Nsfl1c cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Nsfl1c |
| Entrez Gene ID | 386649 |
| Full Name | NSFL1 (p97) cofactor (p47) |
| Synonyms | Munc-18c,Stxbp3a,p47 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_001291074.1 | NP_001278003.1 | NSFL1 cofactor p47 isoform b |
| NM_198326.3 | NP_938085.1 | NSFL1 cofactor p47 isoform a |
| Bos taurus (cattle) | NSFL1C | NP_001029729.1 |
| Mus musculus (house mouse) | Nsfl1c | NP_938085.1 |
| Rattus norvegicus (Norway rat) | Nsfl1c | NP_114187.1 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP005122 | XP_314003.4 |
| Kluyveromyces lactis | KLLA0E20043g | XP_454858.1 |
| Schizosaccharomyces pombe (fission yeast) | ubx3 | NP_593429.1 |
| Arabidopsis thaliana (thale cress) | PUX5 | NP_567463.1 |
| Arabidopsis thaliana (thale cress) | PUX3 | NP_193946.2 |
| Homo sapiens (human) | NSFL1C | NP_001193665.1 |
| Pan troglodytes (chimpanzee) | NSFL1C | XP_003953711.1 |
| Gallus gallus (chicken) | NSFL1C | NP_001026030.1 |
| Danio rerio (zebrafish) | nsfl1c | NP_001007447.1 |
| Magnaporthe oryzae (rice blast fungus) | MGG_04882 | XP_003712363.1 |
| NSFL1C | XP_001113312.1 | |
| Canis lupus familiaris (dog) | NSFL1C | XP_003433246.2 |
| Saccharomyces cerevisiae (baker's yeast) | SHP1 | NP_009495.1 |
| Eremothecium gossypii | AGOS_ABR211C | NP_983160.1 |
| Oryza sativa (rice) | Os04g0464500 | NP_001053018.1 |
| Drosophila melanogaster (fruit fly) | p47 | NP_610284.1 |
| Arabidopsis thaliana (thale cress) | PUX4 | NP_567262.1 |
| Danio rerio (zebrafish) | LOC100537232 | XP_003201235.1 |
| Neurospora crassa | NCU01100 | XP_961712.1 |
Related articles in PubMed
Binding of EBP50 to Nox organizing subunit p47phox is pivotal to cellular reactive species generation and altered vascular phenotype.
Al Ghouleh I, Meijles DN, Mutchler S, Zhang Q, Sahoo S, Gorelova A, Henrich Amaral J, Rodr?guez AI, Mamonova T, Song GJ, Bisello A, Friedman PA, Cifuentes-Pagano ME, Pagano PJ
Proceedings of the National Academy of Sciences of the United States of America113(36)E5308-17(2016 09)
NADPH oxidase inhibition prevents beta cell dysfunction induced by prolonged elevation of oleate in rodents.
Koulajian K, Desai T, Liu GC, Ivovic A, Patterson JN, Tang C, El-Benna J, Joseph JW, Scholey JW, Giacca A
Diabetologia56(5)1078-87(2013 May)
RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly.
Lo JC, Jamsai D, O'Connor AE, Borg C, Clark BJ, Whisstock JC, Field MC, Adams V, Ishikawa T, Aitken RJ, Whittle B, Goodnow CC, Ormandy CJ, O'Bryan MK
PLoS genetics8(10)e1002969(2012)
Sepsis induces early alterations in innate immunity that impact mortality to secondary infection.
Delano MJ, Thayer T, Gabrilovich S, Kelly-Scumpia KM, Winfield RD, Scumpia PO, Cuenca AG, Warner E, Wallet SM, Wallet MA, O'Malley KA, Ramphal R, Clare-Salzer M, Efron PA, Mathews CE, Moldawer LL
Journal of immunology (Baltimore, Md. : 1950)186(1)195-202(2011 Jan)
Genetic ablation of NADPH oxidase enhances susceptibility to cigarette smoke-induced lung inflammation and emphysema in mice.
Yao H, Edirisinghe I, Yang SR, Rajendrasozhan S, Kode A, Caito S, Adenuga D, Rahman I
The American journal of pathology172(5)1222-37(2008 May)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Data suggest that NADPH oxidase-derived cytosolic superoxide is increased in islets upon oleate exposure and leads to beta cell dysfunction; whole-body NADPH oxidase inhibition (via p47 knockout) decreases superoxide and restores islet function.
Title: NADPH oxidase inhibition prevents beta cell dysfunction induced by prolonged elevation of oleate in rodents.
genetic ablation of components of NADPH oxidase enhances susceptibility to the proinflammatory effects of CS leading to airspace enlargement and alveolar damage.
Title: Genetic ablation of NADPH oxidase enhances susceptibility to cigarette smoke-induced lung inflammation and emphysema in mice.
that p47 ubiquitin regulatory X domain domains may act as general p97/valosin containing protein/CDC48 binding modules and that adaptor binding for N-ethylmaleimide sensitive factor and p97 might involve different binding sites
Title: Structural basis of the interaction between the AAA ATPase p97/VCP and its adaptor protein p47.
The following Nsfl1c gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nsfl1c cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu17108 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001291074.1 | |
| Accession Version | NM_001291074.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1113bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-02-23 | |
| Organism | Mus musculus(house mouse) | |
| Product | NSFL1 cofactor p47 isoform b | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ152490.1, AK013024.1 and AL928719.6. On Mar 22, 2014 this sequence version replaced XM_006499844.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a. ##Evidence-Data-START## Transcript exon combination :: AK013024.1, BC106101.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGCGGAGG AGCGGCAGGA CGCGTTGAGG GAGTTCGTGG CGGTGACTGG CACTGAGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001278003.1 |
| CDS | 127..1239 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001291074.1 |
ORF Insert Sequence:
1 | ATGGCGGAGG AGCGGCAGGA CGCGTTGAGG GAGTTCGTGG CGGTGACTGG CACTGAGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu14428 | |
| Clone ID Related Accession (Same CDS sequence) | NM_198326.3 | |
| Accession Version | NM_198326.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1119bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-02-23 | |
| Organism | Mus musculus(house mouse) | |
| Product | NSFL1 cofactor p47 isoform a | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ152490.1, AK137088.1 and AL928719.6. On Mar 22, 2014 this sequence version replaced NM_198326.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). ##Evidence-Data-START## Transcript exon combination :: AK137088.1, BC050936.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGCGGAGG AGCGGCAGGA CGCGTTGAGG GAGTTCGTGG CGGTGACTGG CACTGAGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_938085.1 |
| CDS | 127..1245 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_198326.3 |
ORF Insert Sequence:
1 | ATGGCGGAGG AGCGGCAGGA CGCGTTGAGG GAGTTCGTGG CGGTGACTGG CACTGAGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Binding of EBP50 to Nox organizing subunit p47phox is pivotal to cellular reactive species generation and altered vascular phenotype. |
|
NADPH oxidase inhibition prevents beta cell dysfunction induced by prolonged elevation of oleate in rodents. |
|
RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. |
|
Sepsis induces early alterations in innate immunity that impact mortality to secondary infection. |
|
Genetic ablation of NADPH oxidase enhances susceptibility to cigarette smoke-induced lung inflammation and emphysema in mice. |