Gene Symbol | Sec62 |
Entrez Gene ID | 69276 |
Full Name | SEC62 homolog (S. cerevisiae) |
Synonyms | 3100002M17Rik,AI844545,AW545092,Dtrp1,HTP1,Tloc1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Sec62 cDNA ORF clone
Gene Symbol | Sec62 |
Entrez Gene ID | 69276 |
Full Name | SEC62 homolog (S. cerevisiae) |
Synonyms | 3100002M17Rik,AI844545,AW545092,Dtrp1,HTP1,Tloc1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006535534.3 | XP_006535597.1 | translocation protein SEC62 isoform X1 |
NM_027016.2 | NP_081292.1 | translocation protein SEC62 isoform 2 |
NM_001357528.1 | NP_001344457.1 | translocation protein SEC62 isoform 1 |
Bos taurus (cattle) | SEC62 | NP_001192533.1 |
Gallus gallus (chicken) | SEC62 | NP_001012620.1 |
Homo sapiens (human) | SEC62 | NP_003253.1 |
Rattus norvegicus (Norway rat) | Sec62 | NP_001029301.1 |
Xenopus tropicalis (tropical clawed frog) | sec62 | NP_001121518.1 |
Danio rerio (zebrafish) | sec62 | NP_001020701.1 |
SEC62 | XP_001090325.1 | |
Canis lupus familiaris (dog) | SEC62 | XP_851757.2 |
Pan troglodytes (chimpanzee) | SEC62 | XP_001162878.1 |
Mus musculus (house mouse) | Sec62 | NP_081292.1 |
Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery.
Fumagalli F, Noack J, Bergmann TJ, Cebollero E, Pisoni GB, Fasana E, Fregno I, Galli C, Loi M, Sold? T, D'Antuono R, Raimondi A, Jung M, Melnyk A, Schorr S, Schreiber A, Simonelli L, Varani L, Wilson-Zbinden C, Zerbe O, Hofmann K, Peter M, Quadroni M, Zimmermann R, Molinari M
Nature cell biology18(11)1173-1184(2016 Nov)
Initial evidence for Sec62 as a prognostic marker in advanced head and neck squamous cell carcinoma.
Wemmert S, Lindner Y, Linxweiler J, Wagenpfeil S, Bohle R, Niewald M, Schick B
Oncology letters11(3)1661-1670(2016 Mar)
Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation.
Jadhav B, McKenna M, Johnson N, High S, Sinning I, Pool MR
Nature communications610133(2015 Dec)
Cotranslational stabilization of Sec62/63 within the ER Sec61 translocon is controlled by distinct substrate-driven translocation events.
Conti BJ, Devaraneni PK, Yang Z, David LL, Skach WR
Molecular cell58(2)269-83(2015 Apr)
The Sec62-Sec63 translocon facilitates translocation of the C-terminus of membrane proteins.
Jung SJ, Kim JE, Reithinger JH, Kim H
Journal of cell science127(Pt 19)4270-8(2014 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
identify Sec62 as a critical molecular component in maintenance and recovery of endoplasmic reticulum homeostasis
Title: Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery.
Interaction of ribosomes and Sec62 with the core Sec61 translocon is mutually exclusive.
Title: Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation.
The Sec62 protein plays a role in post-translational transport of presecretory proteins into endoplasmic reticulum.
Title: Different effects of Sec61?, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells.
The following Sec62 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sec62 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu03421 | |
Clone ID Related Accession (Same CDS sequence) | NM_027016.2 | |
Accession Version | NM_027016.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1197bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-16 | |
Organism | Mus musculus(house mouse) | |
Product | translocation protein SEC62 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC158135.5 and DV657309.1. On Jan 5, 2006 this sequence version replaced NM_027016.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660821.99913.1, SRR1660819.25612.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGGAAC GCAGGCGACA CAAGAAGCGG ATCCAGGAAG TTGGTGAACC ATCTAAAGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_081292.1 |
CDS | 473..1669 |
Translation |
Target ORF information:
Target ORF information:
|
NM_027016.2 |
1 | ATGGCGGAAC GCAGGCGACA CAAGAAGCGG ATCCAGGAAG TTGGTGAACC ATCTAAAGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu31421 | |
Clone ID Related Accession (Same CDS sequence) | XM_006535534.3 , NM_001357528.1 | |
Accession Version | NM_001357528.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1233bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-25 | |
Organism | Mus musculus(house mouse) | |
Product | translocation protein SEC62 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC158135.5. On Nov 4, 2017 this sequence version replaced XM_006535534.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660811.220860.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGGAAC GCAGGCGACA CAAGAAGCGG ATCCAGGAAG TTGGTGAACC ATCTAAAGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001344457.1 |
CDS | 473..1705 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001357528.1 |
1 | ATGGCGGAAC GCAGGCGACA CAAGAAGCGG ATCCAGGAAG TTGGTGAACC ATCTAAAGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu31421 | |
Clone ID Related Accession (Same CDS sequence) | XM_006535534.3 , NM_001357528.1 | |
Accession Version | XM_006535534.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1233bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(House mouse) | |
Product | translocation protein SEC62 isoform X1 | |
Comment | MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006535534.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCGGAAC GCAGGCGACA CAAGAAGCGG ATCCAGGAAG TTGGTGAACC ATCTAAAGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006535597.1 |
CDS | 584..1816 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006535534.3 |
1 | ATGGCGGAAC GCAGGCGACA CAAGAAGCGG ATCCAGGAAG TTGGTGAACC ATCTAAAGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery. |
Initial evidence for Sec62 as a prognostic marker in advanced head and neck squamous cell carcinoma. |
Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation. |
Cotranslational stabilization of Sec62/63 within the ER Sec61 translocon is controlled by distinct substrate-driven translocation events. |
The Sec62-Sec63 translocon facilitates translocation of the C-terminus of membrane proteins. |