Gadd45gip1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gadd45gip1
Entrez Gene ID	102060
Full Name	growth arrest and DNA-damage-inducible, gamma interacting protein 1
Synonyms	2310040G17Rik,AI425883,Crif1,MRP-L59,Plinp1
General protein information	Preferred Names growth arrest and DNA-damage-inducible, gamma interacting protein 1 Names growth arrest and DNA damage-inducible proteins-interacting protein 1 39S ribosomal protein L59, mitochondrial papillomavirus L2 interacting nuclear protein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8\|8 C2

mRNA and Protein(s)

mRNA	Protein	Name
NM_183358.4	NP_899202.3	growth arrest and DNA damage-inducible proteins-interacting protein 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	GADD45GIP1	XP_533898.2
Bos taurus (cattle)	GADD45GIP1	NP_001073693.1
Mus musculus (house mouse)	Gadd45gip1	NP_899202.3
Danio rerio (zebrafish)	gadd45gip1	XP_001345133.3
Homo sapiens (human)	GADD45GIP1	NP_443082.2
Xenopus tropicalis (tropical clawed frog)	gadd45gip1	XP_002939166.1
Pan troglodytes (chimpanzee)	GADD45GIP1	XP_001170430.1
Rattus norvegicus (Norway rat)	Gadd45gip1	NP_001093974.1

Gene Ontology
Bibliography

Related articles in PubMed

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis.
Chung HK, Ryu D, Kim KS, Chang JY, Kim YK, Yi HS, Kang SG, Choi MJ, Lee SE, Jung SB, Ryu MJ, Kim SJ, Kweon GR, Kim H, Hwang JH, Lee CH, Lee SJ, Wall CE, Downes M, Evans RM, Auwerx J, Shong M
The Journal of cell biology216(1)149-165(2017 Jan)

Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.
Liu X, Jiao Y, Cao Y, Deng N, Ma Y, Hasty KA, Kang A, Chen H, Stuart JM, Gu W
BMC immunology17(1)25(2016 08)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results identify the ROS-Sp1-Crif1 pathway to be a new mechanism underlying Abeta-induced mitochondrial dysfunction and suggest that ROS-mediated downregulation of Crif1 is a crucial event in AD pathology.
Title: CR6-interacting factor 1 is a key regulator in A?-induced mitochondrial disruption and pathogenesis of Alzheimer's disease.

Crif1(beta-/-) mouse is a useful model for the study of beta cell failure caused by mitochondrial OxPhos dysfunction.
Title: Disruption of CR6-interacting factor-1 (CRIF1) in mouse islet beta cells leads to mitochondrial diabetes with progressive beta cell failure.

CRIF1 knockdown partially induces endothelial activation via increased ROS production and phosphorylation of p66shc
Title: CRIF1 deficiency induces p66shc-mediated oxidative stress and endothelial activation.

Study showed that loss of Crif1 impairs mitochondrial oxidative phosphorylation and adipocyte differentiation in vitro and in vivo.
Title: Mitochondrial oxidative phosphorylation reserve is required for hormone- and PPAR? agonist-induced adipogenesis.

Although adipose-specific Crif1-haploinsufficient mice showed normal growth and development, they became insulin-resistant.
Title: Crif1 deficiency reduces adipose OXPHOS capacity and triggers inflammation and insulin resistance in mice.

The following Gadd45gip1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gadd45gip1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu08595	NM_183358.4 Latest version!	Mus musculus growth arrest and DNA-damage-inducible, gamma interacting protein 1 (Gadd45gip1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gadd45gip1 ( NM_183358.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_899202.3 Mus musculus growth arrest and DNA-damage-inducible, gamma interacting protein 1 (Gadd45gip1), mRNA.

Price & Availability↑

CloneID	OMu08595
Clone ID Related Accession (Same CDS sequence)	NM_183358.4
Accession Version	NM_183358.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 669bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	growth arrest and DNA damage-inducible proteins-interacting protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK002738.1 and AK028227.1. On Nov 20, 2009 this sequence version replaced NM_183358.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK028227.1, AK009723.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGCGC TCGCAATGCG GAGTGGCTAT CTCCTGCGGC TCTCTGTGGC TCTGGGTCCC 
AGGTCCCGCA GCTACCGTGC GCCCCCGCCC CCGCGCCGCC GTCCCGGGCC CCACTCGCCA 
GACCCGGAGA ACCTGCTGAC CCCGCGATGG CAGCTAACGC CCCGCTATGT GGCCAAGCAG 
TTCGGACGAC ATGGCGCCAT CTCCGGGGTG CCCCCGGCCT CCCTGTGGCC CACCCCAGAG 
CAGCTGCGCG AGTTGGAGGC CGAGGAGCAA GAATGGTACC CGAGCTTAGC GACCATGCAA 
GAGTCGCTGC GCTTGCAGCA GCAGGCCTTG GAGGCAAGGC GCCAAGCCAG GGAGCAGCGT 
ATCGCAGAGT GCATGGCCAA GATGCCACAA ATGATTGAAA ACTGGCGAAA GCAGAAGCGA 
GAACGCTGGG AGAAAATTCA GGCTGACAAG GAGCGGAGGG CCCGGTTACA GGCTGAGGCC 
CAGGAACGCC TGGGCTACCA CGTGGACCCA AGGAGTGCTC GCTTCCAGGA ACTATTACAG 
GACCTAGACA AGCAGCAACG AAAGCGCCTA AAGGAAGAAA GACAACGACA GAAGAAGGAG 
GCACGAATTG CTGCTATGGC CTCTGCTGAA GCCCAGGACT CAGCAGTGTC TGGTGAACCC 
AGCTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_899202.3
CDS	10..678
Translation	MAALAMRSGYLLRLSVALGPRSRSYRAPPPPRRRPGPHSPDPENLLTPRWQLTPRYVAKQFGRHGAISGVPPASLWPTPEQLRELEAEEQEWYPSLATMQESLRLQQQALEARRQAREQRIAECMAKMPQMIENWRKQKRERWEKIQADKERRARLQAEAQERLGYHVDPRSARFQELLQDLDKQQRKRLKEERQRQKKEARIAAMASAEAQDSAVSGEPSS

Target ORF information:

RefSeq Version	NM_183358.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus growth arrest and DNA-damage-inducible, gamma interacting protein 1 (Gadd45gip1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_183358.4

ORF Insert Sequence:

ATGGCGGCGC TCGCAATGCG GAGTGGCTAT CTCCTGCGGC TCTCTGTGGC TCTGGGTCCC 
AGGTCCCGCA GCTACCGTGC GCCCCCGCCC CCGCGCCGCC GTCCCGGGCC CCACTCGCCA 
GACCCGGAGA ACCTGCTGAC CCCGCGATGG CAGCTAACGC CCCGCTATGT GGCCAAGCAG 
TTCGGACGAC ATGGCGCCAT CTCCGGGGTG CCCCCGGCCT CCCTGTGGCC CACCCCAGAG 
CAGCTGCGCG AGTTGGAGGC CGAGGAGCAA GAATGGTACC CGAGCTTAGC GACCATGCAA 
GAGTCGCTGC GCTTGCAGCA GCAGGCCTTG GAGGCAAGGC GCCAAGCCAG GGAGCAGCGT 
ATCGCAGAGT GCATGGCCAA GATGCCACAA ATGATTGAAA ACTGGCGAAA GCAGAAGCGA 
GAACGCTGGG AGAAAATTCA GGCTGACAAG GAGCGGAGGG CCCGGTTACA GGCTGAGGCC 
CAGGAACGCC TGGGCTACCA CGTGGACCCA AGGAGTGCTC GCTTCCAGGA ACTATTACAG 
GACCTAGACA AGCAGCAACG AAAGCGCCTA AAGGAAGAAA GACAACGACA GAAGAAGGAG 
GCACGAATTG CTGCTATGGC CTCTGCTGAA GCCCAGGACT CAGCAGTGTC TGGTGAACCC 
AGCTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis.
The Journal of cell biology216(1)149-165(2017 Jan)
Chung HK,Ryu D,Kim KS,Chang JY,Kim YK,Yi HS,Kang SG,Choi MJ,Lee SE,Jung SB,Ryu MJ,Kim SJ,Kweon GR,Kim H,Hwang JH,Lee CH,Lee SJ,Wall CE,Downes M,Evans RM,Auwerx J,Shong M

Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.
BMC immunology17(1)25(2016 08)
Liu X,Jiao Y,Cao Y,Deng N,Ma Y,Hasty KA,Kang A,Chen H,Stuart JM,Gu W

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Gadd45gip1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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