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Enhanced uptake of blood coagulation factor VIII containing immune complexes by antigen presenting cells

J. Thromb. Haemost.. 2017-02; 
HartholtR B, WroblewskaA, HerczenikE, PeyronI, Ten BrinkeA, RispensT, NolteM A, SlotE, ClaassensJ W, NimmerjahnF, VerbeekJ S, Voorb
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Abstract

Essentials Anti-factor (F) VIII antibody formation is a major complication in the treatment of hemophilia A. We investigated uptake of FVIII and FVIII immune complex by bone marrow derived dendritic cells. Immune complex formation increased uptake of FVIII 3-4 fold in a Fcγ receptor dependent manner. FVIII immune complex binding to Fcγ receptors may modulate immune tolerance induction.

Keywords

Fc gamma receptors,endocytosis,factor VIII,hemophilia A,immune com