sox11a cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	sox11a
Entrez Gene ID	30602
Full Name	SRY (sex determining region Y)-box 11a
Synonyms	cb237,id:ibd2104,wu:fb16g02,zgc:136533
General protein information	Preferred Names SRY (sex determining region Y)-box 11a Names transcription factor SOX-11 SRY-box containing gene 11a etID309973.17
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_131336.1	NP_571411.1	transcription factor SOX-11

Pathways from BioSystems

Homologies

	SOX11	XP_001098988.1
Danio rerio (zebrafish)	sox11a	NP_571411.1
Homo sapiens (human)	SOX11	NP_003099.1
Rattus norvegicus (Norway rat)	Sox11	NP_445801.1
Xenopus tropicalis (tropical clawed frog)	sox11	NP_001008053.1
Mus musculus (house mouse)	Sox11	NP_033260.4
Gallus gallus (chicken)	SOX11	NP_990518.1
Pan troglodytes (chimpanzee)	SOX11	XP_003308919.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression of SoxC Transcription Factors during Zebrafish Retinal and Optic Nerve Regeneration.
Mu Z, Zhang S, He C, Hou H, Liu D, Hu N, Xu H
Neuroscience bulletin33(1)53-61(2017 Feb)

The guanine nucleotide exchange factor Net1 facilitates the specification of dorsal cell fates in zebrafish embryos by promoting maternal ?-catenin activation.
Wei S, Dai M, Liu Z, Ma Y, Shang H, Cao Y, Wang Q
Cell research27(2)202-225(2017 Feb)

Protein palmitoylation activate zygotic gene expression during the maternal-to-zygotic transition.
Du Z, Chen X, Li X, He K, Ji S, Shi W, Hao A
Biochemical and biophysical research communications475(2)194-201(2016 06)

RFX transcription factors are essential for hearing in mice.
Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R
Nature communications68549(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study demonstrated that SOX11a strongly expressed in retinal ganglion cells (RGCs), and knockdown of Sox11a inhibited RGC axon regrowth in retinal explants.
Title: Expression of SoxC Transcription Factors during Zebrafish Retinal and Optic Nerve Regeneration.

our study reveals a novel role for Sox11 in controlling Hedgehog signaling, and suggests that SOX11 variants contribute to pediatric eye disorders.
Title: Sox11 is required to maintain proper levels of Hedgehog signaling during vertebrate ocular morphogenesis.

Sox11a/b knockdown in zebrafish causes brain abnormalities, potentially explaining the brain phenotype of Coffin-Siris syndrome in humans.
Title: De novo SOX11 mutations cause Coffin-Siris syndrome.

the duplicated zebrafish sox11a and -b loci were used to test the duplication, degeneration, complementation model of genome evolution through whole genome duplication.
Title: Regulatory divergence of the duplicated chromosomal loci sox11a/b by subpartitioning and sequence evolution of enhancers in zebrafish.

The following sox11a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the sox11a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa03538	NM_131336.1 Latest version!	Danio rerio SRY-box transcription factor 11a (sox11a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

sox11a ( NM_131336.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_571411.1 Danio rerio SRY-box transcription factor 11a (sox11a), mRNA.

Price & Availability↑

CloneID	ODa03538
Clone ID Related Accession (Same CDS sequence)	NM_131336.1
Accession Version	NM_131336.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-30
Organism	Danio rerio(zebrafish)
Product	transcription factor SOX-11
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ237812.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ237812.1 [ECO:0000332] ##Evidence-Data-END##

ATGGTGCAGC AAACGGACAA CAGCGAAACG GACAGCATGT CTAGAGAAGC CACTGACTCT 
GATGAAAGCG AATTCATGGT CTCGATAAAC CCAGACTGGT GCAAGACAGC CACCGGACAC 
ATAAAGCGAC CGATGAACGC GTTCATGGTG TGGTCTAAAA TCGAGCGGAG AAAGATCATG 
GAACAGTCTC CAGACATGCA CAACGCCGAG ATCTCCAAAC GCTTGGGGAA GCGCTGGAAA 
ATGCTGAAAG ACAGCGAAAA GATACCTTTC ATCAGGGAAG CCGAGAGACT CCGGTTGAAA 
CACATGGCTG ACTACCCCGA CTACAAATAC AGACCGAAGA AGAAACCAAA GCTGGACAGT 
TCATCCAAAC CTTCAGCCCC GTCTCCGGAA AAGTGCAGCA AGACTTCCAA GAGCTCCAAG 
AAATGTCCCA AACTGAAAGC GAACAAGACG GGGAGCAAGT CGTCGTCTCA CGGCTACGGA 
GACGAGTACG CGTTCAAGAG CACGAAAGTT TCAAAGACTG TTCACATTAA AAGTGAATTC 
ACGGACGAAG ACGACGATGA CGACTCCGAG GAGGACTCTC GGGTCAGGGT GAAAGAGGAG 
GAAGAGGATC CGATACGAGC CTACAATGTA GCAAAAGTTC CCGCCAGCCC AACTTTGAGC 
TCGTCCACCG AGTCTGAAGG CGCCAGCATG TACGAGGAGG TCCGGAACAA CAGACTCTAT 
TACAACTTCA AAAACATCAC CAAGCAGAGC ACAATGTATC CCGCATCCGT CTCACCAGCA 
TCCTCTAGGT CCGTTTCCAC GTCTTCCAGC TCGAGCGAAG ACGCGGACGA CTTGCTTTTT 
GACTTCAGTT TGAACTTCGC CTCCTCCGCG CAAAGCTCGG AGCTGGGCAG CCAAAATCCA 
GGGAATCTCT CCCTCTCTCT GGTGGATAAG GAGTTGGAGT CTTTTAGCGA GGGCAGCCTG 
GGCTCCCACT TTGAATTTCC AGACTATTGC ACGCCTGAGC TCAGCGAAAT GATAGCTGGG 
GACTGGCTCG AAGCGAACTT TTCGGACTTG GTTTTTACAT ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_571411.1
CDS	75..1139
Translation	MVQQTDNSETDSMSREATDSDESEFMVSINPDWCKTATGHIKRPMNAFMVWSKIERRKIMEQSPDMHNAEISKRLGKRWKMLKDSEKIPFIREAERLRLKHMADYPDYKYRPKKKPKLDSSSKPSAPSPEKCSKTSKSSKKCPKLKANKTGSKSSSHGYGDEYAFKSTKVSKTVHIKSEFTDEDDDDDSEEDSRVRVKEEEEDPIRAYNVAKVPASPTLSSSTESEGASMYEEVRNNRLYYNFKNITKQSTMYPASVSPASSRSVSTSSSSSEDADDLLFDFSLNFASSAQSSELGSQNPGNLSLSLVDKELESFSEGSLGSHFEFPDYCTPELSEMIAGDWLEANFSDLVFTY

Target ORF information:

RefSeq Version	NM_131336.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio SRY-box transcription factor 11a (sox11a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_131336.1

ORF Insert Sequence:

ATGGTGCAGC AAACGGACAA CAGCGAAACG GACAGCATGT CTAGAGAAGC CACTGACTCT 
GATGAAAGCG AATTCATGGT CTCGATAAAC CCAGACTGGT GCAAGACAGC CACCGGACAC 
ATAAAGCGAC CGATGAACGC GTTCATGGTG TGGTCTAAAA TCGAGCGGAG AAAGATCATG 
GAACAGTCTC CAGACATGCA CAACGCCGAG ATCTCCAAAC GCTTGGGGAA GCGCTGGAAA 
ATGCTGAAAG ACAGCGAAAA GATACCTTTC ATCAGGGAAG CCGAGAGACT CCGGTTGAAA 
CACATGGCTG ACTACCCCGA CTACAAATAC AGACCGAAGA AGAAACCAAA GCTGGACAGT 
TCATCCAAAC CTTCAGCCCC GTCTCCGGAA AAGTGCAGCA AGACTTCCAA GAGCTCCAAG 
AAATGTCCCA AACTGAAAGC GAACAAGACG GGGAGCAAGT CGTCGTCTCA CGGCTACGGA 
GACGAGTACG CGTTCAAGAG CACGAAAGTT TCAAAGACTG TTCACATTAA AAGTGAATTC 
ACGGACGAAG ACGACGATGA CGACTCCGAG GAGGACTCTC GGGTCAGGGT GAAAGAGGAG 
GAAGAGGATC CGATACGAGC CTACAATGTA GCAAAAGTTC CCGCCAGCCC AACTTTGAGC 
TCGTCCACCG AGTCTGAAGG CGCCAGCATG TACGAGGAGG TCCGGAACAA CAGACTCTAT 
TACAACTTCA AAAACATCAC CAAGCAGAGC ACAATGTATC CCGCATCCGT CTCACCAGCA 
TCCTCTAGGT CCGTTTCCAC GTCTTCCAGC TCGAGCGAAG ACGCGGACGA CTTGCTTTTT 
GACTTCAGTT TGAACTTCGC CTCCTCCGCG CAAAGCTCGG AGCTGGGCAG CCAAAATCCA 
GGGAATCTCT CCCTCTCTCT GGTGGATAAG GAGTTGGAGT CTTTTAGCGA GGGCAGCCTG 
GGCTCCCACT TTGAATTTCC AGACTATTGC ACGCCTGAGC TCAGCGAAAT GATAGCTGGG 
GACTGGCTCG AAGCGAACTT TTCGGACTTG GTTTTTACAT ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression of SoxC Transcription Factors during Zebrafish Retinal and Optic Nerve Regeneration.
Neuroscience bulletin33(1)53-61(2017 Feb)
Mu Z,Zhang S,He C,Hou H,Liu D,Hu N,Xu H

The guanine nucleotide exchange factor Net1 facilitates the specification of dorsal cell fates in zebrafish embryos by promoting maternal ?-catenin activation.
Cell research27(2)202-225(2017 Feb)
Wei S,Dai M,Liu Z,Ma Y,Shang H,Cao Y,Wang Q

Protein palmitoylation activate zygotic gene expression during the maternal-to-zygotic transition.
Biochemical and biophysical research communications475(2)194-201(2016 06)
Du Z,Chen X,Li X,He K,Ji S,Shi W,Hao A

RFX transcription factors are essential for hearing in mice.
Nature communications68549(2015 Oct)
Elkon R,Milon B,Morrison L,Shah M,Vijayakumar S,Racherla M,Leitch CC,Silipino L,Hadi S,Weiss-Gayet M,Barras E,Schmid CD,Ait-Lounis A,Barnes A,Song Y,Eisenman DJ,Eliyahu E,Frolenkov GI,Strome SE,Durand B,Zaghloul NA,Jones SM,Reith W,Hertzano R

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sox11a cDNA ORF clone, Danio rerio(zebrafish)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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