PDGFRL cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PDGFRL
Entrez Gene ID	5157
Full Name	platelet derived growth factor receptor like
Synonyms	PDGRL,PRLTS
General protein information	Preferred Names platelet derived growth factor receptor like Names platelet-derived growth factor receptor-like protein PDGF receptor beta-like tumor suppressor PDGFR-like protein platelet-derived growth factor-beta-like tumor suppressor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8p22
Summary	This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor. [provided by RefSeq, Jul 2008].
Disorder MIM:	604584
Disorder Html:	Hepatocellular cancer, somatic, 114550 (3); Colorectal cancer, somatic, 114500 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001372073.1	NP_001359002.1	platelet-derived growth factor receptor-like protein precursor
NM_006207.2	NP_006198.1	platelet-derived growth factor receptor-like protein precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Pdgfrl	NP_001011921.1
Pan troglodytes (chimpanzee)	PDGFRL	XP_519619.3
	PDGFRL	XP_001096474.1
Bos taurus (cattle)	PDGFRL	NP_001030378.1
Homo sapiens (human)	PDGFRL	NP_006198.1
Canis lupus familiaris (dog)	PDGFRL	XP_005629999.1
Danio rerio (zebrafish)	pdgfrl	NP_956608.1
Xenopus tropicalis (tropical clawed frog)	pdgfrl	NP_001025586.1
Mus musculus (house mouse)	Pdgfrl	NP_081116.3
Gallus gallus (chicken)	PDGFRL	XP_001231868.2

Gene Ontology
Bibliography

Related articles in PubMed

Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
Xie T, Deng L, Mei P, Zhou Y, Wang B, Zhang J, Lin J, Wei Y, Zhang X, Xu R
Neurobiology of aging35(7)1778.e9-1778.e23(2014 Jul)

PDGF/PDGFR signaling and targeting in cancer growth and progression: Focus on tumor microenvironment and cancer-associated fibroblasts.
Gialeli C, Nikitovic D, Kletsas D, Theocharis AD, Tzanakakis GN, Karamanos NK
Current pharmaceutical design20(17)2843-8(2014)

Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
Deng X, Sabino EC, Cunha-Neto E, Ribeiro AL, Ianni B, Mady C, Busch MP, Seielstad M,
PloS one8(11)e79629(2013)

Genetic variant on PDGFRL associated with Beh?et disease in Chinese Han populations.
Hou S, Xiao X, Zhou Y, Zhu X, Li F, Kijlstra A, Yang P
Human mutation34(1)74-8(2013 Jan)

Expression and functional characterization of platelet-derived growth factor receptor-like gene.
Guo FJ, Zhang WJ, Li YL, Liu Y, Li YH, Huang J, Wang JJ, Xie PL, Li GC
World journal of gastroenterology16(12)1465-72(2010 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

review elucidates the role of tumor stroma interactions, the roles of PDGF receptor signaling in cancer-associated fibroblasts via alteration of stromal matrix composition and the mitogenic effects of cancer-derived PDGFs.
Title: PDGF/PDGFR signaling and targeting in cancer growth and progression: Focus on tumor microenvironment and cancer-associated fibroblasts.

Data indicate the association between SNP rs17633132:C/T in PDGFRL with Behcet disease and suggest that the PDGFRL gene may be involved in Behcet disease by modulating its transcription.
Title: Genetic variant on PDGFRL associated with Beh?et disease in Chinese Han populations.

Observational study of gene-disease association. (HuGE Navigator)
Title: New genetic associations detected in a host response study to hepatitis B vaccine.

Results indicate that PDGFRL functions as a tumor suppressor, inhibiting the growth of colorectal cancer cells.
Title: Expression and functional characterization of platelet-derived growth factor receptor-like gene.

The following PDGFRL gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PDGFRL cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu22856	NM_006207.2 Latest version!	Homo sapiens platelet derived growth factor receptor like (PDGFRL), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu59591	NM_001372073.1 Latest version!	Homo sapiens platelet derived growth factor receptor like (PDGFRL), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PDGFRL ( NM_006207.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006198.1 Homo sapiens platelet derived growth factor receptor like (PDGFRL), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu22856
Clone ID Related Accession (Same CDS sequence)	NM_006207.2
Accession Version	NM_006207.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1128bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	platelet-derived growth factor receptor-like protein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK289450.1, AC124069.7 and BQ446405.1. This sequence is a reference standard in the RefSeqGene project. On Jul 2, 2010 this sequence version replaced NM_006207.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK289450.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467143 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGAAGGTCT GGCTGCTGCT TGGTCTTCTG CTGGTGCACG AAGCGCTGGA GGATGTTACT 
GGCCAACACC TTCCCAAGAA CAAGCGTCCA AAAGAACCAG GAGAGAATAG AATCAAACCT 
ACCAACAAGA AGGTGAAGCC CAAAATTCCT AAAATGAAGG ACAGGGACTC AGCCAATTCA 
GCACCAAAGA CGCAGTCTAT CATGATGCAA GTGCTGGATA AAGGTCGCTT CCAGAAACCC 
GCCGCTACCC TGAGTCTGCT GGCGGGGCAA ACTGTAGAGC TTCGATGTAA AGGGAGTAGA 
ATTGGGTGGA GCTACCCTGC GTATCTGGAC ACCTTTAAGG ATTCTCGCCT CAGCGTCAAG 
CAGAATGAGC GCTACGGCCA GTTGACTCTG GTCAACTCCA CCTCGGCAGA CACAGGTGAA 
TTCAGCTGCT GGGTGCAGCT CTGCAGCGGC TACATCTGCA GGAAGGACGA GGCCAAAACG 
GGCTCCACCT ACATCTTTTT TACAGAGAAA GGAGAACTCT TTGTACCTTC TCCCAGCTAC 
TTCGATGTTG TCTACTTGAA CCCGGACAGA CAGGCTGTGG TTCCTTGTCG GGTGACCGTG 
CTGTCGGCCA AAGTCACGCT CCACAGGGAA TTCCCAGCCA AGGAGATCCC AGCCAATGGA 
ACGGACATTG TTTATGACAT GAAGCGGGGC TTTGTGTATC TGCAACCTCA TTCCGAGCAC 
CAGGGTGTGG TTTACTGCAG GGCGGAGGCC GGGGGCAGAT CTCAGATCTC CGTCAAGTAC 
CAGCTGCTCT ACGTGGCGGT TCCCAGTGGC CCTCCCTCAA CAACCATCTT GGCTTCTTCA 
AACAAAGTGA AAAGTGGGGA CGACATCAGT GTGCTCTGCA CTGTCCTGGG GGAGCCCGAT 
GTGGAGGTGG AGTTCACCTG GATCTTCCCA GGGCAGAAGG ATGAAAGGCC TGTGACGATC 
CAAGACACTT GGAGGTTGAT CCACAGAGGA CTGGGACACA CCACGAGAAT CTCCCAGAGT 
GTCATTACAG TGGAAGACTT TGAGACGATT GATGCAGGAT ATTACATTTG CACTGCTCAG 
AATCTTCAAG GACAGACCAC AGTAGCTACC ACTGTTGAGT TTTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006198.1
CDS	446..1573
Translation	MKVWLLLGLLLVHEALEDVTGQHLPKNKRPKEPGENRIKPTNKKVKPKIPKMKDRDSANSAPKTQSIMMQVLDKGRFQKPAATLSLLAGQTVELRCKGSRIGWSYPAYLDTFKDSRLSVKQNERYGQLTLVNSTSADTGEFSCWVQLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPSYFDVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYLQPHSEHQGVVYCRAEAGGRSQISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQTTVATTVEFS

Target ORF information:

RefSeq Version	NM_006207.2
Organism	Homo sapiens(human)
Definition	Homo sapiens platelet derived growth factor receptor like (PDGFRL), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006207.2

ORF Insert Sequence:

ATGAAGGTCT GGCTGCTGCT TGGTCTTCTG CTGGTGCACG AAGCGCTGGA GGATGTTACT 
GGCCAACACC TTCCCAAGAA CAAGCGTCCA AAAGAACCAG GAGAGAATAG AATCAAACCT 
ACCAACAAGA AGGTGAAGCC CAAAATTCCT AAAATGAAGG ACAGGGACTC AGCCAATTCA 
GCACCAAAGA CGCAGTCTAT CATGATGCAA GTGCTGGATA AAGGTCGCTT CCAGAAACCC 
GCCGCTACCC TGAGTCTGCT GGCGGGGCAA ACTGTAGAGC TTCGATGTAA AGGGAGTAGA 
ATTGGGTGGA GCTACCCTGC GTATCTGGAC ACCTTTAAGG ATTCTCGCCT CAGCGTCAAG 
CAGAATGAGC GCTACGGCCA GTTGACTCTG GTCAACTCCA CCTCGGCAGA CACAGGTGAA 
TTCAGCTGCT GGGTGCAGCT CTGCAGCGGC TACATCTGCA GGAAGGACGA GGCCAAAACG 
GGCTCCACCT ACATCTTTTT TACAGAGAAA GGAGAACTCT TTGTACCTTC TCCCAGCTAC 
TTCGATGTTG TCTACTTGAA CCCGGACAGA CAGGCTGTGG TTCCTTGTCG GGTGACCGTG 
CTGTCGGCCA AAGTCACGCT CCACAGGGAA TTCCCAGCCA AGGAGATCCC AGCCAATGGA 
ACGGACATTG TTTATGACAT GAAGCGGGGC TTTGTGTATC TGCAACCTCA TTCCGAGCAC 
CAGGGTGTGG TTTACTGCAG GGCGGAGGCC GGGGGCAGAT CTCAGATCTC CGTCAAGTAC 
CAGCTGCTCT ACGTGGCGGT TCCCAGTGGC CCTCCCTCAA CAACCATCTT GGCTTCTTCA 
AACAAAGTGA AAAGTGGGGA CGACATCAGT GTGCTCTGCA CTGTCCTGGG GGAGCCCGAT 
GTGGAGGTGG AGTTCACCTG GATCTTCCCA GGGCAGAAGG ATGAAAGGCC TGTGACGATC 
CAAGACACTT GGAGGTTGAT CCACAGAGGA CTGGGACACA CCACGAGAAT CTCCCAGAGT 
GTCATTACAG TGGAAGACTT TGAGACGATT GATGCAGGAT ATTACATTTG CACTGCTCAG 
AATCTTCAAG GACAGACCAC AGTAGCTACC ACTGTTGAGT TTTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PDGFRL ( NM_001372073.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001359002.1 Homo sapiens platelet derived growth factor receptor like (PDGFRL), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu59591
Clone ID Related Accession (Same CDS sequence)	NM_001372073.1
Accession Version	NM_001372073.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1128bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	platelet-derived growth factor receptor-like protein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP006248.1 and AC124069.7. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.296021.1, SRR5189667.236514.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGAAGGTCT GGCTGCTGCT TGGTCTTCTG CTGGTGCACG AAGCGCTGGA GGATGTTACT 
GGCCAACACC TTCCCAAGAA CAAGCGTCCA AAAGAACCAG GAGAGAATAG AATCAAACCT 
ACCAACAAGA AGGTGAAGCC CAAAATTCCT AAAATGAAGG ACAGGGACTC AGCCAATTCA 
GCACCAAAGA CGCAGTCTAT CATGATGCAA GTGCTGGATA AAGGTCGCTT CCAGAAACCC 
GCCGCTACCC TGAGTCTGCT GGCGGGGCAA ACTGTAGAGC TTCGATGTAA AGGGAGTAGA 
ATTGGGTGGA GCTACCCTGC GTATCTGGAC ACCTTTAAGG ATTCTCGCCT CAGCGTCAAG 
CAGAATGAGC GCTACGGCCA GTTGACTCTG GTCAACTCCA CCTCGGCAGA CACAGGTGAA 
TTCAGCTGCT GGGTGCAGCT CTGCAGCGGC TACATCTGCA GGAAGGACGA GGCCAAAACG 
GGCTCCACCT ACATCTTTTT TACAGAGAAA GGAGAACTCT TTGTACCTTC TCCCAGCTAC 
TTCGATGTTG TCTACTTGAA CCCGGACAGA CAGGCTGTGG TTCCTTGTCG GGTGACCGTG 
CTGTCGGCCA AAGTCACGCT CCACAGGGAA TTCCCAGCCA AGGAGATCCC AGCCAATGGA 
ACGGACATTG TTTATGACAT GAAGCGGGGC TTTGTGTATC TGCAACCTCA TTCCGAGCAC 
CAGGGTGTGG TTTACTGCAG GGCGGAGGCC GGGGGCAGAT CTCAGATCTC CGTCAAGTAC 
CAGCTGCTCT ATGTGGCGGT TCCCAGTGGC CCTCCCTCAA CAACCATCTT GGCTTCTTCA 
AACAAAGTGA AAAGTGGGGA CGACATCAGT GTGCTCTGCA CTGTCCTGGG GGAGCCCGAT 
GTGGAGGTGG AGTTCACCTG GATCTTCCCA GGGCAGAAGG ATGAAAGGCC TGTGACGATC 
CAAGACACTT GGAGGTTGAT CCACAGAGGA CTGGGACACA CCACGAGAAT CTCCCAGAGT 
GTCATTACAG TGGAAGACTT TGAGACGATT GATGCAGGAT ATTACATTTG CACTGCTCAG 
AATCTTCAAG GACAGACCAC AGTAGCTACC ACTGTTGAGT TTTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001359002.1
CDS	38..1165
Translation	MKVWLLLGLLLVHEALEDVTGQHLPKNKRPKEPGENRIKPTNKKVKPKIPKMKDRDSANSAPKTQSIMMQVLDKGRFQKPAATLSLLAGQTVELRCKGSRIGWSYPAYLDTFKDSRLSVKQNERYGQLTLVNSTSADTGEFSCWVQLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPSYFDVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYLQPHSEHQGVVYCRAEAGGRSQISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQTTVATTVEFS

Target ORF information:

RefSeq Version	NM_001372073.1
Organism	Homo sapiens(human)
Definition	Homo sapiens platelet derived growth factor receptor like (PDGFRL), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001372073.1

ORF Insert Sequence:

ATGAAGGTCT GGCTGCTGCT TGGTCTTCTG CTGGTGCACG AAGCGCTGGA GGATGTTACT 
GGCCAACACC TTCCCAAGAA CAAGCGTCCA AAAGAACCAG GAGAGAATAG AATCAAACCT 
ACCAACAAGA AGGTGAAGCC CAAAATTCCT AAAATGAAGG ACAGGGACTC AGCCAATTCA 
GCACCAAAGA CGCAGTCTAT CATGATGCAA GTGCTGGATA AAGGTCGCTT CCAGAAACCC 
GCCGCTACCC TGAGTCTGCT GGCGGGGCAA ACTGTAGAGC TTCGATGTAA AGGGAGTAGA 
ATTGGGTGGA GCTACCCTGC GTATCTGGAC ACCTTTAAGG ATTCTCGCCT CAGCGTCAAG 
CAGAATGAGC GCTACGGCCA GTTGACTCTG GTCAACTCCA CCTCGGCAGA CACAGGTGAA 
TTCAGCTGCT GGGTGCAGCT CTGCAGCGGC TACATCTGCA GGAAGGACGA GGCCAAAACG 
GGCTCCACCT ACATCTTTTT TACAGAGAAA GGAGAACTCT TTGTACCTTC TCCCAGCTAC 
TTCGATGTTG TCTACTTGAA CCCGGACAGA CAGGCTGTGG TTCCTTGTCG GGTGACCGTG 
CTGTCGGCCA AAGTCACGCT CCACAGGGAA TTCCCAGCCA AGGAGATCCC AGCCAATGGA 
ACGGACATTG TTTATGACAT GAAGCGGGGC TTTGTGTATC TGCAACCTCA TTCCGAGCAC 
CAGGGTGTGG TTTACTGCAG GGCGGAGGCC GGGGGCAGAT CTCAGATCTC CGTCAAGTAC 
CAGCTGCTCT ATGTGGCGGT TCCCAGTGGC CCTCCCTCAA CAACCATCTT GGCTTCTTCA 
AACAAAGTGA AAAGTGGGGA CGACATCAGT GTGCTCTGCA CTGTCCTGGG GGAGCCCGAT 
GTGGAGGTGG AGTTCACCTG GATCTTCCCA GGGCAGAAGG ATGAAAGGCC TGTGACGATC 
CAAGACACTT GGAGGTTGAT CCACAGAGGA CTGGGACACA CCACGAGAAT CTCCCAGAGT 
GTCATTACAG TGGAAGACTT TGAGACGATT GATGCAGGAT ATTACATTTG CACTGCTCAG 
AATCTTCAAG GACAGACCAC AGTAGCTACC ACTGTTGAGT TTTCCTGA