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Bacterial artificial chromosome

Bacterial artificial chromosome is the technique of placing a nucleus from another source into an enucleated cell.

A bacterial artificial chromosome (BAC) is a DNA construct based on a functional fertility plasmid (or F-plasmid) used for transforming and cloning in bacteria, usually E. coli. F-plasmids play a crucial role because they contain partition genes that promote the even distribution of plasmids after bacterial cell division.

A bacterial artificial chromosome is often used in connection with DNA sequencing. Segments of an organism's DNA, ranging from 100,000 to about 300,000 base pairs, can be inserted into BACs. The BACs, with their inserted DNA, are then taken up by bacterial cells. As the bacterial cells grow and divide, they amplify the BAC DNA, which can then be isolated and used in sequencing DNA.

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