| Gene Symbol | clk-1 |
| Entrez Gene ID | 175729 |
| Full Name | 5-demethoxyubiquinone hydroxylase, mitochondrial |
| Gene Type | protein-coding |
| Organism | Caenorhabditis elegans |
IVD Raw Materials
ORF » Species Summary » Caenorhabditis elegans » clk-1 cDNA ORF clone
| Gene Symbol | clk-1 |
| Entrez Gene ID | 175729 |
| Full Name | 5-demethoxyubiquinone hydroxylase, mitochondrial |
| Gene Type | protein-coding |
| Organism | Caenorhabditis elegans |
| mRNA | Protein | Name |
|---|---|---|
| NM_065727.3 | NP_498128.1 | 5-demethoxyubiquinone hydroxylase, mitochondrial |
| NM_065727.4 | NP_498128.1 | 5-demethoxyubiquinone hydroxylase, mitochondrial |
| Homo sapiens (human) | COQ7 | NP_057222.2 |
| Pan troglodytes (chimpanzee) | COQ7 | XP_001153055.1 |
| Kluyveromyces lactis | KLLA0E02421g | XP_454057.1 |
| Magnaporthe oryzae (rice blast fungus) | MGG_00959 | XP_003717991.1 |
| Neurospora crassa | NCU03957 | XP_957596.1 |
| Bos taurus (cattle) | COQ7 | NP_001106712.1 |
| Eremothecium gossypii | AGOS_ACL162C | NP_983242.1 |
| LOC716130 | XP_001114193.1 | |
| Canis lupus familiaris (dog) | COQ7 | XP_536955.2 |
| Mus musculus (house mouse) | Coq7 | NP_034070.1 |
| Caenorhabditis elegans (roundworm) | clk-1 | NP_498128.1 |
| Saccharomyces cerevisiae (baker's yeast) | CAT5 | NP_014768.2 |
| Schizosaccharomyces pombe (fission yeast) | coq7 | NP_595416.1 |
| Xenopus tropicalis (tropical clawed frog) | coq7 | NP_001016068.2 |
| COQ7 | XP_001083388.1 | |
| Rattus norvegicus (Norway rat) | Coq7 | NP_036917.2 |
| Gallus gallus (chicken) | COQ7 | NP_001264101.1 |
| Danio rerio (zebrafish) | coq7 | NP_001076480.1 |
| Drosophila melanogaster (fruit fly) | COQ7 | NP_651967.2 |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Nuclear CLK-1 mediates a retrograde signalling pathway that is conserved from Caenorhabditis elegans to humans and is responsive to mitochondrial reactive oxygen species, thus acting as a barometer of oxidative metabolism.
Title: A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity.
no measurable intrinsic ETC defect exists in clk-1 mitochondria. The data indicate that DMQ(9) specifically inhibits electron transfer from complex I to ubiquinone.
Title: The role of DMQ(9) in the long-lived mutant clk-1.
action of clioquinol on several age-dependent neurodegenerative diseases with distinct etiologies might result from a slowing down of the aging process through action of the drug on CLK-1.
Title: The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1.
Suppressors of the missense mutation of clk-1 were identified; each mutant suppresses a different subset of phenotypes.
Title: Uncoupling the pleiotropic phenotypes of clk-1 with tRNA missense suppressors in Caenorhabditis elegans.
differential fertility of clk-1 mutant nematodes fed Q isoforms may result from changes in Q localization, altered recognition by Q-binding proteins, and/or potential defects in mitochondrial function resulting from the mutant CLK-1 polypeptide itself.
Title: Reproductive fitness and quinone content of Caenorhabditis elegans clk-1 mutants fed coenzyme Q isoforms of varying length.
The following clk-1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the clk-1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OCa341229 | |
| Clone ID Related Accession (Same CDS sequence) | NM_065727.3 , NM_065727.4 | |
| Accession Version | NM_065727.3 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 564bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-04-08 | |
| Organism | Caenorhabditis elegans | |
| Product | 5-demethoxyubiquinone hydroxylase, mitochondrial | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Jun 26, 2012 this sequence version replaced NM_065727.2. COMPLETENESS: incomplete on both ends. | |
1 | ATGTTCCGTG TAATAACCCG TGGAGCACAT ACTGCTGCTT CTCGTCAAGC ACTTATAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_498128.1 |
| CDS | 1..564 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_065727.3 |
1 | ATGTTCCGTG TAATAACCCG TGGAGCACAT ACTGCTGCTT CTCGTCAAGC ACTTATAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OCa341229 | |
| Clone ID Related Accession (Same CDS sequence) | NM_065727.3 , NM_065727.4 | |
| Accession Version | NM_065727.4 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 564bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-10-17 | |
| Organism | Caenorhabditis elegans | |
| Product | 5-demethoxyubiquinone hydroxylase, mitochondrial | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Sep 4, 2019 this sequence version replaced NM_065727.3. COMPLETENESS: incomplete on the 5' end. | |
1 | ATGTTCCGTG TAATAACCCG TGGAGCACAT ACTGCTGCTT CTCGTCAAGC ACTTATAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_498128.1 |
| CDS | 1..564 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_065727.4 |
1 | ATGTTCCGTG TAATAACCCG TGGAGCACAT ACTGCTGCTT CTCGTCAAGC ACTTATAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |