In molecular biology, truncation refers to the process of shortening a molecule or sequence by removing a portion of it. This can refer to DNA, RNA, proteins, or other biological molecules. Truncation can occur naturally or through laboratory techniques. Natural truncation can occur through various processes, such as alternative splicing of RNA transcripts or degradation of proteins by proteases. These processes can result in removing specific domains or regions of the molecule, altering its function or activity. In the laboratory, truncation can be used as a technique to study the function of specific domains or regions of a molecule. For example, a protein containing multiple domains can be truncated to remove one or more domains, allowing researchers to study the function of the remaining domains in isolation. Truncation can also be used to create mutant forms of a molecule with altered activity or specificity. In DNA sequencing, truncation can occur when the sequencing reaction is terminated prematurely, resulting in a partial sequence of the DNA fragment. This can be useful for identifying the presence of specific DNA sequences or mutations, but may not provide a complete picture of the target sequence. Truncation can also occur in >protein expression In summary, truncation refers to the process of shortening a biological molecule by removing a portion of it. This can occur naturally or through laboratory techniques and can be used to study the function of specific domains or regions of a molecule, create mutant forms of a molecule, or aid in the purification or stabilization of a protein.
GenSmart Optimization is a free online tool for performing codon optimization to improve gene expression. GenScript's patented algorithms are integrated into the tool to optimize the computing capability of high-performance sequence generation.
GenSmart™ Design is a free online DNA construct design tool developed by GenScript. GenSmart™ Design has two design modules, the Create Construct module for individual plasmid design and the Create Library module for DNA library design.
This online tool shows commonly used genetic codon frequency table in expression host organisms including Escherichia coli and other common host organisms.
GenScript recombinant protein and rAb services provide high quality recombinant proteins and rAbs for a variety of downstream research applications.
One-stop service from Sequence to Protein starting from $1600, 4 weeks.
GenScript's BacuVance baculovirus expression system was developed by our in-house team of scientists for virus production and expression of recombinant proteins from baculovirus-infected insect cells.
Mammalian Transient Expression
Proprietary High Density (HD) expression system, enhance the protein yield up to 100 fold, achieve antibody titers up to 3 g/L.
Reagents for COVID-19 Research
Gram level, ready to ship RBD proteins, ACE2 assay cell lines and pseudovirus.
If you know of any terms that have been omitted from this glossary that you feel would be useful to include, please send detail to the Editorial Office at GenScript: [email protected]