Gene Symbol | TNFAIP8L1 |
Entrez Gene ID | 126282 |
Full Name | TNF alpha induced protein 8 like 1 |
Synonyms | TIPE1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » TNFAIP8L1 cDNA ORF clone
gRNAs
Gene Symbol | TNFAIP8L1 |
Entrez Gene ID | 126282 |
Full Name | TNF alpha induced protein 8 like 1 |
Synonyms | TIPE1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
XM_011527680.1 | XP_011525982.1 | tumor necrosis factor alpha-induced protein 8-like protein 1 isoform X1 |
XM_011527680.2 | XP_011525982.1 | tumor necrosis factor alpha-induced protein 8-like protein 1 isoform X1 |
NM_152362.3 | NP_689575.2 | tumor necrosis factor alpha-induced protein 8-like protein 1 |
NM_152362.2 | NP_689575.2 | tumor necrosis factor alpha-induced protein 8-like protein 1 |
XM_005259487.2 | XP_005259544.1 | tumor necrosis factor alpha-induced protein 8-like protein 1 isoform X1 |
XM_005259487.3 | XP_005259544.1 | tumor necrosis factor alpha-induced protein 8-like protein 1 isoform X1 |
NM_001167942.1 | NP_001161414.1 | tumor necrosis factor alpha-induced protein 8-like protein 1 |
Mus musculus (house mouse) | Tnfaip8l1 | NP_079842.2 |
Homo sapiens (human) | TNFAIP8L1 | NP_001161414.1 |
TNFAIP8L1 | XP_001081997.1 | |
Gallus gallus (chicken) | TNFAIP8L1 | NP_001006343.1 |
Bos taurus (cattle) | TNFAIP8L1 | NP_001096740.1 |
Rattus norvegicus (Norway rat) | Tnfaip8l1 | XP_006244433.1 |
Pan troglodytes (chimpanzee) | TNFAIP8L1 | XP_524063.2 |
Canis lupus familiaris (dog) | TNFAIP8L1 | XP_005633087.1 |
Danio rerio (zebrafish) | tnfaip8l1 | NP_956626.1 |
TIPE1 suppresses invasion and migration through down-regulating Wnt/?-catenin pathway in gastric cancer.
Liu W, Chen Y, Xie H, Guo Y, Ren D, Li Y, Jing X, Li D, Wang X, Zhao M, Zhu T, Wang Z, Wei X, Gao F, Wang X, Liu S, Zhang Y, Yi F
Journal of cellular and molecular medicine(2017 Oct)
TIPE1 induces apoptosis by negatively regulating Rac1 activation in hepatocellular carcinoma cells.
Zhang Z, Liang X, Gao L, Ma H, Liu X, Pan Y, Yan W, Shan H, Wang Z, Chen YH, Ma C
Oncogene34(20)2566-74(2015 May)
Tnfaip8?l1/Oxi-? binds to FBXW5, increasing autophagy through activation of TSC2 in a Parkinson's disease model.
Ha JY, Kim JS, Kang YH, Bok E, Kim YS, Son JH
Journal of neurochemistry129(3)527-38(2014 May)
The TIPE (TNFAIP8) family in inflammation, immunity, and cancer.
Lou Y, Liu S
Molecular immunology49(1-2)4-7(2011 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
TIPE1 induced apoptosis in HCC cells by negatively regulating Rac1 pathway
Title: TIPE1 induces apoptosis by negatively regulating Rac1 activation in hepatocellular carcinoma cells.
oxidative stress induces Tnfaip8 l1/Oxi-beta, which results in increased autophagy by its exclusive binding with FBXW5 to stabilize TSC2
Title: Tnfaip8?l1/Oxi-? binds to FBXW5, increasing autophagy through activation of TSC2 in a Parkinson's disease model.
high levels of TIPE1 (TNFAIP8-like 1) mRNA were detected in most human carcinoma cell lines, especially in cells transformed with viral genomes
Title: The expression of TIPE1 in murine tissues and human cell lines.
The following TNFAIP8L1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TNFAIP8L1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
Online Only Promotion
Up to 50% OFF! Starting
from $49/clone
CloneID | OHu28757![]() |
|
Clone ID Related Accession (Same CDS sequence) | XM_011527680.1 , XM_011527680.2 , NM_152362.3 , NM_152362.2 , XM_005259487.2 , XM_005259487.3 , NM_001167942.1 | |
Accession Version | NM_152362.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-05-27 | |
Organism | Homo sapiens(human) | |
Product | tumor necrosis factor alpha-induced protein 8-like protein 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX282702.1 and AC005339.1. On Nov 23, 2018 this sequence version replaced NM_152362.2. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.874435.1, BC017672.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000327473.9/ ENSP00000331827.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGGACACCT TCAGCACCAA GAGCCTGGCT CTGCAGGCGC AGAAGAAGCT CCTGAGTAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_689575.2 |
CDS | 118..678 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGACACCT TCAGCACCAA GAGCCTGGCT CTGCAGGCGC AGAAGAAGCT CCTGAGTAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu28757![]() |
|
Clone ID Related Accession (Same CDS sequence) | XM_011527680.1 , XM_011527680.2 , NM_152362.3 , NM_152362.2 , XM_005259487.2 , XM_005259487.3 , NM_001167942.1 | |
Accession Version | NM_152362.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-01 | |
Organism | Homo sapiens(human) | |
Product | tumor necrosis factor alpha-induced protein 8-like protein 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX282702.1 and AC005339.1. On Nov 24, 2009 this sequence version replaced NM_152362.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BI828661.1, BC017672.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGACACCT TCAGCACCAA GAGCCTGGCT CTGCAGGCGC AGAAGAAGCT CCTGAGTAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_689575.2 |
CDS | 119..679 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGACACCT TCAGCACCAA GAGCCTGGCT CTGCAGGCGC AGAAGAAGCT CCTGAGTAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu28757![]() |
|
Clone ID Related Accession (Same CDS sequence) | XM_011527680.1 , XM_011527680.2 , NM_152362.3 , NM_152362.2 , XM_005259487.2 , XM_005259487.3 , NM_001167942.1 | |
Accession Version | NM_001167942.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-05-27 | |
Organism | Homo sapiens(human) | |
Product | tumor necrosis factor alpha-induced protein 8-like protein 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC011498.7 and AC005339.1. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: HY018065.1, HY021164.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGACACCT TCAGCACCAA GAGCCTGGCT CTGCAGGCGC AGAAGAAGCT CCTGAGTAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001161414.1 |
CDS | 147..707 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGACACCT TCAGCACCAA GAGCCTGGCT CTGCAGGCGC AGAAGAAGCT CCTGAGTAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu28757![]() |
|
Clone ID Related Accession (Same CDS sequence) | XM_011527680.1 , XM_011527680.2 , NM_152362.3 , NM_152362.2 , XM_005259487.2 , XM_005259487.3 , NM_001167942.1 | |
Accession Version | XM_011527680.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-03-11 | |
Organism | Homo sapiens(Human) | |
Product | tumor necrosis factor alpha-induced protein 8-like protein 1 isoform X1 | |
Comment |
1 | ATGGACACCT TCAGCACCAA GAGCCTGGCT CTGCAGGCGC AGAAGAAGCT CCTGAGTAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011525982.1 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGACACCT TCAGCACCAA GAGCCTGGCT CTGCAGGCGC AGAAGAAGCT CCTGAGTAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu28757![]() |
|
Clone ID Related Accession (Same CDS sequence) | XM_011527680.1 , XM_011527680.2 , NM_152362.3 , NM_152362.2 , XM_005259487.2 , XM_005259487.3 , NM_001167942.1 | |
Accession Version | XM_011527680.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | tumor necrosis factor alpha-induced protein 8-like protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011527680.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGACACCT TCAGCACCAA GAGCCTGGCT CTGCAGGCGC AGAAGAAGCT CCTGAGTAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011525982.1 |
CDS | 125..685 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGACACCT TCAGCACCAA GAGCCTGGCT CTGCAGGCGC AGAAGAAGCT CCTGAGTAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu28757![]() |
|
Clone ID Related Accession (Same CDS sequence) | XM_011527680.1 , XM_011527680.2 , NM_152362.3 , NM_152362.2 , XM_005259487.2 , XM_005259487.3 , NM_001167942.1 | |
Accession Version | XM_005259487.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-03-11 | |
Organism | Homo sapiens(Human) | |
Product | tumor necrosis factor alpha-induced protein 8-like protein 1 isoform X1 | |
Comment |
1 | ATGGACACCT TCAGCACCAA GAGCCTGGCT CTGCAGGCGC AGAAGAAGCT CCTGAGTAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005259544.1 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGACACCT TCAGCACCAA GAGCCTGGCT CTGCAGGCGC AGAAGAAGCT CCTGAGTAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu28757![]() |
|
Clone ID Related Accession (Same CDS sequence) | XM_011527680.1 , XM_011527680.2 , NM_152362.3 , NM_152362.2 , XM_005259487.2 , XM_005259487.3 , NM_001167942.1 | |
Accession Version | XM_005259487.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | tumor necrosis factor alpha-induced protein 8-like protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005259487.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGACACCT TCAGCACCAA GAGCCTGGCT CTGCAGGCGC AGAAGAAGCT CCTGAGTAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005259544.1 |
CDS | 834..1394 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGACACCT TCAGCACCAA GAGCCTGGCT CTGCAGGCGC AGAAGAAGCT CCTGAGTAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
TIPE1 suppresses invasion and migration through down-regulating Wnt/?-catenin pathway in gastric cancer. |
TIPE1 induces apoptosis by negatively regulating Rac1 activation in hepatocellular carcinoma cells. |
Tnfaip8?l1/Oxi-? binds to FBXW5, increasing autophagy through activation of TSC2 in a Parkinson's disease model. |
The TIPE (TNFAIP8) family in inflammation, immunity, and cancer. |