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transcriptional activation

A transcriptional activator is a protein (transcription factor) that increases the transcription of a gene or set of genes. Activators are considered to have positive control over gene expression, as they function to promote gene transcription and, in some cases, are required for the transcription of genes to occur.

Transcriptional activators are required to turn on the expression of genes in a eukaryotic cell.

The transcriptional activation activity of the variant was evaluated through methods of the relative activity of luciferase. And the transcriptional activators of the two splicing variants are detected with a luciferase reporter in transient transfections of human embryonic kidney 293T cells.

The yeast transcriptional activator GAL4, like many sequence-specific DNA-binding proteins, binds to DNA as a symmetrical dimer. The dimerization element of GAL4 is a segment of approximately 50 amino acids containing the heptad repeat characteristic of a coiled coil.

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