TUBB4B cDNA ORF clone, Homo sapiens(human)
Gene Symbol | TUBB4B |
Entrez Gene ID | 10383 |
Full Name | tubulin beta 4B class IVb |
Synonyms | Beta2,TUBB2,TUBB2C |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA and Protein(s)
mRNA | Protein | Name |
---|---|---|
NM_006088.6 | NP_006079.1 | tubulin beta-4B chain |
NM_006088.5 | NP_006079.1 | tubulin beta-4B chain |

Bos taurus (cattle) | TUBB4B | NP_001029835.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP010929 | XP_309765.4 |
Eremothecium gossypii | AGOS_ACR225C | NP_983627.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_00604 | XP_003718429.1 |
Arabidopsis thaliana (thale cress) | TUB1 | NP_177706.1 |
Gallus gallus (chicken) | TUBB2C | NP_001074329.2 |
Caenorhabditis elegans (roundworm) | tbb-4 | NP_509585.1 |
Saccharomyces cerevisiae (baker's yeast) | TUB2 | NP_116616.1 |
Neurospora crassa | NCU04054 | XP_957669.2 |
Oryza sativa (rice) | Os03g0780600 | NP_001051451.1 |
Pan troglodytes (chimpanzee) | TUBB2C | NP_001233307.1 |
Canis lupus familiaris (dog) | LOC102153202 | XP_005625117.1 |
Rattus norvegicus (Norway rat) | Tubb4b | NP_954525.1 |
Drosophila melanogaster (fruit fly) | betaTub56D | NP_523795.2 |
Schizosaccharomyces pombe (fission yeast) | nda3 | NP_596650.1 |
Arabidopsis thaliana (thale cress) | TUB5 | NP_564101.1 |
Danio rerio (zebrafish) | tubb4b | NP_942104.2 |
Homo sapiens (human) | TUBB4B | NP_006079.1 |
TUBB2C | XP_002799957.1 | |
Mus musculus (house mouse) | Tubb4b | NP_666228.1 |
Danio rerio (zebrafish) | zgc:55461 | NP_998655.1 |
Kluyveromyces lactis | KLLA0D05269g | XP_453295.1 |
Oryza sativa (rice) | Os02g0167300 | NP_001046006.1 |
Xenopus tropicalis (tropical clawed frog) | tubb4b | NP_001072450.1 |

Related articles in PubMed
Mutations in TUBB4B Cause a Distinctive Sensorineural Disease.
Luscan R, Mechaussier S, Paul A, Tian G, G?rard X, Defoort-Dellhemmes S, Loundon N, Audo I, Bonnin S, LeGargasson JF, Dumont J, Goudin N, Garfa-Traor? M, Bras M, Pouliet A, Bessi?res B, Boddaert N, Sahel JA, Lyonnet S, Kaplan J, Cowan NJ, Rozet JM, Marlin S, Perrault I
American journal of human genetics101(6)1006-1012(2017 Dec)
Tubulin beta 3 and 4 are involved in the generation of early fibrotic stages.
Wawro ME, Sobierajska K, Ciszewski WM, Wagner W, Frontczak M, Wieczorek K, Niewiarowska J
Cellular signalling3826-38(2017 Oct)
Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.
Chiasserini D, van Weering JR, Piersma SR, Pham TV, Malekzadeh A, Teunissen CE, de Wit H, Jim?nez CR
Journal of proteomics106191-204(2014 Jun)
A direct interaction between leucine-rich repeat kinase 2 and specific ?-tubulin isoforms regulates tubulin acetylation.
Law BM, Spain VA, Leinster VH, Chia R, Beilina A, Cho HJ, Taymans JM, Urban MK, Sancho RM, Blanca Ram?rez M, Biskup S, Baekelandt V, Cai H, Cookson MR, Berwick DC, Harvey K
The Journal of biological chemistry289(2)895-908(2014 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The authors identified TUBB4B mutations as the cause of a previously unreported autosomal-dominant syndrome manifesting as early-onset and severe photoreceptor and cochlear cell loss.
Title: Mutations in TUBB4B Cause a Distinctive Sensorineural Disease.
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
Title: Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
The results od this study found that betaI-tubulin protein expression was decreased in the anterior cingulate cortex and increased in the dorsolateral prefrontal cortex, but not changed in superior temporal gyrus or hippocampus in schizophrenia.
Title: Regional differences in expression of ?-tubulin isoforms in schizophrenia.
Data suggest that increased expression of hnRNP A1, Ezrin, tubulin beta-2C and Annexin A1 in SLNMM indicate a significantly elevated early colorectal cancer metastasis.
Title: Up-regulation of hnRNP A1, Ezrin, tubulin ?-2C and Annexin A1 in sentinel lymph nodes of colorectal cancer.
Studies show that BFBTS bound and modified beta-tubulin at residue Cys12, forming beta-tubulin-SS-fluorobenzyl.
Title: Natural product derivative Bis(4-fluorobenzyl)trisulfide inhibits tumor growth by modification of beta-tubulin at Cys 12 and suppression of microtubule dynamics.
The following TUBB4B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TUBB4B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OHu29613![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_006088.6 , NM_006088.5 | |
Accession Version | NM_006088.6 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1338bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-10 | |
Organism | Homo sapiens(human) | |
Product | tubulin beta-4B chain | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB139156.1 and BC004188.2. On Nov 22, 2018 this sequence version replaced NM_006088.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC029529.1, AK000560.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000340384.5/ ENSP00000341289.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGAGGGAAA TCGTGCACTT GCAGGCCGGG CAGTGCGGCA ACCAAATCGG CGCCAAGTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_006079.1 |
CDS | 75..1412 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGAGGGAAA TCGTGCACTT GCAGGCCGGG CAGTGCGGCA ACCAAATCGG CGCCAAGTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu29613![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_006088.6 , NM_006088.5 | |
Accession Version | NM_006088.5 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1338bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-09-30 | |
Organism | Homo sapiens(human) | |
Product | tubulin beta-4B chain | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB139156.1 and BC004188.2. On Jun 21, 2005 this sequence version replaced NM_006088.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.183641.1, SRR1163658.384490.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGAGGGAAA TCGTGCACTT GCAGGCCGGG CAGTGCGGCA ACCAAATCGG CGCCAAGTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_006079.1 |
CDS | 103..1440 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGAGGGAAA TCGTGCACTT GCAGGCCGGG CAGTGCGGCA ACCAAATCGG CGCCAAGTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
![]() |
Mutations in TUBB4B Cause a Distinctive Sensorineural Disease. |
![]() |
Tubulin beta 3 and 4 are involved in the generation of early fibrotic stages. |
![]() |
Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset. |
![]() |
A direct interaction between leucine-rich repeat kinase 2 and specific ?-tubulin isoforms regulates tubulin acetylation. |