Bcl10 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Gene Symbol	Bcl10
Entrez Gene ID	12042
Full Name	B cell leukemia/lymphoma 10
Synonyms	AI132454,BCL-10,C81403,CARMEN,CIPER,CLAP,ME10,cE10
General protein information	Preferred Names B cell leukemia/lymphoma 10 Names B-cell lymphoma/leukemia 10 B-cell CLL/lymphoma 10 CARD-containing molecule enhancing NF-kappa-B CARD-like apoptotic protein CED-3/ICH-1 prodomain homologous E10-like regulator cellular homolog of vCARMEN cellular-E10 mammalian CARD-containing adapter molecule E10
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 H2

mRNA and Protein(s)

mRNA Protein Name

NM_009740.2 NP_033870.1 B-cell lymphoma/leukemia 10
Pathways from BioSystems

mRNA	Protein	Name
NM_009740.2	NP_033870.1	B-cell lymphoma/leukemia 10

Homologies

Gallus gallus (chicken)	BCL10	NP_001188416.2
Canis lupus familiaris (dog)	BCL10	XP_547304.2
Xenopus tropicalis (tropical clawed frog)	bcl10	NP_001015777.2
Homo sapiens (human)	BCL10	NP_003912.1
Bos taurus (cattle)	BCL10	NP_001071496.1
Rattus norvegicus (Norway rat)	Bcl10	NP_112618.1
Pan troglodytes (chimpanzee)	BCL10	XP_513526.2
Mus musculus (house mouse)	Bcl10	NP_033870.1
	BCL10	XP_001104846.2
Danio rerio (zebrafish)	LOC100334750	XP_002660738.1

Gene Ontology
Bibliography

Related articles in PubMed

Nociceptors Boost the Resolution of Fungal Osteoinflammation via the TRP Channel-CGRP-Jdp2 Axis.
Maruyama K, Takayama Y, Kondo T, Ishibashi KI, Sahoo BR, Kanemaru H, Kumagai Y, Martino MM, Tanaka H, Ohno N, Iwakura Y, Takemura N, Tominaga M, Akira S
Cell reports19(13)2730-2742(2017 Jun)

Zinc rescues obesity-induced cardiac hypertrophy via stimulating metallothionein to suppress oxidative stress-activated BCL10/CARD9/p38 MAPK pathway.
Wang S, Gu J, Xu Z, Zhang Z, Bai T, Xu J, Cai J, Barnes G, Liu QJ, Freedman JH, Wang Y, Liu Q, Zheng Y, Cai L
Journal of cellular and molecular medicine21(6)1182-1192(2017 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Inherited BCL10 deficiency impairs hematopoietic and nonhematopoietic immunity.
Title: Inherited BCL10 deficiency impairs hematopoietic and nonhematopoietic immunity.

Bcl10 mediates angiotensin II-induced cardiac damage and electrical remodeling.
Title: Bcl10 mediates angiotensin II-induced cardiac damage and electrical remodeling.

Trehalose 6,6'-dimycolate-induced Mincle expression is dependent on Dectin-3-mediated NF-kappaB activation through the CARD9-BCL10-MALT1 complex.
Title: C-type lectin receptor dectin-3 mediates trehalose 6,6'-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent nuclear factor (NF)-?B activation.

cell receptor-dependent activation of mTOR signaling in T cells is mediated by Carma1 and MALT1, but not Bcl10.
Title: T cell receptor-dependent activation of mTOR signaling in T cells is mediated by Carma1 and MALT1, but not Bcl10.

TCR-stimulated activation of NF-kappaB requires the assembly of cytosolic p62-Bcl10-Malt1-IKK signalosomes, which may ensure highly regulated activation of NF-kappaB in response to TCR engagement.
Title: T cell receptor signals to NF-?B are transmitted by a cytosolic p62-Bcl10-Malt1-IKK signalosome.

The following Bcl10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bcl10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu04751	NM_009740.2 Latest version!	Mus musculus B cell leukemia/lymphoma 10 (Bcl10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Bcl10 ( NM_009740.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033870.1 Mus musculus B cell leukemia/lymphoma 10 (Bcl10), mRNA.

Price & Availability↑

CloneID	OMu04751
Clone ID Related Accession (Same CDS sequence)	NM_009740.2
Accession Version	NM_009740.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 702bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	B-cell lymphoma/leukemia 10
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BU707261.1, AK150883.1, AK140179.1 and AC123684.8. On Aug 13, 2013 this sequence version replaced NM_009740.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BU707261.1, AK156890.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGCTC CCGCACCGTC CCTCACGGAG GAGGATTTGA CTGAAGTGAA GAAGGACGCT 
TTAGAGAATT TACGTGTTTA CCTGTGTGAG AAAATCATAG CTGAGAGACA TTTTGATCAT 
CTACGTGCAA AAAAAATACT AAGTAGAGAA GACACAGAAG AAATTTCTTG CCGAACTTCA 
AGTAGAAAAC GGGCTGGGAA GTTGTTAGAC TACTTACAGG AGAACCCCAG GGGCCTGGAC 
ACCCTGGTGG AATCCATCCG CAGGGAGAAA ACACAGAGCT TCCTGATTCA GAAGATAACG 
GATGAGGTGC TAAAGCTTCG GAATATAAAA CTGGAGCACC TCAAAGGCCT GAAGTGCAGC 
AGCTGTGAGC CCTTTGCAGC CGGAGCCACC AACAACCTCT CTAGGTGCAA TTCCGATGAG 
AGCAATCTCT CTGAGAAACA GAGAGCATCC ACTGTCATGT ACCACCCGGA GGGAGAGTCC 
AGCACGGCTC CCTTCTTCTC TATGGCGTCG TCCCTGAACT TGCCAGTCCT GGAAGTTGGC 
AGGACTGAAA ACAGCAGCTT CTCTTCAGCC ACTCTTCCTC GACCTGGGGA CCCTGGGGCT 
CCCCCTTTGC CCCCAGACCT TCGGTTGGAA GAGGGGGGAA GTTGTGGAAA CTCAAGTGAG 
ATGTTTCTCC CCTTACGGTC ACGGGCTCTT TCACGCCAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033870.1
CDS	198..899
Translation	MEAPAPSLTEEDLTEVKKDALENLRVYLCEKIIAERHFDHLRAKKILSREDTEEISCRTSSRKRAGKLLDYLQENPRGLDTLVESIRREKTQSFLIQKITDEVLKLRNIKLEHLKGLKCSSCEPFAAGATNNLSRCNSDESNLSEKQRASTVMYHPEGESSTAPFFSMASSLNLPVLEVGRTENSSFSSATLPRPGDPGAPPLPPDLRLEEGGSCGNSSEMFLPLRSRALSRQ

Target ORF information:

RefSeq Version	NM_009740.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus B cell leukemia/lymphoma 10 (Bcl10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009740.2

ORF Insert Sequence:

ATGGAGGCTC CCGCACCGTC CCTCACGGAG GAGGATTTGA CTGAAGTGAA GAAGGACGCT 
TTAGAGAATT TACGTGTTTA CCTGTGTGAG AAAATCATAG CTGAGAGACA TTTTGATCAT 
CTACGTGCAA AAAAAATACT AAGTAGAGAA GACACAGAAG AAATTTCTTG CCGAACTTCA 
AGTAGAAAAC GGGCTGGGAA GTTGTTAGAC TACTTACAGG AGAACCCCAG GGGCCTGGAC 
ACCCTGGTGG AATCCATCCG CAGGGAGAAA ACACAGAGCT TCCTGATTCA GAAGATAACG 
GATGAGGTGC TAAAGCTTCG GAATATAAAA CTGGAGCACC TCAAAGGCCT GAAGTGCAGC 
AGCTGTGAGC CCTTTGCAGC CGGAGCCACC AACAACCTCT CTAGGTGCAA TTCCGATGAG 
AGCAATCTCT CTGAGAAACA GAGAGCATCC ACTGTCATGT ACCACCCGGA GGGAGAGTCC 
AGCACGGCTC CCTTCTTCTC TATGGCGTCG TCCCTGAACT TGCCAGTCCT GGAAGTTGGC 
AGGACTGAAA ACAGCAGCTT CTCTTCAGCC ACTCTTCCTC GACCTGGGGA CCCTGGGGCT 
CCCCCTTTGC CCCCAGACCT TCGGTTGGAA GAGGGGGGAA GTTGTGGAAA CTCAAGTGAG 
ATGTTTCTCC CCTTACGGTC ACGGGCTCTT TCACGCCAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Nociceptors Boost the Resolution of Fungal Osteoinflammation via the TRP Channel-CGRP-Jdp2 Axis.
Cell reports19(13)2730-2742(2017 Jun)
Maruyama K,Takayama Y,Kondo T,Ishibashi KI,Sahoo BR,Kanemaru H,Kumagai Y,Martino MM,Tanaka H,Ohno N,Iwakura Y,Takemura N,Tominaga M,Akira S

Zinc rescues obesity-induced cardiac hypertrophy via stimulating metallothionein to suppress oxidative stress-activated BCL10/CARD9/p38 MAPK pathway.
Journal of cellular and molecular medicine21(6)1182-1192(2017 Jun)
Wang S,Gu J,Xu Z,Zhang Z,Bai T,Xu J,Cai J,Barnes G,Liu QJ,Freedman JH,Wang Y,Liu Q,Zheng Y,Cai L

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Bcl10 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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