Scrt1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Gene Symbol	Scrt1
Entrez Gene ID	170729
Full Name	scratch family zinc finger 1
General protein information	Preferred Names scratch family zinc finger 1 Names transcriptional repressor scratch 1 SCRT mScrt scratch 1 scratch homolog 1, zinc finger protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15\|15 D3

mRNA and Protein(s)

mRNA Protein Name

NM_130893.3 NP_570963.1 transcriptional repressor scratch 1
Pathways from BioSystems

mRNA	Protein	Name
NM_130893.3	NP_570963.1	transcriptional repressor scratch 1

Homologies

Rattus norvegicus (Norway rat)	Scrt1	NP_001124042.1
Danio rerio (zebrafish)	scrt1a	NP_001107073.1
Xenopus tropicalis (tropical clawed frog)	scrt1	XP_004920080.1
Mus musculus (house mouse)	Scrt1	NP_570963.1
Danio rerio (zebrafish)	scrt1b	NP_001014369.1
Homo sapiens (human)	SCRT1	NP_112599.2
	LOC714311	XP_001103989.2
Bos taurus (cattle)	SCRT1	NP_001193752.1
Pan troglodytes (chimpanzee)	SCRT1	XP_001156904.1
Canis lupus familiaris (dog)	SCRT1	XP_005628369.1

Gene Ontology
Bibliography

Related articles in PubMed

REST corepressors RCOR1 and RCOR2 and the repressor INSM1 regulate the proliferation-differentiation balance in the developing brain.
Monaghan CE, Nechiporuk T, Jeng S, McWeeney SK, Wang J, Rosenfeld MG, Mandel G
Proceedings of the National Academy of Sciences of the United States of America114(3)E406-E415(2017 Jan)

Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates.
Miller JA, Nathanson J, Franjic D, Shim S, Dalley RA, Shapouri S, Smith KA, Sunkin SM, Bernard A, Bennett JL, Lee CK, Hawrylycz MJ, Jones AR, Amaral DG, ?estan N, Gage FH, Lein ES
Development (Cambridge, England)140(22)4633-44(2013 Nov)

Scratch regulates neuronal migration onset via an epithelial-mesenchymal transition-like mechanism.
Itoh Y, Moriyama Y, Hasegawa T, Endo TA, Toyoda T, Gotoh Y
Nature neuroscience16(4)416-25(2013 Apr)

The SNAIL family member SCRATCH1 is not expressed in human tumors.
Bastid J, Bouchet BP, Ciancia C, Pourchet J, Audoynaud C, Grelier G, Puisieux A, Ansieau S
Oncology reports23(2)523-9(2010 Feb)

A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Developmental cell17(6)836-48(2009 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Scratch proteins (1 and 2) mediate the conversion of neuroepithelial cells to migrating neurons through an epithelial-mesenchymal transition.
Title: Scratch regulates neuronal migration onset via an epithelial-mesenchymal transition-like mechanism.

SCRT1 transcripts are undetectable in nearly all of the examined tumors suggesting that SCRATCH1 plays a minor role, if any, in tumorigenesis.
Title: The SNAIL family member SCRATCH1 is not expressed in human tumors.

From perinatal to adult stages, Scratch1 remains strongly expressed in almost all brain regions, although it is not found in some ventral structures such as motor nuclei and hypothalamic regions.
Title: The expression of Scratch genes in the developing and adult brain.

The following Scrt1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Scrt1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu09853	NM_130893.3 Latest version!	Mus musculus scratch family zinc finger 1 (Scrt1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Scrt1 ( NM_130893.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_570963.1 Mus musculus scratch family zinc finger 1 (Scrt1), mRNA.

Price & Availability↑

CloneID	OMu09853
Clone ID Related Accession (Same CDS sequence)	NM_130893.3
Accession Version	NM_130893.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1047bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	transcriptional repressor scratch 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB525529.1, BC089316.1 and AC157566.6. On Mar 8, 2007 this sequence version replaced NM_130893.2. ##Evidence-Data-START## Transcript exon combination :: CB525529.1, BC089316.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849378, SAMN00849379 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCAGGT CCTTCCTGGT TAAGAAGGTC AAACTTGACA CATTCTCTTC GGCAGACCTC 
GACAGCTCCT ACGGGCGCGC CCGCAGCGAT CTCGGAGTGC GACTGCAAGA TAAAGGATAC 
CTCAGTGACT ACGTGGGGCC TGCGTCGGTC TACGATGGCG ACGCTGAGGC GGCGTTGCTC 
AAAGGGCCAT CCCCGGAGCC TATGTATGCT GCGGCTGTGC GGGGAGAGCT GGGTCCCGCG 
GCCTCTGGCT CAGCACCGCC GCCCACCCCT CGCCCAGAGC TGGCTACTGC TGCTGGCGGC 
TACATCAACG GCGACGCGGC GGTCAGCGAA GGCTACGCGG CCGACGCCTT CTTCATCACT 
GACGGGCGCT CACGCCGTAA GGCTGCTAAT GCCAACGCTG CCGCGGCCCC CTCGACAGCC 
TCGGTGGCAG CCCCCGACAG CGACGCTGGA GGTGGGGGCG GGCCGGGCAC GCGAGGCTCT 
GGATCAGGGT CCGCTAGTCG GGGCGGCACG CGCGTGGGGG CGGGCACCGA GGCGCGTGCG 
GGGTCGGGAG CCACGGGCGC TGGTGGCCGG CACGCGTGCG GAGAGTGTGG CAAAACTTAC 
GCCACGTCGT CGAACCTGAG CCGCCACAAG CAAACGCACC GCAGCTTGGA CAGCCAGCTG 
GCAAGGCGTT GCCCAACGTG TGGCAAGGTG TACGTGTCCA TGCCGGCCAT GGCTATGCAC 
CTGCTCACGC ACGATCTGCG CCACAAGTGC GGCGTGTGCG GCAAAGCCTT CTCCCGGCCC 
TGGCTGCTGC AGGGCCATAT GCGCTCGCAC ACGGGCGAGA AACCCTTCGG CTGTGCGCAC 
TGCGGCAAGG CCTTTGCAGA CCGCTCCAAC CTGCGCGCGC ACATGCAGAC GCACTCCGCC 
TTCAAGCACT TCCAGTGCAA GCGCTGCAAG AAGAGCTTCG CGCTCAAGTC TTATCTCAAC 
AAGCACTACG AGTCAGCCTG CTTCAAGGGC GGCGCTAGCG GCCCCGCAAC CCCTGCGCCG 
CCGCAGCTCA GCCCGGTTCA AGCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_570963.1
CDS	425..1471
Translation	MPRSFLVKKVKLDTFSSADLDSSYGRARSDLGVRLQDKGYLSDYVGPASVYDGDAEAALLKGPSPEPMYAAAVRGELGPAASGSAPPPTPRPELATAAGGYINGDAAVSEGYAADAFFITDGRSRRKAANANAAAAPSTASVAAPDSDAGGGGGPGTRGSGSGSASRGGTRVGAGTEARAGSGATGAGGRHACGECGKTYATSSNLSRHKQTHRSLDSQLARRCPTCGKVYVSMPAMAMHLLTHDLRHKCGVCGKAFSRPWLLQGHMRSHTGEKPFGCAHCGKAFADRSNLRAHMQTHSAFKHFQCKRCKKSFALKSYLNKHYESACFKGGASGPATPAPPQLSPVQA

Target ORF information:

RefSeq Version	NM_130893.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus scratch family zinc finger 1 (Scrt1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_130893.3

ORF Insert Sequence:

ATGCCCAGGT CCTTCCTGGT TAAGAAGGTC AAACTTGACA CATTCTCTTC GGCAGACCTC 
GACAGCTCCT ACGGGCGCGC CCGCAGCGAT CTCGGAGTGC GACTGCAAGA TAAAGGATAC 
CTCAGTGACT ACGTGGGGCC TGCGTCGGTC TACGATGGCG ACGCTGAGGC GGCGTTGCTC 
AAAGGGCCAT CCCCGGAGCC TATGTATGCT GCGGCTGTGC GGGGAGAGCT GGGTCCCGCG 
GCCTCTGGCT CAGCACCGCC GCCCACCCCT CGCCCAGAGC TGGCTACTGC TGCTGGCGGC 
TACATCAACG GCGACGCGGC GGTCAGCGAA GGCTACGCGG CCGACGCCTT CTTCATCACT 
GACGGGCGCT CACGCCGTAA GGCTGCTAAT GCCAACGCTG CCGCGGCCCC CTCGACAGCC 
TCGGTGGCAG CCCCCGACAG CGACGCTGGA GGTGGGGGCG GGCCGGGCAC GCGAGGCTCT 
GGATCAGGGT CCGCTAGTCG GGGCGGCACG CGCGTGGGGG CGGGCACCGA GGCGCGTGCG 
GGGTCGGGAG CCACGGGCGC TGGTGGCCGG CACGCGTGCG GAGAGTGTGG CAAAACTTAC 
GCCACGTCGT CGAACCTGAG CCGCCACAAG CAAACGCACC GCAGCTTGGA CAGCCAGCTG 
GCAAGGCGTT GCCCAACGTG TGGCAAGGTG TACGTGTCCA TGCCGGCCAT GGCTATGCAC 
CTGCTCACGC ACGATCTGCG CCACAAGTGC GGCGTGTGCG GCAAAGCCTT CTCCCGGCCC 
TGGCTGCTGC AGGGCCATAT GCGCTCGCAC ACGGGCGAGA AACCCTTCGG CTGTGCGCAC 
TGCGGCAAGG CCTTTGCAGA CCGCTCCAAC CTGCGCGCGC ACATGCAGAC GCACTCCGCC 
TTCAAGCACT TCCAGTGCAA GCGCTGCAAG AAGAGCTTCG CGCTCAAGTC TTATCTCAAC 
AAGCACTACG AGTCAGCCTG CTTCAAGGGC GGCGCTAGCG GCCCCGCAAC CCCTGCGCCG 
CCGCAGCTCA GCCCGGTTCA AGCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

REST corepressors RCOR1 and RCOR2 and the repressor INSM1 regulate the proliferation-differentiation balance in the developing brain.
Proceedings of the National Academy of Sciences of the United States of America114(3)E406-E415(2017 Jan)
Monaghan CE,Nechiporuk T,Jeng S,McWeeney SK,Wang J,Rosenfeld MG,Mandel G

Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates.
Development (Cambridge, England)140(22)4633-44(2013 Nov)
Miller JA,Nathanson J,Franjic D,Shim S,Dalley RA,Shapouri S,Smith KA,Sunkin SM,Bernard A,Bennett JL,Lee CK,Hawrylycz MJ,Jones AR,Amaral DG,?estan N,Gage FH,Lein ES

Scratch regulates neuronal migration onset via an epithelial-mesenchymal transition-like mechanism.
Nature neuroscience16(4)416-25(2013 Apr)
Itoh Y,Moriyama Y,Hasegawa T,Endo TA,Toyoda T,Gotoh Y

The SNAIL family member SCRATCH1 is not expressed in human tumors.
Oncology reports23(2)523-9(2010 Feb)
Bastid J,Bouchet BP,Ciancia C,Pourchet J,Audoynaud C,Grelier G,Puisieux A,Ansieau S

A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Developmental cell17(6)836-48(2009 Dec)
Yokoyama S,Ito Y,Ueno-Kudoh H,Shimizu H,Uchibe K,Albini S,Mitsuoka K,Miyaki S,Kiso M,Nagai A,Hikata T,Osada T,Fukuda N,Yamashita S,Harada D,Mezzano V,Kasai M,Puri PL,Hayashizaki Y,Okado H,Hashimoto M,Asahara H

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Scrt1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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