Dll3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dll3
Entrez Gene ID	13389
Full Name	delta like canonical Notch ligand 3
Synonyms	pu,pudgy
General protein information	Preferred Names delta like canonical Notch ligand 3 Names delta-like protein 3 M-Delta-3 delta-like 3 delta3 drosophila Delta homolog 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 A3\|7 16.67 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_007866.2	NP_031892.2	delta-like protein 3 precursor

Pathways from BioSystems

Homologies

	DLL3	XP_001088937.2
Rattus norvegicus (Norway rat)	Dll3	NP_446118.1
Mus musculus (house mouse)	Dll3	NP_031892.2
Homo sapiens (human)	DLL3	NP_058637.1
Canis lupus familiaris (dog)	DLL3	XP_005616942.1
Pan troglodytes (chimpanzee)	DLL3	XP_003316395.1
Bos taurus (cattle)	DLL3	NP_001179009.2

Gene Ontology
Bibliography

Related articles in PubMed

Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception.
Bicker F, Vasic V, Horta G, Ortega F, Nolte H, Kavyanifar A, Keller S, Stankovic ND, Harter PN, Benedito R, Lutz B, B?uerle T, Hartwig J, Baumgart J, Kr?ger M, Radyushkin K, Alberi L, Berninger B, Schmidt MHH
Nature communications815922(2017 Jun)

The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina.
Ha T, Moon KH, Dai L, Hatakeyama J, Yoon K, Park HS, Kong YY, Shimamura K, Kim JW
Cell reports19(2)351-363(2017 Apr)

The Notch ligand delta-like 3 promotes tumor growth and inhibits Notch signaling in lung cancer cells in mice.
Deng SM, Yan XC, Liang L, Wang L, Liu Y, Duan JL, Yang ZY, Chang TF, Ruan B, Zheng QJ, Han H
Biochemical and biophysical research communications483(1)488-494(2017 01)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Dll3 overexpression promoted PI3K/Akt signaling through inhibiting Notch signaling in lung cancer.
Title: The Notch ligand delta-like 3 promotes tumor growth and inhibits Notch signaling in lung cancer cells in mice.

Structural deformities of the vertebral column and adjacent ribs in the pudgy mouse are caused by mutations in Dll3. Review.
Title: Disordered vertebral and rib morphology in pudgy mice. Structural relationships to human scoliosis.

O-fucosylation of DLL3 is required for its function during somitogenesis.
Title: O-fucosylation of DLL3 is required for its function during somitogenesis.

Intriguing changes are observed in the cranio-caudal borders of multifidus muscle in mutant Dll3 and Lfng models of idiopathic scoliosis.
Title: Mutations in the Notch pathway alter the patterning of multifidus.

Dll3 has a unique function during T-cell development that is distinct from the role played by the other DSL ligands of Notch.
Title: A cell autonomous role for the Notch ligand Delta-like 3 in ?? T-cell development.

The following Dll3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dll3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00934	NM_007866.2 Latest version!	Mus musculus delta like canonical Notch ligand 3 (Dll3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dll3 ( NM_007866.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031892.2 Mus musculus delta like canonical Notch ligand 3 (Dll3), mRNA.

Price & Availability↑

CloneID	OMu00934
Clone ID Related Accession (Same CDS sequence)	NM_007866.2
Accession Version	NM_007866.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1758bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	delta-like protein 3 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB868475.1 and BC052002.1. On Oct 20, 2006 this sequence version replaced NM_007866.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC052002.1, AK144282.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164139, SAMN01164141 [ECO:0000348] ##Evidence-Data-END##

ATGGTCTCTC TGCAGGTGTC TCCGCTTTCC CAGACGCTGA TCCTGGCTTT TCTTCTTCCT 
CAGGCACTGC CAGCTGGTGT CTTCGAGCTA CAAATTCATT CTTTCGGGCC AGGCCCAGGC 
CTCGGGACCC CACGCTCCCC CTGCAACGCC CGAGGCCCTT GCCGCCTCTT CTTCAGGGTC 
TGCCTGAAGC CCGGAGTCTC CCAGGAGGCC ACCGAGTCCC TGTGCGCCCT GGGCGCAGCA 
CTGAGCACGA GCGTCCCGGT CTATACGGAG CACCCCGGAG AGTCAGCGGC TGCCCTGCCG 
CTGCCTGATG GCCTCGTACG TGTGCCCTTC CGCGATGCTT GGCCGGGCAC CTTCTCCCTC 
GTCATTGAAA CCTGGAGAGA GCAGCTGGGA GAGCATGCTG GAGGGCCCGC CTGGAACCTG 
CTAGCACGTG TGGTCGGCCG TAGACGCCTG GCGGCTGGGG GCCCGTGGGC CCGCGATGTG 
CAGCGCACAG GCACATGGGA GTTGCACTTC TCCTACCGCG CGCGGTGCGA GCCGCCCGCC 
GTCGGGGCCG CCTGCGCGCG CCTGTGCCGC TCACGCAGTG CCCCCTCGCG GTGTGGCCCG 
GGACTGCGAC CCTGCACGCC ATTCCCAGAC GAGTGCGAAG CCCCGTCTGT GTGTCGACCA 
GGCTGCAGCC CCGAGCACGG CTACTGTGAA GAGCCTGATG AATGCCGTTG CCTGGAGGGC 
TGGACTGGAC CCCTCTGCAC GGTCCCTGTC TCCACCAGTA GCTGCCTGAA CTCCAGGGTT 
CCTGGTCCTG CCAGCACTGG ATGCCTTTTA CCTGGGCCTG GACCTTGTGA TGGGAACCCA 
TGTGCCAATG GGGGCAGCTG TAGTGAAACC TCTGGCTCCT TTGAATGTGC CTGTCCCCGG 
GGATTCTACG GGCTTCGATG TGAGGTGAGC GGGGTCACGT GCGCAGATGG ACCCTGCTTC 
AATGGCGGCT TGTGTGTTGG CGGTGAAGAT CCTGACTCTG CCTATGTCTG TCATTGCCCA 
CCTGGTTTCC AAGGCTCTAA CTGTGAGAAG AGGGTGGACC GCTGTAGCCT GCAGCCATGT 
CAGAATGGCG GCCTCTGCCT GGACCTGGGC CACGCGTTGC GCTGCCGCTG TCGCGCGGGA 
TTCGCCGGGC CGCGCTGCGA GCACGACCTG GACGACTGCG CCGGCCGCGC CTGTGCCAAC 
GGCGGCACGT GCGTGGAGGG CGGCGGCTCG CGCCGCTGCT CCTGTGCGCT GGGCTTCGGC 
GGGCGCGACT GCCGAGAACG CGCCGACCCC TGCGCCTCCC GCCCCTGCGC GCATGGAGGC 
CGTTGCTACG CCCACTTCTC TGGCCTGGTC TGCGCCTGCG CGCCCGGCTA CATGGGCGTG 
AGATGCGAGT TCGCTGTGCG CCCGGACGGC GCGGACGCGG TGCCCGCCGC CCCGCGGGGC 
CTGAGGCAGG CGGATCCACA GCGCTTTCTT CTGCCTCCCG CCTTGGGGCT GCTGGTGGCC 
GCCGGTTTGG CTGGCGCCGC ACTCTTGGTC ATCCACGTTC GCCGCCGAGG TCCTGGCCAG 
GATACCGGGA CTCGCCTGCT TTCTGGGACC CGGGAGCCTT CGGTCCACAC GCTCCCGGAT 
GCACTCAACA ACCTGAGGTT ACAAGACGGT GCTGGGGATG GCCCCAGTTC GTCGGCTGAC 
TGGAATCATC CTGAAGATGG AGACTCTAGA TCCATTTATG TCATACCAGC CCCTTCCATT 
TATGCACGAG AGGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031892.2
CDS	40..1797
Translation	MVSLQVSPLSQTLILAFLLPQALPAGVFELQIHSFGPGPGLGTPRSPCNARGPCRLFFRVCLKPGVSQEATESLCALGAALSTSVPVYTEHPGESAAALPLPDGLVRVPFRDAWPGTFSLVIETWREQLGEHAGGPAWNLLARVVGRRRLAAGGPWARDVQRTGTWELHFSYRARCEPPAVGAACARLCRSRSAPSRCGPGLRPCTPFPDECEAPSVCRPGCSPEHGYCEEPDECRCLEGWTGPLCTVPVSTSSCLNSRVPGPASTGCLLPGPGPCDGNPCANGGSCSETSGSFECACPRGFYGLRCEVSGVTCADGPCFNGGLCVGGEDPDSAYVCHCPPGFQGSNCEKRVDRCSLQPCQNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGSRRCSCALGFGGRDCRERADPCASRPCAHGGRCYAHFSGLVCACAPGYMGVRCEFAVRPDGADAVPAAPRGLRQADPQRFLLPPALGLLVAAGLAGAALLVIHVRRRGPGQDTGTRLLSGTREPSVHTLPDALNNLRLQDGAGDGPSSSADWNHPEDGDSRSIYVIPAPSIYAREA

Target ORF information:

RefSeq Version	NM_007866.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus delta like canonical Notch ligand 3 (Dll3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007866.2

ORF Insert Sequence:

ATGGTCTCTC TGCAGGTGTC TCCGCTTTCC CAGACGCTGA TCCTGGCTTT TCTTCTTCCT 
CAGGCACTGC CAGCTGGTGT CTTCGAGCTA CAAATTCATT CTTTCGGGCC AGGCCCAGGC 
CTCGGGACCC CACGCTCCCC CTGCAACGCC CGAGGCCCTT GCCGCCTCTT CTTCAGGGTC 
TGCCTGAAGC CCGGAGTCTC CCAGGAGGCC ACCGAGTCCC TGTGCGCCCT GGGCGCAGCA 
CTGAGCACGA GCGTCCCGGT CTATACGGAG CACCCCGGAG AGTCAGCGGC TGCCCTGCCG 
CTGCCTGATG GCCTCGTACG TGTGCCCTTC CGCGATGCTT GGCCGGGCAC CTTCTCCCTC 
GTCATTGAAA CCTGGAGAGA GCAGCTGGGA GAGCATGCTG GAGGGCCCGC CTGGAACCTG 
CTAGCACGTG TGGTCGGCCG TAGACGCCTG GCGGCTGGGG GCCCGTGGGC CCGCGATGTG 
CAGCGCACAG GCACATGGGA GTTGCACTTC TCCTACCGCG CGCGGTGCGA GCCGCCCGCC 
GTCGGGGCCG CCTGCGCGCG CCTGTGCCGC TCACGCAGTG CCCCCTCGCG GTGTGGCCCG 
GGACTGCGAC CCTGCACGCC ATTCCCAGAC GAGTGCGAAG CCCCGTCTGT GTGTCGACCA 
GGCTGCAGCC CCGAGCACGG CTACTGTGAA GAGCCTGATG AATGCCGTTG CCTGGAGGGC 
TGGACTGGAC CCCTCTGCAC GGTCCCTGTC TCCACCAGTA GCTGCCTGAA CTCCAGGGTT 
CCTGGTCCTG CCAGCACTGG ATGCCTTTTA CCTGGGCCTG GACCTTGTGA TGGGAACCCA 
TGTGCCAATG GGGGCAGCTG TAGTGAAACC TCTGGCTCCT TTGAATGTGC CTGTCCCCGG 
GGATTCTACG GGCTTCGATG TGAGGTGAGC GGGGTCACGT GCGCAGATGG ACCCTGCTTC 
AATGGCGGCT TGTGTGTTGG CGGTGAAGAT CCTGACTCTG CCTATGTCTG TCATTGCCCA 
CCTGGTTTCC AAGGCTCTAA CTGTGAGAAG AGGGTGGACC GCTGTAGCCT GCAGCCATGT 
CAGAATGGCG GCCTCTGCCT GGACCTGGGC CACGCGTTGC GCTGCCGCTG TCGCGCGGGA 
TTCGCCGGGC CGCGCTGCGA GCACGACCTG GACGACTGCG CCGGCCGCGC CTGTGCCAAC 
GGCGGCACGT GCGTGGAGGG CGGCGGCTCG CGCCGCTGCT CCTGTGCGCT GGGCTTCGGC 
GGGCGCGACT GCCGAGAACG CGCCGACCCC TGCGCCTCCC GCCCCTGCGC GCATGGAGGC 
CGTTGCTACG CCCACTTCTC TGGCCTGGTC TGCGCCTGCG CGCCCGGCTA CATGGGCGTG 
AGATGCGAGT TCGCTGTGCG CCCGGACGGC GCGGACGCGG TGCCCGCCGC CCCGCGGGGC 
CTGAGGCAGG CGGATCCACA GCGCTTTCTT CTGCCTCCCG CCTTGGGGCT GCTGGTGGCC 
GCCGGTTTGG CTGGCGCCGC ACTCTTGGTC ATCCACGTTC GCCGCCGAGG TCCTGGCCAG 
GATACCGGGA CTCGCCTGCT TTCTGGGACC CGGGAGCCTT CGGTCCACAC GCTCCCGGAT 
GCACTCAACA ACCTGAGGTT ACAAGACGGT GCTGGGGATG GCCCCAGTTC GTCGGCTGAC 
TGGAATCATC CTGAAGATGG AGACTCTAGA TCCATTTATG TCATACCAGC CCCTTCCATT 
TATGCACGAG AGGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception.
Nature communications815922(2017 Jun)
Bicker F,Vasic V,Horta G,Ortega F,Nolte H,Kavyanifar A,Keller S,Stankovic ND,Harter PN,Benedito R,Lutz B,B?uerle T,Hartwig J,Baumgart J,Kr?ger M,Radyushkin K,Alberi L,Berninger B,Schmidt MHH

The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina.
Cell reports19(2)351-363(2017 Apr)
Ha T,Moon KH,Dai L,Hatakeyama J,Yoon K,Park HS,Kong YY,Shimamura K,Kim JW

The Notch ligand delta-like 3 promotes tumor growth and inhibits Notch signaling in lung cancer cells in mice.
Biochemical and biophysical research communications483(1)488-494(2017 01)
Deng SM,Yan XC,Liang L,Wang L,Liu Y,Duan JL,Yang ZY,Chang TF,Ruan B,Zheng QJ,Han H

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Dll3 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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