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PTGS2 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol PTGS2
Entrez Gene ID 5743
Full Name prostaglandin-endoperoxide synthase 2
Synonyms COX-2,COX2,GRIPGHS,PGG/HS,PGHS-2,PHS-2,hCox-2
General protein information
Preferred Names

prostaglandin-endoperoxide synthase 2

Names

prostaglandin G/H synthase 2
PGH synthase 2
PHS II
cyclooxygenase 2
cyclooxygenase 2b
prostaglandin H2 synthase 2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

1

1q31.1

Summary Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009].
Disorder MIM:

600262


mRNA and Protein(s)

mRNA Protein Name
NM_000963.3 NP_000954.1 prostaglandin G/H synthase 2 precursor



Gallus gallus (chicken) PTGS2 NP_001161191.1
Danio rerio (zebrafish) ptgs2b NP_001020675.1
Mus musculus (house mouse) Ptgs2 NP_035328.2
Canis lupus familiaris (dog) PTGS2 NP_001003354.1
Pan troglodytes (chimpanzee) PTGS2 XP_524999.3
Rattus norvegicus (Norway rat) Ptgs2 NP_058928.3
Macaca mulatta (rhesus monkey) PTGS2 XP_001107538.2
Homo sapiens (human) PTGS2 NP_000954.1
Bos taurus (cattle) PTGS2 NP_776870.1
Xenopus tropicalis (tropical clawed frog) ptgs2 NP_001025697.1


Related articles in PubMed

A Variant in COX-2 Gene Is Associated with Left Main Coronary Artery Disease and Clinical Outcomes of Coronary Artery Bypass Grafting.
Liu H, Xu Z, Sun C, Gu D, Teng X, Zhao Y, Zheng Z
BioMed research international20172924731(2017)

Interaction among COX-2, P2Y1 and GPIIIa gene variants is associated with aspirin resistance and early neurological deterioration in Chinese stroke patients.
Yi X, Wang C, Zhou Q, Lin J
BMC neurology17(1)4(2017 Jan)

Combined Analysis of Vascular Endothelial Growth Factor Expression with Cyclooxygenase-2 and Mast Cell Density in Oral Squamous Cell Carcinoma.
Akbarzadeh Baghban A, Taghavi N, Shahla M
Pathobiology : journal of immunopathology, molecular and cellular biology84(2)80-86(2017)

Cyclooxygenase-2 expression and association with skin cancer: A meta-analysis based on Chinese patients.
Shujiao L, Lilin H, Yong S
Journal of cancer research and therapeutics12(Supplement)C288-C290(2016 Dec)

Prognostic Value of Prostaglandin-endoperoxide Synthase 2 Polymorphisms in Prostate Cancer Recurrence after Radical Prostatectomy.
Lee CH, Pao JB, Lu TL, Lee HZ, Lee YC, Liu CC, Huang CY, Lin VC, Yu CC, Yin HL, Huang SP, Bao BY
International journal of medical sciences13(9)696-700(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Enhanced expression of PTGS2 is associated with ulcerative colitis-associated neoplasia.
Title: Enhanced expression of proproliferative and antiapoptotic genes in ulcerative colitis-associated neoplasia.

AKR1B3 acts as the PGFS in adipocytes and AKR1B3-produced PGF(2alpha) suppresses adipocyte differentiation by acting through FP receptors
Title: Suppression of adipocyte differentiation by aldo-keto reductase 1B3 acting as prostaglandin F2alpha synthase.

in ductal carcinoma in situ lesions, high COX-2 expression is associated with high gammaH2AX, TRF2, activin A, and telomere malfunction
Title: DNA damage drives an activin a-dependent induction of cyclooxygenase-2 in premalignant cells and lesions.

Observational study of gene-disease association. (HuGE Navigator)
Title: [Genetic polymorphisms in STK15 and MMP-2 associated susceptibility to esophageal cancer in Mongolian population].

There was no significant correlation between cyclooxygenase-2 and nm23 (non-metastatic cells protein1) expression or microvessel density in ovarian serous carcinoma
Title: Expression of cyclooxygenase-2 in ovarian serous carcinoma: correlation with angiogenesis, nm23 expression and survival.

The following PTGS2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PTGS2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu27989 NM_000963.3
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Homo sapiens prostaglandin-endoperoxide synthase 2 (PTGS2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
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$379.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu27989
Clone ID Related Accession (Same CDS sequence) NM_000963.3
Accession Version NM_000963.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1815bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-30
Organism Homo sapiens(Human)
Product prostaglandin G/H synthase 2 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA277667.1, BC013734.1, AL033533.5, KF455116.1 and BM978796.1. This sequence is a reference standard in the RefSeqGene project. On Jan 17, 2014 this sequence version replaced NM_000963.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.168650.1, SRR1660807.206449.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
ATGCTCGCCC GCGCCCTGCT GCTGTGCGCG GTCCTGGCGC TCAGCCATAC AGCAAATCCT 
TGCTGTTCCC ACCCATGTCA AAACCGAGGT GTATGTATGA GTGTGGGATT TGACCAGTAT
AAGTGCGATT GTACCCGGAC AGGATTCTAT GGAGAAAACT GCTCAACACC GGAATTTTTG
ACAAGAATAA AATTATTTCT GAAACCCACT CCAAACACAG TGCACTACAT ACTTACCCAC
TTCAAGGGAT TTTGGAACGT TGTGAATAAC ATTCCCTTCC TTCGAAATGC AATTATGAGT
TATGTGTTGA CATCCAGATC ACATTTGATT GACAGTCCAC CAACTTACAA TGCTGACTAT
GGCTACAAAA GCTGGGAAGC CTTCTCTAAC CTCTCCTATT ATACTAGAGC CCTTCCTCCT
GTGCCTGATG ATTGCCCGAC TCCCTTGGGT GTCAAAGGTA AAAAGCAGCT TCCTGATTCA
AATGAGATTG TGGAAAAATT GCTTCTAAGA AGAAAGTTCA TCCCTGATCC CCAGGGCTCA
AACATGATGT TTGCATTCTT TGCCCAGCAC TTCACGCATC AGTTTTTCAA GACAGATCAT
AAGCGAGGGC CAGCTTTCAC CAACGGGCTG GGCCATGGGG TGGACTTAAA TCATATTTAC
GGTGAAACTC TGGCTAGACA GCGTAAACTG CGCCTTTTCA AGGATGGAAA AATGAAATAT
CAGATAATTG ATGGAGAGAT GTATCCTCCC ACAGTCAAAG ATACTCAGGC AGAGATGATC
TACCCTCCTC AAGTCCCTGA GCATCTACGG TTTGCTGTGG GGCAGGAGGT CTTTGGTCTG
GTGCCTGGTC TGATGATGTA TGCCACAATC TGGCTGCGGG AACACAACAG AGTATGCGAT
GTGCTTAAAC AGGAGCATCC TGAATGGGGT GATGAGCAGT TGTTCCAGAC AAGCAGGCTA
ATACTGATAG GAGAGACTAT TAAGATTGTG ATTGAAGATT ATGTGCAACA CTTGAGTGGC
TATCACTTCA AACTGAAATT TGACCCAGAA CTACTTTTCA ACAAACAATT CCAGTACCAA
AATCGTATTG CTGCTGAATT TAACACCCTC TATCACTGGC ATCCCCTTCT GCCTGACACC
TTTCAAATTC ATGACCAGAA ATACAACTAT CAACAGTTTA TCTACAACAA CTCTATATTG
CTGGAACATG GAATTACCCA GTTTGTTGAA TCATTCACCA GGCAAATTGC TGGCAGGGTT
GCTGGTGGTA GGAATGTTCC ACCCGCAGTA CAGAAAGTAT CACAGGCTTC CATTGACCAG
AGCAGGCAGA TGAAATACCA GTCTTTTAAT GAGTACCGCA AACGCTTTAT GCTGAAGCCC
TATGAATCAT TTGAAGAACT TACAGGAGAA AAGGAAATGT CTGCAGAGTT GGAAGCACTC
TATGGTGACA TCGATGCTGT GGAGCTGTAT CCTGCCCTTC TGGTAGAAAA GCCTCGGCCA
GATGCCATCT TTGGTGAAAC CATGGTAGAA GTTGGAGCAC CATTCTCCTT GAAAGGACTT
ATGGGTAATG TTATATGTTC TCCTGCCTAC TGGAAGCCAA GCACTTTTGG TGGAGAAGTG
GGTTTTCAAA TCATCAACAC TGCCTCAATT CAGTCTCTCA TCTGCAATAA CGTGAAGGGC
TGTCCCTTTA CTTCATTCAG TGTTCCAGAT CCAGAGCTCA TTAAAACAGT CACCATCAAT
GCAAGTTCTT CCCGCTCCGG ACTAGATGAT ATCAATCCCA CAGTACTACT AAAAGAACGT
TCGACTGAAC TGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000954.1
CDS138..1952
Misc Feature(1)192..299
Misc Feature(2)360..1823
Misc Feature(3)order(444..446,708..710,1128..1130,1137..1142,1152..1154,1158..1160,1236..1238,1248..1250,1254..1256,1647..1649,1659..1661,1671..1676,1683..1688,1695..1697)
Misc Feature(4)order(468..470,474..482,501..515,519..521,780..782,1050..1064,1071..1076,1083..1085,1092..1097,1104..1106,1194..1217,1704..1709,1716..1730,1734..1742,1746..1751)
Misc Feature(5)order(537..539,690..692,702..704,714..716,723..731,978..980,1239..1241,1248..1259,1266..1268,1317..1319,1425..1427,1431..1436,1443..1445)
Misc Feature(6)1683..1685
Misc Feature(7)1713..1715
Exon (1)1..189
Exon (2)190..306
Exon (3)307..450
Exon (4)451..594
Exon (5)595..776
Exon (6)777..860
Exon (7)861..1107
Exon (8)1108..1394
Exon (9)1395..1542
Exon (10)1543..4493
Translation

Target ORF information:

RefSeq Version NM_000963.3
Organism Homo sapiens(Human)
Definition Homo sapiens prostaglandin-endoperoxide synthase 2 (PTGS2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000963.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
ATGCTCGCCC GCGCCCTGCT GCTGTGCGCG GTCCTGGCGC TCAGCCATAC AGCAAATCCT 
TGCTGTTCCC ACCCATGTCA AAACCGAGGT GTATGTATGA GTGTGGGATT TGACCAGTAT
AAGTGCGATT GTACCCGGAC AGGATTCTAT GGAGAAAACT GCTCAACACC GGAATTTTTG
ACAAGAATAA AATTATTTCT GAAACCCACT CCAAACACAG TGCACTACAT ACTTACCCAC
TTCAAGGGAT TTTGGAACGT TGTGAATAAC ATTCCCTTCC TTCGAAATGC AATTATGAGT
TATGTGTTGA CATCCAGATC ACATTTGATT GACAGTCCAC CAACTTACAA TGCTGACTAT
GGCTACAAAA GCTGGGAAGC CTTCTCTAAC CTCTCCTATT ATACTAGAGC CCTTCCTCCT
GTGCCTGATG ATTGCCCGAC TCCCTTGGGT GTCAAAGGTA AAAAGCAGCT TCCTGATTCA
AATGAGATTG TGGAAAAATT GCTTCTAAGA AGAAAGTTCA TCCCTGATCC CCAGGGCTCA
AACATGATGT TTGCATTCTT TGCCCAGCAC TTCACGCATC AGTTTTTCAA GACAGATCAT
AAGCGAGGGC CAGCTTTCAC CAACGGGCTG GGCCATGGGG TGGACTTAAA TCATATTTAC
GGTGAAACTC TGGCTAGACA GCGTAAACTG CGCCTTTTCA AGGATGGAAA AATGAAATAT
CAGATAATTG ATGGAGAGAT GTATCCTCCC ACAGTCAAAG ATACTCAGGC AGAGATGATC
TACCCTCCTC AAGTCCCTGA GCATCTACGG TTTGCTGTGG GGCAGGAGGT CTTTGGTCTG
GTGCCTGGTC TGATGATGTA TGCCACAATC TGGCTGCGGG AACACAACAG AGTATGCGAT
GTGCTTAAAC AGGAGCATCC TGAATGGGGT GATGAGCAGT TGTTCCAGAC AAGCAGGCTA
ATACTGATAG GAGAGACTAT TAAGATTGTG ATTGAAGATT ATGTGCAACA CTTGAGTGGC
TATCACTTCA AACTGAAATT TGACCCAGAA CTACTTTTCA ACAAACAATT CCAGTACCAA
AATCGTATTG CTGCTGAATT TAACACCCTC TATCACTGGC ATCCCCTTCT GCCTGACACC
TTTCAAATTC ATGACCAGAA ATACAACTAT CAACAGTTTA TCTACAACAA CTCTATATTG
CTGGAACATG GAATTACCCA GTTTGTTGAA TCATTCACCA GGCAAATTGC TGGCAGGGTT
GCTGGTGGTA GGAATGTTCC ACCCGCAGTA CAGAAAGTAT CACAGGCTTC CATTGACCAG
AGCAGGCAGA TGAAATACCA GTCTTTTAAT GAGTACCGCA AACGCTTTAT GCTGAAGCCC
TATGAATCAT TTGAAGAACT TACAGGAGAA AAGGAAATGT CTGCAGAGTT GGAAGCACTC
TATGGTGACA TCGATGCTGT GGAGCTGTAT CCTGCCCTTC TGGTAGAAAA GCCTCGGCCA
GATGCCATCT TTGGTGAAAC CATGGTAGAA GTTGGAGCAC CATTCTCCTT GAAAGGACTT
ATGGGTAATG TTATATGTTC TCCTGCCTAC TGGAAGCCAA GCACTTTTGG TGGAGAAGTG
GGTTTTCAAA TCATCAACAC TGCCTCAATT CAGTCTCTCA TCTGCAATAA CGTGAAGGGC
TGTCCCTTTA CTTCATTCAG TGTTCCAGAT CCAGAGCTCA TTAAAACAGT CACCATCAAT
GCAAGTTCTT CCCGCTCCGG ACTAGATGAT ATCAATCCCA CAGTACTACT AAAAGAACGT
TCGACTGAAC TGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

A Variant in COX-2 Gene Is Associated with Left Main Coronary Artery Disease and Clinical Outcomes of Coronary Artery Bypass Grafting.
BioMed research international20172924731(2017)
Liu H,Xu Z,Sun C,Gu D,Teng X,Zhao Y,Zheng Z


book

Interaction among COX-2, P2Y1 and GPIIIa gene variants is associated with aspirin resistance and early neurological deterioration in Chinese stroke patients.
BMC neurology17(1)4(2017 Jan)
Yi X,Wang C,Zhou Q,Lin J


book

Combined Analysis of Vascular Endothelial Growth Factor Expression with Cyclooxygenase-2 and Mast Cell Density in Oral Squamous Cell Carcinoma.
Pathobiology : journal of immunopathology, molecular and cellular biology84(2)80-86(2017)
Akbarzadeh Baghban A,Taghavi N,Shahla M


book

Cyclooxygenase-2 expression and association with skin cancer: A meta-analysis based on Chinese patients.
Journal of cancer research and therapeutics12(Supplement)C288-C290(2016 Dec)
Shujiao L,Lilin H,Yong S


book

Prognostic Value of Prostaglandin-endoperoxide Synthase 2 Polymorphisms in Prostate Cancer Recurrence after Radical Prostatectomy.
International journal of medical sciences13(9)696-700(2016)
Lee CH,Pao JB,Lu TL,Lee HZ,Lee YC,Liu CC,Huang CY,Lin VC,Yu CC,Yin HL,Huang SP,Bao BY


 
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