| Gene Symbol | Cox15 |
| Entrez Gene ID | 309391 |
| Full Name | COX15 cytochrome c oxidase assembly homolog |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome |
gRNAs
The following Cox15 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cox15 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa08621 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001033699.4 | |
| Accession Version | NM_001033699.4 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1245bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2018-07-24 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | COX15 homolog | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC099368.7. On Sep 16, 2014 this sequence version replaced NM_001033699.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The exon combination used for the transcript record was based on alignment to full-length human mRNA BT007129.1. ##Evidence-Data-START## Transcript exon combination :: BC101929.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGCAACGGT TGTTCCTCCC GCCCCTCAAG GCCTTGATGG GGAGCCGCAA TGTCGGGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001028871.2 |
| CDS | 57..1301 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001033699.4 |
1 | ATGCAACGGT TGTTCCTCCC GCCCCTCAAG GCCTTGATGG GGAGCCGCAA TGTCGGGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Functional and genetic studies demonstrate that mutation in the COX15 gene can cause Leigh syndrome. |
Identification of candidate disease genes by EST alignments, synteny, and expression and verification of Ensembl genes on rat chromosome 1q43-54. |
Proteomic analysis of the mouse liver mitochondrial inner membrane. |
Mutations in COX15 produce a defect in the mitochondrial heme biosynthetic pathway, causing early-onset fatal hypertrophic cardiomyopathy. |
Identification and characterization of human cDNAs specific to BCS1, PET112, SCO1, COX15, and COX11, five genes involved in the formation and function of the mitochondrial respiratory chain. |
