TMED2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TMED2
Entrez Gene ID	10959
Full Name	transmembrane p24 trafficking protein 2
Synonyms	P24A,RNP24,p24,p24b1,p24beta1
General protein information	Preferred Names transmembrane p24 trafficking protein 2 Names transmembrane emp24 domain-containing protein 2 coated vesicle membrane protein membrane protein p24A p24 family protein beta-1 transmembrane emp24 domain trafficking protein 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q24.31

mRNA and Protein(s)

mRNA	Protein	Name
NM_001321445.2	NP_001308374.1	transmembrane emp24 domain-containing protein 2 isoform 2 precursor
NM_006815.4	NP_006806.1	transmembrane emp24 domain-containing protein 2 isoform 1 precursor
NM_001321445.1	NP_001308374.1	transmembrane emp24 domain-containing protein 2 isoform 2 precursor
NM_006815.3	NP_006806.1	transmembrane emp24 domain-containing protein 2 isoform 1 precursor

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	TMED2	NP_001006186.1
Schizosaccharomyces pombe (fission yeast)	emp24	NP_588020.1
Magnaporthe oryzae (rice blast fungus)	MGG_04439	XP_003713534.1
Neurospora crassa	NCU08339	XP_965242.2
Homo sapiens (human)	TMED2	NP_006806.1
Bos taurus (cattle)	TMED2	NP_001153290.1
Mus musculus (house mouse)	Gm21540	XP_003945495.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004743	XP_318076.3
Xenopus tropicalis (tropical clawed frog)	tmed2	NP_001039241.1
Mus musculus (house mouse)	Tmed2	NP_062744.1
Drosophila melanogaster (fruit fly)	CHOp24	NP_572165.1
Caenorhabditis elegans (roundworm)	sel-9	NP_505145.1
Kluyveromyces lactis	KLLA0F12518g	XP_455646.1
Pan troglodytes (chimpanzee)	TMED2	XP_001152449.2
Canis lupus familiaris (dog)	TMED2	XP_003433480.1
Rattus norvegicus (Norway rat)	Tmed2	NP_113910.1
Danio rerio (zebrafish)	tmed2	NP_955842.1
Saccharomyces cerevisiae (baker's yeast)	EMP24	NP_011315.3

Gene Ontology
Bibliography

Related articles in PubMed

3D Structure and Interaction of p24? and p24? Golgi Dynamics Domains: Implication for p24 Complex Formation and Cargo Transport.
Nagae M, Hirata T, Morita-Matsumoto K, Theiler R, Fujita M, Kinoshita T, Yamaguchi Y
Journal of molecular biology428(20)4087-4099(2016 Oct)

Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
Rietveld CA, Esko T, Davies G, Pers TH, Turley P, Benyamin B, Chabris CF, Emilsson V, Johnson AD, Lee JJ, de Leeuw C, Marioni RE, Medland SE, Miller MB, Rostapshova O, van der Lee SJ, Vinkhuyzen AA, Amin N, Conley D, Derringer J, van Duijn CM, Fehrmann R, Franke L, Glaeser EL, Hansell NK, Hayward C, Iacono WG, Ibrahim-Verbaas C, Jaddoe V, Karjalainen J, Laibson D, Lichtenstein P, Liewald DC, Magnusson PK, Martin NG, McGue M, McMahon G, Pedersen NL, Pinker S, Porteous DJ, Posthuma D, Rivadeneira F, Smith BH, Starr JM, Tiemeier H, Timpson NJ, Trzaskowski M, Uitterlinden AG, Verhulst FC, Ward ME, Wright MJ, Davey Smith G, Deary IJ, Johannesson M, Plomin R, Visscher PM, Benjamin DJ, Cesarini D, Koellinger PD
Proceedings of the National Academy of Sciences of the United States of America111(38)13790-4(2014 Sep)

TMED2/p24?1 is expressed in all gestational stages of human placentas and in choriocarcinoma cell lines.
Zakariyah A, Hou W, Slim R, Jerome-Majewska L
Placenta33(3)214-9(2012 Mar)

Proteinase-activated receptors, nucleotide P2Y receptors, and ?-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking.
Luo W, Wang Y, Reiser G
Journal of neurochemistry117(1)71-81(2011 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Surface plasmon resonance and solution NMR analyses revealed that p24beta1 and p24delta1 GOLD domains interact weakly (Kd= ~10(-4)M).
Title: 3D Structure and Interaction of p24? and p24? Golgi Dynamics Domains: Implication for p24 Complex Formation and Cargo Transport.

TMED2/p24beta1 is expressed in all gestational stages of human placentas and in choriocarcinoma cell lines.
Title: TMED2/p24?1 is expressed in all gestational stages of human placentas and in choriocarcinoma cell lines.

Both p24A transmembrane protein and p23 are specific cargo receptors of G protein-coupled receptors (GPCR) and differentially regulate GPCR signaling in astrocytes.
Title: Proteinase-activated receptors, nucleotide P2Y receptors, and ?-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking.

These results suggest that p24A is the limiting factor in CaSR trafficking in the early secretory pathway, and that cycling between the ER and ERGIC protects CaSR from degradation.
Title: The cargo receptor p24A facilitates calcium sensing receptor maturation and stabilization in the early secretory pathway.

p24A is a regulator of signal-dependent trafficking that controls ARF1-dependent resensitization of PAR-2
Title: p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking.

The following TMED2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TMED2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31108	NM_006815.4 Latest version!	Homo sapiens transmembrane p24 trafficking protein 2 (TMED2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu46262	NM_001321445.2 Latest version!	Homo sapiens transmembrane p24 trafficking protein 2 (TMED2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu46262	NM_001321445.1	Homo sapiens transmembrane p24 trafficking protein 2 (TMED2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu31108	NM_006815.3	Homo sapiens transmembrane p24 trafficking protein 2 (TMED2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TMED2 ( NM_006815.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006806.1 Homo sapiens transmembrane p24 trafficking protein 2 (TMED2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu31108
Clone ID Related Accession (Same CDS sequence)	NM_006815.4 , NM_006815.3
Accession Version	NM_006815.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 606bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Homo sapiens(human)
Product	transmembrane emp24 domain-containing protein 2 isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC055713.29, BI086507.1 and BC025957.1. On Nov 22, 2018 this sequence version replaced NM_006815.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.972817.1, SRR1660805.248900.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000262225.8/ ENSP00000262225.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTGACGC TTGCTGAACT GCTGGTGCTT CTGGCCGCTC TCCTGGCCAC GGTCTCGGGC 
TATTTCGTTA GCATCGACGC CCATGCTGAA GAGTGCTTCT TTGAGCGGGT CACCTCGGGC 
ACCAAGATGG GCCTCATCTT CGAGGTGGCG GAGGGCGGCT TCCTGGACAT CGACGTGGAG 
ATTACAGGAC CAGATAACAA AGGAATTTAC AAAGGAGACA GAGAATCCAG TGGGAAATAC 
ACATTTGCTG CTCACATGGA TGGAACATAC AAATTTTGTT TTAGTAACCG GATGTCCACC 
ATGACTCCAA AAATAGTGAT GTTCACCATT GATATTGGGG AGGCTCCAAA AGGACAAGAT 
ATGGAAACAG AAGCTCACCA GAACAAGCTA GAAGAAATGA TCAATGAGCT AGCAGTGGCG 
ATGACAGCTG TAAAGCACGA ACAGGAATAC ATGGAAGTCC GGGAGAGAAT ACACAGAGCC 
ATCAACGACA ACACAAACAG CAGAGTGGTC CTTTGGTCCT TCTTTGAAGC TCTTGTTCTA 
GTTGCCATGA CATTGGGACA GATCTACTAC CTGAAGAGAT TTTTTGAAGT CCGGAGAGTT 
GTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006806.1
CDS	86..691
Translation	MVTLAELLVLLAALLATVSGYFVSIDAHAEECFFERVTSGTKMGLIFEVAEGGFLDIDVEITGPDNKGIYKGDRESSGKYTFAAHMDGTYKFCFSNRMSTMTPKIVMFTIDIGEAPKGQDMETEAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRRVV

Target ORF information:

RefSeq Version	NM_006815.4
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane p24 trafficking protein 2 (TMED2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006815.4

ORF Insert Sequence:

ATGGTGACGC TTGCTGAACT GCTGGTGCTT CTGGCCGCTC TCCTGGCCAC GGTCTCGGGC 
TATTTCGTTA GCATCGACGC CCATGCTGAA GAGTGCTTCT TTGAGCGGGT CACCTCGGGC 
ACCAAGATGG GCCTCATCTT CGAGGTGGCG GAGGGCGGCT TCCTGGACAT CGACGTGGAG 
ATTACAGGAC CAGATAACAA AGGAATTTAC AAAGGAGACA GAGAATCCAG TGGGAAATAC 
ACATTTGCTG CTCACATGGA TGGAACATAC AAATTTTGTT TTAGTAACCG GATGTCCACC 
ATGACTCCAA AAATAGTGAT GTTCACCATT GATATTGGGG AGGCTCCAAA AGGACAAGAT 
ATGGAAACAG AAGCTCACCA GAACAAGCTA GAAGAAATGA TCAATGAGCT AGCAGTGGCG 
ATGACAGCTG TAAAGCACGA ACAGGAATAC ATGGAAGTCC GGGAGAGAAT ACACAGAGCC 
ATCAACGACA ACACAAACAG CAGAGTGGTC CTTTGGTCCT TCTTTGAAGC TCTTGTTCTA 
GTTGCCATGA CATTGGGACA GATCTACTAC CTGAAGAGAT TTTTTGAAGT CCGGAGAGTT 
GTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMED2 ( NM_006815.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006806.1 Homo sapiens transmembrane p24 trafficking protein 2 (TMED2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu31108
Clone ID Related Accession (Same CDS sequence)	NM_006815.4 , NM_006815.3
Accession Version	NM_006815.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 606bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	transmembrane emp24 domain-containing protein 2 isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC055713.29, BI086507.1 and BC025957.1. On Nov 22, 2006 this sequence version replaced NM_006815.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279848.9086.1, SRR1803615.176045.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGACGC TTGCTGAACT GCTGGTGCTT CTGGCCGCTC TCCTGGCCAC GGTCTCGGGC 
TATTTCGTTA GCATCGACGC CCATGCTGAA GAGTGCTTCT TTGAGCGGGT CACCTCGGGC 
ACCAAGATGG GCCTCATCTT CGAGGTGGCG GAGGGCGGCT TCCTGGACAT CGACGTGGAG 
ATTACAGGAC CAGATAACAA AGGAATTTAC AAAGGAGACA GAGAATCCAG TGGGAAATAC 
ACATTTGCTG CTCACATGGA TGGAACATAC AAATTTTGTT TTAGTAACCG GATGTCCACC 
ATGACTCCAA AAATAGTGAT GTTCACCATT GATATTGGGG AGGCTCCAAA AGGACAAGAT 
ATGGAAACAG AAGCTCACCA GAACAAGCTA GAAGAAATGA TCAATGAGCT AGCAGTGGCG 
ATGACAGCTG TAAAGCACGA ACAGGAATAC ATGGAAGTCC GGGAGAGAAT ACACAGAGCC 
ATCAACGACA ACACAAACAG CAGAGTGGTC CTTTGGTCCT TCTTTGAAGC TCTTGTTCTA 
GTTGCCATGA CATTGGGACA GATCTACTAC CTGAAGAGAT TTTTTGAAGT CCGGAGAGTT 
GTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006806.1
CDS	109..714
Translation	MVTLAELLVLLAALLATVSGYFVSIDAHAEECFFERVTSGTKMGLIFEVAEGGFLDIDVEITGPDNKGIYKGDRESSGKYTFAAHMDGTYKFCFSNRMSTMTPKIVMFTIDIGEAPKGQDMETEAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRRVV

Target ORF information:

RefSeq Version	NM_006815.3
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane p24 trafficking protein 2 (TMED2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006815.3

ORF Insert Sequence:

ATGGTGACGC TTGCTGAACT GCTGGTGCTT CTGGCCGCTC TCCTGGCCAC GGTCTCGGGC 
TATTTCGTTA GCATCGACGC CCATGCTGAA GAGTGCTTCT TTGAGCGGGT CACCTCGGGC 
ACCAAGATGG GCCTCATCTT CGAGGTGGCG GAGGGCGGCT TCCTGGACAT CGACGTGGAG 
ATTACAGGAC CAGATAACAA AGGAATTTAC AAAGGAGACA GAGAATCCAG TGGGAAATAC 
ACATTTGCTG CTCACATGGA TGGAACATAC AAATTTTGTT TTAGTAACCG GATGTCCACC 
ATGACTCCAA AAATAGTGAT GTTCACCATT GATATTGGGG AGGCTCCAAA AGGACAAGAT 
ATGGAAACAG AAGCTCACCA GAACAAGCTA GAAGAAATGA TCAATGAGCT AGCAGTGGCG 
ATGACAGCTG TAAAGCACGA ACAGGAATAC ATGGAAGTCC GGGAGAGAAT ACACAGAGCC 
ATCAACGACA ACACAAACAG CAGAGTGGTC CTTTGGTCCT TCTTTGAAGC TCTTGTTCTA 
GTTGCCATGA CATTGGGACA GATCTACTAC CTGAAGAGAT TTTTTGAAGT CCGGAGAGTT 
GTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMED2 ( NM_001321445.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001308374.1 Homo sapiens transmembrane p24 trafficking protein 2 (TMED2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu46262
Clone ID Related Accession (Same CDS sequence)	NM_001321445.2 , NM_001321445.1
Accession Version	NM_001321445.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Homo sapiens(human)
Product	transmembrane emp24 domain-containing protein 2 isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP226125.1, BI086507.1, DA559763.1, BC025957.1, CA445272.1, AI954929.1 and AC055713.29. On May 31, 2019 this sequence version replaced NM_001321445.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.278828.1, SRR1803615.26940.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGACGC TTGCTGAACT GCTGGTGCTT CTGGCCGCTC TCCTGGCCAC GGTCTCGGGC 
TATTTCGTTA GCATCGACGC CCATGCTGAA GAGTGCTTCT TTGAGCGGGT CACCTCGGGC 
ACCAAGATGG GCCTCATCTT CGAGGTGGCG GAGGGCGGCT TCCTGGACAT CGACGTGGAG 
ATTACAGGAC CAGATAACAA AGGAATTTAC AAAGGAGACA GAGAATCCAG TGGGAAATAC 
ACATTTGCTG CTCACATGGA TGGAACATAC AAATTTTGTT TTAGTAACCG GATGTCCACC 
ATGACTCCAA AAATAGTGAT GTTCACCATT GATATTGGGG AGGCTCCAAA AGGACAAGAT 
ATGGAAACAG AAGGTGGTGG AGATACCTGG GATGCTCACC AGAACAAGCT AGAAGAAATG 
ATCAATGAGC TAGCAGTGGC GATGACAGCT GTAAAGCACG AACAGGAATA CATGGAAGTC 
CGGGAGAGAA TACACAGAGC CATCAACGAC AACACAAACA GCAGAGTGGT CCTTTGGTCC 
TTCTTTGAAG CTCTTGTTCT AGTTGCCATG ACATTGGGAC AGATCTACTA CCTGAAGAGA 
TTTTTTGAAG TCCGGAGAGT TGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001308374.1
CDS	86..712
Translation	MVTLAELLVLLAALLATVSGYFVSIDAHAEECFFERVTSGTKMGLIFEVAEGGFLDIDVEITGPDNKGIYKGDRESSGKYTFAAHMDGTYKFCFSNRMSTMTPKIVMFTIDIGEAPKGQDMETEGGGDTWDAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRRVV

Target ORF information:

RefSeq Version	NM_001321445.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane p24 trafficking protein 2 (TMED2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001321445.2

ORF Insert Sequence:

ATGGTGACGC TTGCTGAACT GCTGGTGCTT CTGGCCGCTC TCCTGGCCAC GGTCTCGGGC 
TATTTCGTTA GCATCGACGC CCATGCTGAA GAGTGCTTCT TTGAGCGGGT CACCTCGGGC 
ACCAAGATGG GCCTCATCTT CGAGGTGGCG GAGGGCGGCT TCCTGGACAT CGACGTGGAG 
ATTACAGGAC CAGATAACAA AGGAATTTAC AAAGGAGACA GAGAATCCAG TGGGAAATAC 
ACATTTGCTG CTCACATGGA TGGAACATAC AAATTTTGTT TTAGTAACCG GATGTCCACC 
ATGACTCCAA AAATAGTGAT GTTCACCATT GATATTGGGG AGGCTCCAAA AGGACAAGAT 
ATGGAAACAG AAGGTGGTGG AGATACCTGG GATGCTCACC AGAACAAGCT AGAAGAAATG 
ATCAATGAGC TAGCAGTGGC GATGACAGCT GTAAAGCACG AACAGGAATA CATGGAAGTC 
CGGGAGAGAA TACACAGAGC CATCAACGAC AACACAAACA GCAGAGTGGT CCTTTGGTCC 
TTCTTTGAAG CTCTTGTTCT AGTTGCCATG ACATTGGGAC AGATCTACTA CCTGAAGAGA 
TTTTTTGAAG TCCGGAGAGT TGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMED2 ( NM_001321445.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001308374.1 Homo sapiens transmembrane p24 trafficking protein 2 (TMED2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu46262
Clone ID Related Accession (Same CDS sequence)	NM_001321445.2 , NM_001321445.1
Accession Version	NM_001321445.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-04
Organism	Homo sapiens(human)
Product	transmembrane emp24 domain-containing protein 2 isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP226125.1, BI086507.1, DA559763.1, BC025957.1, CA445272.1 and AI954929.1. On Mar 25, 2016 this sequence version replaced XM_005253544.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189655.71456.1, SRR5189655.135074.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGACGC TTGCTGAACT GCTGGTGCTT CTGGCCGCTC TCCTGGCCAC GGTCTCGGGC 
TATTTCGTTA GCATCGACGC CCATGCTGAA GAGTGCTTCT TTGAGCGGGT CACCTCGGGC 
ACCAAGATGG GCCTCATCTT CGAGGTGGCG GAGGGCGGCT TCCTGGACAT CGACGTGGAG 
ATTACAGGAC CAGATAACAA AGGAATTTAC AAAGGAGACA GAGAATCCAG TGGGAAATAC 
ACATTTGCTG CTCACATGGA TGGAACATAC AAATTTTGTT TTAGTAACCG GATGTCCACC 
ATGACTCCAA AAATAGTGAT GTTCACCATT GATATTGGGG AGGCTCCAAA AGGACAAGAT 
ATGGAAACAG AAGGTGGTGG AGATACCTGG GATGCTCACC AGAACAAGCT AGAAGAAATG 
ATCAATGAGC TAGCAGTGGC GATGACAGCT GTAAAGCACG AACAGGAATA CATGGAAGTC 
CGGGAGAGAA TACACAGAGC CATCAACGAC AACACAAACA GCAGAGTGGT CCTTTGGTCC 
TTCTTTGAAG CTCTTGTTCT AGTTGCCATG ACATTGGGAC AGATCTACTA CCTGAAGAGA 
TTTTTTGAAG TCCGGAGAGT TGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001308374.1
CDS	107..733
Translation	MVTLAELLVLLAALLATVSGYFVSIDAHAEECFFERVTSGTKMGLIFEVAEGGFLDIDVEITGPDNKGIYKGDRESSGKYTFAAHMDGTYKFCFSNRMSTMTPKIVMFTIDIGEAPKGQDMETEGGGDTWDAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRRVV

Target ORF information:

RefSeq Version	NM_001321445.1
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane p24 trafficking protein 2 (TMED2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001321445.1

ORF Insert Sequence:

ATGGTGACGC TTGCTGAACT GCTGGTGCTT CTGGCCGCTC TCCTGGCCAC GGTCTCGGGC 
TATTTCGTTA GCATCGACGC CCATGCTGAA GAGTGCTTCT TTGAGCGGGT CACCTCGGGC 
ACCAAGATGG GCCTCATCTT CGAGGTGGCG GAGGGCGGCT TCCTGGACAT CGACGTGGAG 
ATTACAGGAC CAGATAACAA AGGAATTTAC AAAGGAGACA GAGAATCCAG TGGGAAATAC 
ACATTTGCTG CTCACATGGA TGGAACATAC AAATTTTGTT TTAGTAACCG GATGTCCACC 
ATGACTCCAA AAATAGTGAT GTTCACCATT GATATTGGGG AGGCTCCAAA AGGACAAGAT 
ATGGAAACAG AAGGTGGTGG AGATACCTGG GATGCTCACC AGAACAAGCT AGAAGAAATG 
ATCAATGAGC TAGCAGTGGC GATGACAGCT GTAAAGCACG AACAGGAATA CATGGAAGTC 
CGGGAGAGAA TACACAGAGC CATCAACGAC AACACAAACA GCAGAGTGGT CCTTTGGTCC 
TTCTTTGAAG CTCTTGTTCT AGTTGCCATG ACATTGGGAC AGATCTACTA CCTGAAGAGA 
TTTTTTGAAG TCCGGAGAGT TGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

3D Structure and Interaction of p24? and p24? Golgi Dynamics Domains: Implication for p24 Complex Formation and Cargo Transport.
Journal of molecular biology428(20)4087-4099(2016 Oct)
Nagae M,Hirata T,Morita-Matsumoto K,Theiler R,Fujita M,Kinoshita T,Yamaguchi Y

Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
Proceedings of the National Academy of Sciences of the United States of America111(38)13790-4(2014 Sep)
Rietveld CA,Esko T,Davies G,Pers TH,Turley P,Benyamin B,Chabris CF,Emilsson V,Johnson AD,Lee JJ,de Leeuw C,Marioni RE,Medland SE,Miller MB,Rostapshova O,van der Lee SJ,Vinkhuyzen AA,Amin N,Conley D,Derringer J,van Duijn CM,Fehrmann R,Franke L,Glaeser EL,Hansell NK,Hayward C,Iacono WG,Ibrahim-Verbaas C,Jaddoe V,Karjalainen J,Laibson D,Lichtenstein P,Liewald DC,Magnusson PK,Martin NG,McGue M,McMahon G,Pedersen NL,Pinker S,Porteous DJ,Posthuma D,Rivadeneira F,Smith BH,Starr JM,Tiemeier H,Timpson NJ,Trzaskowski M,Uitterlinden AG,Verhulst FC,Ward ME,Wright MJ,Davey Smith G,Deary IJ,Johannesson M,Plomin R,Visscher PM,Benjamin DJ,Cesarini D,Koellinger PD

TMED2/p24?1 is expressed in all gestational stages of human placentas and in choriocarcinoma cell lines.
Placenta33(3)214-9(2012 Mar)
Zakariyah A,Hou W,Slim R,Jerome-Majewska L

Proteinase-activated receptors, nucleotide P2Y receptors, and ?-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking.
Journal of neurochemistry117(1)71-81(2011 Apr)
Luo W,Wang Y,Reiser G

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TMED2 cDNA ORF clone, Homo sapiens(human)

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