Gene Symbol | BEND3 |
Entrez Gene ID | 57673 |
Full Name | BEN domain containing 3 |
Synonyms | KIAA1553 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » BEND3 cDNA ORF clone
Gene Symbol | BEND3 |
Entrez Gene ID | 57673 |
Full Name | BEN domain containing 3 |
Synonyms | KIAA1553 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
XM_005267079.3 | XP_005267136.1 | BEN domain-containing protein 3 isoform X1 |
XM_011536005.3 | XP_011534307.1 | BEN domain-containing protein 3 isoform X1 |
XM_005267080.3 | XP_005267137.1 | BEN domain-containing protein 3 isoform X1 |
NM_001367314.1 | NP_001354243.1 | BEN domain-containing protein 3 |
XM_005267080.4 | XP_005267137.1 | BEN domain-containing protein 3 isoform X1 |
NM_001080450.2 | NP_001073919.1 | BEN domain-containing protein 3 |
XM_017011138.1 | XP_016866627.1 | BEN domain-containing protein 3 isoform X1 |
XM_011536005.2 | XP_011534307.1 | BEN domain-containing protein 3 isoform X1 |
Pan troglodytes (chimpanzee) | BEND3 | XP_527466.2 |
Canis lupus familiaris (dog) | BEND3 | XP_539070.2 |
Mus musculus (house mouse) | Bend3 | NP_950193.1 |
Bos taurus (cattle) | BEND3 | NP_001179540.1 |
Rattus norvegicus (Norway rat) | Bend3 | XP_006256646.1 |
Danio rerio (zebrafish) | bend3 | NP_001139063.1 |
Xenopus tropicalis (tropical clawed frog) | bend3 | XP_002937205.1 |
Homo sapiens (human) | BEND3 | NP_001073919.1 |
BEND3 | XP_001091339.1 | |
Gallus gallus (chicken) | BEND3 | XP_003641058.2 |
A novel TPR-BEN domain interaction mediates PICH-BEND3 association.
Pitchai GP, Kaulich M, Bizard AH, Mesa P, Yao Q, Sarlos K, Streicher WW, Nigg EA, Montoya G, Hickson ID
Nucleic acids research45(19)11413-11424(2017 Nov)
Characterization of the NTPR and BD1 interacting domains of the human PICH-BEND3 complex.
Pitchai GP, Hickson ID, Streicher W, Montoya G, Mesa P
Acta crystallographica. Section F, Structural biology communications72(Pt 8)646-51(2016 08)
BEND3 is involved in the human-specific repression of calreticulin: Implication for the evolution of higher brain functions in human.
Aghajanirefah A, Nguyen LN, Ohadi M
Gene576(1 Pt 3)577-80(2016 Jan)
BEND3 represses rDNA transcription by stabilizing a NoRC component via USP21 deubiquitinase.
Khan A, Giri S, Wang Y, Chakraborty A, Ghosh AK, Anantharaman A, Aggarwal V, Sathyan KM, Ha T, Prasanth KV, Prasanth SG
Proceedings of the National Academy of Sciences of the United States of America112(27)8338-43(2015 Jul)
BEND3 mediates transcriptional repression and heterochromatin organization.
Khan A, Prasanth SG
Transcription6(5)102-5(2015)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Data indicate BEND3 as a new interaction partner for PICH in mitosis, and have defined the residues within a TPR-BEN domain interface that mediate this interaction.
Title: A novel TPR-BEN domain interaction mediates PICH-BEND3 association.
Characterization of the NTPR and BD1 interacting domains of the human PICH-BEND3 complex has been reported.
Title: Characterization of the NTPR and BD1 interacting domains of the human PICH-BEND3 complex.
propose that there is a link between binding of BEND3 to the CALR rs138452745 C-allele and removal of NFI binding site from this nucleotide, and the evolution of human-specific higher brain functions
Title: BEND3 is involved in the human-specific repression of calreticulin: Implication for the evolution of higher brain functions in human.
Data show that SUMOylated BANP, E5R, and Nac1 (BEN) domain 3 (BEND3) stabilizes NoRC component TTF-1-interacting protein 5 (Tip5)via association with ubiquitin specific protease 21 (USP21) debiquitinase.
Title: BEND3 represses rDNA transcription by stabilizing a NoRC component via USP21 deubiquitinase.
Data shows that BEND3 associates with chromatin remodeling complexes to modulate gene expression and heterochromatin organization.
Title: BEND3 mediates transcriptional repression and heterochromatin organization.
The following BEND3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BEND3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu15144 | |
Clone ID Related Accession (Same CDS sequence) | XM_005267079.3 , XM_011536005.3 , XM_005267080.3 , NM_001367314.1 , XM_005267080.4 , NM_001080450.2 , XM_017011138.1 , XM_011536005.2 | |
Accession Version | NM_001080450.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2487bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-26 | |
Organism | Homo sapiens(human) | |
Product | BEN domain-containing protein 3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC131628.1, AB046773.1 and AL355586.27. On Apr 25, 2009 this sequence version replaced NM_001080450.1. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC131628.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAACTCAA CTGAATTCAC CGAAGATGTA GAAGAAGTTC TAAAAAGTAT CACTGTGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001073919.1 |
CDS | 651..3137 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001080450.2 |
1 | ATGAACTCAA CTGAATTCAC CGAAGATGTA GAAGAAGTTC TAAAAAGTAT CACTGTGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu15144 | |
Clone ID Related Accession (Same CDS sequence) | XM_005267079.3 , XM_011536005.3 , XM_005267080.3 , NM_001367314.1 , XM_005267080.4 , NM_001080450.2 , XM_017011138.1 , XM_011536005.2 | |
Accession Version | NM_001367314.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2487bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-29 | |
Organism | Homo sapiens(human) | |
Product | BEN domain-containing protein 3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL355586.27. On Nov 21, 2018 this sequence version replaced XM_005267079.4. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.414921.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03465403 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAACTCAA CTGAATTCAC CGAAGATGTA GAAGAAGTTC TAAAAAGTAT CACTGTGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001354243.1 |
CDS | 438..2924 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001367314.1 |
1 | ATGAACTCAA CTGAATTCAC CGAAGATGTA GAAGAAGTTC TAAAAAGTAT CACTGTGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu15144 | |
Clone ID Related Accession (Same CDS sequence) | XM_005267079.3 , XM_011536005.3 , XM_005267080.3 , NM_001367314.1 , XM_005267080.4 , NM_001080450.2 , XM_017011138.1 , XM_011536005.2 | |
Accession Version | XM_005267079.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2487bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | BEN domain-containing protein 3 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005267079.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAACTCAA CTGAATTCAC CGAAGATGTA GAAGAAGTTC TAAAAAGTAT CACTGTGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005267136.1 |
CDS | 110..2596 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005267079.3 |
1 | ATGAACTCAA CTGAATTCAC CGAAGATGTA GAAGAAGTTC TAAAAAGTAT CACTGTGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu15144 | |
Clone ID Related Accession (Same CDS sequence) | XM_005267079.3 , XM_011536005.3 , XM_005267080.3 , NM_001367314.1 , XM_005267080.4 , NM_001080450.2 , XM_017011138.1 , XM_011536005.2 | |
Accession Version | XM_011536005.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2487bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | BEN domain-containing protein 3 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011536005.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAACTCAA CTGAATTCAC CGAAGATGTA GAAGAAGTTC TAAAAAGTAT CACTGTGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011534307.1 |
CDS | 141..2627 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011536005.3 |
1 | ATGAACTCAA CTGAATTCAC CGAAGATGTA GAAGAAGTTC TAAAAAGTAT CACTGTGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu15144 | |
Clone ID Related Accession (Same CDS sequence) | XM_005267079.3 , XM_011536005.3 , XM_005267080.3 , NM_001367314.1 , XM_005267080.4 , NM_001080450.2 , XM_017011138.1 , XM_011536005.2 | |
Accession Version | XM_005267080.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2487bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | BEN domain-containing protein 3 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005267080.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAACTCAA CTGAATTCAC CGAAGATGTA GAAGAAGTTC TAAAAAGTAT CACTGTGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005267137.1 |
CDS | 429..2915 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005267080.3 |
1 | ATGAACTCAA CTGAATTCAC CGAAGATGTA GAAGAAGTTC TAAAAAGTAT CACTGTGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu15144 | |
Clone ID Related Accession (Same CDS sequence) | XM_005267079.3 , XM_011536005.3 , XM_005267080.3 , NM_001367314.1 , XM_005267080.4 , NM_001080450.2 , XM_017011138.1 , XM_011536005.2 | |
Accession Version | XM_005267080.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2487bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | BEN domain-containing protein 3 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005267080.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAACTCAA CTGAATTCAC CGAAGATGTA GAAGAAGTTC TAAAAAGTAT CACTGTGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005267137.1 |
CDS | 429..2915 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005267080.4 |
1 | ATGAACTCAA CTGAATTCAC CGAAGATGTA GAAGAAGTTC TAAAAAGTAT CACTGTGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu15144 | |
Clone ID Related Accession (Same CDS sequence) | XM_005267079.3 , XM_011536005.3 , XM_005267080.3 , NM_001367314.1 , XM_005267080.4 , NM_001080450.2 , XM_017011138.1 , XM_011536005.2 | |
Accession Version | XM_017011138.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2487bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | BEN domain-containing protein 3 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAACTCAA CTGAATTCAC CGAAGATGTA GAAGAAGTTC TAAAAAGTAT CACTGTGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016866627.1 |
CDS | 680..3166 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017011138.1 |
1 | ATGAACTCAA CTGAATTCAC CGAAGATGTA GAAGAAGTTC TAAAAAGTAT CACTGTGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu15144 | |
Clone ID Related Accession (Same CDS sequence) | XM_005267079.3 , XM_011536005.3 , XM_005267080.3 , NM_001367314.1 , XM_005267080.4 , NM_001080450.2 , XM_017011138.1 , XM_011536005.2 | |
Accession Version | XM_011536005.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2487bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | BEN domain-containing protein 3 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011536005.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAACTCAA CTGAATTCAC CGAAGATGTA GAAGAAGTTC TAAAAAGTAT CACTGTGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011534307.1 |
CDS | 140..2626 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011536005.2 |
1 | ATGAACTCAA CTGAATTCAC CGAAGATGTA GAAGAAGTTC TAAAAAGTAT CACTGTGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
A novel TPR-BEN domain interaction mediates PICH-BEND3 association. |
Characterization of the NTPR and BD1 interacting domains of the human PICH-BEND3 complex. |
BEND3 is involved in the human-specific repression of calreticulin: Implication for the evolution of higher brain functions in human. |
BEND3 represses rDNA transcription by stabilizing a NoRC component via USP21 deubiquitinase. |
BEND3 mediates transcriptional repression and heterochromatin organization. |