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CDK5 cDNA ORF clone, Homo sapiens (human)

Gene Symbol CDK5
Entrez Gene ID 1020
Full Name cyclin-dependent kinase 5
Synonyms LIS7, PSSALRE
General protein information
Preferred Names
cyclin-dependent kinase 5
Names
cyclin-dependent kinase 5
TPKII catalytic subunit
protein kinase CDK5 splicing
cell division protein kinase 5
serine/threonine-protein kinase PSSALRE
tau protein kinase II catalytic subunit
NP_001157882.1
NP_004926.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7q36

Summary This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]. lac of sum
Disorder MIM:

123831


mRNA and Protein(s)

mRNA Protein Name
NM_001164410 NP_001157882 cyclin-dependent-like kinase 5 isoform 2
NM_004935 NP_004926 cyclin-dependent-like kinase 5 isoform 1



Homo sapiens (human) CDK5 NP_004926.1
Pan troglodytes (chimpanzee) CDK5 XP_519523.2
Macaca mulatta (Rhesus monkey) CDK5 XP_001102523.1
Canis lupus familiaris (dog) CDK5 XP_005629809.1
Bos taurus (cattle) CDK5 NP_776442.1
Mus musculus (house mouse) Cdk5 NP_031694.1
Rattus norvegicus (Norway rat) Cdk5 NP_543161.1
Gallus gallus (chicken) CDK5 NP_001129258.1
Danio rerio (zebrafish) cdk5 NP_571794.1
Drosophila melanogaster (fruit fly) Cdk5 NP_477080.1
Caenorhabditis elegans cdk-5 NP_499783.1
Xenopus (Silurana) tropicalis (western clawed frog) cdk5 NP_001072776.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CDK5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDK5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu12869 NM_001164410 Homo sapiens cyclin-dependent kinase 5 (CDK5), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $188.30
$269.00
OHu12814
NM_004935 Homo sapiens cyclin-dependent kinase 5 (CDK5), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu12869
Clone ID Related Accession (Same CDS sequence) NM_001164410
Accession Version NM_001164410.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 783bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 23-MAY-2015
Organism Homo sapiens (human)
Product cyclin-dependent-like kinase 5 isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB487008.1, AC010973.7, AK026533.1, DQ411039.1 and CA429180.1. On Jan 6, 2015 this sequence version replaced gi:256542305. Transcript Variant: This variant (2), also known as CDK5-SV, omits an in-frame coding exon compared to variant 1 resulting in a shorter predicted protein (isoform 2). Expression of this transcript was described by Li et al. (2009; PubMed ID 19693690). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ411039.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGCAGAAAT ACGAGAAACT GGAAAAGATT GGGGAAGGCA CCTACGGAAC TGTGTTCAAG 
GCCAAAAACC GGGAGACTCA TGAGATCGTG GCTCTGAAAC GGGTGAGGCT GGATGACGAT
GATGAGGGTG TGCCGAGTTC CGCCCTCCGG GAGATCTGCC TACTCAAGGA GCTGAAGCAC
AAGAACATCG TCAGGCTTCA TGACGTCCTG CACAGCGACA AGAAGCTGAC TTTGGTTTTT
GAATTCTGTG ACCAGGACCT GAAGAAGTAT TTTGACAGTT GCAATGGTGA CCTCGATCCT
GAGATTGTAA AGAATGGGGA GCTGAAATTG GCTGATTTTG GCCTGGCTCG AGCCTTTGGG
ATTCCCGTCC GCTGTTACTC AGCTGAGGTG GTCACACTGT GGTACCGCCC ACCGGATGTC
CTCTTTGGGG CCAAGCTGTA CTCCACGTCC ATCGACATGT GGTCAGCCGG CTGCATCTTT
GCAGAGCTGG CCAATGCTGG GCGGCCTCTT TTTCCCGGCA ATGATGTCGA TGACCAGTTG
AAGAGGATCT TCCGACTGCT GGGGACGCCC ACCGAGGAGC AGTGGCCCTC TATGACCAAG
CTGCCAGACT ATAAGCCCTA TCCGATGTAC CCGGCCACAA CATCCCTGGT GAACGTCGTG
CCCAAACTCA ATGCCACAGG GAGGGATCTG CTGCAGAACC TTCTGAAGTG TAACCCTGTC
CAGCGTATCT CAGCAGAAGA GGCCCTGCAG CACCCCTACT TCTCCGACTT CTGTCCGCCC
TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001157882.1
CDS118..900
Misc Feature(1)79..81(+)
Misc Feature(2)118..885(+)
Misc Feature(3)124..879(+)
Misc Feature(4)145..453(+)
Exon (1)1..154
Gene:CDK5
Gene Synonym:
Exon (2)155..243
Gene:CDK5
Gene Synonym:
Exon (3)244..311
Gene:CDK5
Gene Synonym:
Exon (4)312..372
Gene:CDK5
Gene Synonym:
Exon (5)373..429
Gene:CDK5
Gene Synonym:
Exon (6)430..504
Gene:CDK5
Gene Synonym:
Exon (7)505..601
Gene:CDK5
Gene Synonym:
Exon (8)602..671
Gene:CDK5
Gene Synonym:
Exon (9)672..732
Gene:CDK5
Gene Synonym:
Exon (10)733..813
Gene:CDK5
Gene Synonym:
Exon (11)814..1097
Gene:CDK5
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001164410
Organism Homo sapiens (human)
Definition Homo sapiens cyclin-dependent kinase 5 (CDK5), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001164410

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGCAGAAAT ACGAGAAACT GGAAAAGATT GGGGAAGGCA CCTACGGAAC TGTGTTCAAG 
GCCAAAAACC GGGAGACTCA TGAGATCGTG GCTCTGAAAC GGGTGAGGCT GGATGACGAT
GATGAGGGTG TGCCGAGTTC CGCCCTCCGG GAGATCTGCC TACTCAAGGA GCTGAAGCAC
AAGAACATCG TCAGGCTTCA TGACGTCCTG CACAGCGACA AGAAGCTGAC TTTGGTTTTT
GAATTCTGTG ACCAGGACCT GAAGAAGTAT TTTGACAGTT GCAATGGTGA CCTCGATCCT
GAGATTGTAA AGAATGGGGA GCTGAAATTG GCTGATTTTG GCCTGGCTCG AGCCTTTGGG
ATTCCCGTCC GCTGTTACTC AGCTGAGGTG GTCACACTGT GGTACCGCCC ACCGGATGTC
CTCTTTGGGG CCAAGCTGTA CTCCACGTCC ATCGACATGT GGTCAGCCGG CTGCATCTTT
GCAGAGCTGG CCAATGCTGG GCGGCCTCTT TTTCCCGGCA ATGATGTCGA TGACCAGTTG
AAGAGGATCT TCCGACTGCT GGGGACGCCC ACCGAGGAGC AGTGGCCCTC TATGACCAAG
CTGCCAGACT ATAAGCCCTA TCCGATGTAC CCGGCCACAA CATCCCTGGT GAACGTCGTG
CCCAAACTCA ATGCCACAGG GAGGGATCTG CTGCAGAACC TTCTGAAGTG TAACCCTGTC
CAGCGTATCT CAGCAGAAGA GGCCCTGCAG CACCCCTACT TCTCCGACTT CTGTCCGCCC
TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu12814
Clone ID Related Accession (Same CDS sequence) NM_004935
Accession Version NM_004935.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 879bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 27-MAY-2015
Organism Homo sapiens (human)
Product cyclin-dependent-like kinase 5 isoform 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB487008.1, AC010973.7, BP309068.1, BC005115.1, AK026533.1 and CA429180.1. This sequence is a reference standard in the RefSeqGene project. On Aug 26, 2009 this sequence version replaced gi:38454327. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK026533.1, BC005115.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGCAGAAAT ACGAGAAACT GGAAAAGATT GGGGAAGGCA CCTACGGAAC TGTGTTCAAG 
GCCAAAAACC GGGAGACTCA TGAGATCGTG GCTCTGAAAC GGGTGAGGCT GGATGACGAT
GATGAGGGTG TGCCGAGTTC CGCCCTCCGG GAGATCTGCC TACTCAAGGA GCTGAAGCAC
AAGAACATCG TCAGGCTTCA TGACGTCCTG CACAGCGACA AGAAGCTGAC TTTGGTTTTT
GAATTCTGTG ACCAGGACCT GAAGAAGTAT TTTGACAGTT GCAATGGTGA CCTCGATCCT
GAGATTGTAA AGTCATTCCT CTTCCAGCTA CTAAAAGGGC TGGGATTCTG TCATAGCCGC
AATGTGCTAC ACAGGGACCT GAAGCCCCAG AACCTGCTAA TAAACAGGAA TGGGGAGCTG
AAATTGGCTG ATTTTGGCCT GGCTCGAGCC TTTGGGATTC CCGTCCGCTG TTACTCAGCT
GAGGTGGTCA CACTGTGGTA CCGCCCACCG GATGTCCTCT TTGGGGCCAA GCTGTACTCC
ACGTCCATCG ACATGTGGTC AGCCGGCTGC ATCTTTGCAG AGCTGGCCAA TGCTGGGCGG
CCTCTTTTTC CCGGCAATGA TGTCGATGAC CAGTTGAAGA GGATCTTCCG ACTGCTGGGG
ACGCCCACCG AGGAGCAGTG GCCCTCTATG ACCAAGCTGC CAGACTATAA GCCCTATCCG
ATGTACCCGG CCACAACATC CCTGGTGAAC GTCGTGCCCA AACTCAATGC CACAGGGAGG
GATCTGCTGC AGAACCTTCT GAAGTGTAAC CCTGTCCAGC GTATCTCAGC AGAAGAGGCC
CTGCAGCACC CCTACTTCTC CGACTTCTGT CCGCCCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_004926.1
CDS118..996
Misc Feature(1)79..81(+)
Misc Feature(2)118..981(+)
Misc Feature(3)124..975(+)
Misc Feature(4)145..735(+)
Misc Feature(5)145..549(+)
Misc Feature(6)160..162(+)
Misc Feature(7)160..162(+)
Misc Feature(8)160..162(+)
Misc Feature(9)226..594(+)
Misc Feature(10)265..732(+)
Misc Feature(11)283..285(+)
Misc Feature(12)331..333(+)
Misc Feature(13)544..615(+)
Misc Feature(14)592..594(+)
Misc Feature(15)592..594(+)
Exon (1)1..154
Gene:CDK5
Gene Synonym:
Exon (2)155..243
Gene:CDK5
Gene Synonym:
Exon (3)244..311
Gene:CDK5
Gene Synonym:
Exon (4)312..372
Gene:CDK5
Gene Synonym:
Exon (5)373..429
Gene:CDK5
Gene Synonym:
Exon (6)430..525
Gene:CDK5
Gene Synonym:
Exon (7)526..600
Gene:CDK5
Gene Synonym:
Exon (8)601..697
Gene:CDK5
Gene Synonym:
Exon (9)698..767
Gene:CDK5
Gene Synonym:
Exon (10)768..828
Gene:CDK5
Gene Synonym:
Exon (11)829..909
Gene:CDK5
Gene Synonym:
Exon (12)910..1193
Gene:CDK5
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_004935
Organism Homo sapiens (human)
Definition Homo sapiens cyclin-dependent kinase 5 (CDK5), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_004935

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGCAGAAAT ACGAGAAACT GGAAAAGATT GGGGAAGGCA CCTACGGAAC TGTGTTCAAG 
GCCAAAAACC GGGAGACTCA TGAGATCGTG GCTCTGAAAC GGGTGAGGCT GGATGACGAT
GATGAGGGTG TGCCGAGTTC CGCCCTCCGG GAGATCTGCC TACTCAAGGA GCTGAAGCAC
AAGAACATCG TCAGGCTTCA TGACGTCCTG CACAGCGACA AGAAGCTGAC TTTGGTTTTT
GAATTCTGTG ACCAGGACCT GAAGAAGTAT TTTGACAGTT GCAATGGTGA CCTCGATCCT
GAGATTGTAA AGTCATTCCT CTTCCAGCTA CTAAAAGGGC TGGGATTCTG TCATAGCCGC
AATGTGCTAC ACAGGGACCT GAAGCCCCAG AACCTGCTAA TAAACAGGAA TGGGGAGCTG
AAATTGGCTG ATTTTGGCCT GGCTCGAGCC TTTGGGATTC CCGTCCGCTG TTACTCAGCT
GAGGTGGTCA CACTGTGGTA CCGCCCACCG GATGTCCTCT TTGGGGCCAA GCTGTACTCC
ACGTCCATCG ACATGTGGTC AGCCGGCTGC ATCTTTGCAG AGCTGGCCAA TGCTGGGCGG
CCTCTTTTTC CCGGCAATGA TGTCGATGAC CAGTTGAAGA GGATCTTCCG ACTGCTGGGG
ACGCCCACCG AGGAGCAGTG GCCCTCTATG ACCAAGCTGC CAGACTATAA GCCCTATCCG
ATGTACCCGG CCACAACATC CCTGGTGAAC GTCGTGCCCA AACTCAATGC CACAGGGAGG
GATCTGCTGC AGAACCTTCT GAAGTGTAAC CCTGTCCAGC GTATCTCAGC AGAAGAGGCC
CTGCAGCACC CCTACTTCTC CGACTTCTGT CCGCCCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with a loss-of-function mutation in CDK5
Hum. Genet. 134 (3), 305-314 (2015)
Magen D, Ofir A, Berger L, Goldsher D, Eran A, Katib N, Nijem Y, Vlodavsky E, Tzur S, Behar DM, Fellig Y and Mandel H.


book

Cyclin-dependent kinase 5 phosphorylation of familial prion protein mutants exacerbates conversion into amyloid structure
J. Biol. Chem. 290 (9), 5759-5771 (2015)
Rouget R, Sharma G and LeBlanc AC.


book

Phosphorylation of synaptic GTPase-activating protein (synGAP) by Ca2+/calmodulin-dependent protein kinase II (CaMKII) and cyclin-dependent kinase 5 (CDK5) alters the ratio of its GAP activity toward Ras and Rap GTPases
J. Biol. Chem. 290 (8), 4908-4927 (2015)
Walkup WG 4th, Washburn L, Sweredoski MJ, Carlisle HJ, Graham RL, Hess S and Kennedy MB.


book

Structural basis for the different stability and activity between the Cdk5 complexes with p35 and p39 activators
J. Biol. Chem. 288 (45), 32433-32439 (2013)
Saito T, Yano M, Kawai Y, Asada A, Wada M, Doi H and Hisanaga S.


book

The role of Cdk5 in neuroendocrine thyroid cancer
Cancer Cell 24 (4), 499-511 (2013)
Pozo K, Castro-Rivera E, Tan C, Plattner F, Schwach G, Siegl V, Meyer D, Guo A, Gundara J, Mettlach G, Richer E, Guevara JA, Ning L, Gupta A, Hao G, Tsai LH, Sun X, Antich P, Sidhu S, Robinson BG, Chen H, Nwariaku FE, Pfragner R, Richardson JA and Bibb JA.


book

Characterization of a novel human CDK5 splicing variant that inhibits Wnt/beta-catenin signaling
Mol. Biol. Rep. 37 (5), 2415-2421 (2010)
Li Q, Liu X, Zhang M, Ye G, Qiao Q, Ling Y, Wu Y, Zhang Y and Yu L.


book

Structure and regulation of the CDK5-p25(nck5a) complex
Mol. Cell 8 (3), 657-669 (2001)
Tarricone C, Dhavan R, Peng J, Areces LB, Tsai LH and Musacchio A.


book

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
Nature 402 (6762), 615-622 (1999)
Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P and Tsai LH.


book

p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected]
FEBS Lett. 312 (1), 95-99 (1992)
Goedert M, Cohen ES, Jakes R and Cohen P.


book

A family of human cdc2-related protein kinases
EMBO J. 11 (8), 2909-2917 (1992)
Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E and Tsai LH.


 
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