3 NP_001028113.1
Canis lupus familiaris (dog) SLCO1B3 NP_001159519.1


Related articles in PubMed

Endogenous retroviral promoter exaptation in human cancer.
Babaian A, Mager DL
Mobile DNA724(2016)

Preclinical Mouse Models To Study Human OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions in Vivo.
Durmus S, Lozano-Mena G, van Esch A, Wagenaar E, van Tellingen O, Schinkel AH
Molecular pharmaceutics12(12)4259-69(2015 Dec)

Comparison of genetic variations of the SLCO1B1, SLCO1B3, and SLCO2B1 genes among five ethnic groups.
Namgoong S, Cheong HS, Kim JO, Kim LH, Na HS, Koh IS, Chung MW, Shin HD
Environmental toxicology and pharmacology40(3)692-7(2015 Nov)

Identification of a new organic anion transporting polypeptide 1B3 mRNA isoform primarily expressed in human cancerous tissues and cells.
Nagai M, Furihata T, Matsumoto S, Ishii S, Motohashi S, Yoshino I, Ugajin M, Miyajima A, Matsumoto S, Chiba K
Biochemical and biophysical research communications418(4)818-23(2012 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

demonstrate that the N-terminal region is important for the membrane localization of the OATP1B subfamily members and should facilitate future investigations of the mechanisms involved in the regulation and membrane trafficking of these important transporter proteins
Title: The N-terminal region of organic anion transporting polypeptide 1B3 (OATP1B3) plays an essential role in regulating its plasma membrane trafficking.

Our results did not indicate a strong association between OATP1B1 or OATP1B3 inhibition and hyperbilirubinemia
Title: Linking organic anion transporting polypeptide 1B1 and 1B3 (OATP1B1 and OATP1B3) interaction profiles to hepatotoxicity - The hyperbilirubinemia use case.

SLCO1B3 was significantly downregulated in docetaxel-resistant patient-derived prostatic tumours xenografted into mice. SLCO1B3 determines intracellular concentrations of docetaxel and cabazitaxel and consequently influences taxane efficacy. Loss of the drug transporter SLCO1B3 may drive taxane resistance in prostate cancer.
Title: Loss of SLCO1B3 drives taxane resistance in prostate cancer.

OATP1B1- and OATP1B3-humanized mice can be used as in vivo tools to assess and possibly predict clinically relevant DDIs.
Title: Preclinical Mouse Models To Study Human OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions in Vivo.

Results identified interethnic differences of genetic variations of the SLCO1B1, SLCO1B3, and SLCO2B1 genes in Korean population compared with other ethnic groups.
Title: Comparison of genetic variations of the SLCO1B1, SLCO1B3, and SLCO2B1 genes among five ethnic groups.

The following SLCO1B3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLCO1B3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu21499
NM_019844.3
Latest version!
Homo sapiens solute carrier organic anion transporter family member 1B3 (SLCO1B3), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$279.50-$391.30
$559.00
OHu101300 NM_001349920.1
Latest version!
Homo sapiens solute carrier organic anion transporter family member 1B3 (SLCO1B3), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 14-16 $391.30
$559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu21499
Clone ID Related Accession (Same CDS sequence) NM_019844.3
Accession Version NM_019844.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2109bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-03-30
Organism Homo sapiens(Human)
Product solute carrier organic anion transporter family member 1B3 isoform 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG567966.1, AK055874.1, AC011604.10, AJ251506.1 and BM968322.1. This sequence is a reference standard in the RefSeqGene project. On Feb 9, 2012 this sequence version replaced NM_019844.2. Transcript Variant: This variant (1) encodes the longer isoform (1), which is highly expressed in the liver. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK055874.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145122, SAMN03465408 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
ATGGACCAAC ATCAACATTT GAATAAAACA GCAGAGTCAG CATCTTCAGA GAAAAAGAAA 
ACAAGACGCT GCAATGGATT CAAGATGTTC TTGGCAGCCC TGTCATTCAG CTATATTGCT
AAAGCACTAG GTGGAATCAT TATGAAAATT TCCATCACTC AAATAGAAAG GAGATTTGAC
ATATCCTCTT CTCTTGCTGG TTTAATTGAT GGAAGCTTTG AAATTGGAAA TTTGCTTGTG
ATTGTATTTG TAAGTTACTT TGGATCTAAA CTACACAGAC CGAAGTTAAT TGGAATTGGT
TGTCTCCTTA TGGGAACTGG AAGTATTTTG ACATCTTTAC CACATTTCTT CATGGGATAT
TATAGGTATT CTAAAGAAAC CCATATTAAT CCATCAGAAA ATTCAACATC AAGTTTATCA
ACCTGTTTAA TTAATCAAAC CTTATCATTC AATGGAACAT CACCTGAGAT AGTAGAAAAA
GATTGTGTAA AGGAATCTGG GTCACACATG TGGATCTATG TCTTCATGGG GAATATGCTT
CGTGGCATAG GGGAAACCCC CATAGTACCA TTGGGGATTT CATACATTGA TGATTTTGCA
AAAGAAGGAC ATTCTTCCTT GTATTTAGGT AGTTTGAATG CAATAGGAAT GATTGGTCCA
GTCATTGGCT TTGCACTGGG ATCTCTGTTT GCTAAAATGT ACGTGGATAT TGGATATGTA
GATCTGAGCA CTATCAGAAT AACTCCTAAG GACTCTCGTT GGGTTGGAGC TTGGTGGCTT
GGTTTCCTTG TGTCTGGACT ATTTTCCATT ATTTCTTCCA TACCATTTTT TTTCTTGCCG
AAAAATCCAA ATAAACCACA AAAAGAAAGA AAAATTTCAC TATCATTGCA TGTGCTGAAA
ACAAATGATG ATAGAAATCA AACAGCTAAT TTGACCAACC AAGGAAAAAA TGTTACCAAA
AATGTGACTG GTTTTTTCCA GTCTTTGAAA AGCATCCTTA CCAATCCCCT GTATGTTATA
TTTCTGCTTT TGACATTGTT ACAAGTAAGC AGCTTTATTG GTTCTTTTAC TTACGTCTTT
AAATATATGG AGCAACAGTA CGGTCAGTCT GCATCTCATG CTAACTTTTT GTTGGGAATC
ATAACCATTC CTACGGTTGC AACTGGAATG TTTTTAGGAG GATTTATCAT TAAAAAATTC
AAATTGTCTT TAGTTGGAAT TGCCAAATTT TCATTTCTTA CTTCGATGAT ATCCTTCTTG
TTTCAACTTC TATATTTCCC TCTAATCTGC GAAAGCAAAT CAGTTGCCGG CCTAACCTTG
ACCTATGATG GAAATAATTC AGTGGCATCT CATGTAGATG TACCACTTTC TTATTGCAAC
TCAGAGTGCA ATTGTGATGA AAGTCAGTGG GAACCAGTCT GTGGGAACAA TGGAATAACT
TACCTGTCAC CTTGTCTAGC AGGATGCAAA TCCTCAAGTG GTATTAAAAA GCATACAGTG
TTTTATAACT GTAGTTGTGT GGAAGTAACT GGTCTCCAGA ACAGAAATTA CTCAGCACAC
TTGGGTGAAT GCCCAAGAGA TAATACTTGT ACAAGGAAAT TTTTCATCTA TGTTGCAATT
CAAGTCATAA ACTCTTTGTT CTCTGCAACA GGAGGTACCA CATTTATCTT GTTGACTGTG
AAGATTGTTC AACCTGAATT GAAAGCACTT GCAATGGGTT TCCAGTCAAT GGTTATAAGA
ACACTAGGAG GAATTCTAGC TCCAATATAT TTTGGGGCTC TGATTGATAA AACATGTATG
AAGTGGTCCA CCAACAGCTG TGGAGCACAA GGAGCTTGTA GGATATATAA TTCCGTATTT
TTTGGAAGGG TCTACTTGGG CTTATCTATA GCTTTAAGAT TCCCAGCACT TGTTTTATAT
ATTGTTTTCA TTTTTGCTAT GAAGAAAAAA TTTCAAGGAA AAGATACCAA GGCATCGGAC
AATGAAAGAA AAGTAATGGA TGAAGCAAAC TTAGAATTCT TAAATAATGG TGAACATTTT
GTACCTTCTG CTGGAACAGA TAGTAAAACA TGTAATTTGG ACATGCAAGA CAATGCTGCT
GCCAACTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_062818.1
CDS242..2350
Misc Feature(1)209..211
Misc Feature(2)326..2104
Misc Feature(3)326..385
Misc Feature(4)332..>1528
Misc Feature(5)443..505
Misc Feature(6)524..598
Misc Feature(7)746..832
Misc Feature(8)890..952
Misc Feature(9)1007..1081
Misc Feature(10)1118..1120
Misc Feature(11)1124..1126
Misc Feature(12)1235..1300
Misc Feature(13)1361..1432
Misc Feature(14)1445..1516
Misc Feature(15)1604..1765
Misc Feature(16)1853..1921
Misc Feature(17)1949..2026
Misc Feature(18)2129..2182
Misc Feature(19)2288..2290
Exon (1)1..61
Exon (2)62..176
Exon (3)177..325
Exon (4)326..467
Exon (5)468..600
Exon (6)601..722
Exon (7)723..869
Exon (8)870..968
Exon (9)969..1211
Exon (10)1212..1376
Exon (11)1377..1572
Exon (12)1573..1738
Exon (13)1739..1923
Exon (14)1924..1988
Exon (15)1989..2106
Exon (16)2107..3014
Translation

Target ORF information:

RefSeq Version NM_019844.3
Organism Homo sapiens(Human)
Definition Homo sapiens solute carrier organic anion transporter family member 1B3 (SLCO1B3), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_019844.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
ATGGACCAAC ATCAACATTT GAATAAAACA GCAGAGTCAG CATCTTCAGA GAAAAAGAAA 
ACAAGACGCT GCAATGGATT CAAGATGTTC TTGGCAGCCC TGTCATTCAG CTATATTGCT
AAAGCACTAG GTGGAATCAT TATGAAAATT TCCATCACTC AAATAGAAAG GAGATTTGAC
ATATCCTCTT CTCTTGCTGG TTTAATTGAT GGAAGCTTTG AAATTGGAAA TTTGCTTGTG
ATTGTATTTG TAAGTTACTT TGGATCTAAA CTACACAGAC CGAAGTTAAT TGGAATTGGT
TGTCTCCTTA TGGGAACTGG AAGTATTTTG ACATCTTTAC CACATTTCTT CATGGGATAT
TATAGGTATT CTAAAGAAAC CCATATTAAT CCATCAGAAA ATTCAACATC AAGTTTATCA
ACCTGTTTAA TTAATCAAAC CTTATCATTC AATGGAACAT CACCTGAGAT AGTAGAAAAA
GATTGTGTAA AGGAATCTGG GTCACACATG TGGATCTATG TCTTCATGGG GAATATGCTT
CGTGGCATAG GGGAAACCCC CATAGTACCA TTGGGGATTT CATACATTGA TGATTTTGCA
AAAGAAGGAC ATTCTTCCTT GTATTTAGGT AGTTTGAATG CAATAGGAAT GATTGGTCCA
GTCATTGGCT TTGCACTGGG ATCTCTGTTT GCTAAAATGT ACGTGGATAT TGGATATGTA
GATCTGAGCA CTATCAGAAT AACTCCTAAG GACTCTCGTT GGGTTGGAGC TTGGTGGCTT
GGTTTCCTTG TGTCTGGACT ATTTTCCATT ATTTCTTCCA TACCATTTTT TTTCTTGCCG
AAAAATCCAA ATAAACCACA AAAAGAAAGA AAAATTTCAC TATCATTGCA TGTGCTGAAA
ACAAATGATG ATAGAAATCA AACAGCTAAT TTGACCAACC AAGGAAAAAA TGTTACCAAA
AATGTGACTG GTTTTTTCCA GTCTTTGAAA AGCATCCTTA CCAATCCCCT GTATGTTATA
TTTCTGCTTT TGACATTGTT ACAAGTAAGC AGCTTTATTG GTTCTTTTAC TTACGTCTTT
AAATATATGG AGCAACAGTA CGGTCAGTCT GCATCTCATG CTAACTTTTT GTTGGGAATC
ATAACCATTC CTACGGTTGC AACTGGAATG TTTTTAGGAG GATTTATCAT TAAAAAATTC
AAATTGTCTT TAGTTGGAAT TGCCAAATTT TCATTTCTTA CTTCGATGAT ATCCTTCTTG
TTTCAACTTC TATATTTCCC TCTAATCTGC GAAAGCAAAT CAGTTGCCGG CCTAACCTTG
ACCTATGATG GAAATAATTC AGTGGCATCT CATGTAGATG TACCACTTTC TTATTGCAAC
TCAGAGTGCA ATTGTGATGA AAGTCAGTGG GAACCAGTCT GTGGGAACAA TGGAATAACT
TACCTGTCAC CTTGTCTAGC AGGATGCAAA TCCTCAAGTG GTATTAAAAA GCATACAGTG
TTTTATAACT GTAGTTGTGT GGAAGTAACT GGTCTCCAGA ACAGAAATTA CTCAGCACAC
TTGGGTGAAT GCCCAAGAGA TAATACTTGT ACAAGGAAAT TTTTCATCTA TGTTGCAATT
CAAGTCATAA ACTCTTTGTT CTCTGCAACA GGAGGTACCA CATTTATCTT GTTGACTGTG
AAGATTGTTC AACCTGAATT GAAAGCACTT GCAATGGGTT TCCAGTCAAT GGTTATAAGA
ACACTAGGAG GAATTCTAGC TCCAATATAT TTTGGGGCTC TGATTGATAA AACATGTATG
AAGTGGTCCA CCAACAGCTG TGGAGCACAA GGAGCTTGTA GGATATATAA TTCCGTATTT
TTTGGAAGGG TCTACTTGGG CTTATCTATA GCTTTAAGAT TCCCAGCACT TGTTTTATAT
ATTGTTTTCA TTTTTGCTAT GAAGAAAAAA TTTCAAGGAA AAGATACCAA GGCATCGGAC
AATGAAAGAA AAGTAATGGA TGAAGCAAAC TTAGAATTCT TAAATAATGG TGAACATTTT
GTACCTTCTG CTGGAACAGA TAGTAAAACA TGTAATTTGG ACATGCAAGA CAATGCTGCT
GCCAACTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu101300
Clone ID Related Accession (Same CDS sequence) NM_001349920.1
Accession Version NM_001349920.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2025bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-12
Organism Homo sapiens(Human)
Product solute carrier organic anion transporter family member 1B3 isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC011604.10. Transcript Variant: This variant (2) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. The promoter and 5' terminal exon sequence is from an endogenous retroviral LTR. (PMID: 22326869) The resulting isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1. The protein encoded is primarily expressed in colon and pancreas cancers. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1968968, SAMN04284274 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
ATGTTCTTGG CAGCCCTGTC ATTCAGCTAT ATTGCTAAAG CACTAGGTGG AATCATTATG 
AAAATTTCCA TCACTCAAAT AGAAAGGAGA TTTGACATAT CCTCTTCTCT TGCTGGTTTA
ATTGATGGAA GCTTTGAAAT TGGAAATTTG CTTGTGATTG TATTTGTAAG TTACTTTGGA
TCTAAACTAC ACAGACCGAA GTTAATTGGA ATTGGTTGTC TCCTTATGGG AACTGGAAGT
ATTTTGACAT CTTTACCACA TTTCTTCATG GGATATTATA GGTATTCTAA AGAAACCCAT
ATTAATCCAT CAGAAAATTC AACATCAAGT TTATCAACCT GTTTAATTAA TCAAACCTTA
TCATTCAATG GAACATCACC TGAGATAGTA GAAAAAGATT GTGTAAAGGA ATCTGGGTCA
CACATGTGGA TCTATGTCTT CATGGGGAAT ATGCTTCGTG GCATAGGGGA AACCCCCATA
GTACCATTGG GGATTTCATA CATTGATGAT TTTGCAAAAG AAGGACATTC TTCCTTGTAT
TTAGGTAGTT TGAATGCAAT AGGAATGATT GGTCCAGTCA TTGGCTTTGC ACTGGGATCT
CTGTTTGCTA AAATGTACGT GGATATTGGA TATGTAGATC TGAGCACTAT CAGAATAACT
CCTAAGGACT CTCGTTGGGT TGGAGCTTGG TGGCTTGGTT TCCTTGTGTC TGGACTATTT
TCCATTATTT CTTCCATACC ATTTTTTTTC TTGCCGAAAA ATCCAAATAA ACCACAAAAA
GAAAGAAAAA TTTCACTATC ATTGCATGTG CTGAAAACAA ATGATGATAG AAATCAAACA
GCTAATTTGA CCAACCAAGG AAAAAATGTT ACCAAAAATG TGACTGGTTT TTTCCAGTCT
TTGAAAAGCA TCCTTACCAA TCCCCTGTAT GTTATATTTC TGCTTTTGAC ATTGTTACAA
GTAAGCAGCT TTATTGGTTC TTTTACTTAC GTCTTTAAAT ATATGGAGCA ACAGTACGGT
CAGTCTGCAT CTCATGCTAA CTTTTTGTTG GGAATCATAA CCATTCCTAC GGTTGCAACT
GGAATGTTTT TAGGAGGATT TATCATTAAA AAATTCAAAT TGTCTTTAGT TGGAATTGCC
AAATTTTCAT TTCTTACTTC GATGATATCC TTCTTGTTTC AACTTCTATA TTTCCCTCTA
ATCTGCGAAA GCAAATCAGT TGCCGGCCTA ACCTTGACCT ATGATGGAAA TAATTCAGTG
GCATCTCATG TAGATGTACC ACTTTCTTAT TGCAACTCAG AGTGCAATTG TGATGAAAGT
CAGTGGGAAC CAGTCTGTGG GAACAATGGA ATAACTTACC TGTCACCTTG TCTAGCAGGA
TGCAAATCCT CAAGTGGTAT TAAAAAGCAT ACAGTGTTTT ATAACTGTAG TTGTGTGGAA
GTAACTGGTC TCCAGAACAG AAATTACTCA GCACACTTGG GTGAATGCCC AAGAGATAAT
ACTTGTACAA GGAAATTTTT CATCTATGTT GCAATTCAAG TCATAAACTC TTTGTTCTCT
GCAACAGGAG GTACCACATT TATCTTGTTG ACTGTGAAGA TTGTTCAACC TGAATTGAAA
GCACTTGCAA TGGGTTTCCA GTCAATGGTT ATAAGAACAC TAGGAGGAAT TCTAGCTCCA
ATATATTTTG GGGCTCTGAT TGATAAAACA TGTATGAAGT GGTCCACCAA CAGCTGTGGA
GCACAAGGGG CTTGTAGGAT ATATAATTCC GTATTTTTTG GAAGGGTCTA CTTGGGCTTA
TCTATAGCTT TAAGATTCCC AGCACTTGTT TTATATATTG TTTTCATTTT TGCTATGAAG
AAAAAATTTC AAGGAAAAGA TACCAAGGCA TCGGACAATG AAAGAAAAGT AATGGATGAA
GCAAACTTAG AATTCTTAAA TAATGGTGAA CATTTTGTAC CTTCTGCTGG AACAGATAGT
AAAACATGTA ATTTGGACAT GCAAGACAAT GCTGCTGCCA ACTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001336849.1
CDS132..2156
Misc Feature(1)126..128
Exon (1)1..131
Exon (2)132..273
Exon (3)274..406
Exon (4)407..528
Exon (5)529..675
Exon (6)676..774
Exon (7)775..1017
Exon (8)1018..1182
Exon (9)1183..1378
Exon (10)1379..1544
Exon (11)1545..1729
Exon (12)1730..1794
Exon (13)1795..1912
Exon (14)1913..2820
Translation

Target ORF information:

RefSeq Version NM_001349920.1
Organism Homo sapiens(Human)
Definition Homo sapiens solute carrier organic anion transporter family member 1B3 (SLCO1B3), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001349920.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
ATGTTCTTGG CAGCCCTGTC ATTCAGCTAT ATTGCTAAAG CACTAGGTGG AATCATTATG 
AAAATTTCCA TCACTCAAAT AGAAAGGAGA TTTGACATAT CCTCTTCTCT TGCTGGTTTA
ATTGATGGAA GCTTTGAAAT TGGAAATTTG CTTGTGATTG TATTTGTAAG TTACTTTGGA
TCTAAACTAC ACAGACCGAA GTTAATTGGA ATTGGTTGTC TCCTTATGGG AACTGGAAGT
ATTTTGACAT CTTTACCACA TTTCTTCATG GGATATTATA GGTATTCTAA AGAAACCCAT
ATTAATCCAT CAGAAAATTC AACATCAAGT TTATCAACCT GTTTAATTAA TCAAACCTTA
TCATTCAATG GAACATCACC TGAGATAGTA GAAAAAGATT GTGTAAAGGA ATCTGGGTCA
CACATGTGGA TCTATGTCTT CATGGGGAAT ATGCTTCGTG GCATAGGGGA AACCCCCATA
GTACCATTGG GGATTTCATA CATTGATGAT TTTGCAAAAG AAGGACATTC TTCCTTGTAT
TTAGGTAGTT TGAATGCAAT AGGAATGATT GGTCCAGTCA TTGGCTTTGC ACTGGGATCT
CTGTTTGCTA AAATGTACGT GGATATTGGA TATGTAGATC TGAGCACTAT CAGAATAACT
CCTAAGGACT CTCGTTGGGT TGGAGCTTGG TGGCTTGGTT TCCTTGTGTC TGGACTATTT
TCCATTATTT CTTCCATACC ATTTTTTTTC TTGCCGAAAA ATCCAAATAA ACCACAAAAA
GAAAGAAAAA TTTCACTATC ATTGCATGTG CTGAAAACAA ATGATGATAG AAATCAAACA
GCTAATTTGA CCAACCAAGG AAAAAATGTT ACCAAAAATG TGACTGGTTT TTTCCAGTCT
TTGAAAAGCA TCCTTACCAA TCCCCTGTAT GTTATATTTC TGCTTTTGAC ATTGTTACAA
GTAAGCAGCT TTATTGGTTC TTTTACTTAC GTCTTTAAAT ATATGGAGCA ACAGTACGGT
CAGTCTGCAT CTCATGCTAA CTTTTTGTTG GGAATCATAA CCATTCCTAC GGTTGCAACT
GGAATGTTTT TAGGAGGATT TATCATTAAA AAATTCAAAT TGTCTTTAGT TGGAATTGCC
AAATTTTCAT TTCTTACTTC GATGATATCC TTCTTGTTTC AACTTCTATA TTTCCCTCTA
ATCTGCGAAA GCAAATCAGT TGCCGGCCTA ACCTTGACCT ATGATGGAAA TAATTCAGTG
GCATCTCATG TAGATGTACC ACTTTCTTAT TGCAACTCAG AGTGCAATTG TGATGAAAGT
CAGTGGGAAC CAGTCTGTGG GAACAATGGA ATAACTTACC TGTCACCTTG TCTAGCAGGA
TGCAAATCCT CAAGTGGTAT TAAAAAGCAT ACAGTGTTTT ATAACTGTAG TTGTGTGGAA
GTAACTGGTC TCCAGAACAG AAATTACTCA GCACACTTGG GTGAATGCCC AAGAGATAAT
ACTTGTACAA GGAAATTTTT CATCTATGTT GCAATTCAAG TCATAAACTC TTTGTTCTCT
GCAACAGGAG GTACCACATT TATCTTGTTG ACTGTGAAGA TTGTTCAACC TGAATTGAAA
GCACTTGCAA TGGGTTTCCA GTCAATGGTT ATAAGAACAC TAGGAGGAAT TCTAGCTCCA
ATATATTTTG GGGCTCTGAT TGATAAAACA TGTATGAAGT GGTCCACCAA CAGCTGTGGA
GCACAAGGGG CTTGTAGGAT ATATAATTCC GTATTTTTTG GAAGGGTCTA CTTGGGCTTA
TCTATAGCTT TAAGATTCCC AGCACTTGTT TTATATATTG TTTTCATTTT TGCTATGAAG
AAAAAATTTC AAGGAAAAGA TACCAAGGCA TCGGACAATG AAAGAAAAGT AATGGATGAA
GCAAACTTAG AATTCTTAAA TAATGGTGAA CATTTTGTAC CTTCTGCTGG AACAGATAGT
AAAACATGTA ATTTGGACAT GCAAGACAAT GCTGCTGCCA ACTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Endogenous retroviral promoter exaptation in human cancer.
Mobile DNA724(2016)
Babaian A,Mager DL


book

Preclinical Mouse Models To Study Human OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions in Vivo.
Molecular pharmaceutics12(12)4259-69(2015 Dec)
Durmus S,Lozano-Mena G,van Esch A,Wagenaar E,van Tellingen O,Schinkel AH


book

Comparison of genetic variations of the SLCO1B1, SLCO1B3, and SLCO2B1 genes among five ethnic groups.
Environmental toxicology and pharmacology40(3)692-7(2015 Nov)
Namgoong S,Cheong HS,Kim JO,Kim LH,Na HS,Koh IS,Chung MW,Shin HD


book

Identification of a new organic anion transporting polypeptide 1B3 mRNA isoform primarily expressed in human cancerous tissues and cells.
Biochemical and biophysical research communications418(4)818-23(2012 Feb)
Nagai M,Furihata T,Matsumoto S,Ishii S,Motohashi S,Yoshino I,Ugajin M,Miyajima A,Matsumoto S,Chiba K


 
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