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IGF2 cDNA ORF clone, Homo sapiens (human)

Gene Symbol IGF2
Entrez Gene ID 3481
Full Name insulin-like growth factor 2
Synonyms C11orf43, GRDF, IGF-II, PP9974
General protein information
Preferred Names
insulin-like growth factor II
Names
insulin-like growth factor II
somatomedin-A
insulin-like growth factor type 2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11p15.5

Summary This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]. lac of sum
Disorder MIM:

147470

Disorder Html: Intrauterine and postnatal growth retardation (1)

mRNA and Protein(s)

mRNA Protein Name
NM_001007139 NP_001007140 insulin-like growth factor II isoform 1 preproprotein
NM_001291862 NP_001278791 insulin-like growth factor II isoform 1 preproprotein
NM_001127598 NP_001121070 insulin-like growth factor II isoform 2
NM_000612 NP_000603 insulin-like growth factor II isoform 1 preproprotein
NM_001291861 NP_001278790 insulin-like growth factor II isoform 1 preproprotein



Homo sapiens (human) IGF2 NP_001121070.1
Pan troglodytes (chimpanzee) IGF2 XP_001153640.3
Macaca mulatta (Rhesus monkey) LOC721120 XP_002799486.1
Canis lupus familiaris (dog) IGF2 NP_001182755.1
Bos taurus (cattle) IGF2 NP_776512.2
Mus musculus (house mouse) Igf2 NP_034644.2
Rattus norvegicus (Norway rat) Igf2 NP_113699.2
Gallus gallus (chicken) IGF2 NP_001025513.1
Danio rerio (zebrafish) igf2b NP_001001815.1
Danio rerio (zebrafish) igf2a NP_571508.1
Xenopus (Silurana) tropicalis (western clawed frog) igf2 NP_001107144.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following IGF2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IGF2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu28274 NM_001007139 Homo sapiens insulin-like growth factor 2 (IGF2), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu28274 NM_001291862 Homo sapiens insulin-like growth factor 2 (IGF2), transcript variant 5, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $69.30
$99.00
OHu28283 NM_001127598 Homo sapiens insulin-like growth factor 2 (IGF2), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $188.30
$269.00
OHu28274 NM_000612 Homo sapiens insulin-like growth factor 2 (IGF2), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $69.30
$99.00
OHu28274 NM_001291861 Homo sapiens insulin-like growth factor 2 (IGF2), transcript variant 4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $69.30
$99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu28274
Clone ID Related Accession (Same CDS sequence) NM_000612 , NM_001007139 , NM_001291861 , NM_001291862
Accession Version NM_001007139.5 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 543bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 31-JUL-2015
Organism Homo sapiens (human)
Product insulin-like growth factor II isoform 1 preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DQ104203.1, AC132217.15, X00910.1, AK025719.1, BC073756.1 and BQ014465.1. This sequence is a reference standard in the RefSeqGene project. On Aug 19, 2014 this sequence version replaced gi:183603938. Transcript Variant: This variant (2) contains two alternate 5' non-coding exons, therefore, has a different 5' UTR compared to variant 1. Variants 1, 2, 4 and 5 encode the same isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: X00910.1, DQ104203.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA2162895 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## imprinted gene :: PMID: 8385745 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
ATGGGAATCC CAATGGGGAA GTCGATGCTG GTGCTTCTCA CCTTCTTGGC CTTCGCCTCG 
TGCTGCATTG CTGCTTACCG CCCCAGTGAG ACCCTGTGCG GCGGGGAGCT GGTGGACACC
CTCCAGTTCG TCTGTGGGGA CCGCGGCTTC TACTTCAGCA GGCCCGCAAG CCGTGTGAGC
CGTCGCAGCC GTGGCATCGT TGAGGAGTGC TGTTTCCGCA GCTGTGACCT GGCCCTCCTG
GAGACGTACT GTGCTACCCC CGCCAAGTCC GAGAGGGACG TGTCGACCCC TCCGACCGTG
CTTCCGGACA ACTTCCCCAG ATACCCCGTG GGCAAGTTCT TCCAATATGA CACCTGGAAG
CAGTCCACCC AGCGCCTGCG CAGGGGCCTG CCTGCCCTCC TGCGTGCCCG CCGGGGTCAC
GTGCTCGCCA AGGAGCTCGA GGCGTTCAGG GAGGCCAAAC GTCACCGTCC CCTGATTGCT
CTACCCACCC AAGACCCCGC CCACGGGGGC GCCCCCCCAG AGATGGCCAG CAATCGGAAG
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001007140.2
CDS727..1269
Misc Feature(1)625..627(+)
Misc Feature(2)799..882(+)
Misc Feature(3)808..999(+)
Misc Feature(4)814..879(+)
Misc Feature(5)868..927(+)
Misc Feature(6)883..918(+)
Misc Feature(7)919..981(+)
Misc Feature(8)940..963(+)
Misc Feature(9)982..999(+)
Misc Feature(10)1060..1224(+)
Exon (1)1..478
Gene:IGF2
Gene Synonym:
Exon (2)479..720
Gene:IGF2
Gene Synonym:
Exon (3)721..883
Gene:IGF2
Gene Synonym:
Exon (4)884..1032
Gene:IGF2
Gene Synonym:
Exon (5)1033..5144
Gene:IGF2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001007139
Organism Homo sapiens (human)
Definition Homo sapiens insulin-like growth factor 2 (IGF2), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001007139

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGGGAATCC CAATGGGGAA GTCGATGCTG GTGCTTCTCA CCTTCTTGGC CTTCGCCTCG 
TGCTGCATTG CTGCTTACCG CCCCAGTGAG ACCCTGTGCG GCGGGGAGCT GGTGGACACC
CTCCAGTTCG TCTGTGGGGA CCGCGGCTTC TACTTCAGCA GGCCCGCAAG CCGTGTGAGC
CGTCGCAGCC GTGGCATCGT TGAGGAGTGC TGTTTCCGCA GCTGTGACCT GGCCCTCCTG
GAGACGTACT GTGCTACCCC CGCCAAGTCC GAGAGGGACG TGTCGACCCC TCCGACCGTG
CTTCCGGACA ACTTCCCCAG ATACCCCGTG GGCAAGTTCT TCCAATATGA CACCTGGAAG
CAGTCCACCC AGCGCCTGCG CAGGGGCCTG CCTGCCCTCC TGCGTGCCCG CCGGGGTCAC
GTGCTCGCCA AGGAGCTCGA GGCGTTCAGG GAGGCCAAAC GTCACCGTCC CCTGATTGCT
CTACCCACCC AAGACCCCGC CCACGGGGGC GCCCCCCCAG AGATGGCCAG CAATCGGAAG
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu28274
Clone ID Related Accession (Same CDS sequence) NM_000612 , NM_001007139 , NM_001291861 , NM_001291862
Accession Version NM_001291862.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 543bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 31-JUL-2015
Organism Homo sapiens (human)
Product insulin-like growth factor II isoform 1 preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC132217.15, CN277570.1, HM481220.1, S77035.1 and BQ014465.1. On Aug 19, 2014 this sequence version replaced gi:630044873. Transcript Variant: This variant (5) differs in the 5' UTR exon, compared to variant 1. Variants 1, 2, 4 and 5 encode the same isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HM481220.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153307, SAMEA962333 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## imprinted gene :: PMID: 8385745 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
ATGGGAATCC CAATGGGGAA GTCGATGCTG GTGCTTCTCA CCTTCTTGGC CTTCGCCTCG 
TGCTGCATTG CTGCTTACCG CCCCAGTGAG ACCCTGTGCG GCGGGGAGCT GGTGGACACC
CTCCAGTTCG TCTGTGGGGA CCGCGGCTTC TACTTCAGCA GGCCCGCAAG CCGTGTGAGC
CGTCGCAGCC GTGGCATCGT TGAGGAGTGC TGTTTCCGCA GCTGTGACCT GGCCCTCCTG
GAGACGTACT GTGCTACCCC CGCCAAGTCC GAGAGGGACG TGTCGACCCC TCCGACCGTG
CTTCCGGACA ACTTCCCCAG ATACCCCGTG GGCAAGTTCT TCCAATATGA CACCTGGAAG
CAGTCCACCC AGCGCCTGCG CAGGGGCCTG CCTGCCCTCC TGCGTGCCCG CCGGGGTCAC
GTGCTCGCCA AGGAGCTCGA GGCGTTCAGG GAGGCCAAAC GTCACCGTCC CCTGATTGCT
CTACCCACCC AAGACCCCGC CCACGGGGGC GCCCCCCCAG AGATGGCCAG CAATCGGAAG
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001278791.1
CDS275..817
Misc Feature(1)227..229(+)
Misc Feature(2)347..430(+)
Misc Feature(3)356..547(+)
Misc Feature(4)362..427(+)
Misc Feature(5)416..475(+)
Misc Feature(6)431..466(+)
Misc Feature(7)467..529(+)
Misc Feature(8)488..511(+)
Misc Feature(9)530..547(+)
Misc Feature(10)608..772(+)
Exon (1)1..268
Gene:IGF2
Gene Synonym:
Exon (2)269..431
Gene:IGF2
Gene Synonym:
Exon (3)432..580
Gene:IGF2
Gene Synonym:
Exon (4)581..4692
Gene:IGF2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001291862
Organism Homo sapiens (human)
Definition Homo sapiens insulin-like growth factor 2 (IGF2), transcript variant 5, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001291862

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGGGAATCC CAATGGGGAA GTCGATGCTG GTGCTTCTCA CCTTCTTGGC CTTCGCCTCG 
TGCTGCATTG CTGCTTACCG CCCCAGTGAG ACCCTGTGCG GCGGGGAGCT GGTGGACACC
CTCCAGTTCG TCTGTGGGGA CCGCGGCTTC TACTTCAGCA GGCCCGCAAG CCGTGTGAGC
CGTCGCAGCC GTGGCATCGT TGAGGAGTGC TGTTTCCGCA GCTGTGACCT GGCCCTCCTG
GAGACGTACT GTGCTACCCC CGCCAAGTCC GAGAGGGACG TGTCGACCCC TCCGACCGTG
CTTCCGGACA ACTTCCCCAG ATACCCCGTG GGCAAGTTCT TCCAATATGA CACCTGGAAG
CAGTCCACCC AGCGCCTGCG CAGGGGCCTG CCTGCCCTCC TGCGTGCCCG CCGGGGTCAC
GTGCTCGCCA AGGAGCTCGA GGCGTTCAGG GAGGCCAAAC GTCACCGTCC CCTGATTGCT
CTACCCACCC AAGACCCCGC CCACGGGGGC GCCCCCCCAG AGATGGCCAG CAATCGGAAG
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu28283
Clone ID Related Accession (Same CDS sequence) NM_001127598
Accession Version NM_001127598.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 711bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 31-JUL-2015
Organism Homo sapiens (human)
Product insulin-like growth factor II isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC132217.15, BE270173.1, BP233290.1, AK025719.1, BC073756.1 and BQ014465.1. This sequence is a reference standard in the RefSeqGene project. On Aug 19, 2014 this sequence version replaced gi:189083845. Transcript Variant: This variant (3) contains two alternate exons at the 5' end, one non-coding and another coding, compared to variant 1. This results in the use of an upstream AUG (not found in variants 1 and 2) and a longer isoform (2) with a distinct N-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HM481219.1, BP232340.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2145774 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## imprinted gene :: PMID: 8385745 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
ATGGTTTCCC CAGACCCCCA AATTATCGTG GTGGCCCCCG AGACCGAACT CGCGTCTATG 
CAAGTCCAAC GCACTGAGGA CGGGGTAACC ATTATCCAGA TATTTTGGGT GGGCCGCAAA
GGCGAGCTAC TTAGACGCAC CCCGGTGAGC TCGGCCATGC AGACACCAAT GGGAATCCCA
ATGGGGAAGT CGATGCTGGT GCTTCTCACC TTCTTGGCCT TCGCCTCGTG CTGCATTGCT
GCTTACCGCC CCAGTGAGAC CCTGTGCGGC GGGGAGCTGG TGGACACCCT CCAGTTCGTC
TGTGGGGACC GCGGCTTCTA CTTCAGCAGG CCCGCAAGCC GTGTGAGCCG TCGCAGCCGT
GGCATCGTTG AGGAGTGCTG TTTCCGCAGC TGTGACCTGG CCCTCCTGGA GACGTACTGT
GCTACCCCCG CCAAGTCCGA GAGGGACGTG TCGACCCCTC CGACCGTGCT TCCGGACAAC
TTCCCCAGAT ACCCCGTGGG CAAGTTCTTC CAATATGACA CCTGGAAGCA GTCCACCCAG
CGCCTGCGCA GGGGCCTGCC TGCCCTCCTG CGTGCCCGCC GGGGTCACGT GCTCGCCAAG
GAGCTCGAGG CGTTCAGGGA GGCCAAACGT CACCGTCCCC TGATTGCTCT ACCCACCCAA
GACCCCGCCC ACGGGGGCGC CCCCCCAGAG ATGGCCAGCA ATCGGAAGTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001121070.1
CDS272..982
Misc Feature(1)227..229(+)
Misc Feature(2)281..424(+)
Misc Feature(3)419..424(+)
Misc Feature(4)521..712(+)
Misc Feature(5)527..592(+)
Misc Feature(6)581..640(+)
Misc Feature(7)653..676(+)
Misc Feature(8)773..937(+)
Exon (1)1..268
Gene:IGF2
Gene Synonym:
Exon (2)269..433
Gene:IGF2
Gene Synonym:
Exon (3)434..596
Gene:IGF2
Gene Synonym:
Exon (4)597..745
Gene:IGF2
Gene Synonym:
Exon (5)746..4857
Gene:IGF2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001127598
Organism Homo sapiens (human)
Definition Homo sapiens insulin-like growth factor 2 (IGF2), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001127598

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGGTTTCCC CAGACCCCCA AATTATCGTG GTGGCCCCCG AGACCGAACT CGCGTCTATG 
CAAGTCCAAC GCACTGAGGA CGGGGTAACC ATTATCCAGA TATTTTGGGT GGGCCGCAAA
GGCGAGCTAC TTAGACGCAC CCCGGTGAGC TCGGCCATGC AGACACCAAT GGGAATCCCA
ATGGGGAAGT CGATGCTGGT GCTTCTCACC TTCTTGGCCT TCGCCTCGTG CTGCATTGCT
GCTTACCGCC CCAGTGAGAC CCTGTGCGGC GGGGAGCTGG TGGACACCCT CCAGTTCGTC
TGTGGGGACC GCGGCTTCTA CTTCAGCAGG CCCGCAAGCC GTGTGAGCCG TCGCAGCCGT
GGCATCGTTG AGGAGTGCTG TTTCCGCAGC TGTGACCTGG CCCTCCTGGA GACGTACTGT
GCTACCCCCG CCAAGTCCGA GAGGGACGTG TCGACCCCTC CGACCGTGCT TCCGGACAAC
TTCCCCAGAT ACCCCGTGGG CAAGTTCTTC CAATATGACA CCTGGAAGCA GTCCACCCAG
CGCCTGCGCA GGGGCCTGCC TGCCCTCCTG CGTGCCCGCC GGGGTCACGT GCTCGCCAAG
GAGCTCGAGG CGTTCAGGGA GGCCAAACGT CACCGTCCCC TGATTGCTCT ACCCACCCAA
GACCCCGCCC ACGGGGGCGC CCCCCCAGAG ATGGCCAGCA ATCGGAAGTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu28274
Clone ID Related Accession (Same CDS sequence) NM_000612 , NM_001007139 , NM_001291861 , NM_001291862
Accession Version NM_000612.5 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 543bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 31-JUL-2015
Organism Homo sapiens (human)
Product insulin-like growth factor II isoform 1 preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC053318.1, M17426.1, AC132217.15, AK025719.1, BC073756.1 and BQ014465.1. This sequence is a reference standard in the RefSeqGene project. On Aug 19, 2014 this sequence version replaced gi:183603939. Transcript Variant: This variant (1) represents the most predominant transcript. Variants 1, 2, 4 and 5 encode the same isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: J03242.1, BC000531.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149398, SAMEA2153307 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## imprinted gene :: PMID: 8385745 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
ATGGGAATCC CAATGGGGAA GTCGATGCTG GTGCTTCTCA CCTTCTTGGC CTTCGCCTCG 
TGCTGCATTG CTGCTTACCG CCCCAGTGAG ACCCTGTGCG GCGGGGAGCT GGTGGACACC
CTCCAGTTCG TCTGTGGGGA CCGCGGCTTC TACTTCAGCA GGCCCGCAAG CCGTGTGAGC
CGTCGCAGCC GTGGCATCGT TGAGGAGTGC TGTTTCCGCA GCTGTGACCT GGCCCTCCTG
GAGACGTACT GTGCTACCCC CGCCAAGTCC GAGAGGGACG TGTCGACCCC TCCGACCGTG
CTTCCGGACA ACTTCCCCAG ATACCCCGTG GGCAAGTTCT TCCAATATGA CACCTGGAAG
CAGTCCACCC AGCGCCTGCG CAGGGGCCTG CCTGCCCTCC TGCGTGCCCG CCGGGGTCAC
GTGCTCGCCA AGGAGCTCGA GGCGTTCAGG GAGGCCAAAC GTCACCGTCC CCTGATTGCT
CTACCCACCC AAGACCCCGC CCACGGGGGC GCCCCCCCAG AGATGGCCAG CAATCGGAAG
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000603.1
CDS753..1295
Misc Feature(1)474..476(+)
Misc Feature(2)825..908(+)
Misc Feature(3)834..1025(+)
Misc Feature(4)840..905(+)
Misc Feature(5)894..953(+)
Misc Feature(6)909..944(+)
Misc Feature(7)945..1007(+)
Misc Feature(8)966..989(+)
Misc Feature(9)1008..1025(+)
Misc Feature(10)1086..1250(+)
Exon (1)1..746
Gene:IGF2
Gene Synonym:
Exon (2)747..909
Gene:IGF2
Gene Synonym:
Exon (3)910..1058
Gene:IGF2
Gene Synonym:
Exon (4)1059..5170
Gene:IGF2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000612
Organism Homo sapiens (human)
Definition Homo sapiens insulin-like growth factor 2 (IGF2), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000612

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGGGAATCC CAATGGGGAA GTCGATGCTG GTGCTTCTCA CCTTCTTGGC CTTCGCCTCG 
TGCTGCATTG CTGCTTACCG CCCCAGTGAG ACCCTGTGCG GCGGGGAGCT GGTGGACACC
CTCCAGTTCG TCTGTGGGGA CCGCGGCTTC TACTTCAGCA GGCCCGCAAG CCGTGTGAGC
CGTCGCAGCC GTGGCATCGT TGAGGAGTGC TGTTTCCGCA GCTGTGACCT GGCCCTCCTG
GAGACGTACT GTGCTACCCC CGCCAAGTCC GAGAGGGACG TGTCGACCCC TCCGACCGTG
CTTCCGGACA ACTTCCCCAG ATACCCCGTG GGCAAGTTCT TCCAATATGA CACCTGGAAG
CAGTCCACCC AGCGCCTGCG CAGGGGCCTG CCTGCCCTCC TGCGTGCCCG CCGGGGTCAC
GTGCTCGCCA AGGAGCTCGA GGCGTTCAGG GAGGCCAAAC GTCACCGTCC CCTGATTGCT
CTACCCACCC AAGACCCCGC CCACGGGGGC GCCCCCCCAG AGATGGCCAG CAATCGGAAG
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu28274
Clone ID Related Accession (Same CDS sequence) NM_000612 , NM_001007139 , NM_001291861 , NM_001291862
Accession Version NM_001291861.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 543bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 31-JUL-2015
Organism Homo sapiens (human)
Product insulin-like growth factor II isoform 1 preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK313938.1, BC000531.1, AC132217.15 and BQ014465.1. On Aug 19, 2014 this sequence version replaced gi:630044871. Transcript Variant: This variant (4) differs in the 5' UTR exon, compared to variant 1. Variants 1, 2, 4 and 5 encode the same isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK291594.1, BG827308.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## imprinted gene :: PMID: 8385745 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
ATGGGAATCC CAATGGGGAA GTCGATGCTG GTGCTTCTCA CCTTCTTGGC CTTCGCCTCG 
TGCTGCATTG CTGCTTACCG CCCCAGTGAG ACCCTGTGCG GCGGGGAGCT GGTGGACACC
CTCCAGTTCG TCTGTGGGGA CCGCGGCTTC TACTTCAGCA GGCCCGCAAG CCGTGTGAGC
CGTCGCAGCC GTGGCATCGT TGAGGAGTGC TGTTTCCGCA GCTGTGACCT GGCCCTCCTG
GAGACGTACT GTGCTACCCC CGCCAAGTCC GAGAGGGACG TGTCGACCCC TCCGACCGTG
CTTCCGGACA ACTTCCCCAG ATACCCCGTG GGCAAGTTCT TCCAATATGA CACCTGGAAG
CAGTCCACCC AGCGCCTGCG CAGGGGCCTG CCTGCCCTCC TGCGTGCCCG CCGGGGTCAC
GTGCTCGCCA AGGAGCTCGA GGCGTTCAGG GAGGCCAAAC GTCACCGTCC CCTGATTGCT
CTACCCACCC AAGACCCCGC CCACGGGGGC GCCCCCCCAG AGATGGCCAG CAATCGGAAG
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001278790.1
CDS104..646
Misc Feature(1)92..94(+)
Misc Feature(2)176..259(+)
Misc Feature(3)185..376(+)
Misc Feature(4)191..256(+)
Misc Feature(5)245..304(+)
Misc Feature(6)260..295(+)
Misc Feature(7)296..358(+)
Misc Feature(8)317..340(+)
Misc Feature(9)359..376(+)
Misc Feature(10)437..601(+)
Exon (1)1..97
Gene:IGF2
Gene Synonym:
Exon (2)98..260
Gene:IGF2
Gene Synonym:
Exon (3)261..409
Gene:IGF2
Gene Synonym:
Exon (4)410..4521
Gene:IGF2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001291861
Organism Homo sapiens (human)
Definition Homo sapiens insulin-like growth factor 2 (IGF2), transcript variant 4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001291861

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGGGAATCC CAATGGGGAA GTCGATGCTG GTGCTTCTCA CCTTCTTGGC CTTCGCCTCG 
TGCTGCATTG CTGCTTACCG CCCCAGTGAG ACCCTGTGCG GCGGGGAGCT GGTGGACACC
CTCCAGTTCG TCTGTGGGGA CCGCGGCTTC TACTTCAGCA GGCCCGCAAG CCGTGTGAGC
CGTCGCAGCC GTGGCATCGT TGAGGAGTGC TGTTTCCGCA GCTGTGACCT GGCCCTCCTG
GAGACGTACT GTGCTACCCC CGCCAAGTCC GAGAGGGACG TGTCGACCCC TCCGACCGTG
CTTCCGGACA ACTTCCCCAG ATACCCCGTG GGCAAGTTCT TCCAATATGA CACCTGGAAG
CAGTCCACCC AGCGCCTGCG CAGGGGCCTG CCTGCCCTCC TGCGTGCCCG CCGGGGTCAC
GTGCTCGCCA AGGAGCTCGA GGCGTTCAGG GAGGCCAAAC GTCACCGTCC CCTGATTGCT
CTACCCACCC AAGACCCCGC CCACGGGGGC GCCCCCCCAG AGATGGCCAG CAATCGGAAG
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

A targetable GATA2-IGF2 axis confers aggressiveness in lethal prostate cancer
Cancer Cell 27 (2), 223-239 (2015)
Vidal SJ, Rodriguez-Bravo V, Quinn SA, Rodriguez-Barrueco R, Lujambio A, Williams E, Sun X, de la Iglesia-Vicente J, Lee A, Readhead B, Chen X, Galsky M, Esteve B, Petrylak DP, Dudley JT, Rabadan R, Silva JM, Hoshida Y, Lowe SW, Cordon-Cardo C and Domingo-Domenech J.


book

[Changes in markers of proliferation, neoangiogenesis and plasminogen activation system in rectal cancer tissue]
Eksp Klin Gastroenterol 2, 40-45 (2015)
Kit,O.I., Frantsiyants,E.M., Nikipelova,E.A., Komarova,E.F., Kozlova,L.S., Tavaryan,I.S., Averkin,M.A. and Cheryarina,N.D.


book

A proteome-scale map of the human interactome network
Cell 159 (5), 1212-1226 (2014)
Rolland T, Tasan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, Yi S, Lemmens I, Fontanillo C, Mosca R, Kamburov A, Ghiassian SD, Yang X, Ghamsari L, Balcha D, Begg BE, Braun P, Brehme M, Broly MP, Carvunis AR, Convery-Zupan D, Corominas R, Coulombe-Huntington J, Dann E, Dreze M, Dricot A, Fan C, Franzosa E, Gebreab F, Gutierrez BJ, Hardy MF, Jin M, Kang S, Kiros R, Lin GN, Luck K, MacWilliams A, Menche J, Murray RR, Palagi A, Poulin MM, Rambout X, Rasla J, Reichert P, Romero V, Ruyssinck E, Sahalie JM, Scholz A, Shah AA, Sharma A, Shen Y, Spirohn K, Tam S, Tejeda AO, Trigg SA, Twizere JC, Vega K, Walsh J, Cusick ME, Xia Y, Barabasi AL, Iakoucheva LM, Aloy P, De Las Rivas J, Tavernier J, Calderwood MA, Hill DE, Hao T, Roth FP and Vidal M.


book

Relaxation of imprinted genes in human cancer
Nature 362 (6422), 747-749 (1993)
Rainier S, Johnson LA, Dobry CJ, Ping AJ, Grundy PE and Feinberg AP.


book

Beckwith-Wiedemann Syndrome
(in) Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Shuman,C., Beckwith,J.B., Smith,A.C. and Weksberg,R.


book

Russell-Silver Syndrome
(in) Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Saal,H.M.


book

Wilms Tumor Overview
(in) Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJH, Bird TD, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Dome,J.S. and Huff,V.


book

The third IGF-II promoter specifies transcription of three transcripts out of five in human placenta
Mol. Reprod. Dev. 33 (4), 413-417 (1992)
Daimon M, Johnson TR, Ilan J and Ilan J.


book

Structure and expression of the human insulin-like growth factor genes
Growth Regul. 2 (1), 1-9 (1992)
Sussenbach JS, Steenbergh PH and Holthuizen P.


book

Primary structure of human insulin-like growth factor II
FEBS Lett. 89 (2), 283-286 (1978)
Rinderknecht,E. and Humbel,R.E.


 
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