Efna4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Efna4
Entrez Gene ID	13639
Full Name	ephrin A4
Synonyms	EFL-4,Epl4,LERK-4
General protein information	Preferred Names ephrin A4 Names ephrin-A4 EPH-related receptor tyrosine kinase ligand 4
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3 F1\|3 39.07 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_007910.2	NP_031936.2	ephrin-A4 precursor

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	LOC100003450	XP_001343018.4
Pan troglodytes (chimpanzee)	EFNA4	XP_003308471.1
Homo sapiens (human)	EFNA4	NP_005218.1
Canis lupus familiaris (dog)	EFNA4	XP_547555.2
Bos taurus (cattle)	EFNA4	NP_001094719.1
Mus musculus (house mouse)	Efna4	NP_031936.2
Rattus norvegicus (Norway rat)	Efna4	NP_001101162.1

Gene Ontology
Bibliography

Related articles in PubMed

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.
Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundstr?m E, Pachnis V, Marklund U
Gastroenterology(2017 Oct)

Proper closure of the optic fissure requires ephrin A5-EphB2-JNK signaling.
Noh H, Lee H, Park E, Park S
Development (Cambridge, England)143(3)461-72(2016 Feb)

The Ephrin-A5/EphA4 Interaction Modulates Neurogenesis and Angiogenesis by the p-Akt and p-ERK Pathways in a Mouse Model of TLE.
Shu Y, Xiao B, Wu Q, Liu T, Du Y, Tang H, Chen S, Feng L, Long L, Li Y
Molecular neurobiology53(1)561-576(2016 Jan)

Nephric duct insertion requires EphA4/EphA7 signaling from the pericloacal mesenchyme.
Weiss AC, Airik R, Bohnenpoll T, Greulich F, Foik A, Trowe MO, Rudat C, Costantini F, Adams RH, Kispert A
Development (Cambridge, England)141(17)3420-30(2014 Sep)

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In a model of temporal lobe epilepsy, Ephrin-A4 and Ephrin-A5 increase in the hippocampus in a spatiotemporal course.
Title: The Ephrin-A5/EphA4 Interaction Modulates Neurogenesis and Angiogenesis by the p-Akt and p-ERK Pathways in a Mouse Model of TLE.

ephrin-A4 plays an important role in retinal NV and is a potential target against retinal NV. The proangiogenic function of ephrin-A4 may be linked to its crucial role in the VEGF signaling pathway.
Title: Ephrin-a4 is involved in retinal neovascularization by regulating the VEGF signaling pathway.

Downregulation of the EphA4 receptor via siRNA transfection reduced the repulsive effect of ephrin-A3, indicating that EphA4 mediates at least in part the repulsive effect of ephrin-A3.
Title: Ephrins guide migrating cortical interneurons in the basal telencephalon.

Ephrin A4 receptor in the thalamus and ephrin A4 in the cerebral cortex control intra-areal topographic mapping of thalamocortical axons.
Title: Area specificity and topography of thalamocortical projections are controlled by ephrin/Eph genes.

LIM homeodomain proteins control axon pathways topographic projections in the limb through control of EphA receptors and ephrin-A ligands in motor neurons and limb mesenchymal cells.
Title: Topographic motor projections in the limb imposed by LIM homeodomain protein regulation of ephrin-A:EphA interactions.

The following Efna4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Efna4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu01030	NM_007910.2 Latest version!	Mus musculus ephrin A4 (Efna4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Efna4 ( NM_007910.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031936.2 Mus musculus ephrin A4 (Efna4), mRNA.

Price & Availability↑

CloneID	OMu01030
Clone ID Related Accession (Same CDS sequence)	NM_007910.2
Accession Version	NM_007910.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 621bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Mus musculus(house mouse)
Product	ephrin-A4 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK142604.1, AK012195.1, AA764182.1 and BB472066.1. On Jul 29, 2006 this sequence version replaced NM_007910.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK142604.1, AK012195.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164137, SAMN01164138 [ECO:0000348] ##Evidence-Data-END##

ATGCGGCTGC TGCCCCTGCT GCGGACTGTG CTCTGGGCCG CGCTGCTCGG CTCGCGCCTG 
CCGGGGTGCT CCAGCCTCCG CCACCCAATC TACTGGAACT CCTCTAACCC CAGGTTGCTC 
CGAGGAGATG CCGTGGTGGA GCTGGGCTTC AACGATTACC TAGACATCTT CTGCCCACAT 
TATGAAAGCC CAGGGCCCCC AGAAGGCCCG GAAACCTTTG CATTATACAT GGTGGACTGG 
TCAGGCTACG AGGCCTGCAC GGCAGAGGGG GCAAATGCCT TCCAGCGCTG GAATTGCTCG 
ATGCCTTTTG CCCCTTTCAG CCCTGTTCGA TTCTCAGAAA AGATTCAGCG CTACACACCC 
TTCCCGCTGG GCTTTGAGTT CTTGCCTGGA GAGACTTACT ACTACATCTC GGTGCCGACT 
CCGGAGAGTC CTGGCCGGTG CCTGAGACTC CAGGTGTCTG TCTGCTGCAA GGAGAGCGGG 
TCATCACATG AGTCAGCTCA TCCTGTTGGG AGTCCTGGAG AAAGCGGTAC GTCCGGGTGG 
CGGGGAGGAC ACGCGCCCAG CCCCCTGTGT CTCTTGCTGC TGCTGCTGCT CCCAATCCTC 
CGTCTCCTGA GAGTTCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031936.2
CDS	79..699
Translation	MRLLPLLRTVLWAALLGSRLPGCSSLRHPIYWNSSNPRLLRGDAVVELGFNDYLDIFCPHYESPGPPEGPETFALYMVDWSGYEACTAEGANAFQRWNCSMPFAPFSPVRFSEKIQRYTPFPLGFEFLPGETYYYISVPTPESPGRCLRLQVSVCCKESGSSHESAHPVGSPGESGTSGWRGGHAPSPLCLLLLLLLPILRLLRVL

Target ORF information:

RefSeq Version	NM_007910.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus ephrin A4 (Efna4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007910.2

ORF Insert Sequence:

ATGCGGCTGC TGCCCCTGCT GCGGACTGTG CTCTGGGCCG CGCTGCTCGG CTCGCGCCTG 
CCGGGGTGCT CCAGCCTCCG CCACCCAATC TACTGGAACT CCTCTAACCC CAGGTTGCTC 
CGAGGAGATG CCGTGGTGGA GCTGGGCTTC AACGATTACC TAGACATCTT CTGCCCACAT 
TATGAAAGCC CAGGGCCCCC AGAAGGCCCG GAAACCTTTG CATTATACAT GGTGGACTGG 
TCAGGCTACG AGGCCTGCAC GGCAGAGGGG GCAAATGCCT TCCAGCGCTG GAATTGCTCG 
ATGCCTTTTG CCCCTTTCAG CCCTGTTCGA TTCTCAGAAA AGATTCAGCG CTACACACCC 
TTCCCGCTGG GCTTTGAGTT CTTGCCTGGA GAGACTTACT ACTACATCTC GGTGCCGACT 
CCGGAGAGTC CTGGCCGGTG CCTGAGACTC CAGGTGTCTG TCTGCTGCAA GGAGAGCGGG 
TCATCACATG AGTCAGCTCA TCCTGTTGGG AGTCCTGGAG AAAGCGGTAC GTCCGGGTGG 
CGGGGAGGAC ACGCGCCCAG CCCCCTGTGT CTCTTGCTGC TGCTGCTGCT CCCAATCCTC 
CGTCTCCTGA GAGTTCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.
Gastroenterology(2017 Oct)
Memic F,Knoflach V,Morarach K,Sadler R,Laranjeira C,Hjerling-Leffler J,Sundstr?m E,Pachnis V,Marklund U

Proper closure of the optic fissure requires ephrin A5-EphB2-JNK signaling.
Development (Cambridge, England)143(3)461-72(2016 Feb)
Noh H,Lee H,Park E,Park S

The Ephrin-A5/EphA4 Interaction Modulates Neurogenesis and Angiogenesis by the p-Akt and p-ERK Pathways in a Mouse Model of TLE.
Molecular neurobiology53(1)561-576(2016 Jan)
Shu Y,Xiao B,Wu Q,Liu T,Du Y,Tang H,Chen S,Feng L,Long L,Li Y

Nephric duct insertion requires EphA4/EphA7 signaling from the pericloacal mesenchyme.
Development (Cambridge, England)141(17)3420-30(2014 Sep)
Weiss AC,Airik R,Bohnenpoll T,Greulich F,Foik A,Trowe MO,Rudat C,Costantini F,Adams RH,Kispert A

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

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Efna4 cDNA ORF clone, Mus musculus(house mouse)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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