Resources

List by Alphabet: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Cellular oncogene

An oncogene is a gene that can potentially cause cancer. In tumor cells, these genes are often mutated or expressed at high levels. Most normal cells will undergo a programmed form of rapid cell death (apoptosis) when critical functions are altered and malfunctioning.

The cellular oncogenes are derived from their normal counterparts, the protooncogenes, by activating mutations or transcriptional activations.

Unlike many may misunderstand, cellular oncogenes are actually normal genes with essential functions in the cell nucleus.

Four cellular oncogenes, fos, myc, Ha-ras, and Ki-ras, are routinely expressed in ovarian adenocarcinomas and have been examined to determine whether the molecular lesion in ovarian carcinoma was a genetic rearrangement or amplification of expressed oncogenes. It is found that genetic rearrangement or amplification of these cellular oncogenes is not the primary molecular lesion leading to their expression in ovarian carcinomas.

Related Biology Tools

  • GenSmart™ Codon Optimization

    GenSmart Optimization is a free online tool for performing codon optimization to improve gene expression. GenScript's patented algorithms are integrated into the tool to optimize the computing capability of high-performance sequence generation.

    Learn More

  • DNA Construct Design Tool

    GenSmart™ Design is a free online DNA construct design tool developed by GenScript. GenSmart™ Design has two design modules, the Create Construct module for individual plasmid design and the Create Library module for DNA library design.

    Learn More

  • Codon Frequency Tables

    This online tool shows commonly used genetic codon frequency table in expression host organisms including Escherichia coli and other common host organisms.

    Learn More

Service and Products

Cell Engineering

From lentivirus packaging to generating clonal cell lines, let us assist you on your assay cell line creation project.

Assay Cell Line Development

For Drug Discovery, Toxicity Testing and Basic Research.

Research Grade Lentiviral Vector Packaging

Lentiviruses are a powerful gene delivery vector that ensures long-term expression of your target transgene.

Research Grade AAV

Our beta-testers are important to us and we are offering heavily discounted prices and additional guarantees.

If you know of any terms that have been omitted from this glossary that you feel would be useful to include, please send detail to the Editorial Office at GenScript: [email protected]

If your term is adopted, we will send 1,000 EzCoupon points to your GenScript account.