Gene Symbol | SH3RF2 |
Entrez Gene ID | 153769 |
Full Name | SH3 domain containing ring finger 2 |
Synonyms | HEPP1,POSHER,PPP1R39,RNF158 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » SH3RF2 cDNA ORF clone
Gene Symbol | SH3RF2 |
Entrez Gene ID | 153769 |
Full Name | SH3 domain containing ring finger 2 |
Synonyms | HEPP1,POSHER,PPP1R39,RNF158 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
XM_011537569.2 | XP_011535871.1 | E3 ubiquitin-protein ligase SH3RF2 isoform X2 |
NM_152550.4 | NP_689763.4 | E3 ubiquitin-protein ligase SH3RF2 |
XM_017009136.1 | XP_016864625.1 | E3 ubiquitin-protein ligase SH3RF2 isoform X2 |
XM_006714757.1 | XP_006714820.1 | E3 ubiquitin-protein ligase SH3RF2 isoform X2 |
XM_011537567.2 | XP_011535869.1 | E3 ubiquitin-protein ligase SH3RF2 isoform X1 |
NM_152550.3 | NP_689763.3 | putative E3 ubiquitin-protein ligase SH3RF2 |
XM_011537568.2 | XP_011535870.1 | E3 ubiquitin-protein ligase SH3RF2 isoform X1 |
XM_005268380.2 | XP_005268437.1 | E3 ubiquitin-protein ligase SH3RF2 isoform X1 |
Pan troglodytes (chimpanzee) | SH3RF2 | XP_003310936.1 |
SH3RF2 | XP_001099248.1 | |
Mus musculus (house mouse) | Sh3rf2 | NP_001139771.1 |
Xenopus tropicalis (tropical clawed frog) | sh3rf2 | XP_002935311.1 |
Canis lupus familiaris (dog) | SH3RF2 | XP_858579.1 |
Gallus gallus (chicken) | SH3RF2 | XP_414662.3 |
Homo sapiens (human) | SH3RF2 | NP_689763.3 |
Rattus norvegicus (Norway rat) | Sh3rf2 | NP_001029359.1 |
Bos taurus (cattle) | PPP1R39 | NP_001077222.1 |
SH3RF2 functions as an oncogene by mediating PAK4 protein stability.
Kim TW, Kang YK, Park ZY, Kim YH, Hong SW, Oh SJ, Sohn HA, Yang SJ, Jang YJ, Lee DC, Kim SY, Yoo HS, Kim E, Yeom YI, Park KC
Carcinogenesis35(3)624-34(2014 Mar)
Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein.
Wilhelm M, Kukekov NV, Schmit TL, Biagas KV, Sproul AA, Gire S, Maes ME, Xu Z, Greene LA
The Journal of biological chemistry287(3)2247-56(2012 Jan)
Protein phosphatase 1? interacting proteins in the human brain.
Esteves SL, Domingues SC, da Cruz e Silva OA, Fardilha M, da Cruz e Silva EF
Omics : a journal of integrative biology16(1-2)3-17(2012 Jan-Feb)
FLJ23654 encodes a heart protein phosphatase 1-binding protein (Hepp1).
Chen CY, Lai NS, Yang JJ, Huang HL, Hung WC, Li C, Lin TH, Huang HB
Biochemical and biophysical research communications391(1)698-702(2010 Jan)
Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.
Voss M, Lettau M, Janssen O
BMC immunology1053(2009 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
the novel protein heart protein phosphatase 1-binding protein (Hepp1), encoded by FLJ23654, was identified.Hepp1 can play a role in cardiac functions by working in concert with PP1.
Title: FLJ23654 encodes a heart protein phosphatase 1-binding protein (Hepp1).
The following SH3RF2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SH3RF2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu39821 | |
Clone ID Related Accession (Same CDS sequence) | XM_011537569.2 , NM_152550.4 , XM_017009136.1 , XM_006714757.1 | |
Accession Version | NM_152550.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2190bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-05-01 | |
Organism | Homo sapiens(human) | |
Product | E3 ubiquitin-protein ligase SH3RF2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC011359.5, AC005351.1, AC005216.1 and AC091887.3. On Nov 23, 2018 this sequence version replaced NM_152550.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK074234.1, SRR1803617.280437.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000359120.9/ ENSP00000352028.4 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGGATGATT TGACGTTACT TGATCTTCTG GAGTGCCCTG TGTGCTTTGA GAAGCTCGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_689763.4 |
CDS | 224..2413 |
Translation |
Target ORF information:
Target ORF information:
|
NM_152550.4 |
1 | ATGGATGATT TGACGTTACT TGATCTTCTG GAGTGCCCTG TGTGCTTTGA GAAGCTCGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu08746 | |
Clone ID Related Accession (Same CDS sequence) | NM_152550.3 | |
Accession Version | NM_152550.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2190bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-01 | |
Organism | Homo sapiens(human) | |
Product | putative E3 ubiquitin-protein ligase SH3RF2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP352041.1, BC125106.1, BC125107.1 and AC091887.3. On Feb 4, 2009 this sequence version replaced NM_152550.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK074234.1, SRR1803617.280437.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGATGATT TGACGTTACT TGATCTTCTG GAGTGCCCTG TGTGCTTTGA GAAGCTCGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_689763.3 |
CDS | 239..2428 |
Translation |
Target ORF information:
Target ORF information:
|
NM_152550.3 |
1 | ATGGATGATT TGACGTTACT TGATCTTCTG GAGTGCCCTG TGTGCTTTGA GAAGCTCGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu39820 | |
Clone ID Related Accession (Same CDS sequence) | XM_011537567.2 , XM_011537568.2 , XM_005268380.2 | |
Accession Version | XM_011537567.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2208bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | E3 ubiquitin-protein ligase SH3RF2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011537567.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGATGATT TGACGTTACT TGATCTTCTG GAGTGCCCTG TGTGCTTTGA GAAGCTCGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011535869.1 |
CDS | 235..2442 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011537567.2 |
1 | ATGGATGATT TGACGTTACT TGATCTTCTG GAGTGCCCTG TGTGCTTTGA GAAGCTCGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu39820 | |
Clone ID Related Accession (Same CDS sequence) | XM_011537567.2 , XM_011537568.2 , XM_005268380.2 | |
Accession Version | XM_011537568.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2208bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | E3 ubiquitin-protein ligase SH3RF2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011537568.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGATGATT TGACGTTACT TGATCTTCTG GAGTGCCCTG TGTGCTTTGA GAAGCTCGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011535870.1 |
CDS | 229..2436 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011537568.2 |
1 | ATGGATGATT TGACGTTACT TGATCTTCTG GAGTGCCCTG TGTGCTTTGA GAAGCTCGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu39820 | |
Clone ID Related Accession (Same CDS sequence) | XM_011537567.2 , XM_011537568.2 , XM_005268380.2 | |
Accession Version | XM_005268380.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2208bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | E3 ubiquitin-protein ligase SH3RF2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 3, 2014 this sequence version replaced XM_005268380.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGATGATT TGACGTTACT TGATCTTCTG GAGTGCCCTG TGTGCTTTGA GAAGCTCGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005268437.1 |
CDS | 235..2442 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005268380.2 |
1 | ATGGATGATT TGACGTTACT TGATCTTCTG GAGTGCCCTG TGTGCTTTGA GAAGCTCGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu39821 | |
Clone ID Related Accession (Same CDS sequence) | XM_011537569.2 , NM_152550.4 , XM_017009136.1 , XM_006714757.1 | |
Accession Version | XM_011537569.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2190bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | E3 ubiquitin-protein ligase SH3RF2 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011537569.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGATGATT TGACGTTACT TGATCTTCTG GAGTGCCCTG TGTGCTTTGA GAAGCTCGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011535871.1 |
CDS | 235..2424 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011537569.2 |
1 | ATGGATGATT TGACGTTACT TGATCTTCTG GAGTGCCCTG TGTGCTTTGA GAAGCTCGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu39821 | |
Clone ID Related Accession (Same CDS sequence) | XM_011537569.2 , NM_152550.4 , XM_017009136.1 , XM_006714757.1 | |
Accession Version | XM_017009136.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2190bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | E3 ubiquitin-protein ligase SH3RF2 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGATGATT TGACGTTACT TGATCTTCTG GAGTGCCCTG TGTGCTTTGA GAAGCTCGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016864625.1 |
CDS | 229..2418 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017009136.1 |
1 | ATGGATGATT TGACGTTACT TGATCTTCTG GAGTGCCCTG TGTGCTTTGA GAAGCTCGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu39821 | |
Clone ID Related Accession (Same CDS sequence) | XM_011537569.2 , NM_152550.4 , XM_017009136.1 , XM_006714757.1 | |
Accession Version | XM_006714757.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2190bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | E3 ubiquitin-protein ligase SH3RF2 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGATGATT TGACGTTACT TGATCTTCTG GAGTGCCCTG TGTGCTTTGA GAAGCTCGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006714820.1 |
CDS | 235..2424 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006714757.1 |
1 | ATGGATGATT TGACGTTACT TGATCTTCTG GAGTGCCCTG TGTGCTTTGA GAAGCTCGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
SH3RF2 functions as an oncogene by mediating PAK4 protein stability. |
Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein. |
Protein phosphatase 1? interacting proteins in the human brain. |
FLJ23654 encodes a heart protein phosphatase 1-binding protein (Hepp1). |
Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. |