×

M6PR cDNA ORF clone, Homo sapiens(Human)

Gene Symbol M6PR
Entrez Gene ID 4074
Full Name mannose-6-phosphate receptor, cation dependent
Synonyms CD-M6PR,CD-MPR,MPR 46,MPR-46,MPR46,SMPR
General protein information
Preferred Names

mannose-6-phosphate receptor, cation dependent

Names

cation-dependent mannose-6-phosphate receptor
46-kDa mannose 6-phosphate receptor
CD Man-6-P receptor
Mr 46,000 Man6PR
small mannose 6-phosphate receptor

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

12

12p13.31

Disorder MIM:

154540


mRNA and Protein(s)

mRNA Protein Name
XM_005253376.1 XP_005253433.1 cation-dependent mannose-6-phosphate receptor isoform X1
XM_011520672.1 XP_011518974.1 cation-dependent mannose-6-phosphate receptor isoform X1
XM_005253376.2 XP_005253433.1 cation-dependent mannose-6-phosphate receptor isoform X1
NM_001207024.1 NP_001193953.1 cation-dependent mannose-6-phosphate receptor isoform 2 precursor
NM_002355.3 NP_002346.1 cation-dependent mannose-6-phosphate receptor isoform 1 precursor



Mus musculus (house mouse) M6pr NP_034879.2
Rattus norvegicus (Norway rat) LOC100909548 XP_003752148.1
Danio rerio (zebrafish) m6pr NP_998370.1
Bos taurus (cattle) M6PR NP_786973.1
Gallus gallus (chicken) M6PR XP_416477.3
Xenopus tropicalis (tropical clawed frog) m6pr NP_001008115.1
Macaca mulatta (rhesus monkey) M6PR XP_001114044.2
Pan troglodytes (chimpanzee) M6PR XP_001138077.1
Rattus norvegicus (Norway rat) M6pr NP_001007701.1
Canis lupus familiaris (dog) M6PR XP_005637236.1
Homo sapiens (human) M6PR NP_002346.1


Related articles in PubMed

Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation.
Follett J, Bugarcic A, Yang Z, Ariotti N, Norwood SJ, Collins BM, Parton RG, Teasdale RD
The Journal of biological chemistry291(35)18283-98(2016 Aug)

Clathrin terminal domain-ligand interactions regulate sorting of mannose 6-phosphate receptors mediated by AP-1 and GGA adaptors.
Stahlschmidt W, Robertson MJ, Robinson PJ, McCluskey A, Haucke V
The Journal of biological chemistry289(8)4906-18(2014 Feb)

A role of Rab29 in the integrity of the trans-Golgi network and retrograde trafficking of mannose-6-phosphate receptor.
Wang S, Ma Z, Xu X, Wang Z, Sun L, Zhou Y, Lin X, Hong W, Wang T
PloS one9(5)e96242(2014)

Mannose 6-phosphate receptor and sortilin mediated endocytosis of α-galactosidase A in kidney endothelial cells.
Prabakaran T, Nielsen R, Satchell SC, Mathieson PW, Feldt-Rasmussen U, Sørensen SS, Christensen EI
PloS one7(6)e39975(2012)

Differences in the endosomal distributions of the two mannose 6-phosphate receptors.
Klumperman J, Hille A, Veenendaal T, Oorschot V, Stoorvogel W, von Figura K, Geuze HJ
The Journal of cell biology121(5)997-1010(1993 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In light of existing report suggesting critical role of Nef-GCC185 interaction reveals valuable mechanistic insights affecting specific protein transport pathway in docking of late endosome derived Rab9 bearing transport vesicle at TGN elucidating role of Nef during viral pathogenesis.
Title: HIV-1 Nef binds with human GCC185 protein and regulates mannose 6 phosphate receptor recycling.

These data indicate that clathrin is required for the function of AP-1- and GGA-coated carriers at the trans-Golgi network but may be dispensable for outward traffic en route to the plasma membrane.
Title: Clathrin terminal domain-ligand interactions regulate sorting of mannose 6-phosphate receptors mediated by AP-1 and GGA adaptors.

Results suggest that Rab protein Rab29 is essential for the integrity of the trans-Golgi network (TGN) and participates in the retrograde trafficking of mannose-6-phosphate receptor (M6PR).
Title: A role of Rab29 in the integrity of the trans-Golgi network and retrograde trafficking of mannose-6-phosphate receptor.

Sortilin is a new alpha-Gal A receptor expressed in renal endothelial cells and that this receptor together with the M6PR is able to internalize circulating alpha-Gal A.
Title: Mannose 6-phosphate receptor and sortilin mediated endocytosis of α-galactosidase A in kidney endothelial cells.

Mannose receptor (MR) engagement by mesothelin GPI anchor polarizes tumor-associated macrophages and is blocked by anti-MR human recombinant antibody
Title: Mannose receptor (MR) engagement by mesothelin GPI anchor polarizes tumor-associated macrophages and is blocked by anti-MR human recombinant antibody.

The following M6PR gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the M6PR cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

Online Only Promotion

Up to 50% OFF! Starting
from $49/clone

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu19246 NM_002355.3
Latest version!
Homo sapiens mannose-6-phosphate receptor, cation dependent (M6PR), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$99.50-$139.30
$199.00
OHu19246 XM_011520672.1
Latest version!
Homo sapiens mannose-6-phosphate receptor (cation dependent) (M6PR), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$99.50-$139.30
$199.00
OHu19246 XM_005253376.2
Latest version!
Homo sapiens mannose-6-phosphate receptor, cation dependent (M6PR), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$99.50-$139.30
$199.00
OHu19557 NM_001207024.1
Latest version!
Homo sapiens mannose-6-phosphate receptor, cation dependent (M6PR), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
View Old Accession Versions >>
OHu19246 XM_005253376.1 Homo sapiens mannose-6-phosphate receptor (cation dependent) (M6PR), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$99.50-$139.30
$199.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu19246
Clone ID Related Accession (Same CDS sequence) XM_005253376.1 , XM_011520672.1 , XM_005253376.2 , NM_002355.3
Accession Version NM_002355.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 834bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-10-06
Organism Homo sapiens(Human)
Product cation-dependent mannose-6-phosphate receptor isoform 1 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC341018.1, M16985.1 and AA648974.1. On May 19, 2011 this sequence version replaced NM_002355.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC024206.1, M16985.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2149178 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGTTCCCTT TCTACAGCTG CTGGAGGACT GGACTGCTAC TACTACTCCT GGCTGTGGCA 
GTGAGAGAAT CCTGGCAGAC AGAAGAAAAA ACTTGCGACT TGGTAGGAGA AAAGGGTAAA
GAGTCAGAGA AAGAGTTGGC TCTAGTGAAG AGGCTGAAAC CACTGTTTAA TAAAAGCTTT
GAGAGCACTG TGGGCCAGGG TTCAGACACA TACATCTACA TCTTCAGGGT GTGCCGGGAA
GCTGGCAACC ACACTTCTGG GGCAGGCCTG GTGCAAATCA ACAAAAGTAA TGGGAAGGAG
ACAGTGGTAG GGAGACTCAA CGAGACTCAC ATCTTCAACG GAAGTAATTG GATCATGCTG
ATCTATAAAG GGGGTGATGA ATATGACAAC CACTGTGGCA AGGAGCAGCG TCGTGCAGTG
GTGATGATCT CCTGCAATCG ACACACCCTA GCGGACAATT TTAACCCTGT GTCTGAGGAG
CGTGGCAAAG TCCAAGATTG TTTCTACCTC TTTGAGATGG ATAGCAGCCT GGCCTGTTCA
CCAGAGATCT CCCACCTCAG TGTGGGTTCC ATCTTACTTG TCACGTTTGC ATCACTGGTT
GCTGTTTATG TTGTTGGGGG GTTCCTATAC CAGCGACTGG TAGTGGGAGC CAAAGGAATG
GAGCAGTTTC CCCACTTAGC CTTCTGGCAG GATCTTGGCA ACCTGGTAGC AGATGGCTGT
GACTTTGTCT GCCGTTCTAA ACCTCGAAAT GTGCCTGCAG CATATCGTGG TGTGGGGGAT
GACCAGCTGG GGGAGGAGTC AGAAGAAAGG GATGACCATT TATTACCAAT GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002346.1
CDS276..1109
Misc Feature(1)106
Misc Feature(2)243..245
Misc Feature(3)276..1106
Misc Feature(4)831..905
Misc Feature(5)1074..1076
Exon (1)1..274
Exon (2)275..451
Exon (3)452..618
Exon (4)619..728
Exon (5)729..859
Exon (6)860..986
Exon (7)987..2566
Translation

Target ORF information:

RefSeq Version NM_002355.3
Organism Homo sapiens(Human)
Definition Homo sapiens mannose-6-phosphate receptor, cation dependent (M6PR), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002355.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGTTCCCTT TCTACAGCTG CTGGAGGACT GGACTGCTAC TACTACTCCT GGCTGTGGCA 
GTGAGAGAAT CCTGGCAGAC AGAAGAAAAA ACTTGCGACT TGGTAGGAGA AAAGGGTAAA
GAGTCAGAGA AAGAGTTGGC TCTAGTGAAG AGGCTGAAAC CACTGTTTAA TAAAAGCTTT
GAGAGCACTG TGGGCCAGGG TTCAGACACA TACATCTACA TCTTCAGGGT GTGCCGGGAA
GCTGGCAACC ACACTTCTGG GGCAGGCCTG GTGCAAATCA ACAAAAGTAA TGGGAAGGAG
ACAGTGGTAG GGAGACTCAA CGAGACTCAC ATCTTCAACG GAAGTAATTG GATCATGCTG
ATCTATAAAG GGGGTGATGA ATATGACAAC CACTGTGGCA AGGAGCAGCG TCGTGCAGTG
GTGATGATCT CCTGCAATCG ACACACCCTA GCGGACAATT TTAACCCTGT GTCTGAGGAG
CGTGGCAAAG TCCAAGATTG TTTCTACCTC TTTGAGATGG ATAGCAGCCT GGCCTGTTCA
CCAGAGATCT CCCACCTCAG TGTGGGTTCC ATCTTACTTG TCACGTTTGC ATCACTGGTT
GCTGTTTATG TTGTTGGGGG GTTCCTATAC CAGCGACTGG TAGTGGGAGC CAAAGGAATG
GAGCAGTTTC CCCACTTAGC CTTCTGGCAG GATCTTGGCA ACCTGGTAGC AGATGGCTGT
GACTTTGTCT GCCGTTCTAA ACCTCGAAAT GTGCCTGCAG CATATCGTGG TGTGGGGGAT
GACCAGCTGG GGGAGGAGTC AGAAGAAAGG GATGACCATT TATTACCAAT GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu19246
Clone ID Related Accession (Same CDS sequence) XM_005253376.1 , XM_011520672.1 , XM_005253376.2 , NM_002355.3
Accession Version XM_005253376.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 834bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2015-03-12
Organism Homo sapiens(Human)
Product cation-dependent mannose-6-phosphate receptor isoform X1
Comment

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGTTCCCTT TCTACAGCTG CTGGAGGACT GGACTGCTAC TACTACTCCT GGCTGTGGCA 
GTGAGAGAAT CCTGGCAGAC AGAAGAAAAA ACTTGCGACT TGGTAGGAGA AAAGGGTAAA
GAGTCAGAGA AAGAGTTGGC TCTAGTGAAG AGGCTGAAAC CACTGTTTAA TAAAAGCTTT
GAGAGCACTG TGGGCCAGGG TTCAGACACA TACATCTACA TCTTCAGGGT GTGCCGGGAA
GCTGGCAACC ACACTTCTGG GGCAGGCCTG GTGCAAATCA ACAAAAGTAA TGGGAAGGAG
ACAGTGGTAG GGAGACTCAA CGAGACTCAC ATCTTCAACG GAAGTAATTG GATCATGCTG
ATCTATAAAG GGGGTGATGA ATATGACAAC CACTGTGGCA AGGAGCAGCG TCGTGCAGTG
GTGATGATCT CCTGCAATCG ACACACCCTA GCGGACAATT TTAACCCTGT GTCTGAGGAG
CGTGGCAAAG TCCAAGATTG TTTCTACCTC TTTGAGATGG ATAGCAGCCT GGCCTGTTCA
CCAGAGATCT CCCACCTCAG TGTGGGTTCC ATCTTACTTG TCACGTTTGC ATCACTGGTT
GCTGTTTATG TTGTTGGGGG GTTCCTATAC CAGCGACTGG TAGTGGGAGC CAAAGGAATG
GAGCAGTTTC CCCACTTAGC CTTCTGGCAG GATCTTGGCA ACCTGGTAGC AGATGGCTGT
GACTTTGTCT GCCGTTCTAA ACCTCGAAAT GTGCCTGCAG CATATCGTGG TGTGGGGGAT
GACCAGCTGG GGGAGGAGTC AGAAGAAAGG GATGACCATT TATTACCAAT GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_005253433.1
Translation

Target ORF information:

RefSeq Version XM_005253376.1
Organism Homo sapiens(Human)
Definition Homo sapiens mannose-6-phosphate receptor (cation dependent) (M6PR), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_005253376.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGTTCCCTT TCTACAGCTG CTGGAGGACT GGACTGCTAC TACTACTCCT GGCTGTGGCA 
GTGAGAGAAT CCTGGCAGAC AGAAGAAAAA ACTTGCGACT TGGTAGGAGA AAAGGGTAAA
GAGTCAGAGA AAGAGTTGGC TCTAGTGAAG AGGCTGAAAC CACTGTTTAA TAAAAGCTTT
GAGAGCACTG TGGGCCAGGG TTCAGACACA TACATCTACA TCTTCAGGGT GTGCCGGGAA
GCTGGCAACC ACACTTCTGG GGCAGGCCTG GTGCAAATCA ACAAAAGTAA TGGGAAGGAG
ACAGTGGTAG GGAGACTCAA CGAGACTCAC ATCTTCAACG GAAGTAATTG GATCATGCTG
ATCTATAAAG GGGGTGATGA ATATGACAAC CACTGTGGCA AGGAGCAGCG TCGTGCAGTG
GTGATGATCT CCTGCAATCG ACACACCCTA GCGGACAATT TTAACCCTGT GTCTGAGGAG
CGTGGCAAAG TCCAAGATTG TTTCTACCTC TTTGAGATGG ATAGCAGCCT GGCCTGTTCA
CCAGAGATCT CCCACCTCAG TGTGGGTTCC ATCTTACTTG TCACGTTTGC ATCACTGGTT
GCTGTTTATG TTGTTGGGGG GTTCCTATAC CAGCGACTGG TAGTGGGAGC CAAAGGAATG
GAGCAGTTTC CCCACTTAGC CTTCTGGCAG GATCTTGGCA ACCTGGTAGC AGATGGCTGT
GACTTTGTCT GCCGTTCTAA ACCTCGAAAT GTGCCTGCAG CATATCGTGG TGTGGGGGAT
GACCAGCTGG GGGAGGAGTC AGAAGAAAGG GATGACCATT TATTACCAAT GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu19246
Clone ID Related Accession (Same CDS sequence) XM_005253376.1 , XM_011520672.1 , XM_005253376.2 , NM_002355.3
Accession Version XM_011520672.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 834bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2015-03-12
Organism Homo sapiens(Human)
Product cation-dependent mannose-6-phosphate receptor isoform X1
Comment

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGTTCCCTT TCTACAGCTG CTGGAGGACT GGACTGCTAC TACTACTCCT GGCTGTGGCA 
GTGAGAGAAT CCTGGCAGAC AGAAGAAAAA ACTTGCGACT TGGTAGGAGA AAAGGGTAAA
GAGTCAGAGA AAGAGTTGGC TCTAGTGAAG AGGCTGAAAC CACTGTTTAA TAAAAGCTTT
GAGAGCACTG TGGGCCAGGG TTCAGACACA TACATCTACA TCTTCAGGGT GTGCCGGGAA
GCTGGCAACC ACACTTCTGG GGCAGGCCTG GTGCAAATCA ACAAAAGTAA TGGGAAGGAG
ACAGTGGTAG GGAGACTCAA CGAGACTCAC ATCTTCAACG GAAGTAATTG GATCATGCTG
ATCTATAAAG GGGGTGATGA ATATGACAAC CACTGTGGCA AGGAGCAGCG TCGTGCAGTG
GTGATGATCT CCTGCAATCG ACACACCCTA GCGGACAATT TTAACCCTGT GTCTGAGGAG
CGTGGCAAAG TCCAAGATTG TTTCTACCTC TTTGAGATGG ATAGCAGCCT GGCCTGTTCA
CCAGAGATCT CCCACCTCAG TGTGGGTTCC ATCTTACTTG TCACGTTTGC ATCACTGGTT
GCTGTTTATG TTGTTGGGGG GTTCCTATAC CAGCGACTGG TAGTGGGAGC CAAAGGAATG
GAGCAGTTTC CCCACTTAGC CTTCTGGCAG GATCTTGGCA ACCTGGTAGC AGATGGCTGT
GACTTTGTCT GCCGTTCTAA ACCTCGAAAT GTGCCTGCAG CATATCGTGG TGTGGGGGAT
GACCAGCTGG GGGAGGAGTC AGAAGAAAGG GATGACCATT TATTACCAAT GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011518974.1
Translation

Target ORF information:

RefSeq Version XM_011520672.1
Organism Homo sapiens(Human)
Definition Homo sapiens mannose-6-phosphate receptor (cation dependent) (M6PR), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011520672.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGTTCCCTT TCTACAGCTG CTGGAGGACT GGACTGCTAC TACTACTCCT GGCTGTGGCA 
GTGAGAGAAT CCTGGCAGAC AGAAGAAAAA ACTTGCGACT TGGTAGGAGA AAAGGGTAAA
GAGTCAGAGA AAGAGTTGGC TCTAGTGAAG AGGCTGAAAC CACTGTTTAA TAAAAGCTTT
GAGAGCACTG TGGGCCAGGG TTCAGACACA TACATCTACA TCTTCAGGGT GTGCCGGGAA
GCTGGCAACC ACACTTCTGG GGCAGGCCTG GTGCAAATCA ACAAAAGTAA TGGGAAGGAG
ACAGTGGTAG GGAGACTCAA CGAGACTCAC ATCTTCAACG GAAGTAATTG GATCATGCTG
ATCTATAAAG GGGGTGATGA ATATGACAAC CACTGTGGCA AGGAGCAGCG TCGTGCAGTG
GTGATGATCT CCTGCAATCG ACACACCCTA GCGGACAATT TTAACCCTGT GTCTGAGGAG
CGTGGCAAAG TCCAAGATTG TTTCTACCTC TTTGAGATGG ATAGCAGCCT GGCCTGTTCA
CCAGAGATCT CCCACCTCAG TGTGGGTTCC ATCTTACTTG TCACGTTTGC ATCACTGGTT
GCTGTTTATG TTGTTGGGGG GTTCCTATAC CAGCGACTGG TAGTGGGAGC CAAAGGAATG
GAGCAGTTTC CCCACTTAGC CTTCTGGCAG GATCTTGGCA ACCTGGTAGC AGATGGCTGT
GACTTTGTCT GCCGTTCTAA ACCTCGAAAT GTGCCTGCAG CATATCGTGG TGTGGGGGAT
GACCAGCTGG GGGAGGAGTC AGAAGAAAGG GATGACCATT TATTACCAAT GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu19246
Clone ID Related Accession (Same CDS sequence) XM_005253376.1 , XM_011520672.1 , XM_005253376.2 , NM_002355.3
Accession Version XM_005253376.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 834bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product cation-dependent mannose-6-phosphate receptor isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005253376.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGTTCCCTT TCTACAGCTG CTGGAGGACT GGACTGCTAC TACTACTCCT GGCTGTGGCA 
GTGAGAGAAT CCTGGCAGAC AGAAGAAAAA ACTTGCGACT TGGTAGGAGA AAAGGGTAAA
GAGTCAGAGA AAGAGTTGGC TCTAGTGAAG AGGCTGAAAC CACTGTTTAA TAAAAGCTTT
GAGAGCACTG TGGGCCAGGG TTCAGACACA TACATCTACA TCTTCAGGGT GTGCCGGGAA
GCTGGCAACC ACACTTCTGG GGCAGGCCTG GTGCAAATCA ACAAAAGTAA TGGGAAGGAG
ACAGTGGTAG GGAGACTCAA CGAGACTCAC ATCTTCAACG GAAGTAATTG GATCATGCTG
ATCTATAAAG GGGGTGATGA ATATGACAAC CACTGTGGCA AGGAGCAGCG TCGTGCAGTG
GTGATGATCT CCTGCAATCG ACACACCCTA GCGGACAATT TTAACCCTGT GTCTGAGGAG
CGTGGCAAAG TCCAAGATTG TTTCTACCTC TTTGAGATGG ATAGCAGCCT GGCCTGTTCA
CCAGAGATCT CCCACCTCAG TGTGGGTTCC ATCTTACTTG TCACGTTTGC ATCACTGGTT
GCTGTTTATG TTGTTGGGGG GTTCCTATAC CAGCGACTGG TAGTGGGAGC CAAAGGAATG
GAGCAGTTTC CCCACTTAGC CTTCTGGCAG GATCTTGGCA ACCTGGTAGC AGATGGCTGT
GACTTTGTCT GCCGTTCTAA ACCTCGAAAT GTGCCTGCAG CATATCGTGG TGTGGGGGAT
GACCAGCTGG GGGAGGAGTC AGAAGAAAGG GATGACCATT TATTACCAAT GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_005253433.1
CDS138..971
Misc Feature(1)138..968
Translation

Target ORF information:

RefSeq Version XM_005253376.2
Organism Homo sapiens(Human)
Definition Homo sapiens mannose-6-phosphate receptor, cation dependent (M6PR), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_005253376.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGTTCCCTT TCTACAGCTG CTGGAGGACT GGACTGCTAC TACTACTCCT GGCTGTGGCA 
GTGAGAGAAT CCTGGCAGAC AGAAGAAAAA ACTTGCGACT TGGTAGGAGA AAAGGGTAAA
GAGTCAGAGA AAGAGTTGGC TCTAGTGAAG AGGCTGAAAC CACTGTTTAA TAAAAGCTTT
GAGAGCACTG TGGGCCAGGG TTCAGACACA TACATCTACA TCTTCAGGGT GTGCCGGGAA
GCTGGCAACC ACACTTCTGG GGCAGGCCTG GTGCAAATCA ACAAAAGTAA TGGGAAGGAG
ACAGTGGTAG GGAGACTCAA CGAGACTCAC ATCTTCAACG GAAGTAATTG GATCATGCTG
ATCTATAAAG GGGGTGATGA ATATGACAAC CACTGTGGCA AGGAGCAGCG TCGTGCAGTG
GTGATGATCT CCTGCAATCG ACACACCCTA GCGGACAATT TTAACCCTGT GTCTGAGGAG
CGTGGCAAAG TCCAAGATTG TTTCTACCTC TTTGAGATGG ATAGCAGCCT GGCCTGTTCA
CCAGAGATCT CCCACCTCAG TGTGGGTTCC ATCTTACTTG TCACGTTTGC ATCACTGGTT
GCTGTTTATG TTGTTGGGGG GTTCCTATAC CAGCGACTGG TAGTGGGAGC CAAAGGAATG
GAGCAGTTTC CCCACTTAGC CTTCTGGCAG GATCTTGGCA ACCTGGTAGC AGATGGCTGT
GACTTTGTCT GCCGTTCTAA ACCTCGAAAT GTGCCTGCAG CATATCGTGG TGTGGGGGAT
GACCAGCTGG GGGAGGAGTC AGAAGAAAGG GATGACCATT TATTACCAAT GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu19557
Clone ID Related Accession (Same CDS sequence) NM_001207024.1
Accession Version NM_001207024.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 576bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-10-06
Organism Homo sapiens(Human)
Product cation-dependent mannose-6-phosphate receptor isoform 2 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC341018.1, BU166950.1, BM546062.1, BG750588.1 and AA648974.1. Transcript Variant: This variant (2) lacks two consecutive exons in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BU166950.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01820693, SAMN01820701 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
ATGTTCCCTT TCTACAGCTG CTGGAGGACT GGACTGCTAC TACTACTCCT GGCTGTGGCA 
GTGAGAGAAT CCTGGCAGAC AGAAGAAAAA ACTTGCGACT TGGTAGGAGA AAAGGGTAAA
GAGTCAGAGA AAGAGTTGGC TCTAGTGAAG AGGCTGAAAC CACTGTTTAA TAAAAGCTTT
GAGAGCACTG TGGGCCAGGG TTCAGACACA TACATCTACA TCTTCAGGGT GTGCCGGGAA
GCTGGCAACC ACACTTCTGG GGCAGGCCTG GTGCAAATCA ACAAAAGTAA TGGGAAGGAG
ACAGTGGTAG GGAGACTCAA CGAGACTCAC ATCTTCAACG GAAGTAATTG GATCATGCTG
ATCTATAAAG GGGGTGATGA ATATGACAAC CACTGTGGCA AGGAGCAGCG TCGTGCAGTG
GTGATGATCT CCTGCAATCG ACACACCCTA GCGGATGGCT GTGACTTTGT CTGCCGTTCT
AAACCTCGAA ATGTGCCTGC AGCATATCGT GGTGTGGGGG ATGACCAGCT GGGGGAGGAG
TCAGAAGAAA GGGATGACCA TTTATTACCA ATGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001193953.1
CDS276..851
Misc Feature(1)106
Misc Feature(2)243..245
Misc Feature(3)276..848
Exon (1)1..274
Exon (2)275..451
Exon (3)452..618
Exon (4)619..728
Exon (5)729..2308
Translation

Target ORF information:

RefSeq Version NM_001207024.1
Organism Homo sapiens(Human)
Definition Homo sapiens mannose-6-phosphate receptor, cation dependent (M6PR), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001207024.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGTTCCCTT TCTACAGCTG CTGGAGGACT GGACTGCTAC TACTACTCCT GGCTGTGGCA 
GTGAGAGAAT CCTGGCAGAC AGAAGAAAAA ACTTGCGACT TGGTAGGAGA AAAGGGTAAA
GAGTCAGAGA AAGAGTTGGC TCTAGTGAAG AGGCTGAAAC CACTGTTTAA TAAAAGCTTT
GAGAGCACTG TGGGCCAGGG TTCAGACACA TACATCTACA TCTTCAGGGT GTGCCGGGAA
GCTGGCAACC ACACTTCTGG GGCAGGCCTG GTGCAAATCA ACAAAAGTAA TGGGAAGGAG
ACAGTGGTAG GGAGACTCAA CGAGACTCAC ATCTTCAACG GAAGTAATTG GATCATGCTG
ATCTATAAAG GGGGTGATGA ATATGACAAC CACTGTGGCA AGGAGCAGCG TCGTGCAGTG
GTGATGATCT CCTGCAATCG ACACACCCTA GCGGATGGCT GTGACTTTGT CTGCCGTTCT
AAACCTCGAA ATGTGCCTGC AGCATATCGT GGTGTGGGGG ATGACCAGCT GGGGGAGGAG
TCAGAAGAAA GGGATGACCA TTTATTACCA ATGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation.
The Journal of biological chemistry291(35)18283-98(2016 Aug)
Follett J,Bugarcic A,Yang Z,Ariotti N,Norwood SJ,Collins BM,Parton RG,Teasdale RD


book

Clathrin terminal domain-ligand interactions regulate sorting of mannose 6-phosphate receptors mediated by AP-1 and GGA adaptors.
The Journal of biological chemistry289(8)4906-18(2014 Feb)
Stahlschmidt W,Robertson MJ,Robinson PJ,McCluskey A,Haucke V


book

A role of Rab29 in the integrity of the trans-Golgi network and retrograde trafficking of mannose-6-phosphate receptor.
PloS one9(5)e96242(2014)
Wang S,Ma Z,Xu X,Wang Z,Sun L,Zhou Y,Lin X,Hong W,Wang T


book

Mannose 6-phosphate receptor and sortilin mediated endocytosis of α-galactosidase A in kidney endothelial cells.
PloS one7(6)e39975(2012)
Prabakaran T,Nielsen R,Satchell SC,Mathieson PW,Feldt-Rasmussen U,Sørensen SS,Christensen EI


book

Differences in the endosomal distributions of the two mannose 6-phosphate receptors.
The Journal of cell biology121(5)997-1010(1993 Jun)
Klumperman J,Hille A,Veenendaal T,Oorschot V,Stoorvogel W,von Figura K,Geuze HJ


 
*
*
*
*