Gene Symbol | Hmox2 |
Entrez Gene ID | 15369 |
Full Name | heme oxygenase 2 |
Synonyms | HO-2,HO2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Hmox2 cDNA ORF clone
Gene Symbol | Hmox2 |
Entrez Gene ID | 15369 |
Full Name | heme oxygenase 2 |
Synonyms | HO-2,HO2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001136066.2 | NP_001129538.1 | heme oxygenase 2 isoform 1 |
XM_006521804.3 | XP_006521867.1 | heme oxygenase 2 isoform X1 |
XM_006521803.3 | XP_006521866.2 | heme oxygenase 2 isoform X1 |
XM_006521804.2 | XP_006521867.1 | heme oxygenase 2 isoform X2 |
NM_001357050.1 | NP_001343979.1 | heme oxygenase 2 isoform 2 |
NM_010443.2 | NP_034573.2 | heme oxygenase 2 isoform 1 |
Homo sapiens (human) | HMOX2 | NP_001273197.1 |
HMOX2 | XP_001097224.1 | |
Danio rerio (zebrafish) | hmox2b | XP_002661145.1 |
Danio rerio (zebrafish) | hmox2a | NP_001096609.1 |
Pan troglodytes (chimpanzee) | HMOX2 | XP_001168835.1 |
Canis lupus familiaris (dog) | HMOX2 | XP_005621663.1 |
Bos taurus (cattle) | HMOX2 | NP_001030259.2 |
Mus musculus (house mouse) | Hmox2 | NP_001129538.1 |
Rattus norvegicus (Norway rat) | Hmox2 | NP_077363.1 |
Gallus gallus (chicken) | HMOX2 | XP_004945442.1 |
Deletion of the hemopexin or heme oxygenase-2 gene aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage.
Ma B, Day JP, Phillips H, Slootsky B, Tolosano E, Dor? S
Journal of neuroinflammation1326(2016 Feb)
Induction and functional significance of the heme oxygenase system in pathological shear stress in vivo.
Kang L, Hillestad ML, Grande JP, Croatt AJ, Barry MA, Farrugia G, Katusic ZS, Nath KA
American journal of physiology. Heart and circulatory physiology308(11)H1402-13(2015 Jun)
Protein kinase G-regulated production of H2S governs oxygen sensing.
Yuan G, Vasavda C, Peng YJ, Makarenko VV, Raghuraman G, Nanduri J, Gadalla MM, Semenza GL, Kumar GK, Snyder SH, Prabhakar NR
Science signaling8(373)ra37(2015 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
This study demonstrated that Deletion of the heme oxygenase-2 aggravates brain injury following stroma-free hemoglobin-induced
Title: Deletion of the hemopexin or heme oxygenase-2 gene aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage.
macrophage HO-2 is required for proper macrophage function but is insufficient to correct the impaired healing of the HO-2(-/-) cornea, suggesting that corneal epithelial expression of HO-2 is a key to resolution and repair in wound healing
Title: Heme oxygenase-2 deletion impairs macrophage function: implication in wound healing.
HO-2 shRNA and HO-2 overexpression plasmids were used to observe the effect of HO-2 in cerebral microvascular endothelial cells. mRNA and protein levels of TNF-alpha and IL6 were increased and decreased, respectively, compared with control groups.
Title: Heme oxygenase-2 suppress TNF-? and IL6 expression via TLR4/MyD88-dependent signaling pathway in mouse cerebral vascular endothelial cells.
Data indicate that injury induced heme oxygenase 1 (HO-1) expression in both heme oxygenase 2 (HO-2) knockout and wild type mice.
Title: Delayed cutaneous wound closure in HO-2 deficient mice despite normal HO-1 expression.
These results demonstrate a sex-specific effect of HO-2 deficiency on the development of renovascular hypertension and its effects on the heart in response to the increase in blood pressure.
Title: Sex-specific effects of heme oxygenase-2 deficiency on renovascular hypertension.
The following Hmox2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hmox2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu67955 | |
Clone ID Related Accession (Same CDS sequence) | XM_006521803.3 , NM_001357050.1 | |
Accession Version | NM_001357050.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1032bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-24 | |
Organism | Mus musculus(house mouse) | |
Product | heme oxygenase 2 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC166903.2. On Oct 18, 2017 this sequence version replaced XM_006521803.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK141426.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAGGTGTG CTGATAAACT GAGTCTGAGG GAAATCTTCA TCTGCTGGGA CCAGAGTGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001343979.1 |
CDS | 178..1209 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001357050.1 |
1 | ATGAGGTGTG CTGATAAACT GAGTCTGAGG GAAATCTTCA TCTGCTGGGA CCAGAGTGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu51882 | |
Clone ID Related Accession (Same CDS sequence) | XM_006521804.3 , XM_006521804.2 | |
Accession Version | XM_006521804.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1005bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | heme oxygenase 2 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000082.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006521804.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCAGGTTG GAGGCTATGA GGACCAGAGT GAGGGCAGCA CAAACTACTC AGCCACAATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006521867.1 |
CDS | 156..1160 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006521804.2 |
1 | ATGCAGGTTG GAGGCTATGA GGACCAGAGT GAGGGCAGCA CAAACTACTC AGCCACAATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu67955 | |
Clone ID Related Accession (Same CDS sequence) | XM_006521803.3 , NM_001357050.1 | |
Accession Version | XM_006521803.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1032bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(House mouse) | |
Product | heme oxygenase 2 isoform X1 | |
Comment | MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000082.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006521803.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGGTGTG CTGATAAACT GAGTCTGAGG GAAATCTTCA TCTGCTGGGA CCAGAGTGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006521866.2 |
CDS | 178..1209 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006521803.3 |
1 | ATGAGGTGTG CTGATAAACT GAGTCTGAGG GAAATCTTCA TCTGCTGGGA CCAGAGTGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu22592 | |
Clone ID Related Accession (Same CDS sequence) | NM_001136066.2 , NM_010443.2 | |
Accession Version | NM_001136066.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 948bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-22 | |
Organism | Mus musculus(house mouse) | |
Product | heme oxygenase 2 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY071995.1, AK134536.1 and BP769523.1. On Mar 17, 2009 this sequence version replaced NM_001136066.1. Transcript Variant: This variant (1) represents the predominant transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC002011.1, AK134536.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTCTTCAG AGGTGGAGAC CTCGGAGGGG GTAGATGAGT CAGAGAAGAA CTCTATGGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001129538.1 |
CDS | 148..1095 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001136066.2 |
1 | ATGTCTTCAG AGGTGGAGAC CTCGGAGGGG GTAGATGAGT CAGAGAAGAA CTCTATGGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu22592 | |
Clone ID Related Accession (Same CDS sequence) | NM_001136066.2 , NM_010443.2 | |
Accession Version | NM_010443.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 948bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-22 | |
Organism | Mus musculus(house mouse) | |
Product | heme oxygenase 2 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CA465845.1, AK134536.1 and BP769523.1. On Mar 17, 2009 this sequence version replaced NM_010443.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to transcript variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF054669.1, AF029874.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849384 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTCTTCAG AGGTGGAGAC CTCGGAGGGG GTAGATGAGT CAGAGAAGAA CTCTATGGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_034573.2 |
CDS | 164..1111 |
Translation |
Target ORF information:
Target ORF information:
|
NM_010443.2 |
1 | ATGTCTTCAG AGGTGGAGAC CTCGGAGGGG GTAGATGAGT CAGAGAAGAA CTCTATGGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu51882 | |
Clone ID Related Accession (Same CDS sequence) | XM_006521804.3 , XM_006521804.2 | |
Accession Version | XM_006521804.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1005bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | heme oxygenase 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000082.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006521804.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCAGGTTG GAGGCTATGA GGACCAGAGT GAGGGCAGCA CAAACTACTC AGCCACAATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006521867.1 |
CDS | 167..1171 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006521804.3 |
1 | ATGCAGGTTG GAGGCTATGA GGACCAGAGT GAGGGCAGCA CAAACTACTC AGCCACAATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Deletion of the hemopexin or heme oxygenase-2 gene aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage. |
Induction and functional significance of the heme oxygenase system in pathological shear stress in vivo. |
Protein kinase G-regulated production of H2S governs oxygen sensing. |