Fstl3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Gene Symbol	Fstl3
Entrez Gene ID	83554
Full Name	follistatin-like 3
Synonyms	E030038F23Rik,Flrg
General protein information	Preferred Names follistatin-like 3 Names follistatin-related protein 3 follistatin-like protein 3 follistatin-related gene protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10\|10 C1

mRNA and Protein(s)

mRNA Protein Name

NM_031380.2 NP_113557.1 follistatin-related protein 3 precursor
Pathways from BioSystems

mRNA	Protein	Name
NM_031380.2	NP_113557.1	follistatin-related protein 3 precursor

Homologies

Canis lupus familiaris (dog)	FSTL3	XP_855222.3
Homo sapiens (human)	FSTL3	NP_005851.1
Mus musculus (house mouse)	Fstl3	NP_113557.1
Gallus gallus (chicken)	FSTL3	XP_001233761.2
Danio rerio (zebrafish)	fstl3	NP_001025282.2
Rattus norvegicus (Norway rat)	Fstl3	NP_446081.1
Pan troglodytes (chimpanzee)	FSTL3	XP_003316016.1
	LOC721100	XP_001117132.1
Bos taurus (cattle)	FSTL3	NP_001069178.1
Xenopus tropicalis (tropical clawed frog)	fstl3	NP_001015870.1

Gene Ontology
Bibliography

Related articles in PubMed

Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice.
Liu TY, Chen YC, Jong YJ, Tsai HJ, Lee CC, Chang YS, Chang JG, Chang YF
Open biology7(1)(2017 Jan)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Activin Enhances ?- to ?-Cell Transdifferentiation as a Source For ?-Cells In Male FSTL3 Knockout Mice.
Brown ML, Andrzejewski D, Burnside A, Schneyer AL
Endocrinology157(3)1043-54(2016 Mar)

Follistatin-like 3 is a mediator of exercise-driven bone formation and strengthening.
Nam J, Perera P, Gordon R, Jeong YH, Blazek AD, Kim DG, Tee BC, Sun Z, Eubank TD, Zhao Y, Lablebecioglu B, Liu S, Litsky A, Weisleder NL, Lee BS, Butterfield T, Schneyer AL, Agarwal S
Bone7862-70(2015 Sep)

Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2.
Lee YS, Lee SJ
Proceedings of the National Academy of Sciences of the United States of America110(39)E3713-22(2013 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

FSTL3 KO lead to increased activin signaling, enhancing alpha- to beta-cell transdifferentiation in mouse islets.
Title: Activin Enhances ?- to ?-Cell Transdifferentiation as a Source For ?-Cells In Male FSTL3 Knockout Mice.

FSTL3 is a critical mediator of exercise-dependent bone formation
Title: Follistatin-like 3 is a mediator of exercise-driven bone formation and strengthening.

Data indicate that deletion of activin antagonists follistatin-like-3 (FSTL3) results in hepatic steatosis
Title: Increased activin bioavailability enhances hepatic insulin sensitivity while inducing hepatic steatosis in male mice.

crucial roles for FSTL3 in limiting testis organ size and promoting age-related testicular regression
Title: Follistatin-like 3 (FSTL3) mediated silencing of transforming growth factor ? (TGF?) signaling is essential for testicular aging and regulating testis size.

These findings link FSTL3 and TGFbeta ligand signaling and a novel subset of the synexpression group of genes to organ/tissue-specific regulatory pathways.
Title: Synexpression group analyses identify new functions of FSTL3, a TGF? ligand inhibitor.

The following Fstl3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fstl3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu17553	NM_031380.2 Latest version!	Mus musculus follistatin-like 3 (Fstl3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fstl3 ( NM_031380.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_113557.1 Mus musculus follistatin-like 3 (Fstl3), mRNA.

Price & Availability↑

CloneID	OMu17553
Clone ID Related Accession (Same CDS sequence)	NM_031380.2
Accession Version	NM_031380.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 771bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	follistatin-related protein 3 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC061052.1, AK082898.1, AK079286.1 and BQ840331.1. On Apr 22, 2009 this sequence version replaced NM_031380.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC061052.1, AK082898.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGCGTTCTG GGGCACTGTG GCCGCTGCTT TGGGGAGCCC TGGTCTGGAC AGTGGGATCC 
GTGGGCGCCG TGATGGGCTC CGAGGATTCT GTGCCCGGTG GCGTGTGCTG GCTCCAGCAG 
GGCAGAGAGG CCACCTGCAG TCTGGTGCTG AAGACTCGTG TCAGCCGGGA GGAGTGCTGT 
GCTTCCGGCA ACATCAACAC CGCCTGGTCC AACTTCACCC ACCCAGGCAA TAAAATCAGC 
CTGCTAGGGT TCCTGGGCCT CGTCCACTGC CTCCCCTGCA AAGATTCCTG CGACGGAGTG 
GAGTGCGGCC CCGGCAAGGC GTGCCGCATG CTGGGGGGCC GTCCACACTG CGAGTGCGTG 
CCCAACTGCG AGGGGCTTCC CGCGGGCTTC CAGGTCTGCG GCTCTGATGG CGCCACCTAC 
CGGGACGAAT GCGAACTGCG CACCGCGCGC TGTCGCGGAC ACCCAGACTT GCGCGTCATG 
TACCGCGGCC GCTGTCAAAA GTCTTGCGCT CAGGTAGTGT GCCCGCGTCC CCAGTCGTGC 
CTTGTGGATC AGACCGGCAG CGCACACTGC GTGGTGTGTC GCGCTGCGCC CTGCCCAGTA 
CCTTCCAACC CCGGCCAAGA ACTCTGTGGC AACAACAACG TTACCTACAT CTCGTCGTGT 
CACCTGCGCC AGGCCACTTG CTTCCTGGGC CGCTCCATTG GGGTTCGGCA CCCAGGCATC 
TGCACAGGTG GCCCCAAAGT ACCAGCAGAG GAGGAAGAGA ACTTCGTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113557.1
CDS	28..798
Translation	MRSGALWPLLWGALVWTVGSVGAVMGSEDSVPGGVCWLQQGREATCSLVLKTRVSREECCASGNINTAWSNFTHPGNKISLLGFLGLVHCLPCKDSCDGVECGPGKACRMLGGRPHCECVPNCEGLPAGFQVCGSDGATYRDECELRTARCRGHPDLRVMYRGRCQKSCAQVVCPRPQSCLVDQTGSAHCVVCRAAPCPVPSNPGQELCGNNNVTYISSCHLRQATCFLGRSIGVRHPGICTGGPKVPAEEEENFV

Target ORF information:

RefSeq Version	NM_031380.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus follistatin-like 3 (Fstl3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031380.2

ORF Insert Sequence:

ATGCGTTCTG GGGCACTGTG GCCGCTGCTT TGGGGAGCCC TGGTCTGGAC AGTGGGATCC 
GTGGGCGCCG TGATGGGCTC CGAGGATTCT GTGCCCGGTG GCGTGTGCTG GCTCCAGCAG 
GGCAGAGAGG CCACCTGCAG TCTGGTGCTG AAGACTCGTG TCAGCCGGGA GGAGTGCTGT 
GCTTCCGGCA ACATCAACAC CGCCTGGTCC AACTTCACCC ACCCAGGCAA TAAAATCAGC 
CTGCTAGGGT TCCTGGGCCT CGTCCACTGC CTCCCCTGCA AAGATTCCTG CGACGGAGTG 
GAGTGCGGCC CCGGCAAGGC GTGCCGCATG CTGGGGGGCC GTCCACACTG CGAGTGCGTG 
CCCAACTGCG AGGGGCTTCC CGCGGGCTTC CAGGTCTGCG GCTCTGATGG CGCCACCTAC 
CGGGACGAAT GCGAACTGCG CACCGCGCGC TGTCGCGGAC ACCCAGACTT GCGCGTCATG 
TACCGCGGCC GCTGTCAAAA GTCTTGCGCT CAGGTAGTGT GCCCGCGTCC CCAGTCGTGC 
CTTGTGGATC AGACCGGCAG CGCACACTGC GTGGTGTGTC GCGCTGCGCC CTGCCCAGTA 
CCTTCCAACC CCGGCCAAGA ACTCTGTGGC AACAACAACG TTACCTACAT CTCGTCGTGT 
CACCTGCGCC AGGCCACTTG CTTCCTGGGC CGCTCCATTG GGGTTCGGCA CCCAGGCATC 
TGCACAGGTG GCCCCAAAGT ACCAGCAGAG GAGGAAGAGA ACTTCGTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice.
Open biology7(1)(2017 Jan)
Liu TY,Chen YC,Jong YJ,Tsai HJ,Lee CC,Chang YS,Chang JG,Chang YF

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Activin Enhances ?- to ?-Cell Transdifferentiation as a Source For ?-Cells In Male FSTL3 Knockout Mice.
Endocrinology157(3)1043-54(2016 Mar)
Brown ML,Andrzejewski D,Burnside A,Schneyer AL

Follistatin-like 3 is a mediator of exercise-driven bone formation and strengthening.
Bone7862-70(2015 Sep)
Nam J,Perera P,Gordon R,Jeong YH,Blazek AD,Kim DG,Tee BC,Sun Z,Eubank TD,Zhao Y,Lablebecioglu B,Liu S,Litsky A,Weisleder NL,Lee BS,Butterfield T,Schneyer AL,Agarwal S

Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2.
Proceedings of the National Academy of Sciences of the United States of America110(39)E3713-22(2013 Sep)
Lee YS,Lee SJ

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Fstl3 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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