Gene Symbol | Ppp1r3a |
Entrez Gene ID | 140491 |
Full Name | protein phosphatase 1, regulatory (inhibitor) subunit 3A |
Synonyms | GM,RG1,RGL |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Ppp1r3a cDNA ORF clone
Gene Symbol | Ppp1r3a |
Entrez Gene ID | 140491 |
Full Name | protein phosphatase 1, regulatory (inhibitor) subunit 3A |
Synonyms | GM,RG1,RGL |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_080464.2 | NP_536712.2 | protein phosphatase 1 regulatory subunit 3A |
Homo sapiens (human) | PPP1R3A | NP_002702.2 |
Canis lupus familiaris (dog) | PPP1R3A | XP_539528.2 |
Pan troglodytes (chimpanzee) | PPP1R3A | XP_519320.3 |
PPP1R3A | XP_001100958.2 | |
Bos taurus (cattle) | PPP1R3A | NP_001192369.1 |
Mus musculus (house mouse) | Ppp1r3a | NP_536712.2 |
Rattus norvegicus (Norway rat) | Ppp1r3a | NP_001102692.1 |
Gallus gallus (chicken) | PPP1R3A | XP_004937598.1 |
PNUTS forms a trimeric protein complex with GABA(C) receptors and protein phosphatase 1.
Rose M, D?tting E, Schr?der N, Sticht H, Brandst?tter JH, Enz R
Molecular and cellular neurosciences37(4)808-19(2008 Apr)
Disruption of the striated muscle glycogen-targeting subunit of protein phosphatase 1: influence of the genetic background.
Paterson J, Kelsall IR, Cohen PT
Journal of molecular endocrinology40(2)47-59(2008 Feb)
A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice.
Savage DB, Zhai L, Ravikumar B, Choi CS, Snaar JE, McGuire AC, Wou SE, Medina-Gomez G, Kim S, Bock CB, Segvich DM, Solanky B, Deelchand D, Vidal-Puig A, Wareham NJ, Shulman GI, Karpe F, Taylor R, Pederson BA, Roach PJ, O'Rahilly S, DePaoli-Roach AA
PLoS medicine5(1)e27(2008 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Backcrossing of G(M)-/- mice onto two different genetic backgrounds gave rise to lean, glucose-tolerant, insulin-sensitive G(M)-/- mice indicating that at least one variant gene,is required for the development of the prediabetic phenotype of obese mice.
Title: Disruption of the striated muscle glycogen-targeting subunit of protein phosphatase 1: influence of the genetic background.
Mice in which human PPP1R3A C1984DeltaAG replaced mouse PP1R3A had decreased muscle glycogen levels because failure of the truncated mutant to bind glycogen & colocalize with glycogen synthase (GS) decreased GS & increased glycogen phosphorylase activity.
Title: A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice.
results show that dysfunction of subunit PPP1R3A of protein phosphatase 1 leads to weight gain, increased fat deposition and insulin resistance
Title: Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin resistance.
Disruption of the Ppp1r3a gene does not result in either fat deposition or insulin resistance, but PPP1r3a is essential for control of glycogen metabolism by exercise.
Title: Insulin control of glycogen metabolism in knockout mice lacking the muscle-specific protein phosphatase PP1G/RGL.
The following Ppp1r3a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ppp1r3a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu09683 | |
Clone ID Related Accession (Same CDS sequence) | NM_080464.2 | |
Accession Version | NM_080464.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3270bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-25 | |
Organism | Mus musculus(house mouse) | |
Product | protein phosphatase 1 regulatory subunit 3A | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK084518.1, BC109007.1 and AC140470.3. On Apr 11, 2007 this sequence version replaced NM_080464.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC109007.1, AK084719.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849390 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGAGCCCG CTGAAGAACC TGGTCAGATT AGCAAAGATA ACTTTTTAGA AGTTCCTAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_536712.2 |
CDS | 29..3298 |
Translation |
Target ORF information:
Target ORF information:
|
NM_080464.2 |
1 | ATGGAGCCCG CTGAAGAACC TGGTCAGATT AGCAAAGATA ACTTTTTAGA AGTTCCTAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
PNUTS forms a trimeric protein complex with GABA(C) receptors and protein phosphatase 1. |
Disruption of the striated muscle glycogen-targeting subunit of protein phosphatase 1: influence of the genetic background. |
A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice. |