Apcs cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Apcs |
| Entrez Gene ID | 20219 |
| Full Name | serum amyloid P-component |
| Synonyms | Sap |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_011318.2 | NP_035448.2 | serum amyloid P-component precursor |
| Pan troglodytes (chimpanzee) | APCS | XP_513916.2 |
| Mus musculus (house mouse) | Apcs | NP_035448.2 |
| Rattus norvegicus (Norway rat) | Apcs | NP_058866.2 |
| Homo sapiens (human) | APCS | NP_001630.1 |
| LOC719421 | XP_001117234.1 | |
| Bos taurus (cattle) | APCS | NP_001029638.1 |
Related articles in PubMed
Hyposialylated IgG activates endothelial IgG receptor Fc?RIIB to promote obesity-induced insulin resistance.
Tanigaki K, Sacharidou A, Peng J, Chambliss KL, Yuhanna IS, Ghosh D, Ahmed M, Szalai AJ, Vongpatanasin W, Mattrey RF, Chen Q, Azadi P, Lingvay I, Botto M, Holland WL, Kohler JJ, Sirsi SR, Hoyt K, Shaul PW, Mineo C
The Journal of clinical investigation128(1)309-322(2018 Jan)
SAP deficiency mitigated atherosclerotic lesions in ApoE(-/-) mice.
Zheng L, Wu T, Zeng C, Li X, Li X, Wen D, Ji T, Lan T, Xing L, Li J, He X, Wang L
Atherosclerosis244179-87(2016 Jan)
DC-SIGN activation mediates the differential effects of SAP and CRP on the innate immune system and inhibits fibrosis in mice.
Cox N, Pilling D, Gomer RH
Proceedings of the National Academy of Sciences of the United States of America112(27)8385-90(2015 Jul)
Expression profile analysis of vulnerable CA1 pyramidal neurons in young-Middle-Aged Ts65Dn mice.
Alldred MJ, Lee SH, Petkova E, Ginsberg SD
The Journal of comparative neurology523(1)61-74(2015 Jan)
Persistent lung inflammation and fibrosis in serum amyloid P component (APCs-/-) knockout mice.
Pilling D, Gomer RH
PloS one9(4)e93730(2014)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
SAP deficiency mitigated foam cell formation and atherosclerotic development in apoE(-/-) mice, due to reduction in macrophages recruitment, polarization and pro-inflammatory cytokines
Title: SAP deficiency mitigated atherosclerotic lesions in ApoE(-/-) mice.
Data suggest that serum amyloid P (SAP) activates CD209 DC-SIGN to regulate the innate immune system differently from C-reactive protein (CRP), and that DC-SIGN is a target for antifibrotics.
Title: DC-SIGN activation mediates the differential effects of SAP and CRP on the innate immune system and inhibits fibrosis in mice.
observations suggest that serum amyloid P, at least in part, uses FcgammaRI and FcRgamma to inhibit fibrocyte differentiation
Title: Fc?RI mediates serum amyloid P inhibition of fibrocyte differentiation.
Bglu3 is confirmed to be a locus affecting diabetes susceptibility, and Apcs is a probable candidate gene.
Title: Characterization of Bglu3, a mouse fasting glucose locus, and identification of Apcs as an underlying candidate gene.
binding of SAP to ALD-DNA could switch macrophage phenotypic polarization from proinflammatory M2b to anti-inflammatory M2a via PI3K/Akt-ERK signaling activation, thus exerting protective and therapeutic interventions on murine lupus nephritis
Title: Macrophage differentiation and polarization via phosphatidylinositol 3-kinase/Akt-ERK signaling pathway conferred by serum amyloid P component.
The following Apcs gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Apcs cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu07907 | |
| Clone ID Related Accession (Same CDS sequence) | NM_011318.2 | |
| Accession Version | NM_011318.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 675bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-09-22 | |
| Organism | Mus musculus(house mouse) | |
| Product | serum amyloid P-component precursor | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AI286531.1 and BC061125.1. On Apr 18, 2009 this sequence version replaced NM_011318.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AI528120.1, Y00426.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164140 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGACAAGC TACTGCTTTG GATGTTTGTC TTCACCAGCC TTCTTTCAGA AGCCTTTTGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_035448.2 |
| CDS | 168..842 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_011318.2 |
ORF Insert Sequence:
1 | ATGGACAAGC TACTGCTTTG GATGTTTGTC TTCACCAGCC TTCTTTCAGA AGCCTTTTGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Hyposialylated IgG activates endothelial IgG receptor Fc?RIIB to promote obesity-induced insulin resistance. |
|
SAP deficiency mitigated atherosclerotic lesions in ApoE(-/-) mice. |
|
DC-SIGN activation mediates the differential effects of SAP and CRP on the innate immune system and inhibits fibrosis in mice. |
|
Expression profile analysis of vulnerable CA1 pyramidal neurons in young-Middle-Aged Ts65Dn mice. |
|
Persistent lung inflammation and fibrosis in serum amyloid P component (APCs-/-) knockout mice. |