×

SLCO1B3 cDNA ORF clone, Homo sapiens (human)

Gene Symbol SLCO1B3
Entrez Gene ID 28234
Full Name solute carrier organic anion transporter family, member 1B3
Synonyms HBLRR, LST-2, LST-3TM13, LST3, OATP-8, OATP1B3, OATP8, SLC21A8
General protein information
Preferred Names
solute carrier organic anion transporter family member 1B3
Names
solute carrier organic anion transporter family member 1B3
organic anion transporter 8
organic anion transporter LST-3c
organic anion-transporting polypeptide 8
liver-specific organic anion transporter 2
liver-specific organic anion transporter 3TM13
solute carrier family 21 (organic anion transporter), member 8
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12p12

Summary This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia. [provided by RefSeq, Feb 2012]. lac of sum
Disorder MIM:

605495


mRNA and Protein(s)

mRNA Protein Name
NM_019844 NP_062818 solute carrier organic anion transporter family member 1B3



Homo sapiens (human) SLCO1B3 NP_062818.1
Macaca mulatta (Rhesus monkey) SLCO1B3 NP_001028113.1
Canis lupus familiaris (dog) SLCO1B3 NP_001159519.1
Bos taurus (cattle) SLCO1B3 NP_991373.1
Mus musculus (house mouse) Slco1b2 NP_065241.1
Rattus norvegicus (Norway rat) Slco1b2 NP_113838.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following SLCO1B3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLCO1B3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu21499
NM_019844 Homo sapiens solute carrier organic anion transporter family, member 1B3 (SLCO1B3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$279.50-$391.30
$559.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu21499
Clone ID Related Accession (Same CDS sequence) NM_019844
Accession Version NM_019844.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2109bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product solute carrier organic anion transporter family member 1B3
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG567966.1, AK055874.1, AC011604.10, AJ251506.1 and BM968322.1. This sequence is a reference standard in the RefSeqGene project. On Feb 9, 2012 this sequence version replaced gi:112421139. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK055874.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145122, SAMEA962335 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
ATGGACCAAC ATCAACATTT GAATAAAACA GCAGAGTCAG CATCTTCAGA GAAAAAGAAA 
ACAAGACGCT GCAATGGATT CAAGATGTTC TTGGCAGCCC TGTCATTCAG CTATATTGCT
AAAGCACTAG GTGGAATCAT TATGAAAATT TCCATCACTC AAATAGAAAG GAGATTTGAC
ATATCCTCTT CTCTTGCTGG TTTAATTGAT GGAAGCTTTG AAATTGGAAA TTTGCTTGTG
ATTGTATTTG TAAGTTACTT TGGATCTAAA CTACACAGAC CGAAGTTAAT TGGAATTGGT
TGTCTCCTTA TGGGAACTGG AAGTATTTTG ACATCTTTAC CACATTTCTT CATGGGATAT
TATAGGTATT CTAAAGAAAC CCATATTAAT CCATCAGAAA ATTCAACATC AAGTTTATCA
ACCTGTTTAA TTAATCAAAC CTTATCATTC AATGGAACAT CACCTGAGAT AGTAGAAAAA
GATTGTGTAA AGGAATCTGG GTCACACATG TGGATCTATG TCTTCATGGG GAATATGCTT
CGTGGCATAG GGGAAACCCC CATAGTACCA TTGGGGATTT CATACATTGA TGATTTTGCA
AAAGAAGGAC ATTCTTCCTT GTATTTAGGT AGTTTGAATG CAATAGGAAT GATTGGTCCA
GTCATTGGCT TTGCACTGGG ATCTCTGTTT GCTAAAATGT ACGTGGATAT TGGATATGTA
GATCTGAGCA CTATCAGAAT AACTCCTAAG GACTCTCGTT GGGTTGGAGC TTGGTGGCTT
GGTTTCCTTG TGTCTGGACT ATTTTCCATT ATTTCTTCCA TACCATTTTT TTTCTTGCCG
AAAAATCCAA ATAAACCACA AAAAGAAAGA AAAATTTCAC TATCATTGCA TGTGCTGAAA
ACAAATGATG ATAGAAATCA AACAGCTAAT TTGACCAACC AAGGAAAAAA TGTTACCAAA
AATGTGACTG GTTTTTTCCA GTCTTTGAAA AGCATCCTTA CCAATCCCCT GTATGTTATA
TTTCTGCTTT TGACATTGTT ACAAGTAAGC AGCTTTATTG GTTCTTTTAC TTACGTCTTT
AAATATATGG AGCAACAGTA CGGTCAGTCT GCATCTCATG CTAACTTTTT GTTGGGAATC
ATAACCATTC CTACGGTTGC AACTGGAATG TTTTTAGGAG GATTTATCAT TAAAAAATTC
AAATTGTCTT TAGTTGGAAT TGCCAAATTT TCATTTCTTA CTTCGATGAT ATCCTTCTTG
TTTCAACTTC TATATTTCCC TCTAATCTGC GAAAGCAAAT CAGTTGCCGG CCTAACCTTG
ACCTATGATG GAAATAATTC AGTGGCATCT CATGTAGATG TACCACTTTC TTATTGCAAC
TCAGAGTGCA ATTGTGATGA AAGTCAGTGG GAACCAGTCT GTGGGAACAA TGGAATAACT
TACCTGTCAC CTTGTCTAGC AGGATGCAAA TCCTCAAGTG GTATTAAAAA GCATACAGTG
TTTTATAACT GTAGTTGTGT GGAAGTAACT GGTCTCCAGA ACAGAAATTA CTCAGCACAC
TTGGGTGAAT GCCCAAGAGA TAATACTTGT ACAAGGAAAT TTTTCATCTA TGTTGCAATT
CAAGTCATAA ACTCTTTGTT CTCTGCAACA GGAGGTACCA CATTTATCTT GTTGACTGTG
AAGATTGTTC AACCTGAATT GAAAGCACTT GCAATGGGTT TCCAGTCAAT GGTTATAAGA
ACACTAGGAG GAATTCTAGC TCCAATATAT TTTGGGGCTC TGATTGATAA AACATGTATG
AAGTGGTCCA CCAACAGCTG TGGAGCACAA GGAGCTTGTA GGATATATAA TTCCGTATTT
TTTGGAAGGG TCTACTTGGG CTTATCTATA GCTTTAAGAT TCCCAGCACT TGTTTTATAT
ATTGTTTTCA TTTTTGCTAT GAAGAAAAAA TTTCAAGGAA AAGATACCAA GGCATCGGAC
AATGAAAGAA AAGTAATGGA TGAAGCAAAC TTAGAATTCT TAAATAATGG TGAACATTTT
GTACCTTCTG CTGGAACAGA TAGTAAAACA TGTAATTTGG ACATGCAAGA CAATGCTGCT
GCCAACTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_062818.1
CDS242..2350
Misc Feature(1)209..211(+)
Misc Feature(2)320..2107(+)
Misc Feature(3)326..385(+)
Misc Feature(4)332..>1528(+)
Misc Feature(5)374..1411(+)
Misc Feature(6)443..505(+)
Misc Feature(7)524..598(+)
Misc Feature(8)746..832(+)
Misc Feature(9)890..952(+)
Misc Feature(10)1007..1081(+)
Misc Feature(11)1235..1300(+)
Misc Feature(12)1361..1432(+)
Misc Feature(13)1445..1516(+)
Misc Feature(14)1604..1765(+)
Misc Feature(15)1853..1921(+)
Misc Feature(16)1949..2026(+)
Misc Feature(17)2129..2182(+)
Exon (1)1..61
Gene:SLCO1B3
Gene Synonym:
Exon (2)62..176
Gene:SLCO1B3
Gene Synonym:
Exon (3)177..325
Gene:SLCO1B3
Gene Synonym:
Exon (4)326..467
Gene:SLCO1B3
Gene Synonym:
Exon (5)468..600
Gene:SLCO1B3
Gene Synonym:
Exon (6)601..722
Gene:SLCO1B3
Gene Synonym:
Exon (7)723..869
Gene:SLCO1B3
Gene Synonym:
Exon (8)870..968
Gene:SLCO1B3
Gene Synonym:
Exon (9)969..1211
Gene:SLCO1B3
Gene Synonym:
Exon (10)1212..1376
Gene:SLCO1B3
Gene Synonym:
Exon (11)1377..1572
Gene:SLCO1B3
Gene Synonym:
Exon (12)1573..1738
Gene:SLCO1B3
Gene Synonym:
Exon (13)1739..1923
Gene:SLCO1B3
Gene Synonym:
Exon (14)1924..1988
Gene:SLCO1B3
Gene Synonym:
Exon (15)1989..2106
Gene:SLCO1B3
Gene Synonym:
Exon (16)2107..3014
Gene:SLCO1B3
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_019844
Organism Homo sapiens (human)
Definition Homo sapiens solute carrier organic anion transporter family, member 1B3 (SLCO1B3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_019844

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
ATGGACCAAC ATCAACATTT GAATAAAACA GCAGAGTCAG CATCTTCAGA GAAAAAGAAA 
ACAAGACGCT GCAATGGATT CAAGATGTTC TTGGCAGCCC TGTCATTCAG CTATATTGCT
AAAGCACTAG GTGGAATCAT TATGAAAATT TCCATCACTC AAATAGAAAG GAGATTTGAC
ATATCCTCTT CTCTTGCTGG TTTAATTGAT GGAAGCTTTG AAATTGGAAA TTTGCTTGTG
ATTGTATTTG TAAGTTACTT TGGATCTAAA CTACACAGAC CGAAGTTAAT TGGAATTGGT
TGTCTCCTTA TGGGAACTGG AAGTATTTTG ACATCTTTAC CACATTTCTT CATGGGATAT
TATAGGTATT CTAAAGAAAC CCATATTAAT CCATCAGAAA ATTCAACATC AAGTTTATCA
ACCTGTTTAA TTAATCAAAC CTTATCATTC AATGGAACAT CACCTGAGAT AGTAGAAAAA
GATTGTGTAA AGGAATCTGG GTCACACATG TGGATCTATG TCTTCATGGG GAATATGCTT
CGTGGCATAG GGGAAACCCC CATAGTACCA TTGGGGATTT CATACATTGA TGATTTTGCA
AAAGAAGGAC ATTCTTCCTT GTATTTAGGT AGTTTGAATG CAATAGGAAT GATTGGTCCA
GTCATTGGCT TTGCACTGGG ATCTCTGTTT GCTAAAATGT ACGTGGATAT TGGATATGTA
GATCTGAGCA CTATCAGAAT AACTCCTAAG GACTCTCGTT GGGTTGGAGC TTGGTGGCTT
GGTTTCCTTG TGTCTGGACT ATTTTCCATT ATTTCTTCCA TACCATTTTT TTTCTTGCCG
AAAAATCCAA ATAAACCACA AAAAGAAAGA AAAATTTCAC TATCATTGCA TGTGCTGAAA
ACAAATGATG ATAGAAATCA AACAGCTAAT TTGACCAACC AAGGAAAAAA TGTTACCAAA
AATGTGACTG GTTTTTTCCA GTCTTTGAAA AGCATCCTTA CCAATCCCCT GTATGTTATA
TTTCTGCTTT TGACATTGTT ACAAGTAAGC AGCTTTATTG GTTCTTTTAC TTACGTCTTT
AAATATATGG AGCAACAGTA CGGTCAGTCT GCATCTCATG CTAACTTTTT GTTGGGAATC
ATAACCATTC CTACGGTTGC AACTGGAATG TTTTTAGGAG GATTTATCAT TAAAAAATTC
AAATTGTCTT TAGTTGGAAT TGCCAAATTT TCATTTCTTA CTTCGATGAT ATCCTTCTTG
TTTCAACTTC TATATTTCCC TCTAATCTGC GAAAGCAAAT CAGTTGCCGG CCTAACCTTG
ACCTATGATG GAAATAATTC AGTGGCATCT CATGTAGATG TACCACTTTC TTATTGCAAC
TCAGAGTGCA ATTGTGATGA AAGTCAGTGG GAACCAGTCT GTGGGAACAA TGGAATAACT
TACCTGTCAC CTTGTCTAGC AGGATGCAAA TCCTCAAGTG GTATTAAAAA GCATACAGTG
TTTTATAACT GTAGTTGTGT GGAAGTAACT GGTCTCCAGA ACAGAAATTA CTCAGCACAC
TTGGGTGAAT GCCCAAGAGA TAATACTTGT ACAAGGAAAT TTTTCATCTA TGTTGCAATT
CAAGTCATAA ACTCTTTGTT CTCTGCAACA GGAGGTACCA CATTTATCTT GTTGACTGTG
AAGATTGTTC AACCTGAATT GAAAGCACTT GCAATGGGTT TCCAGTCAAT GGTTATAAGA
ACACTAGGAG GAATTCTAGC TCCAATATAT TTTGGGGCTC TGATTGATAA AACATGTATG
AAGTGGTCCA CCAACAGCTG TGGAGCACAA GGAGCTTGTA GGATATATAA TTCCGTATTT
TTTGGAAGGG TCTACTTGGG CTTATCTATA GCTTTAAGAT TCCCAGCACT TGTTTTATAT
ATTGTTTTCA TTTTTGCTAT GAAGAAAAAA TTTCAAGGAA AAGATACCAA GGCATCGGAC
AATGAAAGAA AAGTAATGGA TGAAGCAAAC TTAGAATTCT TAAATAATGG TGAACATTTT
GTACCTTCTG CTGGAACAGA TAGTAAAACA TGTAATTTGG ACATGCAAGA CAATGCTGCT
GCCAACTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

OATP1B3 is expressed in pancreatic beta-islet cells and enhances the insulinotropic effect of the sulfonylurea derivative glibenclamide
Diabetes 63 (2), 775-784 (2014)
Meyer Zu Schwabedissen HE, Boettcher K, Steiner T, Schwarz UI, Keiser M, Kroemer HK and Siegmund W.


book

Role of hypoxia inducible factor-1alpha in the regulation of the cancer-specific variant of organic anion transporting polypeptide 1B3 (OATP1B3), in colon and pancreatic cancer
Biochem. Pharmacol. 86 (6), 816-823 (2013)
Han S, Kim K, Thakkar N, Kim D and Lee W.


book

Effects of Rifampin, a potent inducer of drug-metabolizing enzymes and an inhibitor of OATP1B1/3 transport, on the single dose pharmacokinetics of anacetrapib
J Clin Pharmacol 53 (7), 746-752 (2013)
Anderson MS, Cote J, Liu Y, Stypinski D, Auger P, Hohnstein A, Rasmussen S, Johnson-Levonas AO and Gutstein DE.


book

Prognostic value of organic anion transporting polypeptide 1B3 and copper transporter 1 expression in endometrial cancer patients treated with paclitaxel and carboplatin
Biomed. Res. 34 (3), 143-151 (2013)
Ogane N, Yasuda M, Kameda Y, Yokose T, Kato H, Itoh A, Nishino S, Hashimoto Y and Kamoshida S.


book

Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver
J. Clin. Invest. 122 (2), 519-528 (2012)
van de Steeg E, Stranecky V, Hartmannova H, Noskova L, Hrebicek M, Wagenaar E, van Esch A, de Waart DR, Oude Elferink RP, Kenworthy KE, Sticova E, al-Edreesi M, Knisely AS, Kmoch S, Jirsa M and Schinkel AH.


book

Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver
Gastroenterology 121 (5), 1185-1190 (2001)
Ismair MG, Stieger B, Cattori V, Hagenbuch B, Fried M, Meier PJ and Kullak-Ublick GA.


book

LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers
Gastroenterology 120 (7), 1689-1699 (2001)
Abe T, Unno M, Onogawa T, Tokui T, Kondo TN, Nakagomi R, Adachi H, Fujiwara K, Okabe M, Suzuki T, Nunoki K, Sato E, Kakyo M, Nishio T, Sugita J, Asano N, Tanemoto M, Seki M, Date F, Ono K, Kondo Y, Shiiba K, Suzuki M, Ohtani H, Shimosegawa T, Iinuma K, Nagura H, Ito S and Matsuno S.


book

Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver
Gastroenterology 120 (2), 525-533 (2001)
Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ and Hagenbuch B.


book

Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide
J. Biol. Chem. 275 (30), 23161-23168 (2000)
Konig J, Cui Y, Nies AT and Keppler D.


book

Rotor Syndrome
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Jirsa,M., Knisely,A.S., Schinkel,A. and Kmoch,S.


 
*
*
*
*