Bst2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Bst2
Entrez Gene ID	69550
Full Name	bone marrow stromal cell antigen 2
Synonyms	2310015I10Rik,Bst-2,C87040,CD317,DAMP-1,GREG
General protein information	Preferred Names bone marrow stromal cell antigen 2 Names bone marrow stromal antigen 2 DAMP-1 protein homolog HM1.24 antigen tetherin
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8\|8 B3.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_198095.2	NP_932763.1	bone marrow stromal antigen 2 precursor
NM_198095.3	NP_932763.1	bone marrow stromal antigen 2 precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Bst2	NP_937767.1
Mus musculus (house mouse)	Bst2	NP_932763.1

Gene Ontology
Bibliography

Related articles in PubMed

A STING-dependent innate-sensing pathway mediates resistance to corneal HSV-1 infection via upregulation of the antiviral effector tetherin.
Royer DJ, Carr DJ
Mucosal immunology9(4)1065-75(2016 07)

Tetherin/BST-2 promotes dendritic cell activation and function during acute retrovirus infection.
Li SX, Barrett BS, Guo K, Kassiotis G, Hasenkrug KJ, Dittmer U, Gibbert K, Santiago ML
Scientific reports620425(2016 Feb)

Mouse tetherin enhances moloney murine leukemia virus-induced syncytium formation.
Kim HS, Han SY, Jung YT
Acta virologica60(4)372-378(2016)

Bst2/Tetherin Is Induced in Neurons by Type I Interferon and Viral Infection but Is Dispensable for Protection against Neurotropic Viral Challenge.
Holmgren AM, Miller KD, Cavanaugh SE, Rall GF
Journal of virology89(21)11011-8(2015 Nov)

Endogenous Murine BST-2/Tetherin Is Not a Major Restriction Factor of Influenza A Virus Infection.
Londrigan SL, Tate MD, Job ER, Moffat JM, Wakim LM, Gonelli CA, Purcell DF, Brooks AG, Villadangos JA, Reading PC, Mintern JD
PloS one10(11)e0142925(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

contain the spread of herpes simplex virus type 1 in vivo, STING-dependent signaling leads to the upregulation of tetherin, a viral restriction factor
Title: A STING-dependent innate-sensing pathway mediates resistance to corneal HSV-1 infection via upregulation of the antiviral effector tetherin.

Bone marrow stromal antigen 2-mediated dendritic cell activation as a critical mechanism for how Tetherin influenced retrovirus cell-mediated immune responses that subsequently inhibited retrovirus replication in vivo.
Title: Tetherin/BST-2 promotes dendritic cell activation and function during acute retrovirus infection.

Tetherin-mediated retention of R-defective virions on the cell surface could enhance syncytium formation.
Title: Mouse tetherin enhances moloney murine leukemia virus-induced syncytium formation.

Although Bst2 prevented Measles virus (MV) release from nonneuronal cells, its deletion had no effect on viral pathogenesis in MV-challenged mice.
Title: Bst2/Tetherin Is Induced in Neurons by Type I Interferon and Viral Infection but Is Dispensable for Protection against Neurotropic Viral Challenge.

BST-2 does not have a role in modulating Influenza A Virus in the mouse model of infection
Title: Endogenous Murine BST-2/Tetherin Is Not a Major Restriction Factor of Influenza A Virus Infection.

The following Bst2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bst2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu08860	NM_198095.3 Latest version!	Mus musculus bone marrow stromal cell antigen 2 (Bst2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	Quote Price
View Old Accession Versions >>
OMu08860	NM_198095.2	Mus musculus bone marrow stromal cell antigen 2 (Bst2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	Quote Price
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Bst2 ( NM_198095.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_932763.1 Mus musculus bone marrow stromal cell antigen 2 (Bst2), mRNA.

Price & Availability↑

CloneID	OMu08860
Clone ID Related Accession (Same CDS sequence)	NM_198095.2 , NM_198095.3
Accession Version	NM_198095.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 519bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-11
Organism	Mus musculus(house mouse)
Product	bone marrow stromal antigen 2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC027328.1. On Apr 6, 2007 this sequence version replaced NM_198095.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC027328.1, BC087949.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849386 [ECO:0000348] ##Evidence-Data-END##

ATGGCGCCCT CTTTCTATCA CTATCTGCCC GTGCCCATGG ATGAGATGGG GGGGAAGCAA 
GGATGGGGCA GCCACCGGCA GTGGCTGGGG GCCGCGATCT TGGTGGTCCT GTTCGGGGTT 
ACCTTAGTCA TCCTGACAAT CTACTTCGCC GTCACAGCGA ACAGCGTGGC CTGTAGAGAC 
GGGTTGCGAG CGCAGGCTGA GTGCCGGAAC ACCACGCACC TGTTGCAGCG CCAGCTCACC 
CGCACCCAGG ACAGTCTGCT GCAGGCCGAG ACACAGGCAA ACTCCTGCAA CCTGACCGTG 
GTGACCCTTC AGGAGTCCCT GGAGAAGAAG GTGTCTCAAG CCCTGGAGCA GCAGGCCCGC 
ATCAAGGAGC TTGAGAATGA AGTCACGAAG CTGAACCAGG AGCTGGAGAA TCTGAGGATC 
CAAAAGGAGA CTTCTAGCAC AGTGCAGGTG AACTCTGGCA GCTCCATGGT GGTCTCCAGC 
CTACTGGTGC TCAAAGTGTC ACTGTTCCTG CTCTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_932763.1
CDS	11..529
Translation	MAPSFYHYLPVPMDEMGGKQGWGSHRQWLGAAILVVLFGVTLVILTIYFAVTANSVACRDGLRAQAECRNTTHLLQRQLTRTQDSLLQAETQANSCNLTVVTLQESLEKKVSQALEQQARIKELENEVTKLNQELENLRIQKETSSTVQVNSGSSMVVSSLLVLKVSLFLLF

Target ORF information:

RefSeq Version	NM_198095.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus bone marrow stromal cell antigen 2 (Bst2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198095.2

ORF Insert Sequence:

ATGGCGCCCT CTTTCTATCA CTATCTGCCC GTGCCCATGG ATGAGATGGG GGGGAAGCAA 
GGATGGGGCA GCCACCGGCA GTGGCTGGGG GCCGCGATCT TGGTGGTCCT GTTCGGGGTT 
ACCTTAGTCA TCCTGACAAT CTACTTCGCC GTCACAGCGA ACAGCGTGGC CTGTAGAGAC 
GGGTTGCGAG CGCAGGCTGA GTGCCGGAAC ACCACGCACC TGTTGCAGCG CCAGCTCACC 
CGCACCCAGG ACAGTCTGCT GCAGGCCGAG ACACAGGCAA ACTCCTGCAA CCTGACCGTG 
GTGACCCTTC AGGAGTCCCT GGAGAAGAAG GTGTCTCAAG CCCTGGAGCA GCAGGCCCGC 
ATCAAGGAGC TTGAGAATGA AGTCACGAAG CTGAACCAGG AGCTGGAGAA TCTGAGGATC 
CAAAAGGAGA CTTCTAGCAC AGTGCAGGTG AACTCTGGCA GCTCCATGGT GGTCTCCAGC 
CTACTGGTGC TCAAAGTGTC ACTGTTCCTG CTCTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Bst2 ( NM_198095.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_932763.1 Mus musculus bone marrow stromal cell antigen 2 (Bst2), mRNA.

Price & Availability↑

CloneID	OMu08860
Clone ID Related Accession (Same CDS sequence)	NM_198095.2 , NM_198095.3
Accession Version	NM_198095.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 519bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Mus musculus(house mouse)
Product	bone marrow stromal antigen 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY166837.1 and BC087949.1. On Jul 30, 2018 this sequence version replaced NM_198095.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC087949.1, SRR7345562.1840805.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849386 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGCCCT CTTTCTATCA CTATCTGCCC GTGCCCATGG ATGAGATGGG GGGGAAGCAA 
GGATGGGGCA GCCACCGGCA GTGGCTGGGG GCCGCGATCT TGGTGGTCCT GTTCGGGGTT 
ACCTTAGTCA TCCTGACAAT CTACTTCGCC GTCACAGCGA ACAGCGTGGC CTGTAGAGAC 
GGGTTGCGAG CGCAGGCTGA GTGCCGGAAC ACCACGCACC TGTTGCAGCG CCAGCTCACC 
CGCACCCAGG ACAGTCTGCT GCAGGCCGAG ACACAGGCAA ACTCCTGCAA CCTGACCGTG 
GTGACCCTTC AGGAGTCCCT GGAGAAGAAG GTGTCTCAAG CCCTGGAGCA GCAGGCCCGC 
ATCAAGGAGC TTGAGAATGA AGTCACGAAG CTGAACCAGG AGCTGGAGAA TCTGAGGATC 
CAAAAGGAGA CTTCTAGCAC AGTGCAGGTG AACTCTGGCA GCTCCATGGT GGTCTCCAGC 
CTACTGGTGC TCAAAGTGTC ACTGTTCCTG CTCTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_932763.1
CDS	46..564
Translation	MAPSFYHYLPVPMDEMGGKQGWGSHRQWLGAAILVVLFGVTLVILTIYFAVTANSVACRDGLRAQAECRNTTHLLQRQLTRTQDSLLQAETQANSCNLTVVTLQESLEKKVSQALEQQARIKELENEVTKLNQELENLRIQKETSSTVQVNSGSSMVVSSLLVLKVSLFLLF

Target ORF information:

RefSeq Version	NM_198095.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus bone marrow stromal cell antigen 2 (Bst2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198095.3

ORF Insert Sequence:

ATGGCGCCCT CTTTCTATCA CTATCTGCCC GTGCCCATGG ATGAGATGGG GGGGAAGCAA 
GGATGGGGCA GCCACCGGCA GTGGCTGGGG GCCGCGATCT TGGTGGTCCT GTTCGGGGTT 
ACCTTAGTCA TCCTGACAAT CTACTTCGCC GTCACAGCGA ACAGCGTGGC CTGTAGAGAC 
GGGTTGCGAG CGCAGGCTGA GTGCCGGAAC ACCACGCACC TGTTGCAGCG CCAGCTCACC 
CGCACCCAGG ACAGTCTGCT GCAGGCCGAG ACACAGGCAA ACTCCTGCAA CCTGACCGTG 
GTGACCCTTC AGGAGTCCCT GGAGAAGAAG GTGTCTCAAG CCCTGGAGCA GCAGGCCCGC 
ATCAAGGAGC TTGAGAATGA AGTCACGAAG CTGAACCAGG AGCTGGAGAA TCTGAGGATC 
CAAAAGGAGA CTTCTAGCAC AGTGCAGGTG AACTCTGGCA GCTCCATGGT GGTCTCCAGC 
CTACTGGTGC TCAAAGTGTC ACTGTTCCTG CTCTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A STING-dependent innate-sensing pathway mediates resistance to corneal HSV-1 infection via upregulation of the antiviral effector tetherin.
Mucosal immunology9(4)1065-75(2016 07)
Royer DJ,Carr DJ

Tetherin/BST-2 promotes dendritic cell activation and function during acute retrovirus infection.
Scientific reports620425(2016 Feb)
Li SX,Barrett BS,Guo K,Kassiotis G,Hasenkrug KJ,Dittmer U,Gibbert K,Santiago ML

Mouse tetherin enhances moloney murine leukemia virus-induced syncytium formation.
Acta virologica60(4)372-378(2016)
Kim HS,Han SY,Jung YT

Bst2/Tetherin Is Induced in Neurons by Type I Interferon and Viral Infection but Is Dispensable for Protection against Neurotropic Viral Challenge.
Journal of virology89(21)11011-8(2015 Nov)
Holmgren AM,Miller KD,Cavanaugh SE,Rall GF

Endogenous Murine BST-2/Tetherin Is Not a Major Restriction Factor of Influenza A Virus Infection.
PloS one10(11)e0142925(2015)
Londrigan SL,Tate MD,Job ER,Moffat JM,Wakim LM,Gonelli CA,Purcell DF,Brooks AG,Villadangos JA,Reading PC,Mintern JD