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GH1 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol GH1
Entrez Gene ID 2688
Full Name growth hormone 1
Synonyms GH,GH-N,GHB5,GHN,IGHD1B,hGH-N
General protein information
Preferred Names

growth hormone 1

Names

somatotropin
growth hormone B5
pituitary growth hormone

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

17

17q23.3

Summary The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008].
Disorder MIM:

139250

Disorder Html: Growth hormone deficiency, isolated, type IA, 262400 (3); Growth

mRNA and Protein(s)

mRNA Protein Name
NM_022559.3 NP_072053.1 somatotropin isoform 2 precursor
NM_022560.3 NP_072054.1 somatotropin isoform 3 precursor
NM_000515.4 NP_000506.2 somatotropin isoform 1 precursor



Homo sapiens (human) GH1 NP_000506.2
Pan troglodytes (chimpanzee) GH1 NP_001184093.1
Macaca mulatta (rhesus monkey) GH1 NP_001036203.1


Related articles in PubMed

Construction of the plasmid-free strain for human growth hormone production.
Schulga AA, Mechev PV, Kirpichnikov MP, Skryabin KG, Deyev SM
Biochimie128-129148-53(2016 Sep-Oct)

A homozygous point mutation in the GH1 promoter (c.-223C>T) leads to reduced GH1 expression in siblings with isolated GH deficiency (IGHD).
Madeira JL, Jorge AA, Martin RM, Montenegro LR, Franca MM, Costalonga EF, Correa FA, Otto AP, Arnhold IJ, Freitas HS, Machado UF, Mendonca BB, Carvalho LR
European journal of endocrinology175(2)K7-K15(2016 Aug)

Growth Hormone and Cerebral Amyloidosis.
Benvenga S, Guarneri F
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme48(8)520-2(2016 Aug)

Growth hormone is permissive for neoplastic colon growth.
Chesnokova V, Zonis S, Zhou C, Recouvreux MV, Ben-Shlomo A, Araki T, Barrett R, Workman M, Wawrowsky K, Ljubimov VA, Uhart M, Melmed S
Proceedings of the National Academy of Sciences of the United States of America113(23)E3250-9(2016 Jun)

The Effect of Growth Hormone on Lipid Accumulation or Maturation in Adipocytes.
Zhang Y, Yu H, Gao P, Chen J, Yu C, Zong C, Lu S, Li X, Ma X, Liu Y, Wang X
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology39(6)2135-2148(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

To our knowledge, c.-223C>T is the first homozygous point mutation in the GH1 promoter that leads to short stature due to idiopathic growth hormone deficiency.
Title: A homozygous point mutation in the GH1 promoter (c.-223C>T) leads to reduced GH1 expression in siblings with isolated GH deficiency (IGHD).

The intrinsic amyloidogenicity of growth hormone, in the presence of contaminating prion protein (and perhaps prolactin as well) and amyloid-beta contained in some cadavers' pituitaries, may have led to the observed co-occurring of Creutzfeldt-Jakob disease and Alzheimer's disease.
Title: Growth Hormone and Cerebral Amyloidosis.

Our results suggest that the known protective effect of GH signaling deficiency on neoplastic tissue growth is mediated, at least partially, by regulating p53 expression
Title: Growth hormone is permissive for neoplastic colon growth.

Gene polymorphism of leptin (loci rs7799039) and leptin receptor (loci rs1137101) are correlated with Growth hormone deficiency susceptibility.
Title: The Relationship Between Gene Polymorphism of Leptin and Leptin Receptor and Growth Hormone Deficiency.

GH potentially negatively modulates the maturation and accumulation of lipid in adipocytes.
Title: The Effect of Growth Hormone on Lipid Accumulation or Maturation in Adipocytes.

The following GH1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GH1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

Online Only Promotion

Up to 50% OFF! Starting
from $49/clone

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu25686 NM_022559.3
Latest version!
Homo sapiens growth hormone 1 (GH1), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
OHu25687 NM_022560.3
Latest version!
Homo sapiens growth hormone 1 (GH1), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
OHu27940 NM_000515.4
Latest version!
Homo sapiens growth hormone 1 (GH1), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu25686
Clone ID Related Accession (Same CDS sequence) NM_022559.3
Accession Version NM_022559.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 609bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-23
Organism Homo sapiens(Human)
Product somatotropin isoform 2 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AV749353.1, BC062475.1 and AV753220.1. On May 21, 2014 this sequence version replaced NM_022559.2. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD251386.1, CD105630.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2151358, SAMEA2153307 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
ATGGCTACAG GCTCCCGGAC GTCCCTGCTC CTGGCTTTTG GCCTGCTCTG CCTGCCCTGG 
CTTCAAGAGG GCAGTGCCTT CCCAACCATT CCCTTATCCA GGCTTTTTGA CAACGCTATG
CTCCGCGCCC ATCGTCTGCA CCAGCTGGCC TTTGACACCT ACCAGGAGTT TAACCCCCAG
ACCTCCCTCT GTTTCTCAGA GTCTATTCCG ACACCCTCCA ACAGGGAGGA AACACAACAG
AAATCCAACC TAGAGCTGCT CCGCATCTCC CTGCTGCTCA TCCAGTCGTG GCTGGAGCCC
GTGCAGTTCC TCAGGAGTGT CTTCGCCAAC AGCCTGGTGT ACGGCGCCTC TGACAGCAAC
GTCTATGACC TCCTAAAGGA CCTAGAGGAA GGCATCCAAA CGCTGATGGG GAGGCTGGAA
GATGGCAGCC CCCGGACTGG GCAGATCTTC AAGCAGACCT ACAGCAAGTT CGACACAAAC
TCACACAACG ATGACGCACT ACTCAAGAAC TACGGGCTGC TCTACTGCTT CAGGAAGGAC
ATGGACAAGG TCGAGACATT CCTGCGCATC GTGCAGTGCC GCTCTGTGGA GGGCAGCTGT
GGCTTCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_072053.1
CDS77..685
Misc Feature(1)179..676
Misc Feature(2)order(179..181,188..190,197..202,206..208,215..220,227..229,248..250,254..256,290..301,308..313,455..457,464..469,476..478,599..601,608..613,620..625,629..634,641..646,653..655,674..676)
Misc Feature(3)425..427
Misc Feature(4)557..559
Exon (1)1..86
Exon (2)87..247
Exon (3)248..322
Exon (4)323..487
Exon (5)488..801
Translation

Target ORF information:

RefSeq Version NM_022559.3
Organism Homo sapiens(Human)
Definition Homo sapiens growth hormone 1 (GH1), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_022559.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
ATGGCTACAG GCTCCCGGAC GTCCCTGCTC CTGGCTTTTG GCCTGCTCTG CCTGCCCTGG 
CTTCAAGAGG GCAGTGCCTT CCCAACCATT CCCTTATCCA GGCTTTTTGA CAACGCTATG
CTCCGCGCCC ATCGTCTGCA CCAGCTGGCC TTTGACACCT ACCAGGAGTT TAACCCCCAG
ACCTCCCTCT GTTTCTCAGA GTCTATTCCG ACACCCTCCA ACAGGGAGGA AACACAACAG
AAATCCAACC TAGAGCTGCT CCGCATCTCC CTGCTGCTCA TCCAGTCGTG GCTGGAGCCC
GTGCAGTTCC TCAGGAGTGT CTTCGCCAAC AGCCTGGTGT ACGGCGCCTC TGACAGCAAC
GTCTATGACC TCCTAAAGGA CCTAGAGGAA GGCATCCAAA CGCTGATGGG GAGGCTGGAA
GATGGCAGCC CCCGGACTGG GCAGATCTTC AAGCAGACCT ACAGCAAGTT CGACACAAAC
TCACACAACG ATGACGCACT ACTCAAGAAC TACGGGCTGC TCTACTGCTT CAGGAAGGAC
ATGGACAAGG TCGAGACATT CCTGCGCATC GTGCAGTGCC GCTCTGTGGA GGGCAGCTGT
GGCTTCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu25687
Clone ID Related Accession (Same CDS sequence) NM_022560.3
Accession Version NM_022560.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 534bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-23
Organism Homo sapiens(Human)
Product somatotropin isoform 3 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AV749353.1, CD108592.1 and AV753220.1. On May 21, 2014 this sequence version replaced NM_022560.2. Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD108592.1, CD106566.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2151358, SAMEA2162568 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
ATGGCTACAG GCTCCCGGAC GTCCCTGCTC CTGGCTTTTG GCCTGCTCTG CCTGCCCTGG 
CTTCAAGAGG GCAGTGCCTT CCCAACCATT CCCTTATCCA GGCTTTTTGA CAACGCTATG
CTCCGCGCCC ATCGTCTGCA CCAGCTGGCC TTTGACACCT ACCAGGAGTT TAACCTAGAG
CTGCTCCGCA TCTCCCTGCT GCTCATCCAG TCGTGGCTGG AGCCCGTGCA GTTCCTCAGG
AGTGTCTTCG CCAACAGCCT GGTGTACGGC GCCTCTGACA GCAACGTCTA TGACCTCCTA
AAGGACCTAG AGGAAGGCAT CCAAACGCTG ATGGGGAGGC TGGAAGATGG CAGCCCCCGG
ACTGGGCAGA TCTTCAAGCA GACCTACAGC AAGTTCGACA CAAACTCACA CAACGATGAC
GCACTACTCA AGAACTACGG GCTGCTCTAC TGCTTCAGGA AGGACATGGA CAAGGTCGAG
ACATTCCTGC GCATCGTGCA GTGCCGCTCT GTGGAGGGCA GCTGTGGCTT CTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_072054.1
CDS77..610
Misc Feature(1)179..601
Misc Feature(2)350..352
Misc Feature(3)482..484
Exon (1)1..86
Exon (2)87..247
Exon (3)248..412
Exon (4)413..726
Translation

Target ORF information:

RefSeq Version NM_022560.3
Organism Homo sapiens(Human)
Definition Homo sapiens growth hormone 1 (GH1), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_022560.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGGCTACAG GCTCCCGGAC GTCCCTGCTC CTGGCTTTTG GCCTGCTCTG CCTGCCCTGG 
CTTCAAGAGG GCAGTGCCTT CCCAACCATT CCCTTATCCA GGCTTTTTGA CAACGCTATG
CTCCGCGCCC ATCGTCTGCA CCAGCTGGCC TTTGACACCT ACCAGGAGTT TAACCTAGAG
CTGCTCCGCA TCTCCCTGCT GCTCATCCAG TCGTGGCTGG AGCCCGTGCA GTTCCTCAGG
AGTGTCTTCG CCAACAGCCT GGTGTACGGC GCCTCTGACA GCAACGTCTA TGACCTCCTA
AAGGACCTAG AGGAAGGCAT CCAAACGCTG ATGGGGAGGC TGGAAGATGG CAGCCCCCGG
ACTGGGCAGA TCTTCAAGCA GACCTACAGC AAGTTCGACA CAAACTCACA CAACGATGAC
GCACTACTCA AGAACTACGG GCTGCTCTAC TGCTTCAGGA AGGACATGGA CAAGGTCGAG
ACATTCCTGC GCATCGTGCA GTGCCGCTCT GTGGAGGGCA GCTGTGGCTT CTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27940
Clone ID Related Accession (Same CDS sequence) NM_000515.4
Accession Version NM_000515.4 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 654bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-23
Organism Homo sapiens(Human)
Product somatotropin isoform 1 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AV749353.1, BC090045.1 and AV753220.1. This sequence is a reference standard in the RefSeqGene project. On May 21, 2014 this sequence version replaced NM_000515.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY613431.1, AY613432.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162568 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
ATGGCTACAG GCTCCCGGAC GTCCCTGCTC CTGGCTTTTG GCCTGCTCTG CCTGCCCTGG 
CTTCAAGAGG GCAGTGCCTT CCCAACCATT CCCTTATCCA GGCTTTTTGA CAACGCTATG
CTCCGCGCCC ATCGTCTGCA CCAGCTGGCC TTTGACACCT ACCAGGAGTT TGAAGAAGCC
TATATCCCAA AGGAACAGAA GTATTCATTC CTGCAGAACC CCCAGACCTC CCTCTGTTTC
TCAGAGTCTA TTCCGACACC CTCCAACAGG GAGGAAACAC AACAGAAATC CAACCTAGAG
CTGCTCCGCA TCTCCCTGCT GCTCATCCAG TCGTGGCTGG AGCCCGTGCA GTTCCTCAGG
AGTGTCTTCG CCAACAGCCT GGTGTACGGC GCCTCTGACA GCAACGTCTA TGACCTCCTA
AAGGACCTAG AGGAAGGCAT CCAAACGCTG ATGGGGAGGC TGGAAGATGG CAGCCCCCGG
ACTGGGCAGA TCTTCAAGCA GACCTACAGC AAGTTCGACA CAAACTCACA CAACGATGAC
GCACTACTCA AGAACTACGG GCTGCTCTAC TGCTTCAGGA AGGACATGGA CAAGGTCGAG
ACATTCCTGC GCATCGTGCA GTGCCGCTCT GTGGAGGGCA GCTGTGGCTT CTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000506.2
CDS77..730
Misc Feature(1)179..721
Misc Feature(2)order(179..181,188..190,197..202,206..208,215..220,227..229,275..280,287..292,296..298,335..346,353..358,500..502,509..514,521..523,644..646,653..658,665..670,674..679,686..691,698..700,719..721)
Misc Feature(3)order(311..313,647..649)
Misc Feature(4)470..472
Misc Feature(5)470..472
Misc Feature(6)563..565
Misc Feature(7)602..604
Misc Feature(8)602..604
Misc Feature(9)608..610
Misc Feature(10)order(698..700,719..721)
Exon (1)1..86
Exon (2)87..247
Exon (3)248..367
Exon (4)368..532
Exon (5)533..846
Translation

Target ORF information:

RefSeq Version NM_000515.4
Organism Homo sapiens(Human)
Definition Homo sapiens growth hormone 1 (GH1), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000515.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
ATGGCTACAG GCTCCCGGAC GTCCCTGCTC CTGGCTTTTG GCCTGCTCTG CCTGCCCTGG 
CTTCAAGAGG GCAGTGCCTT CCCAACCATT CCCTTATCCA GGCTTTTTGA CAACGCTATG
CTCCGCGCCC ATCGTCTGCA CCAGCTGGCC TTTGACACCT ACCAGGAGTT TGAAGAAGCC
TATATCCCAA AGGAACAGAA GTATTCATTC CTGCAGAACC CCCAGACCTC CCTCTGTTTC
TCAGAGTCTA TTCCGACACC CTCCAACAGG GAGGAAACAC AACAGAAATC CAACCTAGAG
CTGCTCCGCA TCTCCCTGCT GCTCATCCAG TCGTGGCTGG AGCCCGTGCA GTTCCTCAGG
AGTGTCTTCG CCAACAGCCT GGTGTACGGC GCCTCTGACA GCAACGTCTA TGACCTCCTA
AAGGACCTAG AGGAAGGCAT CCAAACGCTG ATGGGGAGGC TGGAAGATGG CAGCCCCCGG
ACTGGGCAGA TCTTCAAGCA GACCTACAGC AAGTTCGACA CAAACTCACA CAACGATGAC
GCACTACTCA AGAACTACGG GCTGCTCTAC TGCTTCAGGA AGGACATGGA CAAGGTCGAG
ACATTCCTGC GCATCGTGCA GTGCCGCTCT GTGGAGGGCA GCTGTGGCTT CTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Construction of the plasmid-free strain for human growth hormone production.
Biochimie128-129148-53(2016 Sep-Oct)
Schulga AA,Mechev PV,Kirpichnikov MP,Skryabin KG,Deyev SM


book

A homozygous point mutation in the GH1 promoter (c.-223C>T) leads to reduced GH1 expression in siblings with isolated GH deficiency (IGHD).
European journal of endocrinology175(2)K7-K15(2016 Aug)
Madeira JL,Jorge AA,Martin RM,Montenegro LR,Franca MM,Costalonga EF,Correa FA,Otto AP,Arnhold IJ,Freitas HS,Machado UF,Mendonca BB,Carvalho LR


book

Growth Hormone and Cerebral Amyloidosis.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme48(8)520-2(2016 Aug)
Benvenga S,Guarneri F


book

Growth hormone is permissive for neoplastic colon growth.
Proceedings of the National Academy of Sciences of the United States of America113(23)E3250-9(2016 Jun)
Chesnokova V,Zonis S,Zhou C,Recouvreux MV,Ben-Shlomo A,Araki T,Barrett R,Workman M,Wawrowsky K,Ljubimov VA,Uhart M,Melmed S


book

The Effect of Growth Hormone on Lipid Accumulation or Maturation in Adipocytes.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology39(6)2135-2148(2016)
Zhang Y,Yu H,Gao P,Chen J,Yu C,Zong C,Lu S,Li X,Ma X,Liu Y,Wang X


 
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