SOX1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SOX1
Entrez Gene ID	6656
Full Name	SRY-box 1
General protein information	Preferred Names SRY-box 1 Names transcription factor SOX-1 SRY (sex determining region Y)-box 1 SRY-related HMG-box gene 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 13 Map Location: 13q34
Summary	This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. In mice, a similar protein regulates the gamma-crystallin genes and is essential for lens development. [provided by RefSeq, Jul 2008].
Disorder MIM:	602148

mRNA and Protein(s)

mRNA	Protein	Name
NM_005986.2	NP_005977.2	transcription factor SOX-1
NM_005986.3	NP_005977.2	transcription factor SOX-1

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	sox1	NP_001074465.1
Homo sapiens (human)	SOX1	NP_005977.2
Mus musculus (house mouse)	Sox1	NP_033259.2
Danio rerio (zebrafish)	sox1a	NP_001002483.1
Rattus norvegicus (Norway rat)	LOC100912302	XP_003752300.1
Danio rerio (zebrafish)	sox1b	NP_001032751.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression of a SOX1 overlapping transcript in neural differentiation and cancer models.
Ahmad A, Strohbuecker S, Tufarelli C, Sottile V
Cellular and molecular life sciences : CMLS74(22)4245-4258(2017 Nov)

Oncogenic activity of SOX1 in glioblastoma.
Garcia I, Aldaregia J, Marjanovic Vicentic J, Aldaz P, Moreno-Cugnon L, Torres-Bayona S, Carrasco-Garcia E, Garros-Regulez L, Ega?a L, Rubio A, Pollard S, Stevanovic M, Sampron N, Matheu A
Scientific reports746575(2017 Apr)

Methylation of SOX1 and VIM promoters in serum as potential biomarkers for hepatocellular carcinoma.
Liu XY, Fan YC, Gao S, Zhao J, Chen LY, Li F, Wang K
Neoplasma64(5)745-753(2017)

SOX1 is correlated to stemness state regulator SALL4 through progression and invasiveness of esophageal squamous cell carcinoma.
Rad A, Esmaeili Dizghandi S, Abbaszadegan MR, Taghechian N, Najafi M, Forghanifard MM
Gene594(2)171-175(2016 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SOX1 overlapping transcript was found to be highly expressed in differentiated neural stem cells across different time points of differentiation, and its expression correlated with SOX1 gene expression.
Title: Expression of a SOX1 overlapping transcript in neural differentiation and cancer models.

the under-expression of SOX1 was associated significantly with SALL4 overexpression. This study was the first to evaluate SOX1 underexpression and its association with poor prognosis in esophageal squamous cell carcinoma.
Title: SOX1 is correlated to stemness state regulator SALL4 through progression and invasiveness of esophageal squamous cell carcinoma.

The sensitivity was found to be 62% and 83% for DAPK1 and SOX1, respectively, when analyzed separately in the singleplex assay, but increased to 90% in the multiplex assay when either or both of the SOX1 and the DAPK1 gene promoters showed methylation.
Title: Development of a multiplex MethyLight assay for the detection of DAPK1 and SOX1 methylation in epithelial ovarian cancer in a north Indian population.

Taken together, these data suggest that SOX1 can function as a tumor suppressor partly by interfering with Wnt/beta-catenin signaling in breast cancer.
Title: SOX1 inhibits breast cancer cell growth and invasion through suppressing the Wnt/?-catenin signaling pathway.

The results of the SRY gene amplification of plasma DNA from pregnant women was the same as that of the amniocyte DNA
Title: Isolation and analysis of cell-free fetal DNA from maternal peripheral blood in Chinese women.

The following SOX1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SOX1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30852	NM_005986.3 Latest version!	Homo sapiens SRY-box transcription factor 1 (SOX1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$164.50-$230.30 $329.00
View Old Accession Versions >>
OHu30852	NM_005986.2	Homo sapiens SRY-box 1 (SOX1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$164.50-$230.30 $329.00
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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SOX1 ( NM_005986.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005977.2 Homo sapiens SRY-box 1 (SOX1), mRNA.

Price & Availability↑

CloneID	OHu30852
Clone ID Related Accession (Same CDS sequence)	NM_005986.2 , NM_005986.3
Accession Version	NM_005986.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1176bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-22
Organism	Homo sapiens(human)
Product	transcription factor SOX-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Y13436.1. On Apr 29, 2003 this sequence version replaced NM_005986.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGTACAGCA TGATGATGGA GACCGACCTG CACTCGCCCG GCGGCGCCCA GGCCCCCACG 
AACCTCTCGG GCCCCGCCGG GGCGGGCGGC GGCGGGGGCG GAGGCGGGGG CGGCGGCGGC 
GGCGGGGGCG CCAAGGCCAA CCAGGACCGG GTCAAACGGC CCATGAACGC CTTCATGGTG 
TGGTCCCGCG GGCAGCGGCG CAAGATGGCC CAGGAGAACC CCAAGATGCA CAACTCGGAG 
ATCAGCAAGC GCCTGGGGGC CGAGTGGAAG GTCATGTCCG AGGCCGAGAA GCGGCCGTTC 
ATCGACGAGG CCAAGCGGCT GCGCGCGCTG CACATGAAGG AGCACCCGGA TTACAAGTAC 
CGGCCGCGCC GCAAGACCAA GACGCTGCTC AAGAAGGACA AGTACTCGCT GGCCGGCGGG 
CTCCTGGCGG CCGGCGCGGG TGGCGGCGGC GCGGCTGTGG CCATGGGCGT GGGCGTGGGC 
GTGGGCGCGG CGGCCGTGGG CCAGCGCCTG GAGAGCCCAG GCGGCGCGGC GGGCGGCGGC 
TACGCGCACG TCAACGGCTG GGCCAACGGC GCCTACCCCG GCTCGGTGGC GGCGGCGGCG 
GCGGCCGCGG CCATGATGCA GGAGGCGCAG CTGGCCTACG GGCAGCACCC GGGCGCGGGC 
GGCGCGCACC CGCACGCGCA CCCCGCGCAC CCGCACCCGC ACCACCCGCA CGCGCACCCG 
CACAACCCGC AGCCCATGCA CCGCTACGAC ATGGGCGCGC TGCAGTACAG CCCCATCTCC 
AACTCGCAGG GCTACATGAG CGCGTCGCCC TCGGGCTACG GCGGCCTCCC CTACGGCGCC 
GCGGCCGCCG CCGCCGCCGC TGCGGGCGGC GCGCACCAGA ACTCGGCCGT GGCGGCGGCG 
GCGGCGGCGG CGGCCGCGTC GTCGGGCGCC CTGGGCGCGC TGGGCTCTCT GGTGAAGTCG 
GAGCCCAGCG GCAGCCCGCC CGCCCCAGCG CACTCGCGGG CGCCGTGCCC CGGGGACCTG 
CGCGAGATGA TCAGCATGTA CTTGCCCGCC GGCGAGGGGG GCGACCCGGC GGCGGCAGCA 
GCGGCCGCGG CGCAGAGCCG GCTGCACTCG CTGCCGCAGC ACTACCAGGG CGCGGGCGCG 
GGCGTGAACG GCACGGTGCC CCTGACGCAC ATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005977.2
CDS	61..1236
Translation	MYSMMMETDLHSPGGAQAPTNLSGPAGAGGGGGGGGGGGGGGGAKANQDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKVMSEAEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLLKKDKYSLAGGLLAAGAGGGGAAVAMGVGVGVGAAAVGQRLESPGGAAGGGYAHVNGWANGAYPGSVAAAAAAAAMMQEAQLAYGQHPGAGGAHPHAHPAHPHPHHPHAHPHNPQPMHRYDMGALQYSPISNSQGYMSASPSGYGGLPYGAAAAAAAAAGGAHQNSAVAAAAAAAAASSGALGALGSLVKSEPSGSPPAPAHSRAPCPGDLREMISMYLPAGEGGDPAAAAAAAAQSRLHSLPQHYQGAGAGVNGTVPLTHI

Target ORF information:

RefSeq Version	NM_005986.2
Organism	Homo sapiens(human)
Definition	Homo sapiens SRY-box 1 (SOX1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005986.2

ORF Insert Sequence:

ATGTACAGCA TGATGATGGA GACCGACCTG CACTCGCCCG GCGGCGCCCA GGCCCCCACG 
AACCTCTCGG GCCCCGCCGG GGCGGGCGGC GGCGGGGGCG GAGGCGGGGG CGGCGGCGGC 
GGCGGGGGCG CCAAGGCCAA CCAGGACCGG GTCAAACGGC CCATGAACGC CTTCATGGTG 
TGGTCCCGCG GGCAGCGGCG CAAGATGGCC CAGGAGAACC CCAAGATGCA CAACTCGGAG 
ATCAGCAAGC GCCTGGGGGC CGAGTGGAAG GTCATGTCCG AGGCCGAGAA GCGGCCGTTC 
ATCGACGAGG CCAAGCGGCT GCGCGCGCTG CACATGAAGG AGCACCCGGA TTACAAGTAC 
CGGCCGCGCC GCAAGACCAA GACGCTGCTC AAGAAGGACA AGTACTCGCT GGCCGGCGGG 
CTCCTGGCGG CCGGCGCGGG TGGCGGCGGC GCGGCTGTGG CCATGGGCGT GGGCGTGGGC 
GTGGGCGCGG CGGCCGTGGG CCAGCGCCTG GAGAGCCCAG GCGGCGCGGC GGGCGGCGGC 
TACGCGCACG TCAACGGCTG GGCCAACGGC GCCTACCCCG GCTCGGTGGC GGCGGCGGCG 
GCGGCCGCGG CCATGATGCA GGAGGCGCAG CTGGCCTACG GGCAGCACCC GGGCGCGGGC 
GGCGCGCACC CGCACGCGCA CCCCGCGCAC CCGCACCCGC ACCACCCGCA CGCGCACCCG 
CACAACCCGC AGCCCATGCA CCGCTACGAC ATGGGCGCGC TGCAGTACAG CCCCATCTCC 
AACTCGCAGG GCTACATGAG CGCGTCGCCC TCGGGCTACG GCGGCCTCCC CTACGGCGCC 
GCGGCCGCCG CCGCCGCCGC TGCGGGCGGC GCGCACCAGA ACTCGGCCGT GGCGGCGGCG 
GCGGCGGCGG CGGCCGCGTC GTCGGGCGCC CTGGGCGCGC TGGGCTCTCT GGTGAAGTCG 
GAGCCCAGCG GCAGCCCGCC CGCCCCAGCG CACTCGCGGG CGCCGTGCCC CGGGGACCTG 
CGCGAGATGA TCAGCATGTA CTTGCCCGCC GGCGAGGGGG GCGACCCGGC GGCGGCAGCA 
GCGGCCGCGG CGCAGAGCCG GCTGCACTCG CTGCCGCAGC ACTACCAGGG CGCGGGCGCG 
GGCGTGAACG GCACGGTGCC CCTGACGCAC ATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SOX1 ( NM_005986.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005977.2 Homo sapiens SRY-box transcription factor 1 (SOX1), mRNA.

Price & Availability↑

CloneID	OHu30852
Clone ID Related Accession (Same CDS sequence)	NM_005986.2 , NM_005986.3
Accession Version	NM_005986.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1176bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	transcription factor SOX-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL138691.15. On May 17, 2019 this sequence version replaced NM_005986.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000330949.3/ ENSP00000330218.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGTACAGCA TGATGATGGA GACCGACCTG CACTCGCCCG GCGGCGCCCA GGCCCCCACG 
AACCTCTCGG GCCCCGCCGG GGCGGGCGGC GGCGGGGGCG GAGGCGGGGG CGGCGGCGGC 
GGCGGGGGCG CCAAGGCCAA CCAGGACCGG GTCAAACGGC CCATGAACGC CTTCATGGTG 
TGGTCCCGCG GGCAGCGGCG CAAGATGGCC CAGGAGAACC CCAAGATGCA CAACTCGGAG 
ATCAGCAAGC GCCTGGGGGC CGAGTGGAAG GTCATGTCCG AGGCCGAGAA GCGGCCGTTC 
ATCGACGAGG CCAAGCGGCT GCGCGCGCTG CACATGAAGG AGCACCCGGA TTACAAGTAC 
CGGCCGCGCC GCAAGACCAA GACGCTGCTC AAGAAGGACA AGTACTCGCT GGCCGGCGGG 
CTCCTGGCGG CCGGCGCGGG TGGCGGCGGC GCGGCTGTGG CCATGGGCGT GGGCGTGGGC 
GTGGGCGCGG CGGCCGTGGG CCAGCGCCTG GAGAGCCCAG GCGGCGCGGC GGGCGGCGGC 
TACGCGCACG TCAACGGCTG GGCCAACGGC GCCTACCCCG GCTCGGTGGC GGCGGCGGCG 
GCGGCCGCGG CCATGATGCA GGAGGCGCAG CTGGCCTACG GGCAGCACCC GGGCGCGGGC 
GGCGCGCACC CGCACGCGCA CCCCGCGCAC CCGCACCCGC ACCACCCGCA CGCGCACCCG 
CACAACCCGC AGCCCATGCA CCGCTACGAC ATGGGCGCGC TGCAGTACAG CCCCATCTCC 
AACTCGCAGG GCTACATGAG CGCGTCGCCC TCGGGCTACG GCGGCCTCCC CTACGGCGCC 
GCGGCCGCCG CCGCCGCCGC TGCGGGCGGC GCGCACCAGA ACTCGGCCGT GGCGGCGGCG 
GCGGCGGCGG CGGCCGCGTC GTCGGGCGCC CTGGGCGCGC TGGGCTCTCT GGTGAAGTCG 
GAGCCCAGCG GCAGCCCGCC CGCCCCAGCG CACTCGCGGG CGCCGTGCCC CGGGGACCTG 
CGCGAGATGA TCAGCATGTA CTTGCCCGCC GGCGAGGGGG GCGACCCGGC GGCGGCAGCA 
GCGGCCGCGG CGCAGAGCCG GCTGCACTCG CTGCCGCAGC ACTACCAGGG CGCGGGCGCG 
GGCGTGAACG GCACGGTGCC CCTGACGCAC ATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005977.2
CDS	511..1686
Translation	MYSMMMETDLHSPGGAQAPTNLSGPAGAGGGGGGGGGGGGGGGAKANQDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKVMSEAEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLLKKDKYSLAGGLLAAGAGGGGAAVAMGVGVGVGAAAVGQRLESPGGAAGGGYAHVNGWANGAYPGSVAAAAAAAAMMQEAQLAYGQHPGAGGAHPHAHPAHPHPHHPHAHPHNPQPMHRYDMGALQYSPISNSQGYMSASPSGYGGLPYGAAAAAAAAAGGAHQNSAVAAAAAAAAASSGALGALGSLVKSEPSGSPPAPAHSRAPCPGDLREMISMYLPAGEGGDPAAAAAAAAQSRLHSLPQHYQGAGAGVNGTVPLTHI

Target ORF information:

RefSeq Version	NM_005986.3
Organism	Homo sapiens(human)
Definition	Homo sapiens SRY-box transcription factor 1 (SOX1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005986.3

ORF Insert Sequence:

ATGTACAGCA TGATGATGGA GACCGACCTG CACTCGCCCG GCGGCGCCCA GGCCCCCACG 
AACCTCTCGG GCCCCGCCGG GGCGGGCGGC GGCGGGGGCG GAGGCGGGGG CGGCGGCGGC 
GGCGGGGGCG CCAAGGCCAA CCAGGACCGG GTCAAACGGC CCATGAACGC CTTCATGGTG 
TGGTCCCGCG GGCAGCGGCG CAAGATGGCC CAGGAGAACC CCAAGATGCA CAACTCGGAG 
ATCAGCAAGC GCCTGGGGGC CGAGTGGAAG GTCATGTCCG AGGCCGAGAA GCGGCCGTTC 
ATCGACGAGG CCAAGCGGCT GCGCGCGCTG CACATGAAGG AGCACCCGGA TTACAAGTAC 
CGGCCGCGCC GCAAGACCAA GACGCTGCTC AAGAAGGACA AGTACTCGCT GGCCGGCGGG 
CTCCTGGCGG CCGGCGCGGG TGGCGGCGGC GCGGCTGTGG CCATGGGCGT GGGCGTGGGC 
GTGGGCGCGG CGGCCGTGGG CCAGCGCCTG GAGAGCCCAG GCGGCGCGGC GGGCGGCGGC 
TACGCGCACG TCAACGGCTG GGCCAACGGC GCCTACCCCG GCTCGGTGGC GGCGGCGGCG 
GCGGCCGCGG CCATGATGCA GGAGGCGCAG CTGGCCTACG GGCAGCACCC GGGCGCGGGC 
GGCGCGCACC CGCACGCGCA CCCCGCGCAC CCGCACCCGC ACCACCCGCA CGCGCACCCG 
CACAACCCGC AGCCCATGCA CCGCTACGAC ATGGGCGCGC TGCAGTACAG CCCCATCTCC 
AACTCGCAGG GCTACATGAG CGCGTCGCCC TCGGGCTACG GCGGCCTCCC CTACGGCGCC 
GCGGCCGCCG CCGCCGCCGC TGCGGGCGGC GCGCACCAGA ACTCGGCCGT GGCGGCGGCG 
GCGGCGGCGG CGGCCGCGTC GTCGGGCGCC CTGGGCGCGC TGGGCTCTCT GGTGAAGTCG 
GAGCCCAGCG GCAGCCCGCC CGCCCCAGCG CACTCGCGGG CGCCGTGCCC CGGGGACCTG 
CGCGAGATGA TCAGCATGTA CTTGCCCGCC GGCGAGGGGG GCGACCCGGC GGCGGCAGCA 
GCGGCCGCGG CGCAGAGCCG GCTGCACTCG CTGCCGCAGC ACTACCAGGG CGCGGGCGCG 
GGCGTGAACG GCACGGTGCC CCTGACGCAC ATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression of a SOX1 overlapping transcript in neural differentiation and cancer models.
Cellular and molecular life sciences : CMLS74(22)4245-4258(2017 Nov)
Ahmad A,Strohbuecker S,Tufarelli C,Sottile V

Oncogenic activity of SOX1 in glioblastoma.
Scientific reports746575(2017 Apr)
Garcia I,Aldaregia J,Marjanovic Vicentic J,Aldaz P,Moreno-Cugnon L,Torres-Bayona S,Carrasco-Garcia E,Garros-Regulez L,Ega?a L,Rubio A,Pollard S,Stevanovic M,Sampron N,Matheu A

Methylation of SOX1 and VIM promoters in serum as potential biomarkers for hepatocellular carcinoma.
Neoplasma64(5)745-753(2017)
Liu XY,Fan YC,Gao S,Zhao J,Chen LY,Li F,Wang K

SOX1 is correlated to stemness state regulator SALL4 through progression and invasiveness of esophageal squamous cell carcinoma.
Gene594(2)171-175(2016 Dec)
Rad A,Esmaeili Dizghandi S,Abbaszadegan MR,Taghechian N,Najafi M,Forghanifard MM