Gene Symbol | ABCA4 |
Entrez Gene ID | 281584 |
Full Name | ATP binding cassette subfamily A member 4 |
General protein information |
|
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
ORF » Species Summary » Bos taurus » ABCA4 cDNA ORF clone
Gene Symbol | ABCA4 |
Entrez Gene ID | 281584 |
Full Name | ATP binding cassette subfamily A member 4 |
General protein information |
|
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
mRNA | Protein | Name |
---|---|---|
XM_010803293.2 | XP_010801595.1 | retinal-specific ATP-binding cassette transporter isoform X1 |
NM_174221.2 | NP_776646.1 | retinal-specific ATP-binding cassette transporter |
Homo sapiens (human) | ABCA4 | NP_000341.2 |
Canis lupus familiaris (dog) | ABCA4 | NP_001003360.2 |
Mus musculus (house mouse) | Abca4 | NP_031404.1 |
Pan troglodytes (chimpanzee) | ABCA4 | XP_001152577.2 |
Gallus gallus (chicken) | ABCA4 | XP_422330.3 |
Danio rerio (zebrafish) | abca4b | XP_683123.5 |
Xenopus tropicalis (tropical clawed frog) | abca4 | NP_001011033.1 |
ABCA4 | XP_002808277.1 | |
Rattus norvegicus (Norway rat) | Abca4 | NP_001101191.1 |
Bos taurus (cattle) | ABCA4 | NP_776646.1 |
ATP-binding cassette transporter ABCA4 and chemical isomerization protect photoreceptor cells from the toxic accumulation of excess 11-cis-retinal.
Quazi F, Molday RS
Proceedings of the National Academy of Sciences of the United States of America111(13)5024-9(2014 Apr)
Molecular organization and ATP-induced conformational changes of ABCA4, the photoreceptor-specific ABC transporter.
Tsybovsky Y, Orban T, Molday RS, Taylor D, Palczewski K
Structure (London, England : 1993)21(5)854-60(2013 May)
Posttranslational modifications of the photoreceptor-specific ABC transporter ABCA4.
Tsybovsky Y, Wang B, Quazi F, Molday RS, Palczewski K
Biochemistry50(32)6855-66(2011 Aug)
A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)
N-retinylidene-phosphatidylethanolamine is the preferred retinoid substrate for the photoreceptor-specific ABC transporter ABCA4 (ABCR).
Beharry S, Zhong M, Molday RS
The Journal of biological chemistry279(52)53972-9(2004 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
ABCA4 can transport N-11-cis-retinylidene-phosphatidylethanolamine (PE), the Schiff-base conjugate of 11-cis-retinal and PE, from the lumen to the cytoplasmic leaflet of disk membranes.
Title: ATP-binding cassette transporter ABCA4 and chemical isomerization protect photoreceptor cells from the toxic accumulation of excess 11-cis-retinal.
An 18 A-resolution structure of ABCA4 isolated from bovine rod outer segments was determined using electron microscopy and single-particle reconstruction
Title: Molecular organization and ATP-induced conformational changes of ABCA4, the photoreceptor-specific ABC transporter.
partial dephosphorylation of native bovine ABCA4 led to reduction of both basal and stimulated ATPase activity. Thus, we present the first evidence that phosphorylation of ABCA4 can regulate its function
Title: Posttranslational modifications of the photoreceptor-specific ABC transporter ABCA4.
results indicate that ATP binding cassette protein ABCA4 preferentially binds N-retinylidene-phosphatidylethanolamine with high affinity
Title: N-retinylidene-phosphatidylethanolamine is the preferred retinoid substrate for the photoreceptor-specific ABC transporter ABCA4 (ABCR).
The following ABCA4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ABCA4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OBa44182 | |
Clone ID Related Accession (Same CDS sequence) | NM_174221.2 | |
Accession Version | NM_174221.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 6846bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-13 | |
Organism | Bos taurus(cattle) | |
Product | retinal-specific ATP-binding cassette transporter | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U90126.1. On or before Mar 29, 2005 this sequence version replaced XM_600037.1, XM_616851.1, NM_174221.1. ##Evidence-Data-START## Transcript exon combination :: U90126.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN03145413, SAMN03145414 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGGGCTTTG CCAGACAGAT CAAGCTTCTG CTGTGGAAGA ACTGGACCCT GCGGAAAAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_776646.1 |
CDS | 101..6946 |
Translation |
Target ORF information:
Target ORF information:
|
NM_174221.2 |
1 | ATGGGCTTTG CCAGACAGAT CAAGCTTCTG CTGTGGAAGA ACTGGACCCT GCGGAAAAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa45172 | |
Clone ID Related Accession (Same CDS sequence) | XM_010803293.2 | |
Accession Version | XM_010803293.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 6147bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-01-25 | |
Organism | Bos taurus(cattle) | |
Product | retinal-specific ATP-binding cassette transporter isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003103869.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 26, 2016 this sequence version replaced XM_010803293.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Bos taurus Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGCTTTG CCAGACAGAT CAAGCTTCTG CTGTGGAAGA ACTGGACCCT GCGGAAAAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_010801595.1 |
CDS | 82..6228 |
Translation |
Target ORF information:
Target ORF information:
|
XM_010803293.2 |
1 | ATGGGCTTTG CCAGACAGAT CAAGCTTCTG CTGTGGAAGA ACTGGACCCT GCGGAAAAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
ATP-binding cassette transporter ABCA4 and chemical isomerization protect photoreceptor cells from the toxic accumulation of excess 11-cis-retinal. |
Molecular organization and ATP-induced conformational changes of ABCA4, the photoreceptor-specific ABC transporter. |
Posttranslational modifications of the photoreceptor-specific ABC transporter ABCA4. |
A whole-genome assembly of the domestic cow, Bos taurus. |
N-retinylidene-phosphatidylethanolamine is the preferred retinoid substrate for the photoreceptor-specific ABC transporter ABCA4 (ABCR). |