NXNL1 cDNA ORF clone, Mus musculus(House mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	NXNL1
Entrez Gene ID	234404
Full Name	nucleoredoxin-like 1
Synonyms	A930031O08Rik,RdCVF,Txnl6
General protein information	Preferred Names nucleoredoxin-like 1 Names nucleoredoxin-like protein 1 rod-derived cone viability factor thioredoxin-like 6 thioredoxin-like protein 6
Gene Type	protein-coding
Organism	Mus musculus(House mouse)
Genome	Chromosome: 8 Map Location: 8\|8 B3.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_145598.2	NP_663573.1	nucleoredoxin-like protein 1
XM_006509663.1	XP_006509726.1	nucleoredoxin-like protein 1 isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Nxnl1	NP_663573.1
Xenopus tropicalis (tropical clawed frog)	nxnl1	XP_002935469.1
Homo sapiens (human)	NXNL1	NP_612463.1
	LOC719125	XP_001113624.1
Bos taurus (cattle)	NXNL1	XP_002688620.1
Rattus norvegicus (Norway rat)	Nxnl1	NP_001258270.1
Canis lupus familiaris (dog)	NXNL1	XP_541952.2
Danio rerio (zebrafish)	nxnl1	NP_001104230.1
Pan troglodytes (chimpanzee)	NXNL1	XP_512493.3
Gallus gallus (chicken)	NXNL1	XP_423688.1
Danio rerio (zebrafish)	LOC100330884	XP_002664792.1

Gene Ontology
Bibliography

Related articles in PubMed

The Thioredoxin Encoded by the Rod-Derived Cone Viability Factor Gene Protects Cone Photoreceptors Against Oxidative Stress.
Mei X, Chaffiol A, Kole C, Yang Y, Millet-Puel G, Cl?rin E, A?t-Ali N, Bennett J, Dalkara D, Sahel JA, Duebel J, L?veillard T
Antioxidants & redox signaling24(16)909-23(2016 Jun)

Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis.
A?t-Ali N, Fridlich R, Millet-Puel G, Cl?rin E, Delalande F, Jaillard C, Blond F, Perrocheau L, Reichman S, Byrne LC, Olivier-Bandini A, Bellalou J, Moyse E, Bouillaud F, Nicol X, Dalkara D, van Dorsselaer A, Sahel JA, L?veillard T
Cell161(4)817-32(2015 May)

Thioredoxin rod-derived cone viability factor protects against photooxidative retinal damage.
Elachouri G, Lee-Rivera I, Cl?rin E, Argentini M, Fridlich R, Blond F, Ferracane V, Yang Y, Raffelsberger W, Wan J, Bennett J, Sahel JA, Zack DJ, L?veillard T
Free radical biology & medicine8122-9(2015 Apr)

Expression of rod-derived cone viability factor: dual role of CRX in regulating promoter activity and cell-type specificity.
Lambard S, Reichman S, Berlinicke C, Niepon ML, Goureau O, Sahel JA, L?veillard T, Zack DJ
PloS one5(10)e13075(2010 Oct)

The disruption of the rod-derived cone viability gene leads to photoreceptor dysfunction and susceptibility to oxidative stress.
Cronin T, Raffelsberger W, Lee-Rivera I, Jaillard C, Niepon ML, Kinzel B, Cl?rin E, Petrosian A, Picaud S, Poch O, Sahel JA, L?veillard T
Cell death and differentiation17(7)1199-210(2010 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RdCVFL is a cell-autonomous mechanism of protection.
Title: The Thioredoxin Encoded by the Rod-Derived Cone Viability Factor Gene Protects Cone Photoreceptors Against Oxidative Stress.

Study shows that RdCVF acts through binding to Basigin-1 (BSG1), a transmembrane protein expressed specifically by photoreceptors. BSG1 binds to the glucose transporter GLUT1, resulting in increased glucose entry into cones.
Title: Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis.

The Nxnl1 gene, through the thioredoxin RdCVF-long isoform, is part of an endogenous defense mechanism against photooxidative stress.
Title: Thioredoxin rod-derived cone viability factor protects against photooxidative retinal damage.

regulation of the Nucleoredoxin-like genes involves a CRX responsive element that can act as both as a positive regulator of promoter activity and as a modulator of cell-type specificity
Title: Expression of rod-derived cone viability factor: dual role of CRX in regulating promoter activity and cell-type specificity.

The RdCVF gene has an essential role in photoreceptor maintenance and resistance to retinal oxidative stress.
Title: The disruption of the rod-derived cone viability gene leads to photoreceptor dysfunction and susceptibility to oxidative stress.

The following NXNL1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NXNL1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu11851	NM_145598.2 Latest version!	Mus musculus nucleoredoxin-like 1 (Nxnl1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu11851	XM_006509663.1 Latest version!	Mus musculus nucleoredoxin-like 1 (Nxnl1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NXNL1 ( NM_145598.2 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_663573.1 Mus musculus nucleoredoxin-like 1 (Nxnl1), mRNA.

Price & Availability↑

CloneID	OMu11851
Clone ID Related Accession (Same CDS sequence)	NM_145598.2 , XM_006509663.1
Accession Version	NM_145598.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 654bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	nucleoredoxin-like protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI738445.1, AC162033.11 and CO426411.1. On Oct 3, 2007 this sequence version replaced NM_145598.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BI738445.1, BC021911.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCATCTC TCTTCTCTGG ACGCATCTTG ATCAGGAACA ACAGCGACCA GGATGAAGTG 
GAGACAGAGG CAGAGCTGAG CCGTAGGTTA GAGAATCGTC TGGTGTTGCT GTTCTTCGGC 
GCCGGCGCCT GTCCCCAGTG CCAGGCCTTT GCCCCAGTCC TCAAAGACTT CTTCGTGCGG 
CTCACTGACG AGTTCTACGT GCTGCGGGCA GCACAGCTGG CCCTGGTCTA TGTGTCCCAG 
GACCCTACAG AGGAGCAACA GGACCTCTTC CTCAGGGACA TGCCTGAAAA ATGGCTCTTC 
CTGCCGTTCC ATGATGAACT GAGGAGGGAC CTCGGGCGCC AGTTCTCTGT CCGTCAACTG 
CCAGCGGTTG TGGTACTTAA GCCTGGTGGG GACGTGCTGA CAAGCGACGC CACGGAGGAG 
ATCCAGCGTC TGGGACCCGC CTGCTTTGCC AACTGGCAGG AGGCCGCAGA GCTCCTGGAC 
CGCAGCTTCC TGCAACCGGA GGATTTGGAT GAGCCTGCGC GGCGCAGCAT CACCGAGCCT 
CTGCGCCGTC GCAAGTACCG AGTAGACCGG GATGTCGGCC GGGAGCGGGG CCGAAACGGC 
CGCGACTCTG GTGACCCCCA GGGGGACGCG GGTACAAGGG CGGAGCTCTG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_663573.1
CDS	71..724
Translation	MASLFSGRILIRNNSDQDEVETEAELSRRLENRLVLLFFGAGACPQCQAFAPVLKDFFVRLTDEFYVLRAAQLALVYVSQDPTEEQQDLFLRDMPEKWLFLPFHDELRRDLGRQFSVRQLPAVVVLKPGGDVLTSDATEEIQRLGPACFANWQEAAELLDRSFLQPEDLDEPARRSITEPLRRRKYRVDRDVGRERGRNGRDSGDPQGDAGTRAELW

Target ORF information:

RefSeq Version	NM_145598.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus nucleoredoxin-like 1 (Nxnl1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145598.2

ORF Insert Sequence:

ATGGCATCTC TCTTCTCTGG ACGCATCTTG ATCAGGAACA ACAGCGACCA GGATGAAGTG 
GAGACAGAGG CAGAGCTGAG CCGTAGGTTA GAGAATCGTC TGGTGTTGCT GTTCTTCGGC 
GCCGGCGCCT GTCCCCAGTG CCAGGCCTTT GCCCCAGTCC TCAAAGACTT CTTCGTGCGG 
CTCACTGACG AGTTCTACGT GCTGCGGGCA GCACAGCTGG CCCTGGTCTA TGTGTCCCAG 
GACCCTACAG AGGAGCAACA GGACCTCTTC CTCAGGGACA TGCCTGAAAA ATGGCTCTTC 
CTGCCGTTCC ATGATGAACT GAGGAGGGAC CTCGGGCGCC AGTTCTCTGT CCGTCAACTG 
CCAGCGGTTG TGGTACTTAA GCCTGGTGGG GACGTGCTGA CAAGCGACGC CACGGAGGAG 
ATCCAGCGTC TGGGACCCGC CTGCTTTGCC AACTGGCAGG AGGCCGCAGA GCTCCTGGAC 
CGCAGCTTCC TGCAACCGGA GGATTTGGAT GAGCCTGCGC GGCGCAGCAT CACCGAGCCT 
CTGCGCCGTC GCAAGTACCG AGTAGACCGG GATGTCGGCC GGGAGCGGGG CCGAAACGGC 
CGCGACTCTG GTGACCCCCA GGGGGACGCG GGTACAAGGG CGGAGCTCTG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NXNL1 ( XM_006509663.1 ) cDNA ORF clone, Mus musculus(House mouse) -> XP_006509726.1 Mus musculus nucleoredoxin-like 1 (Nxnl1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu11851
Clone ID Related Accession (Same CDS sequence)	NM_145598.2 , XM_006509663.1
Accession Version	XM_006509663.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 654bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-08
Organism	Mus musculus(House mouse)
Product	nucleoredoxin-like protein 1 isoform X1
Comment

ATGGCATCTC TCTTCTCTGG ACGCATCTTG ATCAGGAACA ACAGCGACCA GGATGAAGTG 
GAGACAGAGG CAGAGCTGAG CCGTAGGTTA GAGAATCGTC TGGTGTTGCT GTTCTTCGGC 
GCCGGCGCCT GTCCCCAGTG CCAGGCCTTT GCCCCAGTCC TCAAAGACTT CTTCGTGCGG 
CTCACTGACG AGTTCTACGT GCTGCGGGCA GCACAGCTGG CCCTGGTCTA TGTGTCCCAG 
GACCCTACAG AGGAGCAACA GGACCTCTTC CTCAGGGACA TGCCTGAAAA ATGGCTCTTC 
CTGCCGTTCC ATGATGAACT GAGGAGGGAC CTCGGGCGCC AGTTCTCTGT CCGTCAACTG 
CCAGCGGTTG TGGTACTTAA GCCTGGTGGG GACGTGCTGA CAAGCGACGC CACGGAGGAG 
ATCCAGCGTC TGGGACCCGC CTGCTTTGCC AACTGGCAGG AGGCCGCAGA GCTCCTGGAC 
CGCAGCTTCC TGCAACCGGA GGATTTGGAT GAGCCTGCGC GGCGCAGCAT CACCGAGCCT 
CTGCGCCGTC GCAAGTACCG AGTAGACCGG GATGTCGGCC GGGAGCGGGG CCGAAACGGC 
CGCGACTCTG GTGACCCCCA GGGGGACGCG GGTACAAGGG CGGAGCTCTG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006509726.1
Translation	MASLFSGRILIRNNSDQDEVETEAELSRRLENRLVLLFFGAGACPQCQAFAPVLKDFFVRLTDEFYVLRAAQLALVYVSQDPTEEQQDLFLRDMPEKWLFLPFHDELRRDLGRQFSVRQLPAVVVLKPGGDVLTSDATEEIQRLGPACFANWQEAAELLDRSFLQPEDLDEPARRSITEPLRRRKYRVDRDVGRERGRNGRDSGDPQGDAGTRAELW

Target ORF information:

RefSeq Version	XM_006509663.1
Organism	Mus musculus(House mouse)
Definition	Mus musculus nucleoredoxin-like 1 (Nxnl1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006509663.1

ORF Insert Sequence:

ATGGCATCTC TCTTCTCTGG ACGCATCTTG ATCAGGAACA ACAGCGACCA GGATGAAGTG 
GAGACAGAGG CAGAGCTGAG CCGTAGGTTA GAGAATCGTC TGGTGTTGCT GTTCTTCGGC 
GCCGGCGCCT GTCCCCAGTG CCAGGCCTTT GCCCCAGTCC TCAAAGACTT CTTCGTGCGG 
CTCACTGACG AGTTCTACGT GCTGCGGGCA GCACAGCTGG CCCTGGTCTA TGTGTCCCAG 
GACCCTACAG AGGAGCAACA GGACCTCTTC CTCAGGGACA TGCCTGAAAA ATGGCTCTTC 
CTGCCGTTCC ATGATGAACT GAGGAGGGAC CTCGGGCGCC AGTTCTCTGT CCGTCAACTG 
CCAGCGGTTG TGGTACTTAA GCCTGGTGGG GACGTGCTGA CAAGCGACGC CACGGAGGAG 
ATCCAGCGTC TGGGACCCGC CTGCTTTGCC AACTGGCAGG AGGCCGCAGA GCTCCTGGAC 
CGCAGCTTCC TGCAACCGGA GGATTTGGAT GAGCCTGCGC GGCGCAGCAT CACCGAGCCT 
CTGCGCCGTC GCAAGTACCG AGTAGACCGG GATGTCGGCC GGGAGCGGGG CCGAAACGGC 
CGCGACTCTG GTGACCCCCA GGGGGACGCG GGTACAAGGG CGGAGCTCTG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Thioredoxin Encoded by the Rod-Derived Cone Viability Factor Gene Protects Cone Photoreceptors Against Oxidative Stress.
Antioxidants & redox signaling24(16)909-23(2016 Jun)
Mei X,Chaffiol A,Kole C,Yang Y,Millet-Puel G,Cl?rin E,A?t-Ali N,Bennett J,Dalkara D,Sahel JA,Duebel J,L?veillard T

Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis.
Cell161(4)817-32(2015 May)
A?t-Ali N,Fridlich R,Millet-Puel G,Cl?rin E,Delalande F,Jaillard C,Blond F,Perrocheau L,Reichman S,Byrne LC,Olivier-Bandini A,Bellalou J,Moyse E,Bouillaud F,Nicol X,Dalkara D,van Dorsselaer A,Sahel JA,L?veillard T

Thioredoxin rod-derived cone viability factor protects against photooxidative retinal damage.
Free radical biology & medicine8122-9(2015 Apr)
Elachouri G,Lee-Rivera I,Cl?rin E,Argentini M,Fridlich R,Blond F,Ferracane V,Yang Y,Raffelsberger W,Wan J,Bennett J,Sahel JA,Zack DJ,L?veillard T

Expression of rod-derived cone viability factor: dual role of CRX in regulating promoter activity and cell-type specificity.
PloS one5(10)e13075(2010 Oct)
Lambard S,Reichman S,Berlinicke C,Niepon ML,Goureau O,Sahel JA,L?veillard T,Zack DJ

The disruption of the rod-derived cone viability gene leads to photoreceptor dysfunction and susceptibility to oxidative stress.
Cell death and differentiation17(7)1199-210(2010 Jul)
Cronin T,Raffelsberger W,Lee-Rivera I,Jaillard C,Niepon ML,Kinzel B,Cl?rin E,Petrosian A,Picaud S,Poch O,Sahel JA,L?veillard T

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NXNL1 cDNA ORF clone, Mus musculus(House mouse)

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ORF Insert Sequence:

Target ORF information:

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ORF Insert Sequence:

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